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Is Heparin Effective for the Controlled Delivery of High-Dose Bone Morphogenetic Protein-2?
Kim, Ri Youn,Lee, Beomseok,Park, Si-Nae,Ko, Jae-Hyung,Kim, In Sook,Hwang, Soon Jung Mary Ann Liebert 2016 Tissue engineering. Part A Vol.22 No.9
<P>Sustained release of bone morphogenetic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low-dose BMP-2. However, its effect with high-dose BMP-2 is still unclear and should be clarified considering the clinical use of a high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of a heparin-conjugated collagen sponge (HCS) with high-dose BMP-2 delivery by investigating in vivo initial osteogenic regulation and bone healing over 12 weeks in comparison with that of an absorbable collagen sponge (ACS). The in vitro BMP-2 release profile in the HCS exhibited a lower burst followed by a sustained release of BMP-2, whereas that of the ACS showed an initial burst phase only. As a result of a lower burst, the HCS-BMP group showed higher expression of bone-forming/resorbing markers and enhanced activation of osteoclasts than the ACS-BMP group within the scaffold of defect after 7 days, which is presumed to be because of retention of relatively higher amounts of BMP-2. However, the surrounding calvariae were less resorbed in the HCS-BMP group, compared with the aggressive resorptive response in the ACS-BMP group. Microcomputed tomography and histology revealed that HCS-BMP guided more effective bone regeneration of central defect over time inducing minor ossification at the defect exterior, whereas ACS-BMP exhibited excessive ossification at the defect exterior. These results showed that HCS-mediated BMP-2 delivery at a high dose has advantages over ACS, including less early resorption of surrounding bone tissue and higher efficacy in compact bone regeneration over a longer period, highlighting a clinical feasibility of this technology.</P>
Mi-Ri-Nae Park,Kyung-Yae Hyun,Seong-Min Moon,Yun-Tae Kim,Dae-Sik Kim,Shin-Beum Kang,Seok-Cheol Choi 대한의생명과학회 2008 Biomedical Science Letters Vol.14 No.4
The present study was designed to clarify whether scuba diving at 5 meters of seawater influences cerebral hemodynamics, hematological and biochemical variables. Twenty healthy young men well trained scuba diving participated in this study. The blood flow velocity in the right and left middle cerebral arteries (L-MCAV and R-MCAV), blood pressure (BP), heart rate (HR), CBC and differential count, prothrombin time (PT), activated partial thromboplastin time (aPTT), biochemical variables, D-dimer and interleukin-8 (IL-8) levels were determined before, immediately after scuba diving for 30 min, and after 30 min of rest (Pre-scuba, Scuba and R-30m, respectively). L-MCAV and R-MCAV tended to increase, but the only significant increase was in L-MCAV in Scuba. SBP and HR significantly declined in R-30m compared with those of Pre-scuba and the Scuba. IL-8 levels were elevated in Scuba and R-30m compared with that of Pre-scuba. In Scuba and R-30m, hematological variables except PT and biochemical parameters excluding glucose and lactic acid did not significantly changed in comparison with those of Pre-scuba. PT level at Scuba and glucose level at R-30m significantly declined in Scuba, while lactate level at R-30m increased compared with each in Pre-scuba. However, PT level at Scuba was within a normal range. These results suggest that scuba diving at 5 m of seawater for 30 min has no adverse effects, is safe and useful for improving health. However, further study must be performed to clarify the mechanism of elevated IL-8 level following scuba diving.
Affecting factors on the decline of serum antimullerian hormone after ovarian cystectomy
( Bomin Kim ),( Eunbi Jang ),( Nae Ri Kim ),( Eun Jung Yang ),( Seung-hyuk Shim ),( Sun Joo Lee ),( Tae Jin Kim ),( Kyeong A So ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: To investigate the affecting factors on the decline of serum antimullerian hormone (AMH) in the reproductive aged women with ovarian cystectomy. Methods: This retrospective study included reproductive aged women who underwent ovarian cystectomy for benign disease from January 2019 to March 2020 at the Konkuk University Medical Center. Medical charts were reviewed about clinical characteristics, preoperative/postoperative serum AMH levels, operative records, and histopathologic results. Results: During the study period, 40 patients were included. The mean age of the patients was 33.3 years old. All patients except one underwent minimally invasive surgery including robotic and laparoscopic ovarian cystectomy. Twenty-six patients found to be endometriotic cyst and 14 patients were non-endometriotic cyst. During the surgery, the method of hemostasis after ovarian cystectomy was performed mainly by suture (97.5%) instead of electrocoagulation (2.5%). The rate of decline of serum AMH level showed statistically significant associations with age (r=0.325, p=0.040), duration of surgery (r=0.424, p=0.006), endometriosis (p<0.0001), bilaterality of ovarian cyst (p=0.014), and adhesiolysis during surgery (p=0.012). A logistic regression analysis was performed for affecting factors on the postoperative AMH decline (≥ 50%) compared to preoperative AMH level. Endometriosis was the only statistically associated with postoperative AMH decline (Odd ratio 7.10; 95% confidential interval, 1.06-47.76; p= 0.044). Conclusion: The rate of decline of serum AMH level is significant association with age, duration of surgery, endometriosis, bilaterality of ovarian cyst, and adhesiolysis during surgery. In particular, endometriosis appears to be the main cause of AMH decline.
