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( Estate M Sokhadze ),( Kyung Hwa Lee ),( Long Mee Lee ),( Long In Oh ),( Jin Hun Sohn ) 한국감성과학회 2000 춘계학술대회 Vol.2000 No.-
One of the most important topics in attentional and emotional modulation of cardiac responses is time course of cardiac chronotropic response. The reason lies in dual innervation of heart, which leads to occurrence of several phases of cardiac response during exposure to affective stimuli, determined by the balance of sympathetic and parasympathetic influences. Cardiac chronotropic reactivity thus represents QUlte effective measure capable to trace the moment when attending and orienting processes (i.e., sensory intake of stimulus) prime relevant behavioral response (i.e., emotion with approach or avoidance tendencies). The aim of this study was to find the time course of heart rate (HR) responses typical for negative (disgust, surprise, fear, anger) and positive (happiness, pleasant erotic) affective pictures and to identify cardiac response dissociation for emotions with different action tendencies such as "approach" (surprise, anger, happiness) and "avoidance" (fear, sadness, disgust). Forty college students participated in this study where cardiac responses to slides from Laps intended to evoke basic emotions (surprise, fear, anger, sadness, disgust, happiness, pleasant-erotic). Inter-beat intervals of HR were analyzed on every 10 sec basis during 60 sec long exposure to affective visual stimuli. Obtained results demonstrated that differentiation was observed at the very first 10 s of exposure (anger-fear, surprise-sad, surprise-erotic, surprise-happiness pairs), reaching the peak of dissociation at 30 s (same pairs plus surprise-disgust and surprise-fear) and was still effective for some pairs (surprise-erotic, surprise-sad) even at 50 s and 60 s. Discussed are potential cardiac autonomic mechanisms underlying attention and emotion processes evoked by affective stimulation and theoretical considerations implicated to understand the role of differential cardiac reactivity m the behavioral context (e.g., approach-avoidance tendencies, orienting-defense responses).
Paw Edema was Reduced in Carrageenan Induced Acute Inflammation in Stat4 Deficient Mice
Zheng, Long-Tai,Baik, Haing-Woon,Lee, Seong-Kyu,Cho, Jeong-Je,Park, Cheung-Seog,Hong, Mee-Suk,Chung, Joo-Ho,Yim, Sung-Vin The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.4
Signal transducer and activator of transcription 4 (STAT4) is one of the important mediators in generating inflammation and immune responses. To address the role of Stat4 in carrageenan induced acute inflammation, we performed paw edema measurement and 7.4 k mouse cDNA microarray analysis in carrageenan induced acute inflammation in Stat4 knockout (-/-) mice. Male BALB/c (n=8) and Stat4 -/- (n=5) were used and paw edema was induced with injection of $30\;{\mu}L$ of 1% carrageenan into plantar surface of right hind paw. Next, we isolated the mRNA in mouse whole brain and analyzed cDNA microarray profiles for the changes of the brain expression in Stat4 -/- mice. Interestingly, the increase in paw volume of Stat4 -/- mice was reduced by about 30% as compared to that of wild type. The cDNA microarray analysis revealed the altered expressions of several cytokines (Tnf, Il6, and Il4) and pain-associated proteins (Ptgs2, Gabra6, and Gabbr1) in Stat4 -/- mice. Our results suggest that Stat4 may be related to the inhibitory responses on carrageenan induced acute inflammation.
Evaluation of a novel bifunctional xylanase–cellulase constructed by gene fusion
An, Jin Mee,Kim, Young Kyun,Lim, Woo Jin,Hong, Su Young,An, Chang Long,Shin, Eun Chule,Cho, Kye Man,Choi, Byoung Rock,Kang, Jung Mi,Lee, Sun Mi,Kim, Hoon,Yun, Han Dae Elsevier 2005 Enzyme and microbial technology Vol.36 No.7
<P><B>Abstract</B></P><P>An artificial bifunctional enzyme, xylanase–cellulase, has been prepared by gene fusion. Three chimeric genes were constructed that encoded fusion proteins of different lengths. The fusion proteins exhibited both xylanase (XynX) and cellulase (Cel5Z::Ω) activity when <I>cel</I>5Z::Ω was fused downstream of <I>xyn</I>X, but not when <I>xyn</I>X was fused downstream of <I>cel</I>5Z::Ω. Activities of bifunctional enzymes decreased when a shorter xylanase peptide was fused. Three fusion enzymes were purified, and the molecular weights of the enzymes were estimated by CMC-SDS-PAGE and XYN-SDS-PAGE to be 149, 129, and 87kDa, respectively. The fusion enzymes displayed optimum cellulase activity at pH 8.0 and 50°C and optimum xylanase activity at pH 8.0 and 70°C.</P>
김초롱(Kim, Cho Long),권미량(Kwon, Mee Ryang),이숙희(Lee, Suk Hee) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.17
본 연구는 유아기 자녀를 둔 어머니의 태아기 및 영아기 육아를 살펴보는 데 목적이 있다. 이를 위해 2019년 10월 17일부터 2019년 10월 28일까지 U시에 거주하는 만 3세-만 5세 유아기 자녀를 둔 어머니 10인을 대상으로 심층 면담을 실시하였다. 연구결과는 ‘임신은 걱정과 고민의 연속’, ‘조언과 정보 속, 행복한 태교 찾기’, ‘출산의 이상과 현실’, ‘일과 신체 문제로 어려운 완전모유’, ‘엄마표이유식과 간편이유식’, ‘편리성과 원칙 사이, 보행기와 배변훈련’, ‘유혹적인 전자기기의 편리함’, ‘아이 성격발달의 책임자’, ‘책과 온라인 커뮤니티는 육아 상담소’, ‘힘들어도 견뎌내는 육아’ 등 특징지어지는 10가지 내용범주로 유형화하고, 분석하였다. 본 연구가 육아에 대한 어려움과 두려움을 가지는 현 시대의 어머니와 이를 극복해나가고자 하는 시도들에서 의미 있는 자료로 쓰이길 기대한다. The purpose of this study is to examine the fetal and infant care of mothers with early children. To that end, in-depth interviews were conducted between October 17, 2019 and October 28, 2019, for 10 mothers with children aged 3 to 5 who lived in U-city. The results of the study showed 10 categories of content: ‘Pregnancy is a series of worries and worries’, ‘In advice and information, find a happy prenatal education’, ‘The ideal and reality of childbirth’, ‘Complete breastfeeding that is difficult because of work and physical problems.’, ‘Mother-made baby food and purchase baby food’, ‘Between convenience and principle, baby walker and bowel training’, ‘The convenience of seductive electronic devices’, ‘Responsible for the development of children s character’, ‘Books and online communities are parenting counseling centers.’, ‘Hard but bearable parenting’. It is hoped that this study will help today s mothers who have difficulties and fears about childcare and will be used as meaningful data to overcome childcare difficulties.