Mossbauer 분광법에 의한 2605S3 Metglas의 배위수 및 국소자기장 분포

조익한,이상훈,강신규,양재석 嶺南大學校 基礎科學硏究所 1992 基礎科學硏究 Vol.12 No.-

We analysed the Mossbauer spectra of ferromagnetic 2605S3 Metglas submitted to various tilt angles;it is concluded that the hyperfine parameters and their correlations depend on the state of the tilt angle. The fact that the mean coordination number is 10.03, the structure of this material is well defined by Bernal's DRPHS model. Also, methods based on linear combination of spectra can be used.

Modulation of TNFSF expression in Lymphoid tissue inducer cells by dendritic cells activated with Toll-Like receptor Ligands

( Sin Suk Han ),( Ji Hye Koo ),( Jing Yu Bae ),( Soo Chan Kim ),( Song Baik ),( Mi Yeon Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.2

Toll-like receptors (TLRs), which recognize structurally conserved components among pathogens, are mainly expressed by antigen-presenting cells such as dendritic cells (DCs), B cells, and macrophages. Recognition through TLRs triggers innate immune responses and influences antigen-specific adaptive immune responses. Although studies on the expression and functions of TLRs in antigen-presenting cells have been extensively reported, studies in lymphoid tissue inducer (LTi) cells have been limited. In this study, we observed that LTi cells expressed TLR2 and TLR4 mRNA as well as TLR2 protein and upregulated OX40L, CD30L, and TRANCE expression after stimulation with the TLR2 ligand zymosan or TLR4 ligand LPS. The expression of tumor necrosis factor superfamily (TNFSF) members was significantly upregulated when cells were cocultured with DCs, suggesting that upregulated TNFSF expression may contribute to antigen-specific adaptive immune responses. [BMB reports 2011; 44(2): 129-134]

A case of SAPHO syndrome with acne scar

( Sin Wook Chun ),( Suk Young Lee ),( Jong Baik Kim ),( Hoo Min Choi ),( Byung In Ro ),( Han Gyu Choi ),( Han Kyoung Cho ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a systemic inflammatory disorder characterized by involving the skin, bone and joints. This osteoarticular and dermatological inflammatory disease was first reported 1987. Inflammatory osteitis can occur in sternoclavicular and sacroiliac joints with pain and tenderness; these symptoms can be a clue for diagnosis. In dermatologic field, acne on face and pustulosis on palm or sole can be seen. Patient was a 53-year-old woman with neck, chest and back tenderness who was consulted from rheumatologic department for evaluation of pustulosis on the palm and sole. Patient had acne scar on the face. Radiologic evaluation revealed that sternoclavicular osteitis without any infectious sign. Skin biopsy had been obtained from the palm and revealed that intraepidermal cavity filled with polymorphonuclear leukocytes associated with spongiform changes within the surrounding epidermis. The diagnosis of SAPHO syndrome was considered because of these clinical findings. We report a case of SAPHO syndrome, because it is rare and can be helpful for dermatologic doctors to diagnosis this disease.

다카야스 동맥염과 동반된 초점성 분절성 사구체경화증 1예

한대석,송영수,이호영,정현주,김주성,윤수영,최규헌,강신명,이루다,조승연 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5

Takayasu's arteritis(TA) is a chronic inflammatory and obliterative disease of medium- and large-sized arteries characterized by a strong predilection for the aortic arch and its branches. Renal involvement is usually manifested by renovascular hypertension. Glomerular involvement is rare and largely exists as a mild mesangial proliferative glomerulonephritis, commonly manifesting microscopic hematuria and proteinuria. The association of glomerular disease with TA is of interest since common immunologic mechanisms are proposed for the pathogenesis of both entities. We report a case of TA associated with focal segmental glomerulosclerosis. The patient presented with hypertension(Upper limb; Rt. 200/80mmHg, Lt. 95/60mmHg, Lower limb; Rt. 140/90mmHg, Lt. 110/70mmHg) and nephrotic syndrome(Serum albumin: 2.3g/dL, cholesterol: 454mg/dL, BUN: 18.0mg/dL, creatinine 1.3mg/dL, 24-hour urine protein: 5.17g). Digital substraction angiography showed multiple narrowing and occlusive changes of aortic arch and its branches. Renal biopsy was interpreted as focal segmental glomerulosclerosis. Therapy was instituted with prednisolone.

