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내시경적으로 절제된 위용종 126예의 임상적 및 조직학적 고찰
이상혁,조길현,정정명,신형규,설상영,조기정 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.1
The gastrointestinal polyp is a premalignant lesion in varying degree. According to the size, the pathology and the location of polyps, it should be removed. Polyps in the gastrointestinal tract can be removed by surgical excision, electrosurgery, cryotherapy, regional radiotherapy and laser therapy with some limitations. Considerable advance in therapeutic endoscopy as well as in diagnostic endoscopy along with newly developed instruments has now made it possible to excise gastrointestinal polyps by means of high frequency generator. We have underwent endoscopic polypectomy, strip biopsy and $quot;O$quot; ring ligation on gastric polyps in 112 patients who visited in this hospital from July l988 to January 1994, and the clinical characteristics including histopathology has been evaluated. Removed polyps were variable in size from less than 0.5 cm up to 4cm. Finally, we concluded that endoscopic polypectomy is a safe and relativly simple procedure and postpolypectomy complication can be considerably reduced by conservative antiulcer therapy.
Extended three-field Lymphadenectomy for Esophageal
Lee, Sun-Hee,Wang, Young-Pil,Park, Jae-Kil,Kwack, Moon-Syb,Cho, Kyu-Do,Jo, Keon-Hyon,Kim, Se-wha 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-
Because the esophagus has two different embryogenetic origins-branchial arches and york sac-which grow together during embryogenetic development in the area of the tracheal bifurcation. It also has two main lymphatic collection areas. In the abdoment and at the neck. And it is well known that the presence of lymph node metastasis in esophageal cancer is the most important factor cntributing to a poor prognosis.
^14C-요소 호기검사를 이용한 Helicobacter pylori의 3제요법과 2제요법의 제균율 분석
이승현,전상훈,서창균,김상현,이영석,허재웅,전석길,안성훈 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1
H. pylori 감염은 만성 활동성 위염, 위 또는 십이지장 궤양의 가장 중요한 원인이며, 위선암, 위임파선종의 발생과 관계있고 H. pylori가 제균되면 궤양치유가 촉진되고 재발율을 줄인다. H. pylori의 초기 제균요법 실시 후 ^14C-요소 호기검사를 이용하여 제균 효과를 비교 분석하였다. 이 연구에서는 H. pylori에 감염된 소화성 궤양환자 79명을 대상으로 무작위로 두 군으로 나누어 H. pylori 제균요법 중 3제요법(omeprazole, clarithromycin, amoxicillin)과 2제요법(omeprazole, clarithromycin)을 실시하였고, 치료 4-8주 경과후 ^14C-요소 호기검사를 이용하여 H. pylori의 제균 효과를 비교하였다. 치료 후 요소 호기검사에서는 3제요법을 사용한 군 59명중 52명이 음성으로 나와 88.1%의 제균율을 보였고 2제요법을 사용한 군 20명중 7명이 음성으로 나와 35%의 제균율을 보여 3제요법군이 2제요법군보다 유의한 제균율의 차이를 보였다. Helicobacter pylori (H. pylori) infection is associated with chronic active gastritis, duodenal and gastric ulcers, gastric adenocarcinoma, and gastric lymphoma. The eradication of H. pylori not only results in the healing of ulcer but also reduces recurrence of peptic ulcer. Using ^14C-urea breath test, we compared the efficacy of omeprazole-based triple therapy and dual therapy in patients with H. pylori-positive peptic ulcer. Seventy nine H. pylori-positive patients with peptic ulcer were enrolled and randomly divided into two groups. Fifty nine patients received triple therapy (omeprazole, clarithromycin and amoxicillin) for 7 days and twenty patients received dual therapy (omeprazole and clarithromycin) for 14 days. The eradication of H. pylori was assessed by ^14C-urea breath test 4-8 weeks after the completion of each therapy. The overall eradication rate of H. pylori, using ^14C-urea breath test, was 88.1% in the triple therapy group and 35% in the dual therapy group, therefore the eradication rate of triple therapy was higher than that of dual therapy.
