선천성 이전부 누공 2예

채구석 ( Koo Seog Chae ),박영민 ( Young Min Park ),이종육 ( Jong Yuk Yi ),김태윤 ( Tae Yoon Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3

The auricle develops from six auricular tubercles which originate from the mesenchyme of the first and second branchial arch. If a defective fusion of these tubercles occur, a preauricular fistula may be formed. We report two cases of congenital preauricular fistula manifested by soft nodules with external openings on the left preauricular area. Histologically, the fistulas are lined by stratified squamous epithelium, and elastic cartilage. and chronic inflammatory cell infiltration are also present. (Kor J Dermatol 1996;34(3): 450-453)

전풍과 동반된 Malassezia (Pityrosporum) 모낭염 1예

채구석,윤두희,이정덕,이준영,김진우,조백기 대한의진균학회 1997 대한의진균학회지 Vol.2 No.2

We report a case of Malassezia folliculitis associated with pityriasis versicolor in a 16-year-old man. He had asymptomatic multiple erythematous papulopustular eruptions and scaly confluent hypopigmented macules on the anterior chest for 2 months. The diagnosis of Malassezia folliculitis was established with the mycological and histological examinations from the specimen of papulopustules on the chest. Pityriasis versicolor was confirmed by KOH examination with the scales of the hypopigmented macules on the chest. Although the association of these two dermatoses is not common, they are generally accepted as being caused by the same organism of the genus Malassezia, which has different pathogenic stages. In our case, both types of skin lesions were improved after 3 weeks of antifungal therapy with systemic itraconazole (200 mg/day) and topical 1% isoconazole nitrate cream.

Roles of Al₂O₃ promoter for an enhanced structural stability of ordered-mesoporous Co₃O₄ catalyst during CO hydrogenation to hydrocarbons

Koo, Hyun Mo,Ahn, Chang-Il,Lee, Dong Hyun,Roh, Hyun-Seog,Shin, Chae-Ho,Kye, Hyoungsan,Bae, Jong Wook Elsevier 2018 Fuel Vol.225 No.-

<P><B>Abstract</B></P> <P>A crucial contribution of Al<SUB>2</SUB>O<SUB>3</SUB> pillar for an enhanced structural stability of a highly ordered mesoporous Co<SUB>3</SUB>O<SUB>4</SUB> (Al/m-Co) for CO hydrogenation activity was verified in terms of newly formed stable phases with their interactions. At an optimal 5 wt%Al<SUB>2</SUB>O<SUB>3</SUB> on the Al/m-Co, the activity and stability of Fischer-Trospch synthesis (FTS) reaction were largely enhanced by preserving the highly ordered original mesoporous Co<SUB>3</SUB>O<SUB>4</SUB> structures due to the newly formed strong Al<SUB>2</SUB>O<SUB>3</SUB>-Co<SUB>3</SUB>O<SUB>4</SUB> interactions with the partial formation of the catalytically inactive spinel-type CoAl<SUB>2</SUB>O<SUB>4</SUB> phases in the matrices of the mesoporous Al/m-Co. The main roles of the Al<SUB>2</SUB>O<SUB>3</SUB> pillar on the Al/m-Co were a structural promoter to maintain the highly ordered mesoporous Co<SUB>3</SUB>O<SUB>4</SUB> structures by easily removing the heavy hydrocarbons formed during FTS reaction without significant coke depositions through those large mesopores. The homogeneously distributed Al<SUB>2</SUB>O<SUB>3</SUB> pillaring material less than monolayer on the Al/m-Co surfaces played a crucial role to preserve the original ordered mesoporous Co<SUB>3</SUB>O<SUB>4</SUB> structures through the partial formation of outer surface CoAl<SUB>2</SUB>O<SUB>4</SUB> phases with less blockages of active metallic cobalt sites by heavy coke precursors formed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Al<SUB>2</SUB>O<SUB>3</SUB> pillared ordered-mesoporous Co<SUB>3</SUB>O<SUB>4</SUB> (Al/m-Co) showed a superior FTS activity and stability. </LI> <LI> Enhanced structural stability of Al/m-Co was from the partially formed thermally stable CoAl<SUB>2</SUB>O<SUB>4</SUB>. </LI> <LI> Main role of Al<SUB>2</SUB>O<SUB>3</SUB> pillar was the structural promoter to maintain the ordered Co<SUB>3</SUB>O<SUB>4</SUB> structures. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Milia en Plaque

