Kim's Femoral Stem의 임상적 고찰

김영민(Young Min Kim),김희중(Hee Joong Kim),진종수(Jong Soo Jin),문영완(Young Wan Moon) 대한정형외과학회 1991 대한정형외과학회지 Vol.26 No.5

관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

Image digitzer의 設計 및 製作

金秀重,權宇鉉 慶北大學校 1983 論文集 Vol.35 No.-

A generalized image digitizer has been designed to accept a atandard NTSC video signal and to digitize an arbitrary selected window of a stationary image by the program. The digitizer has a maximum resolution 512×440 pixel, and each pixel has 256 gray level. The hardware is powerftl and is controlled by the software, so that it is connedted with any microcomputer or minicomputer. Tpe results are displayed on the CROMEMCO graphic terminal.

GH_3 세포(rat somatomammotropic tumor cell)에서 TRH가 Phospholipase D 활성에 미치는 효과

김동선,김태화,이창범,안유헌,윤미섭,한중수 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: GH_3 세포는 TRH에 반응하여 세포막의 수용체와 G 단백, PI-PLC, PKC를 활성시켜 성장호르몬 및 프로락틴을 분비한다고 알려져 있다. PLD는 phosphatidylcholine을 phosphatidic acid(PA)와 choline으로 가수분해하는 효소로서 세포의 증식과 호르몬 분비에 관여한다. 본 연구는 GH_3 세포에서 아직 알려지지 않은 TRH의 PLD 활성에 대한 영향을 규명하고자 하였다. 방법: GH_3 세포를 1.5×10^6씩 분주하고 [^3H] myristate로 표지한 다음에 0.3% 알코올로 전 처치하였다. TRH 등의 시험제를 처치한 후에 메탄올로 반응을 종결하고 세포에서 총 지질을 추출하였다. PLD 활성은 박층크로마토그래피를 이용하여 총 [^3H] phospholipid에서 [^3H] phosphatidylethanol의 비율로 구하였다. 결과: TRH (1μM)의 처치 시에 PLC 활성은 44배 증가하였다. PLD 활성은 TRH (1μM), mastoparan (5μM), PMA(500nM)를 30분간 처치 시에 각각 1.9, 1.5, 2.2배 증가하였다. TRH(1μM)의 시간에 따른 PLD 활성 변동은 15, 30, 60, 120, 240분에 각각 142%, 170%, 172%, 160%, 115%의 증가를 보였다. 결론: GH_3 세포에서 TRH의 호르몬 분비와 세포증식의 신호전달 기전으로서는 PLC 활성뿐 아니라 PLD의 활성도 관여함을 시사한다. Backgroud: GH_3 cells are a well characterized and widely used model used for the in vitro study of growth hormone (GH) secretion. Thyrotropin releasing hormone (TRH) binds to receptors belonging to the family of G protein-coupled receptors, and secrets both GH & prolactin. Phospholipase D (PLD) is and enzyme that hydrolyses phosphatidylcholine to yield phosphatidic acid and choline, and plays important roles in cellular proliferation and hormonal secretion. To elucidate the pathway of the action of TRH in GH_3 cells, we investigated the activities of PLC and PLD in GH_3 cells treated with TRH or phorbor 12-myristate 13-acetate (PMA). Methos : GH_3 cells were labeled with [^3H] myristate, followed by incubation of with 0.3% ethanol, prior to before the addition of the agonists. The total lipids were extracted from the harvested cells following treatment with the agonists. The PLD activity was assessed by measuring [^3H] phosphatidylethanol from the [^3H] phospholipid using thin layer chromatography. Results : TRH (1μM) stimulated the PLD activity by 44-fold over that of the control values. TRH (1μM), mastoparan (5μM), and PMA (500μM) for 30 minutes increased PLD activity by 1.9, 1.5 and 2.2 fold, respectively, in comparison to the controls, The PLD activities after 15, 30, 60, 120 and 240 min treatments of TRH (1μM) were 142%, 170%, 172%, 160% and 115%, respectively. Conclusion : These results suggest that TRH stimulates not only PLC activity, but also the PLD activity in GH_3 cells (J Kor Soc Endocrinol 17:465∼472, 2002).

ART의 부분 병렬 처리 알고리즘

김중수 안동대학교 기초과학연구소 1992 基礎科學 硏究論文集 Vol.3 No.1

It is shown that ART is partially parallel processed by systolic algorithm with matrix-vector multiplication in the learning phase. In the search phase, also MAXNET is adopted because of systolic algorithm. Without limitation of neuron number, this algorithm is designed. Since computation of weights sum is parallelly processed with full pipelinability, time complexity of O(n^(2)) is reduced to O(n).

질감특징과 BP를 이용한 문서영상의 새로운 블록추출 및 유형분류 기법

김중수,심재창 安東大學校 工業技術硏究所 1994 공업기술연구논문집 Vol.1 No.1

Document analysis can be composed of four steps such as block segmentaion, features extraction of the block, block classification, and recognition of character image. This paper introduces a new segmentation and classification techniques for image blocks in document images. Image blocks are segmented by the enhanced smoothing method and Sobel operator is used to reduce the backgroud noises. The classifiction of the segmented image blocks are carried out by BP(back propagation) with the 7 textural features obtained from SGLDM(spatial gray level dependence matrix). This method shows excellent results without the misclassification through the wide range of classification.