Park, Mi-Ri-Nae,Hyun, Kyung-Yae,Moon, Seong-Min,Kim, Yun-Tae,Kim, Dae-Sik,Kang, Shin-Beum,Choi, Seok-Cheol The Korean Society for Biomedical Laboratory Scien 2008 Journal of biomedical laboratory sciences Vol.14 No.4
The present study was designed to clarify whether scuba diving at 5 meters of seawater influences cerebral hemodynamics, hematological and biochemical variables. Twenty healthy young men well trained scuba diving participated in this study. The blood flow velocity in the right and left middle cerebral arteries (L-MCAV and R-MCAV), blood pressure (BP), heart rate (HR), CBC and differential count, prothrombin time (PT), activated partial thromboplastin time (aPTT), biochemical variables, D-dimer and interleukin-8 (IL-8) levels were determined before, immediately after scuba diving for 30 min, and after 30 min of rest (Pre-scuba, Scuba and R-30m, respectively). L-MCAV and R-MCAV tended to increase, but the only significant increase was in L-MCAV in Scuba. SBP and HR significantly declined in R-30m compared with those of Pre-scuba and the Scuba. IL-8 levels were elevated in Scuba and R-30m compared with that of Pre-scuba. In Scuba and R-30m, hematological variables except PT and biochemical parameters excluding glucose and lactic acid did not significantly changed in comparison with those of Pre-scuba. PT level at Scuba and glucose level at R-30m significantly declined in Scuba, while lactate level at R-30m increased compared with each in Pre-scuba. However, PT level at Scuba was within a normal range. These results suggest that scuba diving at 5 m of seawater for 30 min has no adverse effects, is safe and useful for improving health. However, further study must be performed to clarify the mechanism of elevated IL-8 level following scuba diving.
Serum Cadmium Level Is Positively Associated with Unruptured Intracranial Aneurysm Incidence
Bich Nae Ri Yoon,Jun Beom Lee,Ga Heon Jin,Won Yong Kim 대한가정의학회 2019 Korean Journal of Family Medicine Vol.40 No.4
Background: Cadmium is a toxic element in cigarette smoke associated with ischemic vascular disease. Its associa-tion with cerebral aneurysm is unknown.Methods: We retrospectively analyzed the medical records of patients with headache who underwent imaging studies between March 2014 and August 2016. An unruptured intracranial aneurysm (UIA) was confirmed by brain magnetic resonance angiography or computed tomography angiography. A control group included age- and sex-matched patients without an UIA. Whole blood and random urine tests were used for detection of cadmium and arsenic levels, respectively. Student t-test was used to compare subject characteristics, mean cadmium and arsenic levels between groups, and differences between groups with small (<4-mm) and large (≥4-mm) UIAs. Multivariate regression analysis was used to identify risk factors for aneurysm incidence.Results: Of 238 patients, 25 had an UIA. Those with an UIA had more pack-years of smoking (19.5±3.8 vs. 12.5±6.8, P=0.044) and higher mean serum cadmium levels (1.77±0.19 vs. 0.87±0.21 µg/L, P=0.027). Arsenic levels showed no difference between groups. (67.4±23.5 vs. 62.2±18.3 µg/L, P=0.458). There were no significantly different demo-graphic, clinical, or laboratory characteristics between small and large aneurysm groups. According to multivariate analysis, smoking (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.06–2.33; P=0.047) and serum cadmium >2.0 mcg/L (OR, 1.39; 95% CI, 1.15–1.84; P=0.043) were associated with aneurysm incidence.Conclusion: UIA incidence was associated with pack-years of smoking and serum cadmium level, but aneurysm size was not associated with serum cadmium level.