Cho, Sang Hyun,Chae, Koo Seog,Park, Young Min,Cho, Baik Kee Korean Dermatological Association 1997 Annals of Dermatology Vol.9 No.2

비침습적 방법을 이용한 정상 한국인의 성별 , 부위별 , 피부특성 측정

고재숙 ( Jae Sook Koh ),채구석 ( Koo Seog Chae ),김형옥 ( Hyung Ok Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5

Background: During the last few years, the in vivo study of the physiological parameters of the skin by non-invasive methods has been considerably developed. So far, there have been some reports on the skin characteristics only in parts, but there has not been any criteria to classify those of normal subjects. Objective: The aim of the present study was to investigate the skin characteristics of healthy Korean subjects according to sex and sites using non-invasive methods. Methods : To determine normal levels of sebum, skin hydration, transepidermal water loss (TEWL), skin elasticity and skin color according to sex, 163 subjects (male; 124, female; 39) were used to investigate 5 different anatomical sites. 6 different instruments were used: The Sebummeter SM 410, Corneometer CM 820, Evaporimeter EP1, Cutometer SEM 474, Chromameter CR-121, and Mexameter MX 16, for evaluating sebum excretion rate, capacitance, TEWL, mechanical property and skin color respectively. Results : Differences were noticed depending on the anatomical sites and sex. Most of the measuring parameters were significantly different according to sites and sex. The values of sebum levels, capacitance and TEWL were higher in the males on the cheek, forehead and crows foot, whereas in the females, higher values were observed on the dorsum of the hand. The skin elasticity varied considerably among the nine-parameters but, for the elastic ratio (R2, R5), the females showed significantly higher values than the males in all sites except the forehead. Skin lightness (L* value) was higher in the females, whereas the males showed lugher values in the category of redness (a* value) and yellowness (b* value). The values of the eqrthema index (EI) and melanin index (MI) were also higher in the males on all sites. Correlations between the skin parameters mentioned above were calculated. A negative, correlation between capacitance and TEWL was observed only on the cheek (male/female, r =-0.2/ r =-0.4, p<0.05). The L* value correlated negatively with MI. Mioreover the values between a* and El also showed sipificant correlations in the male (cheek and dorsum of hand, y =0.2, forehead and crows foot, r =0.3, p<0.05). There were considerably significant correlations between the visual pigmentation score and instrumental skin parameters in the males (visual pigmentation score vs. L* value measured by Chromameter ; cheek/crows foot, r = -0.3/y =-0.4, visual pigmentation score vs. MI by Mexameter ; cheek/crows foot, r =0.2/ r =0.4, viisual winkle score vs. sebum excretion rate measured by Sebumeter ; cheek, r=0.2, visual winkle score vs. elasticity parameters measured by Cutometer ; cheek, R2/R5/R7, r =-0.3/ r =-0.2/ r =-0.3, p<0.05). Conclusiom : Skin physiological parameters can be evaluated by non-invasive skin bioengineering methods which show quantitative modifications in physiological conditions in relation to sites and sex. (Korean J Dermatol 1998;36(5) 855-864)

The Role of Magnesium Ion Substituted Biphasic Calcium Phosphate Spherical Micro-Scaffolds in Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells.

Kim, Dong-Hyun,Shin, Keun-Koo,Jung, Jin Sup,Chun, Ho Hwan,Park, Seong Soo,Lee, Jong Kook,Park, Hong-Chae,Yoon, Seog-Young American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.8

<P>This study was investigated the role of magnesium (Mg2+) ion substituted biphasic calcium phosphate (Mg-BCP) spherical micro-scaffolds in osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAT-MSCs). Mg-BCP micro-scaffolds with spherical morphology were successfully prepared using in situ co-precipitation and spray drying atomization process. The in vitro cell proliferation and differentiation of hAT-MSCs were determined up to day 14. After in vitro biological tests, Mg-BCP micro-scaffolds with hAT-MSCs showed more enhanced osteogenicity than pure hAT-MSCs as control group by unique biodegradation of TCP phase and influence of substituted Mg2+ ion in biphasic nanostructure. Therefore, these results suggest that Mg-BCP micro-scaffolds promote osteogenic differentiation of hAT-MSCs.</P>

