요추간판 탈출증의 비수술적 치료효과에 관여하는 요인들

윤승호,방덕영 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

This study was undertaken to find out factors predicting the results of the nonoperative treatment for lumbar intervertebral disc. Inclusion criteria were as follows : 1) The patient was comfirmed lumbar intervertebral disc in the computed tomography and/or magnetic resonance imaging by a radiologist's reading. 2) The patient had undergone an intensive physical rehabilitation program for at least four weeks. 3) The patient should have no other medical problems which delayed the period of treatment or aggravated the symptom. 4) The patient should have no previous lumbar surgery. All patients were assessed by the low back pain protocol which was composed of symptom, clinical sign and activities of daily living scales before and after the treatment. Changes in LBP score were evaluated by age, sex, occupation, duration of the symptom, means of the payment, marital status, education period, radiologic finding, self assessement and MMPI. In conclusion, poor result could be predicted after the nonoperative treatment in the patient groups of : 1) duration of the symptom over 6 months, 2) hospital payment by others, and 3) high score in the Hypochondriasis and Hysteria scales in MMPI.

삼각측량 시스템을 이용한 물체의 3-D 정보추출 관한 연구

이호영,김국세,문정환,이철승,방극인,박영옥 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.2

The 3-D shape use to effect of movie, animation, industrial design, medical treatment service, education, engineering etc... But it is not easy to make 3-D shape from the information of 2-D image. There are two methods in restoring 3-D video image through 2-D image; First the method of using a laser; Second, the method of acquiring 3-D image through stereo vision. Instead of doing two methods with many difficulties, I study the method of simple 3-D image in this research paper. We present here a simple and efficient method, called direct calibration, which does not require any equations at all. The direct calibration procedure builds a lookup table(LUT) linking image and 3-D coordinates by a real 3-D triangulation system. The LUT is built by measuring the image coordinates of a grid of known 3-D points, and recording both image and world coordinates for each point; the depth values of all other visible points are obtained by interpolation.

정하중 및 동하중을 받는 강구조물의 최적 설계에 관한 연구

노승훈,방중철,송호중 金烏工科大學校 1994 論文集 Vol.15 No.-

Nowadays, the parking is a very serious problem almost everyhere. It is even more serious in the parking lot of the high storied apartment. Many parking devices have been developed to solve this problem by increasing the parking capacity within the limited areas. In this study parking devices are considered to obtain the optimum for the capability of carrying the required load and for the minimization of the material usage for the structure. The design of the parking structure studied in this work can readily be applied to many different parking devices.

