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<SUP>18</SUP>F-FDG PET-CT에서 진단된 갑상선 우연종의 악성종양 발견율 및 특징
이강영,고건<SUP>1<.SUP>,김선국<SUP>1<.SUP>,고진철<SUP>1<.SUP>,김행수,최상용,박신희,박용휘<SUP>2<.SUP>,Kang Young Rhee,Gun Koh,<SUP>1<.SUP>,Sun Kuk Kim,<SUP>1<.SUP>,Jin Chul Koh,<SUP>1<.SUP>,Haeng Soo Kim,Sang Yong Choi,Shin 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1
<B>Purpose: </B>PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the <SUP>18</SUP>F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV). <B>Methods:</B> <SUP>18</SUP>F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation. <B>Results:</B> The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001). <B>Conclusion:</B> PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:38-42)</B>
홍종철,이형신<SUP>1<.SUP>,김성원<SUP>2<.SUP>,이강대<SUP>2<.SUP>,Jong-Chul Hong,Hyoung-Shin Lee,M.D.<SUP>1<.SUP>,Sung- Won Kim,M.D.<SUP>2<.SUP> and Kang-Dae Lee,M.D.<SUP>2<.SUP> 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.3
Purpose: Vocal symptoms have been reported after thyroidectomy and even in the absence of injury to the recurrent laryngeal nerve or the external branch of the superior laryngeal nerve. The aim of this prospective study was to evaluate the subjective and objective voice changes in patients without laryngeal nerve injury after thyroidectomy. Methods: The subjects had undergone total thyroidectomy for differentiated thyroid carcinoma from November 2007 to December 2008. Twenty-eight subjects (males: 8, females: 20) were selected for this study. Voice analysis was prospectively evaluated in the subjects at the time of preoperation and postoperation (10.8 months for the males and 11.7 months for the females). A subjective analysis was done using the visual analogue scale (VAS, 0: no symptom, 10: severe symptoms) and objective analyses were determined by several parameters such as the fundamental frequency (Fo), jitter, shimmer and the noise to harmonic ratio (NHR) using the multi-dimensional voice program. Maximum phonation time (MPT)was performed as an aerodynamic test. Results: 3 patients (37.5%) among the males and 14 patients (70%) among the females had subjective postoperative voice change. The VAS showed a significant difference for the females (0 to 1.25±0.97, P<0.001), whereas no changes were shown for the males (0 to 0.88±1.25, P>0.05). The vocal parameters (Fo, jitter, shimmer, NHR) and MPT showed no significant changes for both the males and females (P>0.05). Conclusion: Subjective voice changes may occur after thyroidectomy without laryngeal nerve injury. Surgeons should take possible voice changes into consideration when informing patients before thyroidectomy. (Korean J Endocrine Surg 2011;11:175-178)
외과 의사에 의해 시행된 갑상선 결절의 악성 종양을 시사하는 초음파 소견의 분석
고건,고진철<SUP>1<,SUP>,최상용,박신희,이광찬<SUP>1<,SUP>,김진승<SUP>1<,SUP>,Gun Go,M,D,Jin Chul Koh,M,D,<SUP>1<,SUP>,Sang Yong Choi,M,D,Shin Hee Park,M,D,Kwang Chan Lee,M,D,<SUP>1<,SUP> and Chin Seung Kim,M,D,<SUP>1< 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4
Purpose: Ultrasound is most effective study for evaluating thyroid nodules. In this review, we discuss that sonographic findings to differentiate benign from malignant nodules and suggest recommendations for indications of fine needle aspiration biopsy and thyroid nodule management. Methods: Sonographic scans of 206 thyroid nodules in 164 patients were candidated for this study. We evaluated sonographic findings by shape, calcification, margin, and echogenicity, retrospectively. Sonographic findings that suggested malignancy included microcalcifications, a speculated margin, marked hypoechogenicity and a shape that was taller than wide. The final diagnosis of lesion as benign (n=180) or malignant (n=26) was confirmed by fine needle aspiration biopsy and follow-up (>6 months). We demonstrated the difference of the sensitivity, specificity, positive predictive value, negative predictive value and accuracy. Results: Of 206 thyroid nodules, 26 were malignant. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy based on our sonographic classification method were 84.6%, 73.9%, 31.9%, 97.0% and 75.2%. Conclusion: Sonography can be helpful for making the differentiation between and malignant nodules. So, when well trained surgeon find thyroid nodules on sonography, we can make correct diagnosis of malignant nodules. (Korean J Endocrine Surg 2010;10:224-228)