Localized chronic urticaria and palmar pitted keratolysis at the site of healed herpes zoster (Isotopic response)

( Kee Young Roh ),( Won Keun Ahn ),( Koo Seog Chae ),( Hyun Jeong Lee ),( Jin Won Kim ) 대한피부과학회 1998 초록집 Vol.36 No.20

활성탄과 펄라이트로 피복된 원판에서의 생물막 성장

박영식(Young Seek Park),이채남(Chae Nam Lee),안갑환(Dong Seog Kim),김동석(Kab Hwan Ahn),송승구(Seung Koo Song) 大韓環境工學會 1996 대한환경공학회지 Vol.18 No.6

정상인 및 아토피 피부염 환자의 건성 피부에서 Sodium Lauryl Sulphate로 유도된 자극성 피부 반응에 대한 Lactic Acid 와 Sodium Pyrrolidone Carboxylic Acid 도포의 효과

최성우,우혜진,김형옥,이하린,채구석 대한피부과학회 2000 대한피부과학회지 Vol.38 No.1

Background:Natural moisturizing factors such as sodium pyrrolidone carboxylic acid and lactic acid may play an important role in increasing the moisture retention of isolated stratum corneum and reducing the incidence of dry and flaky skin in vivo. Although the precise mechanism of surfactant irritancy is not fully understood, it has been suggested that barrier dysfunction of stratum corneum by surfactants results in skin changes such as scaling, erythema, and even fissuring. Objective:We evaluated the effect of sodium pyrrolidone carboxylic acid(NaPCA) and lactic acid(LA) with several non-invasive measuring methods in the irritated skin reaction induced by sodium lauryl sulphate (SLS) in normal persons and atopic dermatitis patients. Methods:After skin irritation for 24 hours with patch test of 1% SLS on five volar sites of right forearm, we applied nothing(A), 3% LA+3% NaPCA(B), 3% LA(C), 3% NaPCA(D), and vehicle(E) twice a day respectively. Visual score, transepidermal water loss(TEWL), water holding capacity(WHC), and erythema index were measured at 30 min, 24hr, 48hr and 72hr after patch removal. Results: 1. After 72hr, the visual scores of B and C were significantly lower than that of A(control) in atopic dermatitis patients, and that of C in normal persons was significantly lower than that of A, D, and E. 2. TEWL values of B and C in both the normal (after 72hr) and atopic dermatitis group (after 48hr and 72hr) were significantly lower than that of A. 3. WHC values of B, C, D in both the normal and atopic dermatitis group were significantly higher than that of A after 48hr and 72hr. 4. After 72hr, erythema indices by Mexameter of B, C, and D in both the normal and atopic dermatitis group were significantly lower than that of A and values of C were significantly lower than that of E. In the atopic dermatitis group, values of D were also significantly lower than that of E. 5. The mean visual score was significantly correlated with TEWL value and erythema index of Mexameter (r=0.58, r=0.64) and the TEWL value was significantly correlated with erythema index of Mexameter (r=0.64). Conclusion:These results suggest that topical application of a moisturizing factor might improve the surfactant-induced disruption of permeability barrier with improvement of the water holding capacity of the stratum corneum.

A Case of Diffuse Biphasic Cutaneous Amyloidosis

Park, Young Min,Cho, Sang Hyun,Cho, Baik Kee,Chae, Koo Seog,Park, Chan Kum 대한피부과학회 1997 Annals of Dermatology Vol.9 No.4

We described a case of diffuse biphasic cutaneous amyloidosis, a unique form of localized cutaneous amyloidosis. A 41-year-old man has gradually developed a lichenoid papular and a grouped spotted pigmented macular eruption on the trunk and upper extremities over the past 15 years. Histopathologic examination revealed that amyloid deposits were present in the papillary dermis. It was confirmed by Congo red staining, immunohistochemistry and electron microscopy. There was no evidence of systemic amyloidosis.