http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Spatiotemporal analyses of the epidemiological characteristics of diabetes mellitus
Sang Youl Rhee 한국역학회 2021 Epidemiology and Health Vol.43 No.-
Research based on spatiotemporal analysis has been conducted to identify various factors that can affect an individual’s or community’s degree of health and disease. These spatiotemporal studies can effectively illustrate patterns in disease frequency, features, and temporal flow in different parts of a country. Furthermore, identifying these regional characteristics can aid in the development of disease prevention or intervention strategies.
The Role of Advanced Glycation End Products in Diabetic Vascular Complications
Rhee, Sang Youl,Kim, Young Seol Korean Diabetes Association 2018 Diabetes and Metabolism Journal Vol.42 No.3
<P>In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.</P>
Rhee, Sang Youl,Kim, Joo Young,Chon, Suk,Hwang, You Cheol,Jeong, In Kyung,Oh, Seungjoon,Ahn, Kyu Jeung,Chung, Ho Yeon,Woo, Jeong-taek,Kim, Sung Woon,Kim, Jin-Woo,Kim, Young Seol Korean Diabetes Association 2010 Korean diabetes journal Vol.34 No.3
<P><B>Background</B></P><P>There have been no systematic observations regarding changes in early phase insulin secretion among Korean prediabetes and early stage type 2 diabetes mellitus (T2DM) patients.</P><P><B>Methods</B></P><P>We conducted 75-g oral glucose tolerance tests (OGTT) in 873 subjects with suspected abnormal glucose tolerance. All subjects were diagnosed as having normal glucose tolerance (NGT), prediabetes (preDM), or T2DM according to the OGTT results and the insulin secretory and insulin resistance indices of each subject were calculated. Additionally, we analyzed the changes in early phase insulin secretion according to changes in fasting (Glc<SUB>0</SUB>), post-prandial (Glc<SUB>120</SUB>) glucose and HbA1c (A1c) levels.</P><P><B>Results</B></P><P>As compared to subjects with NGT, the insulin secretory indices of the preDM and T2DM subjects progressively declined, and the insulin resistance indices were progressively aggravated. Early phase insulin secretion decreased rapidly according to the increments of Glc<SUB>0</SUB>, Glc<SUB>120</SUB> and A1c, and these changes were most prominent in the NGT stage. Compared to the control group, the early phase insulin secretion levels of the preDM or T2DM subjects were less than 50% when Glc<SUB>0</SUB> was over 100 mg/dL, Glc<SUB>120</SUB> was over 145 mg/dL, and A1c was over 5.8%.</P><P><B>Conclusion</B></P><P>This study suggests that progressive beta cell dysfunction in Koreans may be initiated and rapidly aggravated during the period generally designated as 'normal.'</P>
Rhee, Sang Youl,Chon, Suk,Kwon, Mi Kwang,Park, Ie Byung,Ahn, Kyu Jeung,Kim, In Ju,Kim, Sung-Hoon,Lee, Hyoung Woo,Koh, Kyung Soo,Kim, Doo Man,Baik, Sei Hyun,Lee, Kwan Woo,Nam, Moon Suk,Park, Yong Soo,W Korean Diabetes Association 2011 Diabetes and Metabolism Journal Vol.35 No.5
<P><B>Background</B></P><P>The Korean National Diabetes Program (KNDP) cohort study is performing an ongoing large-scale prospective multicenter investigation to discover the pathogenesis of type 2 diabetes in Korean patients. This study was performed to examine the prevalence of chronic complications in patients with type 2 diabetes among those registered in the KNDP cohort within the past 4 years.</P><P><B>Methods</B></P><P>This study was performed between June 2006 and September 2009 at 13 university hospitals and included 4,265 KNDP cohort participants. Among the participants, the crude prevalence of microvascular and macrovascular diseases of those checked for diabetes-related complications was determined, and the adjusted standard prevalence and standardization of the general population prevalence ratio (SPR) was estimated based on the 2005 Korean National Health and Nutrition Examination Survey (KNHANES) population demographics.</P><P><B>Results</B></P><P>Among the KNDP registrants, 43.2% had hypertension, 34.8% had dyslipidemia, 10.8% had macrovascular disease, and 16.7% had microvascular disease. The SPR of the KNDP registrants was significantly higher than that of the KNHANES subjects after adjusting for demographics in the KNHANES 2005 population. However, with the exception of cardiovascular disease in females, the standardized prevalence for the most complicated items in the survey was significantly higher than that in the KNHANES subjects.</P><P><B>Conclusion</B></P><P>The prevalence of macrovascular disease and peripheral vascular disease were significantly higher in Korean patients with type 2 diabetes than in the normal population. However, no significant difference was noted in the prevalence of cardiovascular disease in females.</P>
