N_3O_2형의 Dibenzoic Polyether Nitrogen과 Fe족 금속이온의 錯物에 關한 硏究(Ⅰ)

丁學鎭,丁梧鎭,曺正煥 조선대학교 기초과학연구소 1984 自然科學硏究 Vol.7 No.1

새로운 N_2O_3형 Dibenzonic Polyether Nitrogen을 합성하여 여러 비양자성 용매하에서〔Acetonitrile (AN), N, N-Dimethylformamide(DMF), Dimethylsulfoxide(DMSO) 및 Tetrahydrofuran(THF)와 Fe족 금속이온염과 합성한 Ligandrks의 착물생성에 따른 안정도 상수를 전기전도도법으로 구하고 착물생성으로 유발되는 음이온효과 용매효과 등을 UV-Spectrum으로부터 알아보았다. 그리고 비양자성 용매하에서의 전기전도도 자료로부터 착물이온들의 행동을 검토하였다. Dibenzonic Polyether Nitrogen (DBPN)의 구조는 원소분석과 IR-Spectrum 자료로부터 확인하였다. DBPN-CoCl_2DBPN-NiCl_2DBPN-Co(NO_3)_2 및 DBPN-Ni(NO_3)_2 착이온들의 비전도도를 Tokyo Electric Conductivitymeter에 의하여 25℃에서 측정하였다. 용매의 첨가량에 따라 Complex ion들의 당량전도도는 용매효과 금속양이온 및 음이온 등에 의하여 영향을 받는다. 특히 DBPN-metal(Co^2+, Ni^2+) Complex의 안정도상수 값은 AN>DMSO>THF 순이다. 일정 용매하에서 DBPN-metal(Co^2+, Ni^2+) 착물들의 안정도정수들은 Co^2+>Ni^2+와 Cl^->NO_3^-의 순으로 증가하였다. 이런 결과들로부터 DBPN-Ni과 Co의 착물들의 안정도정수는 DBPN의 동공 크기와 양이온크기의 상대적인 비에 의하여 크게 의존하였다. 그리고 비양자성 용매하에서 Complex ion들의 최대흡광 Peak는 핵전이 장파장이동 Peak를 보여준다. The ligand of the new Dibenzoic Polyether Nitrogen(DBPN) or the N_3O_2 type has been synthezised. The stability constants for the 1‥1 complexes of DBPN with cobalt and nickel in Acetonitrile, Dimethylsulfoxide, Tetrahydrofrane and and N, N-Dimethylforamide have been determined by electrical conductivitimeter and the effect of solvents, cations and anions indused from formation of complexes with DBPN ligand, have been discussed by the data of the UV-spectrum, and then the behaviors of these complexes ions have been discussed from the data of analysis of elements and IR-spectrum. The structures of DBPN are indentified from the data of analysis of elements and IR-spectrum. The specific conductances of the complexes with DBPN, chloride and nitrate salt of cobalt and nickel are measured Conductances at 25℃. The equivalent conductances are affected by the volume of organosolvents added, kinds of organosolvents, solvation, cations and anions, and the stability constants of complexes with Co^2+ and Ni^2+ are in the order of AN>DMSO>TMF>DMF, and the stability constants of these complexes are in the order of Co^2+>Ni^2+ and Cl^->NO_3^-, respectively. The stability constants of these complexes depends highly on relative ratio of cavity size of DBPN and cation size. The λ_max. of these complexes are shifted by solvents used and these complexes are also shifted in the direction of the long wavelength under the aprotic solvents.

난소 및 난소 종양 염전의 초음파 소견

오연희,이현경,이원재,이성우,박수성,윤혜원,임문환,심재철,김용탁,김성숙,김정란 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Acute torsion of the ovary and ovarian mass is a recognized surgical emergency, but rarely has the diagnosis been made preoperatively on the basis of imaging studies. The sonographic findings in 14 cases of surgically proven torsion of the ovary and ovarian mass are described. Mostly cystic ovarian mass, engorged vessel, dilated uterine tube, beak-like echo(torsion site), smooth mass wall thickening an free-fluid collection in cul-de-sac are described. More significant in terms of specificity were the demonstration in 6 cases(42.9%) of the smooth mass wall thickening and in 8 cases(57.1%) of a free fluid in the cul-de-sac. We report the sonographic findings of ovary and ovarian mass torsion that may suggest the preoperative diagnosis of this condition.

