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이기범,양우익 大韓法醫學會 1987 대한법의학회지 Vol.11 No.2
A 23-year old male patient expired suddenly. He was managed at the hospital under the impression of lumbar intervertebral disc herniation. An autopsy was performed and the cause of death was pulmonary tumor embolism, which occluded the main pulmonary artery completely. The primary tumor was located at the left psoas muscle and it was alveolar rhabdomyosarcoma. The primary tumor infiltrated to the iliac vein and sciatic nerve and patient's symptom was due to nerve compression by the tumor.
양우익,이기범 中央醫學社 1987 中央醫學 Vol.52 No.9
This study is intended to recognize mental and physical health status of Nursing Junior Collegians. The sample data for the study have been collected applying C.M.I. from 462 collegians selected randomly at 4 nursing junior colleges in Taegu city and Kyungbuk province over a period of three months from September to November 1986. The data was treated by a computer (SPSS) using Mean, Standard Deviation, F Ratio, Chi-square test and Pearson's Correlation. The summary of the results in the study are as follows: 1) The relationship between general mental-physical health of Nursing students and places which they have grown up, showed to be not significant. 2) The relationship between mental(p < 0.01), physical (p < 0.05), general mental- physical health (p < 0.01) and living expense satisfaction showed to be significant. 3) In the relations to pride as a nurse, musculoskeletal system (p < 0.01), Fatigability(p < 0.05) Miscellaneous disease (p < 0.01), Inadequacy (p < 0.05), Depression (p < 0.001), Sensitivity(p < 0.01), Anger (p < 0.01), and Tension (p < 0.05) showed to be significant. 4) In the relation to anxiety on registered Nurses Examinication, The frequency of Respiratory (p < 0.05), Cardiovascular (p < 0.001), Digestive (p < 0.05), Musculoskeletal (p < 0.05), Nervous system(p < 0.05) and frequency illness (p < 0.05), Inadequacy (p < 0.05), Depression (p < 0.01), Anxiety (p < 0.05), Sensitivity (p < 0.05), Anger (p < 0.05) and Tension (p < 0.001) showed to be significant.
Lee, Sang-Ryung,Yim, Hyunee,Han, Jae Ho,Lee, Kyi Beom,Lee, Jeonghun,Soh, Euy Young,Kim, Dae Jung,Chung, Yoon-Sok,Jeong, Seon-Yong,Sheen, Seung Soo,Park, So Hyun,Kim, Jang-Hee American Society for Clinical Pathology 2015 American journal of clinical pathology Vol.143 No.3
<P><B>Objectives:</B></P><P>We evaluated the utility of the VE1 antibody that can detect a mutant protein resulting from the <I>BRAF</I> V600E mutation as a diagnostic tool for thyroid fine-needle aspiration cytology (FNAC).</P><P><B>Methods:</B></P><P>We performed VE1 immunocytochemistry on 202 FNAC specimens from surgically confirmed thyroid nodules. The results were compared with the molecular analyses of the <I>BRAF</I> mutation in these specimens matched with their corresponding histology.</P><P><B>Results:</B></P><P>Diagnoses of FNAC specimens included benign (9.4%), atypia of undetermined significance/follicular lesion of undetermined significance (11.4%), follicular neoplasm/suspicious for follicular neoplasm (2.0%), suspicious for malignancy (9.4%), and malignancy (65.8%). VE1 immunostaining was positive in 71.3% of FNAC specimens. The overall sensitivity of the VE1 antibody was 88.8%, specificity was 71.2%, positive predictive value was 88.2%, negative predictive value was 72.4%, and diagnostic accuracy was 83.7%.</P><P><B>Conclusions:</B></P><P>VE1 immunocytochemistry in thyroid FNAC as a screening test for <I>BRAF</I> mutations is highly specific for malignant category cases but can be suboptimal due to its high false-positive rate for the nonmalignant cases.</P>
The Significance of Caspase-Cleaved Cytokeratin 18 in Pleural Effusion
Lee, Keu Sung,Chung, Joo Yang,Jung, Yun Jung,Chung, Wou Young,Park, Joo Hun,Sheen, Seung Soo,Lee, Kyi Beom,Park, Kwang Joo The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.1
Background: Apoptosis plays a role in the development of pleural effusion. Caspase-cleaved cytokeratin 18, a marker for epithelial cell apoptosis, was evaluated in pleural effusion. Methods: A total of 79 patients with pleural effusion were enrolled. The underlying causes were lung cancer (n=24), parapneumonic effusion (n=15), tuberculous effusion (n=28), and transudates (n=12). The levels of M30, an epitope of caspase-cleaved cytokeratin 18, were measured in blood and pleural fluids using enzyme-linked immunosorbent assay along with routine cellular and biochemical parameters. The expression of M30 was evaluated in the pleural tissues using immunohistochemistry for M30. Results: The M30 levels in pleural fluid were significantly higher in patients with tuberculosis ($2,632.1{\pm}1,467.3U/mL$) than in patients with lung cancer ($956.5{\pm}618.5U/mL$), parapneumonic effusion ($689.9{\pm}413.6U/mL$), and transudates ($273.6{\pm}144.5U/mL$; all p<0.01). The serum levels were not significantly different among the disease groups. Based on receiver operating characteristics analysis, the area under the curve of M30 for differentiating tuberculous pleural effusion from all other effusions was 0.93. In the immunohistochemical analysis of M30, all pathologic types of cancer cells showed moderate to high expression, and the epithelioid cells in granulomas showed high expression in tuberculous pleural tissues. Conclusion: Caspase-cleaved cytokeratin 18 was most prominently observed in tuberculous pleural effusion and showed utility as a clinical marker. The main source of M30 was found to be the epithelioid cells of granulomas in tuberculous pleural tissues.
