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Park, Seungjoon,Yang, Inmyung,Suh, Kwangsik 경희대학교 유전공학연구소 1995 遺傳工學論文集 Vol.7 No.-
An earlier study demonstrated that pituitary tumors of good octreotide responders have high density of somatostatin receptor (SSTR). We previously reported that growth hormone (GH)-secreting pituitary tumors with Gα_(s), mutations show good response to octreotide. As Gα_(s) mutations constitutively increase intracellular cAMP, we therefore hypothesized that the mutations may induce high expression of SSTR. As a pilot study for the hypothesis, we investigated whether SSTR gene expression is activated by intracellular cAMP. As somatostatin response of the pituitary gland is believed to be mediated through SSTR2 we examined SSTR2, mRNA expression in various rat organs (cerebral cortex, hypothalamus, cerebellum, brain stem, pituitary, thyroid, adrenal gland, and testis) and tumor cell lines (C6 glioma, AtT-20, GH3, GH1, CA77, and PC12) by Northern blot assay. By using human SSTR2 cDNA probe, we could not detect any mRNA even after 2 weeks in all the rat organs and the cell lines except AtT-20 which produces ACTH. Therefore, we used reverse transcription-polymerase chain reaction (RT-PCR) to detect very small amount of the SSTR2 message. SSTR2 transcript was found in most organs (brain stem>adrenal>hypothalamus>cerebellum>pituitary>testis) and cell lines (AtT-20>GH3>PC12 CA77). GH3 cells were stimulated with forskolin and isobutylmethylxanthine, cholera toxin, and GHRH for 2 hours. The in vitro transcript of SSTR2 was increased remarkably, at 30 min whereas β-actin transcript was comparable. These preliminary data suggest that SSTR2 gene expression is transcriptionally activated by intracellular cAMP, supporting our hypothesis that Gα_(s) mutations induce high expression of SSTR to compensate the putative stimulation of somatotroph. It remains to be investigated whether the mutations of Gα_(s) activate SSTR gene expression.
Park, Seungjoon,Peng, Xiao-ding,Frohman, Lawrence A.,Kineman, Rhonda D. S. Karger AG 2005 Neuroendocrinology Vol.81 No.6
<P>In the fasted and the streptozotocin (STZ)-induced diabetic male rat, hypothalamic growth hormone (GH)-releasing hormone (GHRH) mRNA levels, and pulsatile GH release are decreased. These changes are believed to be due to a rise in hypothalamic neuropeptide Y (NPY) that inhibits GHRH expression. To directly test if NPY is required for metabolic regulation of hypothalamic neuropeptides important in GH secretion, NPY, GHRH and somatostatin (SRIH) mRNA levels were determined in fasted (48 h) and STZ-treated wild-type (NPY<SUP>+/+</SUP>) and NPY-knockout (NPY<SUP>-/-</SUP>) mice by ribonuclease protection assay. In addition, pituitary receptor mRNA levels for GHRH (GHRH-R), ghrelin (GHS-R) and SRIH (sst2) were assessed by RT-PCR. Under fed conditions the GH axis of NPY<SUP>+/+</SUP> and NPY<SUP>-/-</SUP> did not differ. In the NPY<SUP>+/+</SUP> mouse, fasting resulted in a 23% weight loss and >250% increase in NPY mRNA accompanied by a significant reduction in both GHRH and SRIH mRNA. These changes were associated with increases in pituitary expression of GHRH-R and GHS-R and a concomitant suppression of sst2. In the NPY<SUP>-/-</SUP> mouse, fasting also resulted in a 23% weight loss and comparable changes in GHRH-R and sst2, but failed to alter GHRH, SRIH and GHS-R mRNA levels. Fasting resulted in an overall increase in circulating GH, which reached significance in the fasted NPY<SUP>-/-</SUP> mouse. Induction of diabetes in NPY<SUP>+/+</SUP> mice, using a single, high-dose, STZ injection (150 mg/kg), resulted in modest weight loss (5%), and a 158% increase NPY expression which was associated with reciprocal changes in pituitary GHS-R and sst2 expression, similar to that observed in the fasted state, but no change in hypothalamic GHRH or SRIF expression was observed. Induction of diabetes in NPY<SUP>+/+</SUP> and NPY<SUP>-/-</SUP> mice, using a multiple, low-dose, STZ paradigm (5 consecutive daily injections of 40 mg/kg), did not alter body weight, hypothalamic neuropeptide expression or pituitary receptor expression, with the exception that sst2 mRNA levels were suppressed and GH levels did rise in the NPY<SUP>-/-</SUP> mouse. These observations demonstrate that NPY is not required for basal regulation of the GH axis, but is required for fasting-induced suppression of GHRH and SRIH expression, as well as fasting-induced augmentation of pituitary GHS-R mRNA. In contrast to the rat, fasting clearly did not suppress circulating GH levels in mice, but resulted in an overall rise in mean GH levels, similar to that observed in other mammalian species. The fact that many of the fasting-induced changes in the GH axis were observed in the high-dose STZ-treated mice, but were not observed in the multiple, low-dose paradigm, suggests STZ-mediated modulation of GH axis function is dependent on the severity of the catabolic state and not hyperglycemia.</P><P>Copyright © 2005 S. Karger AG, Basel</P>
