Review : What is the proper work-up of the patient with clinical early stage uterine adenocarcinoma

( Bruce Patsner ),( Matthew L Anderson ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.7

Objective: To discuss the proper preoperative workup of patients with uterine adenocarcinoma who present with disease clinically confined to the uterine corpus. Methods: Review of recommendations suggested in major textbooks in gynecologic oncology over the past thirty five years as well as select recent publications in the gynecologic oncology literature in Asia as well as the United States and Europe. Results: The suggested preoperative testing for the patient population under consideration has evolved over the years depending on whether the patient is at low risk or high risk for occult metastatic disease, Conclusion: Standard preoperative testing is always indicated but preoperative CA-125 and advanced radiological imaging are never routinely indicated for "low risk" patients. Either test may be indicated in select high-risk patients in the setting of clinical investigation though it is unclear which test, if either, provides enough meaningful clinical information which will either alter surgical management or which may be justified in light of the predicted high percentage of patients who will have normal preoperative test results.

Optimization of organic bi-layer solar cell through systematic study of anode treatment and material thickness

박진호,Young Wook Kim,Matthew L. Monroe,Jiyoun Seol,Nguyen Tam Nguyen Truong,조성민,Timothy J. Anderson 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.5

The performance of bi-layer organic solar cells with the structure ITO/PEDOT:PSS/CuPc/C60/BCP/Al was optimized. Prior to cell deposition, an optimal indium tin oxide (ITO) surface treatment technique was determined, with N2 plasma treatment providing the highest solar cell efficiency. Parametric studies were performed to identify optimal fabrication conditions and deposition thicknesses for each layer by using solar cell efficiency as the primary performance measure.

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

Blanton, Michael R.,Bershady, Matthew A.,Abolfathi, Bela,Albareti, Franco D.,Prieto, Carlos Allende,Almeida, Andres,Alonso-Garcí,a, Javier,Anders, Friedrich,Anderson, Scott F.,Andrews, Brett,Aqu American Institute of Physics 2017 The Astronomical journal Vol.154 No.1

<P>We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and. high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z similar to 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z similar to 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs. and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the. Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.</P>

Cell signaling heterogeneity is modulated by both cell-intrinsic and -extrinsic mechanisms: An integrated approach to understanding targeted therapy

Kim, Eunjung,Kim, Jae-Young,Smith, Matthew A.,Haura, Eric B.,Anderson, Alexander R. A. Public Library of Science 2018 PLoS biology Vol.16 No.3

<▼1><P>During the last decade, our understanding of cancer cell signaling networks has significantly improved, leading to the development of various targeted therapies that have elicited profound but, unfortunately, short-lived responses. This is, in part, due to the fact that these targeted therapies ignore context and average out heterogeneity. Here, we present a mathematical framework that addresses the impact of signaling heterogeneity on targeted therapy outcomes. We employ a simplified oncogenic rat sarcoma (<I>RAS</I>)-driven mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase-protein kinase B (PI3K-AKT) signaling pathway in lung cancer as an experimental model system and develop a network model of the pathway. We measure how inhibition of the pathway modulates protein phosphorylation as well as cell viability under different microenvironmental conditions. Training the model on this data using Monte Carlo simulation results in a suite of in silico cells whose relative protein activities and cell viability match experimental observation. The calibrated model predicts distributional responses to kinase inhibitors and suggests drug resistance mechanisms that can be exploited in drug combination strategies. The suggested combination strategies are validated using in vitro experimental data. The validated in silico cells are further interrogated through an unsupervised clustering analysis and then integrated into a mathematical model of tumor growth in a homogeneous and resource-limited microenvironment. We assess posttreatment heterogeneity and predict vast differences across treatments with similar efficacy, further emphasizing that heterogeneity should modulate treatment strategies. The signaling model is also integrated into a hybrid cellular automata (HCA) model of tumor growth in a spatially heterogeneous microenvironment. As a proof of concept, we simulate tumor responses to targeted therapies in a spatially segregated tissue structure containing tumor and stroma (derived from patient tissue) and predict complex cell signaling responses that suggest a novel combination treatment strategy.</P></▼1><▼2><P><B>Author summary</B></P><P>A signaling pathway is a network of molecules in a cell that is typically initiated by stimuli (e.g., microenvironmental cues) acting on receptors and internal signaling molecules to determine cell fate. Signaling pathways in cancer cells are different from those in normal cells, and this difference helps cancer cells to grow and thrive indefinitely. Drugs that target the aberrant signaling pathways in cancer cells (often referred to as targeted therapy) are promising for improving treatment outcomes of many different cancers in patients. However, most patients eventually develop resistance to these drugs. Resistance may already be present in the tumor or may emerge via mutation or via microenvironmental mediation. Tumor heterogeneity, which is characterized by subtle or dramatic differences among tumor cells, plays a key role in the development of drug resistance. Some tumor cells respond well to therapy, while others may adapt to the stress induced by the drug within the microenvironment. Moreover, removal of drug-sensitive cells may result in the competitive release of drug-resistant cells. Here, we present mathematical models to assess the impact of heterogeneity in signaling pathways within tumor cells on the outcomes of targeted therapy. We consider a simplified version of two well-known signaling pathways that modulate the growth of lung cancer cells. By using different targeted therapies, we quantify the effect of pathway inhibition on protein activity and cell viability and developed a mathematical model of the network, which is trained to reproduce these data and to develop a panel of heterogeneous in silico cells. The model predicts potential mechanisms of drug resistance and proposes combination therapies that are effective across the panel. We validate th

