Case Report : Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

( Ji Ye Jung ),( Yoon Jae Kim ),( Hee Man Kim ),( Hong Jeoung Kim ),( Seung Woo Park ),( Si Young Song ),( Jae Bock Chung ),( Chang Moo Kang ),( Joo Yeon Pyo ),( Woo Ick Yang ),( Seung Min Bang ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.1

Hepatoid carcinoma is a primary extrahepatic carcinoma whose morphology, immunohistochemistry, and behavior are similar to those of hepatocellular carcinoma. The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature. We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man. Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas. He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin. Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma. The patient was healthy and had no evidence of recurrence at 4 months after the surgery. This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated. (Gut Liver 2010;4:98-102)

Mixer-settler를 이용한 용매추출로 에칭폐액로부터 철과 니켈의 분리

이만승,이경주,이진영,안재우,오영주 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.12

Solvent extraction and stripping experiments were conducted to separate iron from a spent FeC13 etching solution containing nickel. In the operation of mixer-settler, 7 extraction stages with 1.0 M Alamine336 in toluene, led to 98% extraction percentage of iron at equal phase ratio, when the flow rate of organic and aqueous were 35 mL/min and 5 mL/min, respectively. At equal phase ratio of aqueous to organic, 10 stripping stages with 0.01 M HC1 solution resulted in 99% stripping percentage of iron when the flow rate of stripping solution and loaded organic were 5 mL/min and 35 mL/min, respectively. The concentration of iron in the stripped solution was 133 g/L and this solution could be reused in the etching of nickel lead frame. (Received June 15, 2004)

초음파 기관지 내시경으로 진단한 기관기관지 골연골형성증 1예

이천우,옥철호,정만홍,장태원,임성경,조은주,이신준,이혜원,구상건,천봉권 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.2

Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease of unknown etiology characterized by accumulation of calcium phosphate in the submucosa of large airways and benign proliferation of bone and cartilage resulting in nodular formation. We report a case of tracheobronchopathia osteochondroplastica diagnosed by Endobronchial ultrasonography in a 56-year-old man. Chest Computed Tomography revealed thickening of tracheal and bronchial wall, and multiple nodules through whole trachea. Endobronchial ultrasonography showed numerous submucosal nodules with hetero-echogenecity in the third and fourth layers. Histopathological examination revealed nonspecific bronchitis with squamous metaplasia and metaplastic ossification. We confirmed tracheobronchopathia osteochondroplastica. The patient's symptoms were successfully treated with antibiotics and oxygen supplyment. endobronchial ultrasonography can helpful diagnosis in tracheobronchopathia osteochondroplastica.

Mixer-Settler를 이용한 연속공정에 의한 니켈과 코발트의 추출

안재우,안종관,이만승 대진대학교 첨단소재연구소 2001 첨단소재연구소논문집 Vol.4 No.-

Extraction behaviors of Co and Ni in hydrochloric acid solutions by Alamine336(Teritary amine) have been investigated in mixer-settler. The feeding aqueous solution contained 5.0g/L nickel and 0.7g/I, Co in 5.0M hydrochliric acid solution. The organic phase being used for extractant comprised 20 vol. % Alamine336(Teritary amine) in Xylene. The 10 mixer-settler units of count current type consist of 3 extraction, 2 scrubbing, 3 stripping and 2 washing sections. The extraction percent of Co was 99 % but Ni was not extracted during 3 steps. Ni co-extracted with co was removed in 2 steps of scrubbing section by 6M hydrochloric acid solution from organic phase. Over 92% of Co from organic phase was stripped by 0.1M hydrochloric acid solution in 2 volume ratio of organic and aqueous phase. After stripping, the organic phase that was washed by 3.0 M hydrochloric acid solution in 2 volume ratio of organic and aqueous phase could be recycled for the organic solution.

ADP에 의해서 활성화된 인혈관세포의 Prothrombin과 골타액단백 부착에 관여하는 Integrin avβ3, avβ5, a5β1의 특성

주승재,최휘,김성만,차태준,이재우 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1

Background : One of the most important features of integrins is that they exist in active and inactive states. Adenosine diphosphate (ADP), which is usually secreted from activated platelets, may activate integrins on vascular on vascular cells. Each integrin has its own activation-dependent ligands that have much higher affinity to active form than inactive one. Integrins that might mediate adhesion of human vascular cells to prothrombin(PT) and bone sialoprotein (BSP) after ADP stimulation were investigated. Methods : PT and BSP were used as activation-dependent ligands in adhesion assay. Adhesions of human umbilical vein endothelial cells (HUVEC) and human aortic smooth muscle cells (HASMC) were measured after stimulating with 100 μM of ADP, using ligand-coated 24-well plate and Fluorescence Multi-Well Plate Reader. Results : ADP activated HUVEC and HASMC to increase adhesions to PT and BSP in a dose-dependent manner. Adhesions of ADP-stimulated HUVEC to PT and BSP were almost completely inhibited by c7E3, a blocking monoclonal Ab to integrin β₃(96% and 92% inhibition, respectively), but not by P5H9, a blocking monoclonal Ab to integrin α_vβ_5. Adhesion of ADP-stimulated HASMC to PT was completely blocked by P5H9 (92% inhibition), but was not affected by c7E3. Adhesion of ADP-stimulated HASMC to BSP was partially inhibited either by P5H9 (46% inhibition) or by JBS5, a blocking monoclonal Ab to integrin inhibition), but was not affected by c7E3. However, it was completely blocked by cRGD (93% inhibition). Conclusion : These results indicate that the adhesion of ADP-stimulated HUVEC to PT or BSP was mediated by integrin α_vβ₃ and several integrins appeared to be involved in the adhesion of ADP-stimulated HASMC. While the adhesion of HASMC to PT was mediated by integrin α_vβ_5, the adhesion to BSP was associated with integrins α_vβ_5 and α_5β₁.