다자간 / 다중연결 서비스지원을 위한 호와 베어러 분리방안에 대한 연구
박승준(Seungjoon Park),모영범(Youngbyum Mo),송주석(Jooseok Song) 한국정보과학회 1994 한국정보과학회 학술발표논문집 Vol.21 No.1
B-ISDN의 다양한 서비스지원을 위해서는 기존 N-ISDN의 신호방식으로는 한계가 있다. 따라서 향후 최종 신호프로토콜로서 ITU-TS에서 제안하고 있는 ISCP를 위해서는 호와 베어러의 분리제어가 필요하다. 이러한 분리방안이 없이는 앞으로의 다양한 서비스지원에 상당한 제약과 어려움이 예상된다. 따라서 본 고에서는 다자간/다중연결에서의 호설정과 베어러설정을 분리할 수 있는 방안과 설정된 호에 대한 사용자의 새로운 요구사항(새로운 대역폭 요구, QOS 변화, Party의 추가, 새로운 연결의 요구 등)에 따른 호절차를 기존의 연결상태의 중단 및 변화없이 수정할 수 있는 방안을 제시하였다.
태블릿 매거진의 품질요인이 지각된 유용성, 사용자 만족, 지속적 사용의도에 미치는 영향
이승준 ( Seungjoon Lee ),김이환 ( Eehwan Kim ),박주석 ( Jooseok Park ),박재홍 ( Jaehong Park ) 한국정보시스템학회 2015 情報시스템硏究 Vol.24 No.2
Purpose The number of Tablet PC users has recently increased in steep, which started to offer media companies more opportunities to enter into a new business field. Based on Information System Success model, this study finds that tablet magazine’s quality factors influence perceived usefulness, user satisfaction and intention of continuous use. Design/methodology/approach We conducted a survey for 20-40’s Tablet PC users. After pilot study, we analyzed the main survey data by using SPSS 18.0 and AMOS 18.0, and employed structural equation modeling to test the hypotheses. Findings Our research results are summarized as follows : First, information quality has a positive impact on user satisfaction, but not on perceived usefulness. Second, service quality has a positive impact on perceived usefulness, but not on user satisfaction. Third, perceived usefulness positively influences user satisfaction. Fourth, user satisfaction positively influences the intention of continuous use. In particular we found that Tablet PC usage experience had a moderating effect on the relationship between perceived usefulness and user satisfaction.
( Se Jeong Park ),( So Young Park ),( Soo Min Hong ),( Sang Youl Rhee ),( Suk Chon ),( Seungjoon Oh ),( Jeong Taek Woo ),( Sung Woon Kim ),( Young Seol Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Atypical gastrointestinal symptoms are common in patients with type 2 diabetes mellitus (T2DM). The current study was designed to evaluate the symptom improvement after the administration of rebamipide, a mucoprotective drug that stimulates prostaglandin biosynthesis in patients with T2DM. Methods: T2DM subjects whose age was 18 to 80 years with atypical gastrointestinal symptom were enrolled. Participants were obliged to answer DBSQ (Diabetes Bowel Symptom Questionnaire) before and after the 12 weeks administration of rebamipide and the change in gastrointestinal symptoms were assessed. DBSQ is comprised of 10 questions assessing the severity of gastrointestinal symptom by 1 to 6 scoring system. Follow-up assessments were done to identify drug related side effects at 6 weeks and 12 weeks. Results: Total 107 patients were enrolled and 84 patients completed the study. Mean age was 65.0±7.8, 24.8% of the subjects were male, and mean HbA1c level was 6.97±0.82%. Rebamipide 100mg was administered three times daily for each participant. DBSQ total score was reduced from 24.9±8.0 to 20.4±7.3 before and after the administration of rebamipide demonstrating a signifi cant change (p<0.001). Each score of the variables assessing heartburn, refi ux symptoms, postprandial dyspepsia, nausea or vomiting, abdominal bloating or distension, heartburn associated with gastric ulcer, abdominal pain, and constipation were improved after the administration of rebamipide (p<0.05). However, there were no signifi cant changes in irritable bowel symptoms and bowel incontinence. Severe adverse event was not reported throughout the study. Conclusions: Treatment with rebamipide for 12 weeks could be an effective treatment option for atypical gastrointestinal symptoms in subjects with T2DM.