Controlling the morphology of trioctyl phosphine oxide-coated cadmium selenide/poly 3-hexyl thiophene composite active layer for bulk hetero-junction solar cells

Nguyen Tam Nguyen Truong,박진호,Matthew Lowell Monroe,Umme Farva,Timothy James Anderson 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.7

Bulk hetero-junction solar cells with CdSe nanoparticles-P_3HT (poly 3-hexyl thiophene) composite active layer were fabricated, and the control of morphological feature of the nanoparticle-polymer composite thin films was investigated. A binary solvent composed of a primary solvent with intermediate polarity and a secondary solvent with high polarity was found to be effective in controlling the dispersion of the CdSe nanocrystals in the P_3HT matrix, and the modification of the nanocrystal surface by liquid-liquid extraction process was found to be effective in achieving the desired composite film morphology. Surface roughness of the active layer was optimized for various loadings of CdSe nanoparticles and could be reproducibly controlled to less than 10 nm.

Forecasting the flap: predictors for pediatric lower extremity trauma reconstruction

Kasra N. Fallah,Logan A. Konty,Brady J. Anderson,Alfredo Cepeda Jr,Grigorios A. Lamaris,Phuong D. Nguyen,Matthew R. Greives 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.1

Background Predicting the need for post-traumatic reconstruction of lower extremity injuries remains a challenge. Due to the larger volume of cases in adults than in children, the majority of the medical literature has focused on adult lower extremity reconstruction. This study evaluates predictive risk factors associated with the need for free flap reconstruction in pediatric patients following lower extremity trauma. Methods An IRB-approved retrospective chart analysis over a 5-year period (January 1, 2012 to December 31, 2017) was performed, including all pediatric patients (<18 years old) diagnosed with one or more lower extremity wounds. Patient demographics, trauma information, and operative information were reviewed. The statistical analysis consisted of univariate and multivariate regression models to identify predictor variables associated with free flap reconstruction. Results In total, 1,821 patients were identified who fit our search criteria, of whom 41 patients (2.25%) required free flap reconstruction, 65 patients (3.57%) required local flap reconstruction, and 19 patients (1.04%) required skin graft reconstruction. We determined that older age (odds ratio [OR], 1.134; P=0.002), all-terrain vehicle accidents (OR, 6.698; P<0.001), and trauma team activation (OR, 2.443; P=0.034) were associated with the need for free flap reconstruction following lower extremity trauma in our pediatric population. Conclusions Our study demonstrates a higher likelihood of free flap reconstruction in older pediatric patients, those involved in all-terrain vehicle accidents, and cases involving activation of the trauma team. This information can be implemented to help develop an early risk calculator that defines the need for complex lower extremity reconstruction in the pediatric population.

Medicinal Chemistry : A new antimalarial polyether from a marine Streptomyces sp. H668

( Min Kyun Na ),( Damaris A. F. Meujo ),( Doin Kevin ),( Mark T. Hamann ),( Matthew Anderson ) 영남대학교 약품개발연구소 2009 영남대학교 약품개발연구소 연구업적집 Vol.19 No.-

Concentrator photovoltaic module architectures with capabilities for capture and conversion of full global solar radiation

Lee, Kyu-Tae,Yao, Yuan,He, Junwen,Fisher, Brent,Sheng, Xing,Lumb, Matthew,Xu, Lu,Anderson, Mikayla A.,Scheiman, David,Han, Seungyong,Kang, Yongseon,Gumus, Abdurrahman,Bahabry, Rabab R.,Lee, Jung Woo,P National Academy of Sciences 2016 Proceedings of the National Academy of Sciences Vol.113 No.51