Dopamine Transporter Gene의 다형성과 알코올 의존증의 관련

최윤정,방승규,김정진,도규영,백인호 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 도파민계는 알코올 추구와 같은 알코올 의존증과 관련된 행동에 중요한 역할을 한다. Dopamine transporter(DAT1)는 신경연접부위에서 도파민 재흡수에 관여하여 도파민 활성을 종결시키는 물질로 알려져 있다. 그러므로, DAT1 유전자가 알코올 의존증에 대한 감수성에 영향을 줄 수 있다. DAT1 유전자는 다형성을 보이는 반복된 40개의 염기서열(VNTR)을 갖는다. 본 연구에서는 DAT1 유전자 다형성과 알코올 의존증 및 알코올 의존증의 임상변인과의 관련성에 대하여 알아보았다. 방 법 : 알코올 의존증 환자 94명과 정상대조군 113명을 대상으로 말초혈액을 채취하여 분리된 DNA의 DAT1 유전자를 DNA 중합효소연쇄반응으로 증폭하였다. 증폭된 산물을 15% polyacrylamide gel에서 전기영동하여 나타나는 띠의 크기에 따라 유전자형을 구분하였다. 자료의 통계적 처리는 Fisher's exact test, oneway ANOVA를 사용하였다. 결 과 : 환자군과 정상대조군의 유전자형은 모두 Hardy-Weinberg equilibrium의 예상치와 유의한 차이가 없었다. 대립유전자는 7 repeats, 9 repeats, 10 repeats, 11 repeats의 4가지 종류로 구분되었고, 유전자형은 7/7 repeats, 7/10 repeats, 9/10 repeats, 10/10 repeats, 10/11 repeats의 5가지 형태를 보였다. 환자군과 대조군간에 DAT1 유전자형 및 대립유전자 빈도는 유의한 차이가 없었고, DAT1 유전자형에 따른 음주 시작 연령, 알코올 의존증의 발병 연령 및 잠복기간에서도 차이가 없었다. 알코올 의존증의 가족력이 있는 환자군과 없는 환자군은 DAT1 유전자형의 빈도에서 차이가 있는 경향을 보였고(χ²=6.912, p=0.081), DAT1 대립유전자의 빈도에서도 유의한 차이가 있었으며(χ²=10.193, p=0.008), lambda값은 0.046였다. 결 론 : DAT1 유전자의 다형성이 알코올 의존증의 유전적 소인이 될 가능성은 적은 것으로 보이나, 알코올 의존증의 가족내 유전과는 관련있을 것으로 시사된다. Objectives : Alcoholism is known to be a heritable disease. It has been hypothesized that dopaminergic systems play an important heritable role in human behavor related to alcohol dependence, such as alcohol seeking. Therefore, genes involved in this pathway, including dopamine transporter(DAT1), which is responsible for taking released dopamine back up into presynaptic terminals and terminating dopaminergic activity, are potential candidate that may affect susceptibility to alcoholism. Analysis of a 40-base pair(bp) repeat(VNTR) in the 3' untranslated region of the DAT1 gene revealed variable number of the repeat ranging from 3 to 11 copies. Therefore, in the present study, we examined the association between alcoholism and VNTR polymorphism of DAT1. Methods : Genomic DNA analysis with polymerase chain reaction(PCR) was used to identify the presence of a VNTR polymorphism. It was carried out within a group of 94 alcoholic patients and 113 normal controls. Results : 1) There were no significant differences in allelic or genotype frequencies between the group of alcoholic patients and controls. 2) There were no significant differences in the first drinking age, onset age and latency of alcoholism according to DAT1 genotypes. 3) There was a significant difference in allelic frequencies between alcoholics with family history and those without family history. Conclusions : These results suggested that VNTR polymorphism of DAT1 is unlikely to be a factor in the genetic etiology of alcoholism, but might be related to familial transmission of alcoholism.

배당 수익률의 산업효과에 대한 국제 비교 연구

허희영,방승욱,강호정 한국항공대학교 경영연구소 2000 경영연구 Vol.7 No.2

본 연구는 배당의 형태에 산업별 효과가 존재하는가를 실증 분석하였다. 구체적으로는 미국과 캐나다의 기업들을 대상ㅇ로 하여 배당수익률에 산업효과가 존재하는가를 비모수통계기법인 H통계량을 이용하여 분석하였다. 동시에 이 배당 수익률의 산업별 형태가 시계열적으로 안정적인가를 Spearman의 순위상관계수를 이용하여 측정하였다. 검증결과 배당수익율의 산업별 차이가 없다는 귀무가설이 미국과 캐나다의 기업들에 대해 모두 기각되었으며, 산업별 평균 배당수익률의 시계열적인 안정성은 존재하는 것으로 나타났다. 본 연구의 결과는 앞으로의 기업 재무론의 여러분야를 연구시 산업효과를 고려할 필요가 있음을 시사해 주고 있다. This study tests the existence of industry effect at the behavior of dividend. This study analyzes the existence of industry effect of dividend yield using H-statistics, a one method of the non-parametric statistics, on the firms of USA and Canada. and measures time-serial stability of industrial behaviour of dividend yield using rank correlation coefficient of Spearman. The result of this study shows the existence of industry effect of dividend yield and finds time-serial stability of industrial behaviour of dividend yield. The implication based on the this study is that we have to consider industry effect at the research of corporate finance.