Stage II B형 골육종에 대한 술전 항암화학요법 및 수술적 치료 결과

김정만,우영균,김형민,김훈교,이승구,강용구 가톨릭중앙의료원 가톨릭암센터 1997 암심포지움 Vol.- No.1

Recent advances in imaging techniques, surgery and combination anti-cancer chemotherapy have brought high survial rates in osteosarcoma. To investigate the survival rate, local recurrence and complications in treatment, we analysed 25 osteosarcoma cases who had been treated with preoperative neo-adjuvant chemotherapy, surgery and post operative chemotherapy at Department of Orthopedic Surgery, Catholic University. From May 1988 to April 1995, 42 cases of stage IIB osteosarcoma were admitted in Department of Orthopedic surgery. Among them, 17 cases who didn't follow our treatment guidance were excluded in this study. The average age were 19 years. There were 21 males and 4 females. The involved sites were 4 humerus, 10 femur, 10 tibia and 1 talus. Eleven cases had received intra-arterial cisplatin and intravenous adriamycin chemotherapy, and 7 T-10 protocol and 7 intravenous ifosfamide, ADR, methotrexate, cisplatin. Among twenty-three cases were treated with limb salvage surgery, and 2 amputation. The average follow-up was 35 months(3-82). There were 14 cases of continuous disease free, 9 cases of died of desease, 1 case of alive with disease, and 1 case of no evidence of disease at final follow-up. There were three cases of local recurrence at 6,8 and 12 months after operation. The Estimated kaplan-Meier's 5 year survival rates for all, ADR-cisloatin group, T-10 protocol group, and ifosfamide regimen group were 66%, 73%, 44% and 72%, respectively.

PCB 질사에칭액으로부터 질산과 유가금속의 회수

안재욱,安種寬,李晩承 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.1

A study has been made on the recovery of nitric acid and valuable metals such as Cu, Sn and Pb from the spent nitric etching solutions. The nitric acid was extracted effectively by TBP but the heavy metals such as Fe, Cu, Sn and Pb were not extracted by TBP from the spent nitric etching solutions. From the experimental results, 95% of nitric acid in spent etching solution was extracted at O:A ratio of 3:1 in five stages by 60% TBP, and 98% of nitric acid was stripped from the loaded organic phase at O:A ratio of 1:1 in four stages by distilled water. After extraction of nitric acid, Cu was effectively recovered as a metal by electrowinning and Sn was successfully removed by precipitation methode as the form of hydroxide or hydrated oxide by adjusting pH of the raffinate solution. Finally, Pb was recovered by cementation with iron scrap at above 65℃. Parameters controlling the cementation process, such as temperature, pH and the effect of the additives were investigated.

해수에 의한 부식속도 데이터 베이스의 구축과 이용에 관한 연구

윤우생,한주철,박만호,송요승 한국항공대학교 1996 論文集 Vol.34 No.-

해수분위기에서 부식속도에 관한 데이터 베이스를 구축하였다. 본 데이터 베이스 system 프로그램은 커다랗게 두가지의 기능을 가지고 있는데 한가지는 데이터를 입력하는 기능이며 다른 한가지는 검색기능이다. 각각의 기능들은 몇개의 필드로 구성 되어 있다. 데이터베이스의 주된 필드들은 record, key-no, material type, material common name, environmental condition, corrosion rate등이다. 이중 중요한 연결고리용 필드는 각 데이터 들의 key-no로 사용하였다. We construct the Data-Base about corrosion rate of metal material in the sea water. In Data-Base system program have mainly 2 functions, one is data-input mode, the other is search mode. Each mode enclose some fields. Main fields are compose of record, key-no, material type, material common name, environmental condition, corrosion rate. Relation field is key-no of each data.

염산용액에서 Alamine336에 의한 니켈과 코발트의 분리

安鍾寬,安在禹,李晩承 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.7

Solvent extraction experiments with Alamine336 from hydrochloric acid solutions containing cobalt and nickel have been performed to separate both metal ions. Cobalt was preferentially extracted from nickel by Alamine336 due to the difference betwen the complex formation constant of cobalt-chloro and nickel-chloro complex. The extraction percentage of cobalt and nickel were greatly affected by the concentration of chloride ion but were independent of solution pH when the chloride salt of Alamine336 was used as extractant. In the experimental ranges, the separation factor was increased with reaction temperature. The stripping percentage of cobalt decreased with the concentration of HCl in stripping solution.

구리, 니켈 및 코발트를 함유한 염산용액으로부터 LIX84에 의한 구리의 용매추출

안종관,안재우,오영주,이만승 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3

Solvent extraction experiments with LIX84 have been performed to separate copper from synthetic hydrochloric acid solutions containing copper, nickel and cobalt. Experimental conditions such as solution pH, the concentration of chloride ion and LIX84 and manganese ion, the volume ratio of organic to aqueous phase and pH of stripping solution have been investigated. The optimum conditions for the separation of copper from nickel and cobalt were obtained from the experimental results.