( Sang Youl Rhee ),( Seok Won Park ),( Dae Jung Kim ),( Jeong Taek Woo ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.1
Background/Aims: A similar gender-associated trend in obesity is observed worldwide. Nevertheless, systematic analyses of gender-specific characteristics in the general Korean population are rare. Methods: We analyzed the prevalence of obesity in Korean adults aged ≥ 19 years based on data collected from the Korea Health and Nutrition Examination Surveys I to IV, and verified the obesity prevalence characteristics by gender. Results: The prevalence of obesity in Korean males increased during the past 12 years from 25.1% to 35.7%, and the trend for an increase in obesity was significant in all age groups (p < 0.001). In contrast, no significant trend over the past 12 years was identified for females, but the prevalence of obesity in the 30- to 39-year, 40- to 49-year, and 50- to 59-year subgroups decreased significantly (p < 0.05). However, the obesity prevalence in the 60- to 69-year and > 70-year female subgroups increased significantly (p < 0.05). Conclusions: We observed a gradually widening gender disparity due to an increase in the prevalence of male obesity and a decrease in the obesity prevalence among young and middle-aged women.
Familial Clustering of Type 2 Diabetes in Korean Women with Gestational Diabetes Mellitus
( Sang Youl Rhee ),( Joo Young Kim ),( Jeong Taek Woo ),( Young Seol Kim ),( Sung Hoon Kim ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.3
Background/Aims: This study was conducted to examine the relationship between family history of type 2 diabetes (T2DM) and risk of developing gestational diabetes mellitus (GDM) in Korean women. Methods: We performed a 100-g oral glucose tolerance test in 858 pregnant women who had abnormal glucose tolerance in 50-g oral glucose challenge. In addition, we reviewed the incidence of T2DM in the parents and siblings and analyzed the association between the familial history of T2DM and the risk of GDM. Results: Of the 858 subjects, 427 were normal, and 431 were diagnosed with GDM. Compared with women with no family history of T2DM, women with first degree family history of T2DM displayed higher risk of T2DM (odd ratio: parent only 1.91, sibling only 6.24, any 2.27). Conclusions: The risk of developing GDM was significantly increased in Korean women with a family history of T2DM in first-degree relatives. (Korean J Intern Med 2010;25:269-272)
( Sang Youl Rhee ),( Mi Kwang Kwon ),( Byong Jo Park ),( Suk Chon ),( In Kyung Jeong ),( Seung Joon Oh ),( Kyu Jeung Ahn ),( Ho Yeon Chung ),( Sung Woon Kim ),( Jin Woo Kim ),( Young Seol Kim ),( Jeon 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.4
Background: This study examined whether defects in insulin secretion contribute to the development and progression of type 2 diabetes mellitus (T2DM). Methods: Plasma insulin and glucose were measured after a glucose tolerance test to calculate the insulinogenic index (IGI) and the HOMA-IR Homeostasis model assessment of insulin resistance in subjects with normal glucose tolerance (NGT), prediabetes (preDM, n=49), and T2DM patients with disease duration <1 year (n=84), 1~5 years (n=45), or >5 years (n=37). Plasma proinsulin and adiponectin levels were also measured as a parameter of insulin secretion and resistance. Results: The mean HOMA-IR increased and the adiponectin levels decreased relative to the deterioration of glucose tolerance in NGT and preDM subjects. However, differences in the HOMA-IR were not related to disease duration in T2DM subjects. The mean IGI was similar in NGT and preDM subjects, but there were significant deteriorations in IGI relative to the duration of diabetes. Conclusions: Defects in both insulin sensitivity and insulin secretion contribute to T2DM, but decreased insulin secretion may be more important in the development and progression of T2DM.
Monotherapy in patients with type 2 diabetes mellitus
( Sang Youl Rhee ),( Hyun Jin Kim ),( Seung-hyun Ko ),( Kyu Yeon Hur ),( Nan-hee Kim ),( Min Kyong Moon ),( Seok-o Park ),( Byung-wan Lee ),( Kyung Mook Choi ),( Jin Hwa Kim ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.6
In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type <sub>2</sub> diabetes mellitus (T<sub>2</sub>DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.