Song, In Ho,Jeong, Mun Sik,Hong, Hyo Jeong,Shin, Jong Il,Park, Yong Serk,Woo, Sang-Keun,Moon, Byung Seok,Kim, Kwang Il,Lee, Yong Jin,Kang, Joo Hyun,Lee, Tae Sup American Association for Cancer Research 2019 Clinical Cancer Research Vol.25 No.20
<P><B>Purpose:</B></P><P>Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been known as a novel prognostic marker and therapeutic target for cholangiocarcinoma. This study aimed to evaluate the feasibility of immuno-PET imaging–based radioimmunotherapy using radiolabeled anti-L1CAM antibody in cholangiocarcinoma xenograft model.</P><P><B>Experimental Design:</B></P><P>We prepared a theranostic convergence bioradiopharmaceutical using chimeric anti-L1CAM antibody (cA10-A3) conjugated with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) chelator and labeled with <SUP>64</SUP>Cu or <SUP>177</SUP>Lu and evaluated the immuno-PET or SPECT/CT imaging and biodistribution with <SUP>64</SUP>Cu-/<SUP>177</SUP>Lu-cA10-A3 in various cholangiocarcinoma xenograft models. Therapeutic efficacy and response monitoring were performed by <SUP>177</SUP>Lu-cA10-A3 and <SUP>18</SUP>F-FDG-PET, respectively, and immunohistochemistry was done by TUNEL and Ki-67.</P><P><B>Results:</B></P><P>Radiolabeled cA10-A3 antibodies specifically recognized L1CAM <I>in vitro</I>, clearly visualized cholangiocarcinoma tumors in immuno-PET and SPECT/CT imaging, and differentiated the L1CAM expression level in cholangiocarcinoma xenograft models. <SUP>177</SUP>Lu-cA10-A3 (12.95 MBq/100 μg) showed statistically significant reduction in tumor volumes (<I>P</I> < 0.05) and decreased glucose metabolism (<I>P</I> < 0.01). IHC analysis revealed <SUP>177</SUP>Lu-cA10-A3 treatment increased TUNEL-positive and decreased Ki-67-positive cells, compared with saline, cA10-A3, or <SUP>177</SUP>Lu-isotype.</P><P><B>Conclusions:</B></P><P>Anti-L1CAM immuno-PET imaging using <SUP>64</SUP>Cu-cA10-A3 could be translated into the clinic for characterizing the pharmacokinetics and selecting appropriate patients for radioimmunotherapy. Radioimmunotherapy using <SUP>177</SUP>Lu-cA10-A3 may provide survival benefit in L1CAM-expressing cholangiocarcinoma tumor. Theranostic convergence bioradiopharmaceutical strategy would be applied as imaging biomarker-based personalized medicine in L1CAM-expressing patients with cholangiocarcinoma.</P>
폴리비닐클로라이드 해양광생물반응기와 고밀도 폴리에틸렌 해양광생물반응기에서 미세조류, Tetraselmis sp. KCTC12236BP의 생산성 비교
정성균(Seung-Gyun Jung),김수권(Su-Kwon Kim),변문섭(Moon-Sup Bun),조용희(Yonghee Cho),신동우(Dong-Woo Shin),김지훈(Z-Hun Kim),임상민(Sang-Min Lim),이철균(Choul-Gyun Lee) 한국해양바이오학회 2016 한국해양바이오학회지 Vol.8 No.1
It is important to design photobioreactor by cheap material for economical microalgal biomass production. In this study, two types of marine photobioreactors (MPBR), made by either polyvinyl chloride (MPBR-PVC) or high density poly ethylene (MPBR-HDPE), are used and performance of these were compared. Tetraselmis sp. KCTC 12236BP is a green marine alga that isolated from Ganghwa Island, Korea, and the strain was used for marine cultivations using MPBR-PVC and MPBR-HDPE. The cultivations were performed three times in the spring season of 2012 using MPBR-PVC and of 2013 using MPBR-HDPE in the coastal area of Young Heung Island. As the results, MPBR-PVC shows higher biomass productivities than MPBR-HDPE, due to its high light transmittance. In the cultivations using MPBR-PVC, the average sea water temperature was 11.5°C during the first experiment and 16.5°C during the second and third experiments. Average light intensities during three times for experiments were 407.5, 268.1 and 273.0 μ·E·m<SUP>-2</SUP>·s<SUP>-1</SUP>, respectively. The maximum fresh cell weight and average biomass productivity were 1.2 g·L<SUP>-1</SUP> and 0.12 g·L<SUP>-1</SUP>·day<SUP>-1</SUP>. These results showed that Tetraselmis sp. KCTC12236BP were adapted well with the environmental conditions from ocean, and grow in the MPBR-PVC and MPBR-HDPE.
