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알카리금속염을 첨착시킨 활성탄을 이용한 CO_2 제어에 관한 흡착특성
오광중,심언봉,최원준,조기철 부산대학교 환경문제연구소 2001 環境硏究報 Vol.19 No.-
Na_2CO_3,K_2CO_3, Li_2CO_3-impregnated activated carbon which had a longer breakthrough time and more enhanced adsorption capacity than the activated carbon was tested with isothermal adsorption and tested for the CO_2 adsorption amount varied with temperature, CO_2 inlet concentration, flow rate, aspect ratio. As a result, when Langmuir, Freundlich and Dubinin-Polanyi adsorption isotherms were used for linear regression of isothermal adsorption data, Langmuir adsorption isothermal was the most suitable. And, The optical condition for Na_2CO_3 and K_2CO_3 impregnated activated carbon make-up was 1N and Li_2CO_3 was 0.1N. It could be concluded that adsorption capacity was decreased with adsorption temperature and increased gas concentration. When the aspect ratio(L/D) was varied 0.5, 1.0, and 2.0, the significant drop of adsorption amount was observed below 1.0 and breakthrough time was shortened with gas flow rate.
심광용(Kwang Yong Shim),안중배(Joong Bae Ahn),김귀언(Gwi Eon Kim),정현철(Hyun Cheol Chung),김주항(Joo Hang Kim),김병수(Byung Soo Kim),노재경(Jae Kyung Roh) 대한두경부종양학회 1999 대한두경부 종양학회지 Vol.15 No.1
Objectives: This study was carried out to analyze the clinical profile and the results of treatment of a series of patients with extramedullary plasmacytoma(EMP) of the head and neck. Materials and Methods: The clinical features, treatment and survival of 14 patients with EMP seen at Yonsei Medical Center between 1970 and 1998 were carefully reviewed. Results: The median age was 48 years(range 15-75) and there was a male predominance(M:F 1.8:1). Nasal cavities and paranasal sinuses account for 50% of the primary sites and the most common symptom was airway obstruction(50%). Five patients(36%) showed evidence of adjacent bone destruction, one patient had lymph node involvement and one patient had an IgG monoclonal gammopathy at the time of diagnosis. All 5 patients treated with radiotherapy alone achieved local control. Of 5 patients treated with surgery alone, 2 patients(40%) had local failure. Of 3 patient treated with a combination of surgery and radiotherapy, one patient had local recurrence. A total of7 patients(54%) had local, distant or nodal relapses after primary treatment. Six of them received salvage treatment. With salvage treatment of surgery and/or radiotherapy, local control was achieved in 4 of 6 patients. Conversion to multiple myeloma was seen in one patient. Conclusion: Radiotherapy should be recommanded as treatment of choice for EMP of the head and neck. Surgery should be reserved for radioresistant or recurrent tumors, but tumors that are localized and can be removed relatively easily with little morbidity may be treated by primary surgery.
김현숙,Yeonsil Yu,Kwang Eon Shim,Jin Eop Kim,Junga Koh,Jong-Woo Yoon,안규리,오윤규 전해질고혈압연구회 2018 Electrolytes & Blood Pressure Vol.16 No.1
A 47-year-old female previously diagnosed with ADPKD visited the hospital due to sudden pain in her upper abdomen and back. Esophagogastroduodenoscopy, contrast-enhanced abdominal computed tomography (CT), and CT angiography identified an esophageal artery pseudoaneurysm and hematoma in the esophagus. Urgent angiography and embolization were performed. After the procedure, CT angiography and positron emission tomography were performed due to differences in blood pressure between the arms. The patient was also found to have Takayasu arteritis and subsequently received outpatient follow-up care. The possible mechanisms that cause vascular abnormalities in ADPKD patients include damaged vascular integrity due to abnormal polycystin expression caused by PKD mutations and connective tissue abnormalities. Further research is needed to confirm these mechanisms, and ADPKD patients should be assessed for vascular abnormalities.