게임 시나리오 동기화 모델 GSSM의 설계 및 구현

김달중,성해경,하수철 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.2

기존의 시공간 동기화에 대한 연구는 대부분 멀티미디어 객체의 시간 동기화와 공간 동기화에 관한 연구가 이루어져 왔다. 이러한 연구는 시공간 동기화 표현에 있어서 게임의 운영 상황과 흡족히 일치하지를 못하고 있는 형편이다. 본 논문에서는 시공간 동기화에 대한 연구를 새로 제안된 시간과 공간, 시공간 언명으로 게임 시나리오에 적용하여 표현하고자 한다. 또한 시간과 공간, 시공간 공식으로 제안된 언명을 정형화된 표현법으로 나타내었으며, 게임 시나리오 동기화 모델(Game scenario Spatio-Temporal Synchronization Model : GSSM)을 설계하고 구현하였다. Most previous studies on the spatio-temporal synchronization had focused on either temporal or spatial synchronization of multimedia objects. They are not fully accorded with the status of game operation. In this paper, we apply new proposed temporal, spatial and spatio-temporal assertions for the study of spatio-temporal synchronization to game scenarios and represent them. Proposed assertions are presented with formal representations. Also, we design and implement GSSM(Game scenario Spatio-Temporal Synchronization Model) about assertions.

방사선 조사식품의 검지법

김경수,양재승,권중호 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3

폐좌상시 폐단락률과 PEEP치료의 효과

김영식,황성오,최경훈,안무업,오중환,임경수,윤정환,강성준 大韓應急醫學會 1992 대한응급의학회지 Vol.3 No.1

To evaluate the physiologic extent of pulmonary contusion and effect of PEEP therapy for pulmonary contusion, we studied 16 patients received PEEP therapy with pulmonary contusion from nonpenetrating chest trauma. Hemodynamic parameters including pulmonary vascular resistance index and intrapulmonary shunt fraction were calculated from standard measurement, and arterial oxygen tension was measured. Pulmonary vascular resistance index and intrapulmonary shunt fraction were increased in patient group. Arterial oxygen tension was decreased with increase of the intrapulmonary shunt fraction(R=0.75). Arter minimal PEEP therap(5-10 ㎝H₂O), pulmonary vascular resistance index was remained unchanged and intrapulmonary shunt fraction was decreased without significant changes of pulmonary hemodynamics. Increment of arterial tension was increased with decrease of intrapulmonary shunt fraction(R=0.43). Decreased stroke volume index suggested of cardiac injury such as cardiac contusion in patient group. These results of our study suggested that increased intrapulmonary shunt fraction caused arterial hypoxia in pulmonary contusion and arterial oxygen tension was increased as a result of reduced intrapulmonary shunt by PEEP therapy.

古代 英雄小說 變貌의 一樣相硏究 : Centering around antagonists' power development and transfiguration in the image of a hero 主人公의 能力 培養과 英雄像의 變貌를 中心으로

金重烈,安圻洙 群山大學校 1994 論文集 Vol.21 No.-

The purpose of this paper is to examine the ways of developing heroic power possessed by protagonists in old heroic novels and to investigate how they take advantage of this as a means of self-realization, and to consider what changes the figurative methods show at later stages. Especially, although power development styles were phenomena which appeared throughout old novels, different meanings were represented with different methods. It is noted that in heroic novels whose protagonists are heroes, such power development enabled them to live a successful, ascending life. Since the writers of heroic novels and ther years in which they were written are unknown, we can only make a conjecture in considering their writers and their consciousness of the era. However, it is not very difficult to examine the literary traditions at that time since the heroic novels were produced in the spatio-temporalcontext of the Yi Dynasty. It is conjectured that heroic novels have originated from lyrics in myths. This results from focusing on the heroic lives of protagonits. Consequently, it seems that the personalities of heroes in heroic novels have been changed through this process. First, let us consider the innate supernatural power of a mythological protagonist and the image of a hero. In the myth of Jumong, the protagonist appears as having the image of a hero who overcomes the conflict with the world. The protagonist Jumong's birth to diviner beings reveals that he is a descendant of a god. Her is born with innate, extraordinary power, and confronts the world for himself alone. On the other hand, in heroic novels, the image of a hero is shown through his mother's dream she has when she gets pregnant. Different from divine characters in a myth, the protagonist's divinity is revealed through his mother's dream in which her baby becomes a divine character in the future. There are some heroic novels in which antagonits perform passive power assisted by a savior. Saviors do not exist in myths or early heroic novels, but they always do appear in alte heroic novels, and they recognize the protagonist's greatness and raise heroic power. So we can see the passive image of a hero in late heroic novels. In addition to saviors' raising of protagonits's power, wupplementary tools were given to the protagonist. This made it possible to figurate an ordinary heroic character, who is more like a human being. Thus, we can see that a hero's power transfigurates from having supernatural power to absolute power in early heroic novels, and to ordinary abilities in late heroic novels.