The Significance of Caspase-Cleaved Cytokeratin 18 in Pleural Effusion
( Keu Sung Lee ),( Joo Yang Chung ),( Yun Jung Jung ),( Wou Young Chung ),( Joo Hun Park ),( Seung Soo Sheen ),( Kyi Beom Lee ),( Kwang Joo Park ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.1
Background: Apoptosis plays a role in the development of pleural effusion. Caspase-cleaved cytokeratin 18, a marker for epithelial cell apoptosis, was evaluated in pleural effusion. Methods: A total of 79 patients with pleural effusion were enrolled. The underlying causes were lung cancer (n=24), parapneumonic effusion (n=15), tuberculous effusion (n=28), and transudates (n=12). The levels of M30, an epitope of caspase-cleaved cytokeratin 18, were measured in blood and pleural fluids using enzyme-linked immunosorbent assay along with routine cellular and biochemical parameters. The expression of M30 was evaluated in the pleural tissues using immunohistochemistry for M30. Results: The M30 levels in pleural fluid were significantly higher in patients with tuberculosis (2,632.1±1,467.3 U/mL) than in patients with lung cancer (956.5±618.5 U/mL), parapneumonic effusion (689.9±413.6 U/mL), and transudates (273.6±144.5 U/mL; all p<0.01). The serum levels were not significantly different among the disease groups. Based on receiver operating characteristics analysis, the area under the curve of M30 for differentiating tuberculous pleural effusion from all other effusions was 0.93. In the immunohistochemical analysis of M30, all pathologic types of cancer cells showed moderate to high expression, and the epithelioid cells in granulomas showed high expression in tuberculous pleural tissues. Conclusion: Caspase-cleaved cytokeratin 18 was most prominently observed in tuberculous pleural effusion and showed utility as a clinical marker. The main source of M30 was found to be the epithelioid cells of granulomas in tuberculous pleural tissues.
1 , 2 - dimethylhydrazine 으로 유발되는 대장암발생의 기전에 관한 조직 및 조직화학적 연구
이유복(Yoo Bock Lee),박찬일(Chan Il Park),이기범(Kyi Beom Lee) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2
N/A To investigate the histogenesis of colonic carcinoma, 1,2-dimethylhydrazine(DMH) was injected to Sprague-Dawley rats for 6 to 24 weeks, 20 mg/kg/week, and gross and microscopic studies of the colonic mucosa were made with special emphasis on changes of transitional mucosa(TM), such as the pattern and nature of mucin contents and epithelial dysplasia. The tunor developed in 1/10 in 6~16 weeks treated groups, 1/6 in 20 weeks and 5/6 in 24 weeks treated group. Majority of the tumors were adenocarcinomas, while a few cases of signet ring cell carcinoma wero observed in 24 weeks treated group. Histologic and histochemical changes of the remaining colonic mucosa, especially at the TM consisted of enlargement of the crypts due to goblet cell(G-C) hyperplasia with increased mucin production during 8 to 16 weeks treatment, followed by epithelial dysplasia, such as loss of polarity, nuclear hyperchromacity and reduction of the secretory function. The content of mucin increased during 8 to 16 weeks treatment and was comprised of predominantly sulfomucin, while the content, especially sulfomucin, markedly decreased as dysplastic changes progressed and was accompanied by a relative increase of sialomucin. These findings suggest that the histogenesis of colonic carcinoma takes steps of initia1 G-C hyperplasia with increased sulfomucin production and later dysplastic changes of G-C, accompanied by reduction of sulfomucin secretion and a relative increase of sialomucin.