<P>Emerging classes of concentrator photovoltaic (CPV) modules reach efficiencies that are far greater than those of even the highest performance flat-plate PV technologies, with architectures that have the potential to provide the lowest cost of energy in locations with high direct normal irradiance (DNI). A disadvantage is their inability to effectively use diffuse sunlight, thereby constraining widespread geographic deployment and limiting performance even under the most favorable DNI conditions. This study introduces a module design that integrates capabilities in flat-plate PV directly with the most sophisticated CPV technologies, for capture of both direct and diffuse sunlight, thereby achieving efficiency in PV conversion of the global solar radiation. Specific examples of this scheme exploit commodity silicon (Si) cells integrated with two different CPV module designs, where they capture light that is not efficiently directed by the concentrator optics onto large-scale arrays of miniature multi-junction (MJ) solar cells that use advanced III-V semiconductor technologies. In this CPV+ scheme ('+' denotes the addition of diffuse collector), the Si and MJ cells operate independently on indirect and direct solar radiation, respectively. On-sun experimental studies of CPV+ modules at latitudes of 35.9886 degrees N (Durham, NC), 40.1125 degrees N (Bondville, IL), and 38.9072 degrees N (Washington, DC) show improvements in absolute module efficiencies of between 1.02% and 8.45% over values obtained using otherwise similar CPV modules, depending on weather conditions. These concepts have the potential to expand the geographic reach and improve the cost-effectiveness of the highest efficiency forms of PV power generation.</P>

Impact of hematologic toxicities during concurrent chemoradiation for cervical cancer

Feiya Shi,Alison K. Yoder,Claire Mach,Shraddha Dalwadi,Matthew L Anderson,Tracilyn R Hall,Michelle S Ludwig 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.2

ObjectiveTo evaluate the prognostic significance of hematological toxicities during cervical cancer treatment. MethodsPatients treated for cervical carcinoma with definitive chemoradiation were identified. Toxicities were assessed duringweeks 1 to 6 of concurrent external beam radiation and chemotherapy. Outcomes were analyzed using Cox regressionanalysis. ResultsOne hundred twenty-one patients with Federation of Gynecology and Obstetrics stage I-III disease were eligible foranalysis. Median age at diagnosis was 45 years (interquartile range, 40-52) with median follow-up time of 34 months(95% confidence interval, 30.8-37.2). All patients experienced some grade of hematologic toxicity. The most commongrade 3+ toxicities were low absolute lymphocyte count (n=115, 95%), low white blood cell count (n=21, 17%), andanemia (n=11, 9%). The most common grade 4 toxicity was lymphopenia, experienced by 36% of patients (n=44). Grade 4 lymphopenia was associated with reduced overall survival (hazard ratio [HR], 4.5; P=0.005), progressionfreesurvival (HR, 3.4; P=0.001), and local control (HR, 4.1; P=0.047). Anemia grade 3, 4 was also associated withreduced overall survival (HR, 4.1; P=0.014). After controlling for disease and treatment variables, grade 4 lymphopeniaremained significantly associated with reduced overall survival (HR, 9.85; P=0.007). The association with grade 4lymphopenia only remained significant in women of Hispanic ethnicity. ConclusionSevere lymphopenia was associated with reduced overall survival and progression-free survival in Hispanic womenundergoing definitive chemoradiation for cervical cancer, but not associated with outcomes in non-Hispanic women.

Comparison of transarterial n-BCA and Onyx embolization of brain arteriovenous malformations: A single-center 18-year retrospective analysis

Behzadi Faraz,Heiferman Daniel M,Wozniak Amy,Africk Benjamin,Ballard Matthew,Chazaro Joshua,Zsigray Brandon,Reynolds Matthew,Anderson Douglas E,Joseph C Serrone 대한뇌혈관외과학회 2022 Journal of Cerebrovascular and Endovascular Neuros Vol.24 No.2

Objective: Brain arteriovenous malformations (AVM) are commonly treated with endovascular embolization. Due to the rapid evolution of endovascular technology and lack of consistent practice guidelines regarding AVM embolization, further study of AVM embolization outcomes is warranted.Methods: We conducted a retrospective review of AVMs embolized at a single center from 2002-2019. Patient demographics, AVM characteristics, intention of embolization, and angiographic and clinical outcome after embolization were recorded. We compared the embolization results of those treated with n-butyl cyanoacrylate (n-BCA) and Onyx.Results: Over an 18-year period at our institution, 30 (33%) of 92 AVMs were treated with embolization. n-BCA was used in 12 cases and Onyx in 18 cases. Eighty-seven pedicles were embolized over 47 embolization sessions. Fifty percent of AVMs treated with n-BCA underwent more than one embolization session compared to 22% when Onyx was used. The median total percent volume reduction in the n-BCA AVMs was 52% compared to 51% in Onyx AVMs. There were 2 periprocedural complications in the n-BCA cohort and none in the Onyx cohort.Conclusions: In this small retrospective series, Onyx and n-BCA achieved similar occlusion results, although n-BCA required more sessions and pedicles embolized to do so.