Tyrosine Hydroxylase 및 Tryptophan Hydroxylase와 정신분열병의 관련연구

도규영,방승규,백인호 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

본 연구에서는 세로토닌과 도파민의 속도제한효소인 tryptophan hydroxylase(TPH) 유전자의 A218C 다형성 및 tyrosine hydroxylase(TH) 유전자의 intron 1 VNTR 다형성과 정신분열병 사이의 관련연구를 시행하였다. 환자군은 가톨릭대학교 강남성모병원에 입원하였던 환자 중 정신분열병으로 진단되 374명을 대상으로 하였으며 임상아형에 따랄 양성군과 음성군으로 구분하였다. 대조군은 건강한 지원자를 대상으로 하여 393명을 포함하였다. 말초혈액 단핵구에서 DNA를 분리하였으며, 두 다형성 부위를 각각 중합효소연쇄반응에 의하여 증폭한 후, TPH A 218C 다형성은 RFLP 법으로 그리고 TH intron 1 VNTR 다형성은 은염색으로 확인하였다. TPH 유전자형의 분포는 환자군과 대조군 사이에 차이가 없었으며, 양성군과 음성군 사이에도 차이가 없었다. TH 대립유전자는 Ap : (TCAT)10, Ai : (TCAT)4CAT(TCAT)5, B : (TCAT) 9 C : (TCAT) 8, D : (TCAT) 7, E : (TCAT) 6의 6가지 유형이 확인되었다. 이 대립유전자의 분포는 환자군과 대조군 사이에서 차이가 없었으나, 양성군은 음성군에 비하여 A(Ap/Ai)의 빈도가 유의하게 높은 것으로 나타났다. TPH 유전자형과 TH 대립유전자와의 상호 관계에서는 TPH유전자형이 218C/C인 경우에서만 환자군의 TH 유전자 A형 빈도가 높은 경향을 보였다. 이상의 결과는 양성 정신분열병고 TH 대립유전자 A형 사이에 유의한 관련이 있으며, TPH 유전자형에 따른 TH 유전자의 발현이 일부 정신분열병의 발생에 영향을 미칠 수 있음을 시사한다. Neurochemical investigation has played a major role in the search for the cause of schizophrenia. Among many hypotheses, dopamine hypothesis of schizophrenia prevails despite much criticism and qualification. Recently, evidences showing the atypical antipsychotics act via serotonergic mechanism suggest serotonin system as an etiologic factor for schizophrenia. We examined the possibility of the association of enzymes critical for the synthesis of serotonin(tryptophan hydroxylase, TPH) and dopamine(tyrosine hydroxylase, TH) with schizophrenia. The regions of DNA that has been know to be polymorphic were amplified using polymerase chain reaction from the peripheral blood cells of 374 biologically unrelated schizophrenic patients and 393 healthy controls. RFLP(A218C) and NVTR polymorphism(intron 1) were examined for TPH and TH, respectively. The patterns of polymorphisms and the frequencies of each allele were not significantly different between the control and the patient groups, suggesting no possible associations of the genetic polymorphisms of TPH and TH genes and schizophrenia, However, in schizophrenics, the frequency of A type allele was significantly higher in positive group than negative group. Thess findings suggest the association of positive schizophrenia with A type allele of TH gene.

기업의 자금 조달과 투자 결정, 배당의 상호작용에 관한 실증연구

김기웅,강호정,방승욱 한국항공대학교 경영연구소 2000 경영연구 Vol.7 No.2

본 연구는 기업의 자금 흐름 측면에서 주요 재무의사결정 변수간의 상호 관련성을 고려하여 각 변수간의 실증적인 관계를 파악하였다. 구체적으로 기업의 주요 재무 의사결정 변수인 주식 자금조달 금액, 부채 자금조달 금액, 투자금액, 배당금액을 내생변수로 선정하고 이들에 영향을 주는 외생변수들을 선정한 후에 이들간의 실증적인 관계성이 어떠한지 연립방정식 모형을 설정하였다. 검정가설은 각 내생변수간의 독립적인 관계를 귀무가설로 설정하고 이단계 최소 자승법과 삼단계 최소 자승법을 사용하여 실증분석을 수행하였다. 검증 결과 주요 재무변수간에는 독립적인 관계를 부정할 만한 증거를 얻을 수 없었다. 본 연구는 재무의사결정간의 실증적인 관계성을 파악함에 있어서 기업의 자금흐름 측면에서 상호 관련성을 인정하여 연립방정식을 사용한 점에 그 공헌점이 있다. This study focuses on the empirical relation among the variables considering interrelation of critical financing decision variables in the side of fund flow of firms. This study selects main financing decision variables i,e, financing amount by issuing stock, debt amount, dividend amount as endogenous variables and examines the empirical relation among exogenous variables influencing endogenous variables using the simultaneous equation model. We set the null hypothesis as independent relation among endogenous variables and tests by two stage least square and three stage least square method. The result of this study shows independent relation among critical financing decision variables. The contribution of this study is to use simultaneous equation model to examine empirical relation among critical financing decision variables considering interrelation in the side of fund flow of firms.

