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RISS 인기검색어
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- 저자 : ( Kyoung Myeun Chung ) (검색결과 3 건)
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맹장-S결장루로 인한 세균과다증식과 관련된 대장가성폐쇄 1예
정경면 ( Kyoung Myeun Chung ),임성욱 ( Seong Uk Lim ),홍형주 ( Hyoung Ju Hong ),박선영 ( Seon Young Park ),박창환 ( Chang Hwan Park ),김현수 ( Hyun Soo Kim ),최성규 ( Sung Kyu Choi ),류종선 ( Jong Sun Rew ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.2
Colocolic fistulas are usually a complication of an inflammatory or neoplastic process. Development of these abnormal bowel communications may lead to bacterial overgrowth. We report on a 71-year-old man with a one-year history of recurrent abdominal distension and irregular bowel habits. Abdominal X-rays and computed tomography showed multiple air-fluid levels and loops of distended bowel without evidence of mechanical obstruction or diverticulitis. Colonoscopy showed a fistulous tract between the sigmoid colon and cecum. Results of a lactulose breath test showed high fasting breath CH4 levels, which were thought to be the result of intestinal bacterial overgrowth. The patient was diagnosed with a colonic pseudo-obstruction associated with bacterial overgrowth due to a sigmoidocecal fistula. We recommended surgical correction of the sigmoidocecal fistula; however, the patient requested medical treatment. After antibiotic therapy, the patient still had mild symptoms but no acute exacerbations. (Korean J Gastroenterol 2014;63:125-128)
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정경면 ( Kyoung Myeun Chung ),김현수 ( Hyun Soo Kim ),박선영 ( Seon Young Park ),임성륜 ( Sung Ryoun Lim ),양대열 ( Dae Yeul Ryang ),정혜경 ( Hye Kyong Jeong ),이완식 ( Wan Sik Lee ),박창환 ( Chang Hwan Park ),이재혁 ( Jae Hyuk 대한소화기학회 2008 대한소화기학회지 Vol.52 No.6
목적: 크론병과 장결핵 발생은 지역에 따라 다르고, 같은 지역이라 하더라도 환경 요인에 따라 시기적으로 다른 빈도를 보인다. 이번 연구에서는 크론병과 장결핵의 최근 10년간 발생 변화를 확인하고자 하였다. 대상 및 방법: 1998년 1월부터 2007년 8월까지 전남대학교병원에 입원 및 외래 진료하여 크론병과 장결핵으로 진단 받은 각각 65예(28.2±15.2세, 남자 42예, 여자 23예), 54예(46.2±18.5세, 남자 29예, 여자 25예)를 대상으로 의무 기록을 통하여 임상 증상, 내시경, 병리 소견, 치료에 대해 분석하고 발생 연도별 분포 등을 조사하였다. 결과: 1998년부터 2002년까지 새로 진단된 크론병 환자는 16명(28.6%)이었으며, 2003년부터 2007년 8월까지 새로 진단된 크론병 환자는 40명(71.4%)이었다. 1998년부터 2002년까지 새로 진단된 장결핵 환자는 40명(74.1%)이었고, 2003년부터 2007년 8월까지 새로 진단된 장결핵 환자는 14명(25.9%)이었다. 크론병 및 장결핵의 주요 증상은 복통(89.2%, 77.8%), 설사(70.8%, 35.2%) 등이었다. 내시경 소견에서 종주궤양, 발적, 장관 협착, 가성용종, 조약돌 병변이 크론병에서 장결핵에 비해 유의하게 많았다(p<0.05). 크론병과 장결핵 병리 조직에서 가장 흔한 소견은 궤양(72.3%, 64.8%)과 육아종(29.2%, 42.6%)이었다. 크론병 병변 분포는 소장형이 21.5%, 혼합형이 55.4%, 대장형이 23.1%였다. 장결핵에서는 소장형이 40.7%, 혼합형이 48.1%, 대장형이 11.1%, 결핵 복막염이 동반된 경우는 3.7%였다. 결론: 서구와 같이 크론병 발생이 점점 증가하고 장결핵의 감소 추세이나 추이 관찰이 필요하다. Background/Aims: The incidence of Crohn`s disease (CD) has been steadily increasing in Korea due to westernized life style and widely used imaging studies such as colonoscopy. There were few studies about the status of longterm trend of CD and intestinal tuberculosis (IT). Therefore, we aimed to evaluate the trend of CD and IT in Korea. Methods: We retrospectively reviewed the medical records of newly diagnosed 65 patients with CD and 54 patients with IT at Chonnam National University Hospital between January 1998 and August 2007. Results: Between 1998 and 2002, 16 and 40 patients were newly diagnosed as having CD and IT respectively, but between 2003 and 2007, 39 and 14 patients were newly diagnosed as having CD and IT respectively. CD patients (28.2±15.2 years) were younger than IT (46.2±18.5 years) (p=0.001). The male to female ratio of CD and IT were 2:1 and 1.1:1, respectively. The most common symptom of CD and IT was abdominal pain. Longitudinal ulceration, hyperemia, luminal narrowing, pseudopolyp, and cobble stone appearance were more common in CD than in IT (p<0.05). Conclusions: While the incidence of CD has increased, the incidence of IT has fallen over the last decade.
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Expression of c-FLIP in Gastric Cancer and its Relation to Tumor Cell Proliferation and Apoptosis
( Dae Yeul Ryang ),( Young Eun Joo ),( Kyoung Myeun Chung ),( Sung Ryoun Lim ),( Hye Kyong Jeong ),( Hyung Il Kim ),( Wan Sik Lee ),( Chang Hwan Park ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Re 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.4
Background: The expression of c-FLIP (cellular Fas-associated death domain-like interleukin-1 β-converting enzyme (FLICE)-inhibitory protein), which is a member of the family of inhibitors of apoptosis, has been associated with tumor development and progression. The aim of this study was to evaluate the expression of c-FLIP in gastric cancer and its correlation with tumor cell proliferation, apoptosis and the clinicopathologic features. Methods: Immunohistochemical staining with anti-c-FLIP antibody was performed in 98 tissue samples obtained from gastric cancer patients who underwent surgical treatment. The apoptotic cells were visualized by terminal deoxynucleotidyl transferase (TdT) mediated deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL), and the proliferative cells were visualized by staining with Ki-67 antibody. Results: The positive expression of c-FLIP in the gastric cancer tissues was demonstrated in 57.1% of the cases. The expression of c-FLIP was increased in the gastric cancer tissues compared with the matched normal gastric mucosa. The expression of c-FLIP was significantly associated with histologic differentiation (p=0.038). However, there was no association between the c-FLIP expression and the other clinicopathological parameters, including patient survival. The Ki-67 labeling index (KI) for the 98 tumors ranged from 7.6 to 85.0 with a mean KI of 50.4±15.7. The mean KI value of the c-FLIP positive tumors was 54.1±15.3 and this was significantly higher than that of the c-FLIP negative tumors (p=0.005). The apoptotic index (AI) for the 98 tumors ranged from 0.0 to 10.0 with a mean AI of 7.4±2.3. There was no significant difference between the c-FLIP expression and the AI (p=0.347). Conclusions: These results suggest that the c-FLIP expression may be associated with tumor cell proliferation of gastric cancer.
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