( Sang Sup Shin ),( Hyun Wuk Kim ) 한국녹지환경디자인학회 2005 녹지환경학회지 Vol.1 No.2
This research tries to find the contents of the traditional and modern landscape architectural and the inclination of plans of them with the view of cultural cognition though the competitive method. This study can help make a basis to landscape architecture and qualitative improvement of a space with solution to the environmental space. There are lots of stateless landscape were produced showing tendency of amateurism, reproduction of traditional factors, composition of international style, and logical connection accompanying architecture by physiological function in modern landscape. For understand Korean character and success creatively, landscape architect must attempt to approach into sustaining culture space possessing philosophy and thought. A desirable landscape culture should be connected to living space while awareness of environmental design rule between modernism and traditional space, neo-traditionalism, late modern, architectural ism, and ecological-ism were recognized.
An Empirical Study on the Spectrum License Fee and Consumer Surplus
Sang Sup Cho(조상섭),Han Young Lie(이한영),Shin Won Kang(강신원) 사이버커뮤니케이션학회 2009 사이버 커뮤니케이션 학보 Vol.26 No.4
본 연구에서는 주파수할당대가, 해당 서비스가격 그리고 국민후생에 관한 실증적 연관관계를 탐색하기 위하여 실시하였다. 19개 OECD국가를 대상으로 분석한 결과를 보면 먼저 할당대가와 가격과의 관계는 통계적으로 유의하였으며, 할당대가의 1%증가는 서비스가격의 0.13-0.18%의 상승효과를 초래하였다. 둘째, 시장 구조적 측면에서 경쟁지수보다 사업자 수가 더 중요한 변수로 나타났다. 마지막으로 국민 후생적 관점에서 주파수할당대가는 서비스가격에 매우 큰 영향력이 존재하기 때문에 미래 중요한 정부정책수단으로 활용되어야 한다. The future broadcasting and telecommunications environment will require a wider frequency spectrum. The proper use of limited frequency resources will influence not only the development of related industries but also consumer surplus. This study is aimed at empirically analyzing the relationship between spectrum license fees and related service prices. The results of this study may be summarized as follows. First, the relationship between the spectrum license fee and pricing of telecommunications services is statistically significant: when the spectrum license fee increases by 1%, the price of telecommunication services may rise by 0.13 to 0.18%. Second, the number of service providers in the market may be a more important variable than market concentration, which reflects the way market competition affects the pricing of telecommunications services. Lastly, when looking at the development of the future telecommunications and broadcasting environment, and the trend of frequency utilization, the spectrum license fee might become an important issue, mainly as a means of achieving the policy goal of increasing the consumer surplus by lowering telecommunications service prices. Based on the results of this study, we might add the frequency management policy to the core of the market competition policy as a means of determining telecommunications service pricing. That is, the mixing of a wider range of policy-means will work toward inducing telecommunications service pricing.