( Kyoung Min Kwak ),( Gwang Ho Choi ),( Kwang Eon Shim ),( Ho Yong Jin ),( Seok Hyung Kim ),( Jong Woo Yoon ),( Hyunsuk Kim ) 대한전해질학회 2020 Electrolytes & Blood Pressure Vol.18 No.2
Encapsulating peritoneal sclerosis (EPS) is a potentially fatal complication after long-term peritoneal dialysis, and tamoxifen can be used for its prevention and treatment. However, tamoxifen is known to increase the risk of venous thromboembolism. A 49-year-old woman was admitted with sudden abdominal pain. The patient had received peritoneal dialysis for 20 years and switched to hemodialysis after the diagnosis of EPS. Tamoxifen (10mg) and prednisolone (20mg) had been administered for 8 months. On computed tomography, the left hepatic lobe was hardly illuminated, leading to a diagnosis of liver infarction. A month later, she was re-admitted due to abdominal pain and extensive deep vein thrombosis of the leg. The administration of tamoxifen was stopped and prednisolone was reduced to 10mg. As her malnutrition progressed, she succumbed to death of gram negative sepsis. The patient was concluded to have liver infarction and extensive venous thrombosis as a side effect of tamoxifen.
HPLC determination of irbesartan in human plasma: its application to pharmacokinetic studies
Bae, Soo Kyung,Kim, Min-Jung,Shim, Eon-Jeong,Cho, Doo-Yeoun,Shon, Ji-Hong,Liu, Kwang-Hyeon,Kim, Eun-Young,Shin, Jae-Gook John Wiley Sons, Ltd. 2009 Biomedical chromatography Vol.23 No.6
<P>A simple and rapid HPLC method using fluorescence detection was developed for determination of irbesartan in human plasma. Sample preparation was accomplished through a simple deproteinization procedure with 0.4 mL of acetonitrile containing 800 ng/mL of losartan (internal standard), and to a 0.1 mL plasma sample. Chromatographic separation was performed on a Zorbax Xclipse XDB C<SUB>18</SUB> column (150 × 4.6 mm, i.d., 5 µm) at 40°C. An isocratic mobile phase, acetonitrile:0.1% formic acid (37:63, v/v), was run at a flow-rate of 1.0 mL/min, and the column eluent was monitored using a fluorescence detector set at excitation and emission wavelengths of 250 and 370 nm, respectively. The retention times of irbesartan and losartan were 4.4 and 5.9 min, respectively. This assay was linear over a concentration range of 10–5000 ng/mL with a lower limit of quantification of 10 ng/mL. The coefficient of variation for this assay precision was less than 8.48%, and the accuracy exceeded 94.4%. The mean relative recoveries of irbesartan and losartan were 98.4 and 99.1%, respectively. This method was successfully applied for pharmacokinetic study after oral administration of irbesartan (300 mg) to 23 Korean healthy male volunteers. Copyright © 2009 John Wiley & Sons, Ltd.</P>
Changes in bioimpedance analysis components before and after hemodialysis
( Hyunsuk Kim ),( Gwang Ho Choi ),( Kwang Eon Shim ),( Jung Hoon Lee ),( Nam Ju Heo ),( Kwon-wook Joo ),( Jong-woo Yoon ),( Yun Kyu Oh ) 대한신장학회 2018 Kidney Research and Clinical Practice Vol.37 No.4
Background: This study compared nutritional parameters in hemodialysis (HD) subjects and controls using bioimpedance analysis (BIA) and investigated how BIA components changed before and after HD. Methods: This cross-sectional study included 147 subjects on maintenance HD from two hospitals and 298 propensity score-matched controls from one healthcare center. BIA was performed pre- and post-HD at mid-week dialysis sessions. Results: Extracellular water/total body water (ECW/TBW) and waist-hip ratio were higher in the HD patients; the other variables were higher in the control group. The cardiothoracic ratio correlated best with overhydration (r = 0.425, P < 0.01) in HD subjects. Blood pressure, hemoglobin, creatinine, and uric acid positively correlated with the lean tissue index in controls; however, most of these nutritional markers did not show significant correlations in HD subjects. Normal hydrated weight was predicted to be higher in the pre-HD than post-HD measurements. Predicted ultrafiltration (UF) volume difference based on pre- and post-HD ECW/TBW and measured UF volume difference showed a close correlation (r<sup>2</sup> = 0.924, P < 0.01). Remarkably, the leg phase angle increased in the post-HD period. Conclusion: The estimated normal hydrated weight using ECW/TBW can be a good marker for determining dry weight. HD subjects had higher ECW/TBW but most nutritional indices were inferior to those of controls. It was possible to predict UF volume differences using BIA, but the post-HD increase in leg phase angle, a nutritional marker, must be interpreted with caution.
