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Kyu Ri Hahn,Hyo Young Jung,Dae Young Yoo,Jong Whi Kim,Yang Hee Kim,Young Kwang Jo,Geon A Kim,Jin Young Chung,Jung Hoon Choi,In Koo Hwang,Goo Jang,Yeo Sung Yoon 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and GLUT3, the two main isoforms of GLUTs found in testes, in the left scrotal and right abdominal testes of a German Shepherd dog. Immunohistochemical analysis showed that GLUT1 immunoreactivity was absent in the scrotal and abdominal testes. In contrast, weak to moderate GLUT3 immunoreactivity was observed in mature spermatocytes as well as spermatids in the scrotal testis. In the abdominal testis, relatively strong GLUT3 immunoreactivity was detected in Leydig cells only and was absent in mature spermatocytes and spermatids. GLUT3 immunoreactivity was significantly decreased in the tubular region of abdominal testis and significantly increased in the extra-tubular (interstitial) region of abdominal testis compared to observations in the each region of scrotal testis, respectively. These results suggest that GLUT3 is the major glucose transporter in the testes and that abdominal testes may increase the uptake of glucose into interstitial areas, leading to an increased risk of developing cancer.
Kyu Ri Hahn,Woosuk Kim,Hyo Young Jung,Hyun Jung Kwon,Sung Min Nam,Tae Hyeong Kim,Jong Whi Kim,Dae Young Yoo,Dae Won Kim,Jung Hoon Choi,Yeo Sung Yoon,In Koo Hwang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks. At six weeks after diet feeing, gerbils received transient forebrain ischemia with or without hypothermic preconditioning. Cuprizone treatment for 8 weeks increased the number of astrocytes, microglia, and pro-inflammatory cytokine levels in the hippocampus. In addition, cuprizone treatment significantly decreased the number of proliferating cells and neuroblasts in the dentate gyrus. Brain ischemia caused cell death, disruption of myelin basic proteins, and reactive gliosis in CA1. In addition, ischemia significantly increased pro-inflammatory cytokines and the number of proliferating cells and differentiating neuroblasts in the dentate gyrus. In contrast, hypothermic conditioning attenuated these changes in CA1 and the dentate gyrus. However, cuprizone treatment decreased cell survival induced by hypothermic preconditioning after ischemia and increased the number of reactive microglia and astrocytes in CA1 as well as of macrophages in the subcallosal zone. These changes occurred because the protective effect of hypothermia in ischemic damage was disrupted by cuprizone administration. Furthermore, cuprizone decreased ischemia-induced proliferating cells and neuroblasts in the dentate gyrus
Establishment of an animal model for demyelination: its relationship with hippocampal neurogenesis
Kyu Ri Hahn,Woosuk Kim,Hyo Young Jung,Hyun Jung Kwon,Sung Min Nam,Jong Whi Kim,Joon Ha Park,Dae Young Yoo,Dae Won Kim,Moo-Ho Won,In Koo Hwang,Yeo Sung Yoon 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.7
( Yu Ri Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Jae Wook Jung ),( Yu Na Lee ),( Hyung Jin Hahn ),( Hyun Jung Park ),( Yang Won Lee ),( Yong Beom Choi ),( Kyu Joong Ahn ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: There has been a report suggesting clinical effectiveness of phototherapy using a long-pulsed Nd:YAG laser as the alternative treatment of onychomycosis, but objective evaluation of the therapeutic effect and in-depth study of the mechanism of treatment are still insufficient. The authors performed an in-vitro study of Trichophyton rubrum, a pathogen which has been attributed in more than 80% of onychomycosis, and investigated antifungal effect of 1064 nm long-pulsed Nd:YAG laser. Objectives: To determine whether the growth of T. rubrum is inhibited by direct irradiation of 1064nm long-pulsed Nd:YAG laser. Methods: T. rubrum was collected from the nails of 5 onychomycosis patients, which were irradiated with the laser 200 shots each time at intervals of 3 to 5 days for 29 days. Colony diameter was compared directly with the control group to observe the difference in growth rate. Results: The growth rate was not different between the T. rubrum colony irradiated with 1064 nm long-pulsed Nd:YAG laser and the colony not irradiated with the laser. Conclusion: In this study, the laser did not seem to have a direct effect on T. rubrum. It can be speculated that the therapeutic effect of 1064 nm long-pulsed Nd:YAG laser on onychomycosis may be attributable to tissue changes of the lesion, rather than to damaging of the fungus itself.