지속성 외래 복막투석 환자에서 복막의 이동 특성에 따른 영양상태의 비교

한대석,강신욱,이호영,이루다,황재하,최규헌 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.5

Protein-calorie malnutrition is common in CAPD patients and is associated with increase in morbidity and mortality in CAPD patients. There are many causes of malnutrition in CAPD patients, and it is well known that a large amount of protein losses through peritoneal membrane is one of them. To investigate the effect of the peritoneal membrane transport characteristics on the nutritional status in long-term CAPD patients, we conducted a cross- sectional study on clinically stable 115 patients(63 males and 52 females) who have been on CAPD for more than 2 years, and assessed nutritional status by subjective global assessment(SGA), biochemical, anthropometric and urea kinetic parameters. Patients were divided into 4 groups according to the results of standard peritoneal equilibration test(PET). The results were as follows: 1) The patients were divided into 4 groups according to the PET results: high transporter(n=16, 14%), high average transporter(n=38, 33%), low average transporter(n=50, 43%), and low transporter (n=11, 10%). 2) The mean age of the patients was 50.1±11.6 years(range, 19-75) with sex ratio(M:F) 1.2:1 and mean duration of dialysis was 57.5±27.8 months (range, 24-135). The mean body weight(Bwt) was 59.2±8.9kg, percent ideal body weight(%IBW) was 104.7±15.6%, %lean body mass(LBM)/Bwt was 82.1±11.1%, and malnourished patients by subjective global assessment(SGA) were 32.2%(38/115). 3) The mean BUN, creatinine, total protein, and albumin level of the patients were 54.5±13.1mg/dL, 12.3±3.0mg/dL, 6.7±0.8g/dL, and 3.8±0.6g/dL, respectively. 4) There were no significant differences in age, sex ratio, CAPD duration, peritonitis rate, %LBM/ Bwt, and SGA among the 4 groups. 5) Total protein(g/dL) and albumin(g/dL) levels in high transporters were 6.4±0.5, 3.5±0.4, respectively, and they were significantly lower than those of low transporters(7.2±0.6, 4.2±0.5)(P$lt;0.05). 6) 24 hour dialysate protein(g/day) and albumin (g/day) losses were significantly higher in high transporters(8.10?1) compared to those of low transporters(5.07±1.85, 2.78±0.99)(P$lt;0.05). 7) The level of IGF-1(ng/mL) was significantly lower in high transporters (150.5±86.2) compared to that of low transporters(310.3±162.1)(P$lt;0.05). 8) The level of BUN(mg/dL), Cr(mg/dL) were also lower in high transporters(45.4±13.1, 10.1±2.0) than those of low transporters(61.6±18, 14.7±2.7), but there were no significant differences in Hct, total cholesterol, prealbumin, and transferrin among the 4 groups. 9) There were no statistically significant differences in Kt/Vurea, RRF, NPCR, dietary calorie and protein intakes among the 4 groups. 10) Anthrometric parameters such as TSF, BSF, MAC and LBM measured by three different methods (LBMCr, LBMimp, LBManthro) didn't show any significant differences among the 4 groups. In conclusion, increased peritoneal permeability may not adversely affect SGA and anthropometric status of long-term CAPD patients, although it is associated with lower serum albumin, creatinine, and IGF-1 linical significance of these findings remains to be elucidated.

P160 : A statistical study of dermatoses in Goyang city (2009-2013)

( Suk Young Lee ),( Sang Yoon Lee ),( Hyun Ok Son ),( Sin Wook Chun ),( Han Gyu Choi ),( Han Kyoung Cho ),( Byung In Ro ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: The incidence of skin disease in the general hospital offers available source of information that may represent their province. The population of Goyang city has increased rapidly. Thus, statistical study of the latest data and comparison this with previous reports may be necessary. Objectives: To study the prevalence of common dermatoses and compare this with previous reports. Methods: 21,693 outpatients were reviewed who visited the Department of Dermatology at Myongji Hospital for the first time from 2009 to 2013. The 15 most common dermatoses were statistically analyzed by their sex, age and impression by medical record. Results: The 6 most common dermatoses were found to be dermatophytosis, alopecia, other eczema, urticaria, herpes zoster and viral wart. The distinct characteristic of skin disease of this study was a high incidence of herpes zoster and viral warts, as compared to the previous studies. Conclusion: High incidence of herpes zoster reflects the increasing rate of herpes zoster on a nationwide scale. Also viral wart and molluscum contagiosum which are common dermatoses to under 15 year old children, still showed high incidence as compared to the previous study done by our hospital 5 years(2004-2008) ago.

