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( Kyu Ri Lee ),( Sun Min Yang ),( Sung Min Cho ),( Myunghee Kim ),( Sung-yong Hong ),( Soo Hyun Chung ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.1
Aflatoxins are classified as Group 1 (carcinogenic to humans) by the International Agency for Research on Cancer. In this study, a total of 134 fungal strains were isolated from 65 meju samples, and two fungal isolates were selected as potential aflatoxin B<sub>1</sub> (AFB<sub>1</sub>)-biodetoxification fungi. These fungi were identified as Aspergillus oryzae MAO103 and A. oryzae MAO104 by sequencing the beta-tubulin gene. The two A. oryzae strains were able to degrade more than 90% of AFB1 (initial concentration: 40 μg/l) in a culture broth in 14 days. The mutagenic effects of AFB1 treated with A. oryzae MAO103 and MAO104 significantly decreased to 5.7% and 6.4%, respectively, in the frame-shift mutation of Ames tests using Salmonella typhimurium TA98. The base-substituting mutagenicity of AFB1 was also decreased by the two fungi. Moreover, AFB1 production by Aspergillus flavus was significantly decreased by the two A. oryzae strains on soybean-based agar plates. Our data suggest that the two AFB1- detoxifying A. oryzae strains have potential application to control AFB1 in foods and feeds.
Kyu Ri Hahn,Woosuk Kim,Hyo Young Jung,Hyun Jung Kwon,Sung Min Nam,Tae Hyeong Kim,Jong Whi Kim,Dae Young Yoo,Dae Won Kim,Jung Hoon Choi,Yeo Sung Yoon,In Koo Hwang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks. At six weeks after diet feeing, gerbils received transient forebrain ischemia with or without hypothermic preconditioning. Cuprizone treatment for 8 weeks increased the number of astrocytes, microglia, and pro-inflammatory cytokine levels in the hippocampus. In addition, cuprizone treatment significantly decreased the number of proliferating cells and neuroblasts in the dentate gyrus. Brain ischemia caused cell death, disruption of myelin basic proteins, and reactive gliosis in CA1. In addition, ischemia significantly increased pro-inflammatory cytokines and the number of proliferating cells and differentiating neuroblasts in the dentate gyrus. In contrast, hypothermic conditioning attenuated these changes in CA1 and the dentate gyrus. However, cuprizone treatment decreased cell survival induced by hypothermic preconditioning after ischemia and increased the number of reactive microglia and astrocytes in CA1 as well as of macrophages in the subcallosal zone. These changes occurred because the protective effect of hypothermia in ischemic damage was disrupted by cuprizone administration. Furthermore, cuprizone decreased ischemia-induced proliferating cells and neuroblasts in the dentate gyrus
Establishment of an animal model for demyelination: its relationship with hippocampal neurogenesis
Kyu Ri Hahn,Woosuk Kim,Hyo Young Jung,Hyun Jung Kwon,Sung Min Nam,Jong Whi Kim,Joon Ha Park,Dae Young Yoo,Dae Won Kim,Moo-Ho Won,In Koo Hwang,Yeo Sung Yoon 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.7
( Kyu Min Cheong ),( Hye-been Kim ),( Yun Woo Choi ),( Yu Ri Seo ),( In Young Jeon ),( Sang Ik Choi ),( Ji Won Lee ),( Chi Woo Kim ),( Ki-taek Lim ) 한국농업기계학회 2016 한국농업기계학회 학술발표논문집 Vol.21 No.2
In this work, a new three-dimensional (3D) printing system-toward composite filament, so called “biofilament” named from the our paper, was developed with the fabrication of agricultural byproducts via precision extrusion process technology. Importantly, extrusion-based 3D printing stands as a promising technique owing to its versatility in printing various composite filament types; its capability to print fully mechanical and biological properties. Namely, we hypothesized that composite biofilament with agriculture byproducts might have a reinforced polycaprolactone (PCL) formation, bridging the negative sides of PCL. This (r-PCL) consists in PCL and rice bran powder. An extruder system was set up with basically operation condition of 10.0 rpm and 200℃ degree. To get more information governing the optimal concentration of rice bran powder, composites with loadings of 0.4, 0.6, 0.8, and 1.0 wt% of each group were extruded to fabricate the “biofilaments”. Mechanical properties were evaluated through stress-strain diagram and morphological features of those were analyzed using a scanning electron microscope. Reinforcement led to a moderate enhancement in mechanical properties with the 1.0 wt% loading of rice bran powder. Overall, composite biofilaments with rice bran powder appears to be a promising way to producing solid biofilaments for fused deposition modeling (FDM)-based 3D printing technology. The results of our study can open the best way to the fabrication of environmentally user-friendly composite biofilaments.
Kyu-Ri Lee,Sang-Rae Moon,Jeong-Eun Lee,Gil-Hah Kim 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
Twospotted spider mite, Tetranychus urticae was collected from the rose greenhouse in Gimhae, Gyeongnam province in Jan, 2001. Resistant strain was reared over nine years treated with Acequinocyl (over 400 times), and increased 614 folds as compared to susceptible strain (S). Cross resistance of acequinocylresistant strain adults to eight acaricide was showed high in Cyflumetofen (108 folds) and expressed low in Abamectin (16 folds), Tebufenpyrad (7.6 folds), Fenpyroximate (6.1 folds). Against Chlorfenapyr (0.5 folds), however, showed negatively correlated cross resistance. Synergistic effects with PBO (piperonyl butoxide), an oxygenase inhibitor, DEF (S,S,S-tributyl phosphorotrithioate), an esterase inhibitor, and DEM (diethymaleate), an inhibitor of glutathion S-transferase were also investigated. Synergistic effect showed low in DEM (4.2 folds) but showed high in PBO (12 folds) and DEF (23 folds).
The Effects of TENS Applied to Affected Lower Extremities on Balance in Stroke Patients
( Kyu Ri Lee ),( Sang Hun Jang ) 대한물리의학회 2014 대한물리의학회지 Vol.9 No.3
Purpose : This study was to investigate the effectiveness of TENS on balance in stroke patients by analyzing some components such as foot pressure, limit of stability and velocity sway after providing somatosensroy input using TENS. Methods : Twenty five subjects participated and were randomly divided into two groups, TENS group (n=13) and control group (n=12) by the computer program. Interventions were given to subjects 5 days a week for four weeks. TENS group were treated with TENS for 60 minutes in addition to the conventional therapy which included 30-minute exercise and rehabilitation ergometer training for 15 minutes. Control group performed only conventional therapy. TENS was applied on the skin of soleus, tibialis anterior, tensor fascia latae and vastus medialis in affected side. Foot pressure, limit of stability and velocity sway for balance test were measured using Biorescue. Results : TENS group was significantly increased limit of stability and foot pressure in affected side more than control group. And in eye closed condition, TENS group was significantly decreased velocity sway more than control group. Conclusion : The application of TENS is effective to improve the somatosensory input of affected sideand to increase the motor function and balance ability.