뉴트리아 (Myocastor coypus)의 국내 분포 및 서식 현황에 관한 연구
이도훈 ( Do Hun Lee ),길지현 ( Ji Hyon Kil ),김동언 ( Dong Eon Kim ) 한국환경생태학회 2013 한국환경생태학회지 Vol.27 No.3
본 연구에서는 3년간(2010~2012년) 뉴트리아의 전국적인 확산과 분포 흐름을 확인하고 서식 현황을 조사하였다. 2010년 9개 시?군에 분포하는 것으로 파악된 뉴트리아는 2012년 조사 결과, 13개 시?군에서 서식하는 것으로 나타났으며, 뉴트리아의 서식 흔적 조사에서 확인된 629개의 지점 중 95.9%의 흔적지점이 부산?경남지역을 중심으로 확인되었다. 부산?경남지역의 5개 행정구역 내 위치한 6개 조사구역을 서식지 유형별로 구분하여 개체 밀도를 조사한결과, 2010년 3.89(±2.56)개체/100m, 2011년 2.90(±2.69)개체/100m, 2012년 1.39(±0.66)개체/100m의 개체 밀도를 확인하였다. 조사기간 동안의 서식지 유형별 평균 개체밀도는, 소택형 습지 조사지역 3.48(±2.15)개체/100m, 하천조사지역 1.01(±0.25)개체/100m, 하천형 습지 조사지역 3.69(±2.83)개체/100m로 나타났다. 2010년부터 2012년까지 3년간 조사구역의 연간 평균 개체 밀도는 매년 감소하는 경향을 보였으며, 하천이 습지에 비해 뉴트리아 평균 개체 밀도가 낮게 나타났다. 현재 뉴트리아는 국내의 습지, 하천, 강 등 다양한 환경에 적응하여 서식하고 있으며 특히, 습지와 같이 서식에 유리한 환경이 조성된 지역에서는 급속한 밀도의 증가를 보일 수 있다. 과밀 지역에 서식하는 뉴트리아는 타 지역으로의 확산 가능성을 지니고 있으므로 생태적인 특성을 적용한 효율적인 관리방안의 수립이 필요하다. This study has researched the national expansion, dispersion of nutria and investigated its inhabitation status for the past 3 years. The report has shown that the number of nutria habitat, reported to be distributed in 9 cities or districts in 2010, has been increased to 13 in 2012. In the research of 629 nutria habitats, 95.9% of habitat traces were found in Busan-Kyungnam area. From the research of relative density by location type for the 6 survey areas in these 5 areas above, it was shown 3.98(±2.56)ind./100m in 2010, 2.90(±2.69)ind./100m in 2011 and 1.39(±0.66)ind./100m in 2012. From the research of relative density by habitat types, it was shown 3.48(±2.15)ind./100m in palustrine wetland area, 1.01±(0.25)ind./100m in river area and 3.69±(2.83) ind./100m in riverine wetland area. It was shown that the annual average density in the areas has slightly been decreased for the past 3 years between 2010 and 2012. It also reported that the habitat density in the river area is a bit lower than that in the wetland area. Currently it can be determined that the nutria has fully adapted themselves to the various local environments of wetland, river, stream, and so on in Korea and the Relative density could be remarkably increased especially in the favorable condition like a wetland. As the ones living in the area with over-density could be spread out to other areas, the efficient management plan to control should be prepared considering ecological conditions.
Kang, Jae Myeong,Lee, Sang-Yoon,Seo, Seongho,Jeong, Hye Jin,Woo, Sung-Ho,Lee, Hyon,Lee, Yeong-Bae,Yeon, Byeong Kil,Shin, Dong Hoon,Park, Kee Hyung,Kang, Hyejin,Okamura, Nobuyuki,Furumoto, Shozo,Yanai, Elsevier 2017 NEUROBIOLOGY OF AGING Vol. No.
<P><B>Abstract</B></P> <P>This study aims to evaluate the clinical validity of [<SUP>18</SUP>F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [<SUP>18</SUP>F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed. In patients with AD dementia, [<SUP>18</SUP>F]THK5351 retention was greater in most association cortices as well as the limbic area compared to NC or aMCI participants. Patients with aMCI also showed higher THK5351 retention in those areas compared to NC. [<SUP>18</SUP>F]THK5351 retention significantly correlated with neuropsychological test results. Negative correlations between [<SUP>18</SUP>F]THK5351 and [<SUP>18</SUP>F] fluorodeoxyglucose were observed in AD dementia and aMCI groups. Mirror images of [<SUP>18</SUP>F]THK5351 retention and glucose hypometabolism in [<SUP>18</SUP>F] fluorodeoxyglucose were noticeable in the focal variants of AD. [<SUP>18</SUP>F]THK5351 PET reflects disease severity and symptoms in AD. Our results suggest [<SUP>18</SUP>F]THK5351 is reflective of tau-related AD pathology.</P>
음성 분리를 위한 스펙트로그램의 마루와 골을 이용한 시간-주파수 공간에서 소리 분할 기법
임성길,이현수,Lim, Sung-Kil,Lee, Hyon-Soo 한국음향학회 2008 韓國音響學會誌 Vol.27 No.8
본 논문에서는 스펙트로그램에서 마루와 골을 이용한 주파수 채널 분할 알고리즘을 제안한다. 주파수 채널 분할 문제는 동일한 음원으로부터 발생한 음성이 포함된 주파수 채널들을 하나의 그룹으로 묶는 것을 의미한다. 제안된 알고리즘은 입력 신호의 평탄화된 스펙트럼에 기반한 알고리즘이다. 평탄화된 스펙트럼에서 마루와 골은 각각 세그먼트의 중심과 경계를 판단하기 위해 사용된다. 각 세그먼트를 하나의 소리로 묶는 그룹핑 단계 이전에 제안된 알고리즘에 의한 세그멘테이션 결과가 유용함을 평가하기 위하여 이상적인 마스크에 의한 세그멘테이션 결과와 제안된 방법을 비교한다. 제안된 방법을 협대역 잡음, 광대역 잡음, 다른 음성신호와 혼합된 음성신호에 대하여 실험하였다. In this paper, we propose an algorithm for the frequency channel segmentation using peaks and valleys in spectrogram. The frequency channel segments means that local groups of channels in frequency domain that could be arisen from the same sound source. The proposed algorithm is based on the smoothed spectrum of the input sound. Peaks and valleys in the smoothed spectrum are used to determine centers and boundaries of segments, respectively. To evaluate a suitableness of the proposed segmentation algorithm before that the grouping stage is applied, we compare the synthesized results using ideal mask with that of proposed algorithm. Simulations are performed with mixed speech signals with narrow band noises, wide band noises and other speech signals.