Unusual localization of digit mucous cyst: fingertip

( Sin Wook Chun ),( Hyun Ok Son ),( Suk Young Lee ),( Jong Baik Kim ),( Han Gyu Choi ),( Han Kyoung Cho ),( Byung In Ro ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Digit Mucous Cyst(DMC) is a common condition that is clinically characterized by a round to oval, translucent, smooth nodule. Etiologically, the cyst might rise de novo by fibroblast overproduction of hyaluronic acid. The buildup of mucopolysaccharides pushes the collagen of the dermis upward, forming a pseudocyst. Such pathogenesis is independent from adjacent joint and is considered as a focal cutaneous mucinosis. In addition, a direct connection from an osteoarthritic joint might allow joint fluid to escape and form a mucous cyst. DMC typically involves the lateral or dorsal surfaces of the distal interphalangeal joint or over the proximal nail fold. It is occasionally painful and uncomfortable. Histologically, they are more accurately classified as pseudocysts because there is no epithelial lining of the spaces. Within the stroma, multiple small, cleft-like spaces with a tendency for liquefaction and cavity formation coalesce to form large cystic spaces containing mucin. A 57-year-old male, construction worker patient had a hyperkeratotic corn-like nodule over the tip of his right middle finger for 1 year. Tenderness of the nodule made the patient uncomfortable which eventually made the nodule removed. Shaving biopsy and curettage was performed and mucinous material was drained. Histological examination had revealed characteristic features of a mucinous cyst. Interestingly, the cyst was on the fingertip, a very unusual localization.

P533 : A primary anetoderma at birth in the face

( Sin Wook Chun ),( Sang Yoon Lee ),( Hyun Ok Son ),( Suk Young Lee ),( Han Kyoung Cho ),( Byung In Ro ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

A case of lichen planus following the lines of Blaschko

( Suk Young Lee ),( Sin Wook Chun ),( Jong Baik Kim ),( Hoo Min Choi ),( Byung In Ro ),( Han Kyoung Cho ),( Han Gyu Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Lichen planus has certain clinical variants which may present difficulty in diagnosis especially when the lesions happen to be arranged in a linear pattern. Its pathogenesis is unknown but certainly has an immunological basis. Although lichen planus is common, the variant following the Blaschko’s line distribution could be misdiagnosed such as herpes zoster. A 47-year-old female visited our clinic with intense itching lesion on her right leg, starting 1 month ago. Erythematous and shiny papules, some of which coalesced to form plaques arranged in a linear pattern extending from right foot to inner thigh and buttock following the lines of Blaschko. She was diagnosed as herpes zoster in local clinic, and treated with antiviral agents. Skin biopsy revealed hyperkeratosis with hypergranulosis, irregular rete ridges with saw tooth appearance, and vacuolar degeneration of basal layers in the epidermis. Lichenoid band-like lymphohistiocytic infiltrates were present in the upper dermis. These findings were consistent with lichen planus. She was treated with systemic steroid and applied high potential topical steroid. After 2 months of treatment initiation, her lesions healed with post-inflammatory pigmentation. Herein, we describe a case of lichen planus occurred along the Blaschko’s lines.

P163 : A clinical study on scabies (2009-2013)

( Sin Wook Chun ),( Sang Yoon Lee ),( Hyun Ok Son ),( Suk Young Lee ),( Han Gyu Choi ),( Han Kyoung Cho ),( Byung In Ro ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Scabies is an ectoparasite caused by the mite Sarcoptes scabiei var. hominis. This very contagious dermatologic disease is not rare even today. In Goyang city, there are a lot of nursing home and the elderly. So scabies will not be rare disease and its prevalence could be increasing. Objectives: To evaluate the clinical characteristics of scabies patients and find out etiologic factors in transmission. Methods: We reviewed clinically 377 scabies patients diagnosed by microscopic examination in retrospective manner at the Myongji Hospital (2009-2013). Results: The mean age of the patients was 58.7 (male: 54.7/female: 62.8), and 75% of patients were over 50 years. Scabies was found to be most common in November and December. The suspected routes of transmission is nursing home (38.5%), caregivers (15.4%) and house(13.3%). 67.4% of scabies patients had underlying disease such as hypertension (33.7%), dementia (11.9%) and diabetes mellitus (11.9%). Conclusion: We report this clinical study to evaluate the clinical characteristics of scabies patients and find out etiologic factor in transmission.