사람주나무잎의 페놀성 성분

안영진,이승호,강신정,황방연,박웅양,안병태,노재섭,이경순 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

A chemical examination of the phenolic compounds in the leaves of Sapium japonicum (Euphorbiaceae) has led to the isolation of eleven phenolic compounds. containing five hydrolysable tannins and six flavonoids. On the basis of chemical and spectroscopic evidences, the structures of these compounds were confirmed to be galic acid(1), 5-O-caffeoyl quinic acid(2), 1-O-galloyl-3, 6-(R)-HHDP-β-n-glucose(coriiagin)(3), 1-O-galloyl-2.4-(R)-DHHDP-βn-glucose (furosin)(4), 1-O-galloyl-2.4-(R)-DHHDP-3.6-(R)-HHDP-β-m-glucose(geraniin)(5), astragalin(6), trifolin(7), afzelin(8), quercetin(9), isoquercitrin(10) and rutin(11). Among them geraniin was the main component.

치면열구전색제의 조건에 따른 법랑질 결합강도에 관한 연구

이용근,이흥수,이성재,방기숙,최정민,류승호,강민석 대한치과기재학회 1997 대한치과재료학회지 Vol.24 No.1

In this study, the shear bond strengths and accompanying elastic modulus ratio, displacement at bond failure and work up to fracture of pit and fissure sealants to toothe enamel were analyzed by the following variables, those were acid etching, moisture content of the surface of enamel, dentin bonding agent(species and method), thermocycling, saliva contamination. One kind of chemically cured resin based pit and fissure sealant, two kinds of light cured resin based pit and fissure sealants and one kind of glass ionomer based pit and fissure sealant, and two kinds of dentin bonding agents were studied. The buccal surface of extracted premolars were ground flat with # 600 silicone carbide papers, and the ground surface was treated depending on the experimental conditions. After each treatment, each pit and fissure sealant was filled into plastic tube of 3mm diameter, which were laid on the surface of ground enamel surface, and were cured. Sealant bonded teeth specimens were immersed in 37℃ distilled water form 24 hours. The shear bond strength of sealant to enamel surface was measured with Universal testing machine with the cross head speed of 1mm/min. From the obtained load-deflection curves, modulus ratio, bond strength, displacement at bond failure and work up to fracture were analyzed. From this experiment, the following results were obtained : 1. Comparing the results of standard condition(i. e. acid etching, dry surface, no dentin bonding agent and 300 thermocyling), the elastic modulus ratio of chemically cured resinbased pit and fissure sealant was significantly higher than those of other materials(P<0.05), and the bond strength, displacement at bond failure and work up to fracture of glass ionomer based pit and fissure sealant were significantly lower than those of other materials(P<0.05). 2. The results of ANOVA with the variables of type of material, acid etching, moisture condition of the enamel surface, dentin bonding agents were as follows ; 1) variables showed significant main effect on the shear bond strength of pit and fissure sealant to enamel(P<0.01), 2) type of material, acid etching and moisture condition of enamel influenced the bond strength significantly(P<0.01), 3) type and application methods of dentin bonding agents influenced on the bond strength significantly(P<0.05). 3. There were statistically significant correlation between the work up to fracture and the bond strength, and between the work up to fracture and the displacement at bond failure(P<0.01), and in these cases the correlation coefficient was 0.87.

하악 우악부 골절의 구내접근법에 대한 임상적 평가

진국범,박경옥,이동근,장동호,민승기,방만혁 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Recently, we have used internal fixation with titanium miniplate which introduced by Champy in 1976 in facial bone fractures. In cases of mandibular fractures, particulary mandibular angle fractures, we usually underwent the open reduction extraorally. But extraoral approaches may leave scars and put the facial nerve at greater risk. So, we had undergone the intraoral approaches in 31 patients of mandibular angle fractures (male : 29, female : 2)> These patients visited in Wonkwang university hospital from October 1991 to June 1993. We got easy operation time as average 20 minutes than extraoral approach. And reduced the postoperative nerve injury(14.2%), but postoperative infection is 6.1% nearly as same as extraoral approach. TMJ problems after intraoral open reduction was similar to extraoral approaches.