Kim, Hyunmi,Bae, Soo Kyung,Park, Soo-Jin,Shim, Eon-Jeong,Kim, Ho-Sook,Shon, Ji-Hong,Liu, Kwang-Hyeon,Shin, Jae-Gook Blackwell Publishing Ltd 2010 British journal of clinical pharmacology Vol.70 No.1
<P><B>WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT</B></P><P>• Woohwangcheongsimwon suspension has traditionally been used for the treatment and prevention of stroke, hypertension, palpitations, convulsions and unconsciousness in various Asian countries.</P><P>• Woohwangcheongsimwon suspensions showed an inhibitory effect on CYP2B6 activity <I>in vitro</I>. Two terpenoids, borneol and isoborneol, are major constituents of woohwangcheongsimwon suspension, and show a competitive inhibition of CYP2B6 with <I>K</I><SUB>i</SUB> values of 9.5 and 5.9 µ<SMALL>M</SMALL>, respectively.</P><P>• Bupropion undergoes metabolic transformation to the active metabolite, 4-hydroxybupropion, primarily via CYP2B6 both <I>in vivo</I> and <I>in vitro</I>. It is often used as a CYP2B6 substrate for clinical drug–drug interaction studies.</P><P>• Drug interactions may occur between woohwangcheongsimwon suspension and bupropion.</P><P><B>WHAT THIS STUDY ADDS</B></P><P>• Co-administration with woohwangcheongsimwon suspension did not alter the pharmacokinetics of bupropion or its metabolite, 4-hydroxybupropion.</P><P>• Dosage adjustment of bupropion is unnecessary in patients concomitantly administered the highest recommended daily dose of woohwangcheongsimwon suspension.</P><P>AIMS</P><P>To examine the effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, formed via CYP2B6 <I>in vivo</I>.</P><P>METHODS</P><P>A two-way crossover clinical trial with a 2 week washout period was conducted in 14 healthy volunteers. In phases I and II, subjects received 150 mg bupropion with or without woohwangcheongsimwon suspension four times (at −0.17, 3.5, 23.5 and 47.5 h, with the time of bupropion administration taken as 0 h) in a randomized balanced crossover order. Bupropion and 4-hydroxybupropion plasma concentrations were measured for up to 72 h by LC-MS/MS. Urine was collected up to 24 h to calculate the renal clearance. In addition, the <I>CYP2B6</I>*6 genotype was also analyzed.</P><P>RESULTS</P><P>The geometric mean ratios and 90% confidence interval of bupropion with woohwangcheongsimwon suspension relative to bupropion alone were 0.976 (0.917, 1.04) for AUC(0,∞) and 0.948 (0.830,1.08) for <I>C</I><SUB>max</SUB>, respectively. The corresponding values for 4-hydroxybupropion were 0.856 (0.802, 0.912) and 0.845 (0.782, 0.914), respectively. The <I>t</I><SUB>max</SUB> values of bupropion and 4-hydroxybupropion were not significantly different between the two groups (<I>P</I> > 0.05). The pharmacokinetic parameters of bupropion and 4-hydroxybupropion were unaffected by woohwangcheongsimwon suspension.</P><P>CONCLUSIONS</P><P>These results indicate that woohwangcheongsimwon suspension has a negligible effect on the disposition of a single dose of bupropion <I>in vivo</I>. As a result, temporary co-administration with woohwangcheongsimwon suspension does not seem to require a dosage adjustment of bupropion.</P>