RW-DBR 레이저의 처핑 (chirping)에 따른 발진모드의 동적특성

박정선,오일환 木浦大學校 情報産業硏究所 1997 情報産業硏究誌 Vol.5 No.-

Narrow-linewidth ridge-waveguide distributed Bragg reflector (RW-DBR) lasers with asymmetric cladding are designed. RW-DBR lasers are Ridge structure coupled Fabry-Perot resonator to DBR, First the turning property is investigated for DBR reflectivity and facet effective reflectivity of a ROR. and it is shown that a ROR has narrow linewidth. Secondly, we also show resonant wavelengths shifts as a result of RW-DBR laser's phase variation. and the chirp due to the external modulation is studied.

최근 9년간 신경정신과에 입원한 환자에 대한 임상적 고찰(1972∼1980년)

이정호,안일남,오석환,정영조,최영민,원장섭,김영훈,하혜경,이승탁,이영주 인제대학교 1983 仁濟醫學 Vol.4 No.2

정신질환 환자들에 대한 정확한 생태를 파악함은 정신 건강과 치료 대책을 세우는데 중요하다. 이에 본 저자들은 1972년부터 1980떤 사이에 인제의대 부속 서울백병원 신경정신과에 입원하여 치료 받았던 환자들에 대한 제반 요인들을 분석 검토하였다. Clinical charactristics of neuropsychiatric inpatients were evaluated and discussed with special referrence to their diagnostic distribution. All discharged cases from neuropsychatric ward of Seoul Paik Hospital during nine years from 1972 to 1980 were 2863. Among them 813 cases were discarded from this study because their clinical charts were vague in description of failed to find out. The materials of this study were extracted from 2050 discharged cases. Total number of cases of inpatients were gradually increasing by each year from 1972 to 1980. Psychoneurosis was diagnosed in 45.2%, schizophrenia in 26.9%, organic brain syndrome in 8.9%, major affective disorder in 5.5%, personality disorder in 4.8%, other psychiatric disorder in 1.5%, psychophysiologic disorder in 1.0%, mental retardation in 0.5%, paranoid state in 0.5%, and other psychosis in 0.3%. The gruop of patients, ranging in age from 21 to 40 was the highest (75.2%) in this study. Male patients were 43.9% and female patients were 56.1%. Schizophrenia leas diagnosed in 32.9%, depressive neurosis in II.3%, anxiety neurosis in 9.3%, and personality disorder in 8.1% in male patients. Hysterical neurosis was diagnosed in 25.5%, depressive neurosis in 22.2%, schizophrenia in 22.2%, and anxiety neurosis in 7.0% in female patients. The authors evaluated the route of admission of patients. Sixty-eight point three percent of total studied cases were admitted through outpatient department, 20.9% of cases were admitted through emergeney room, and 8.2% of cases were transfered from other department or hospital. Among patients who were admitted to psychiatric wards through emergency room and transferred from other department or hospital, psychoneurosis was the hightest diagnostic group in rate. Most of patients who were transferred from other department or hospital were from Internal Medical Department. There were no relationship between seasonality of admission and diagnostic group in this study. readmission rate of total studied patients in neuropsychiatric department of Seoul Paik Hospital was 30%. The readmission rate of personality disorder, mental retardation, schizophrenia, and major affective disorder were relatively high. The cases who were discharged against medical advice were 441. Among them misunderstanding about psychiatric treatment was predominent. Twenty seven percent of patients had physical illness at or during admission. The patients who were diagnosd as psychophysiological disorder had physical illness in 42.8%, 35.4% in personality disorder, 33.9% in major affective disorder, and 24.3% in schizophrenia. About nine percent of total studied cases had the history of attempted suicide. Major affective disorder, Personality disorder, Deressive neurosis, and Other Psychosis showed high incidence of history of attempted suicide prior to admission.

이중혈류유발 심폐소생술이 심정지를 유발한 개의 단기 생존율에 미치는 영향

황성오,조준휘,강구현,김성환,문중범,이강현,이승환,윤정한,최경훈,홍은석 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background and Objectives: We previously reported that, compared with standard cardiopulmonary resuscitation(S-CPR), better hemodynamic effects could be achieved by simultaneous sterno-thoracic cardiopulmonary resuscitation(SST-CPR) in which we compressed the sternum and constricted the thorax circumferentially during the systolic period by using a device. This study was designed to assess whether SST-CPR, compared with S-CPR, improve the survival rate of dogs with cardiac arrest. Subjects and methods: Twenty-five mongrel dogs(19∼31㎏) were enrolled in this study. After four minutes of ventricular fibrillation induced by an AC current, animals were randomized to resuscitate with either S-CPR(n=13) or SST-CPR(n=12). Epinephrine(1 ㎎) was injected into the right atrium every three minutes after the beginning of CPR. Defibrillation was attempted after 6 minutes of CPR. Standard advanced cardiac life support was started if defibrillation was not successful. Results: SST-CPR resulted in significantly(p<0.001) higher systolic arterial pressure(91±47 vs 47±24 ㎜ Hg), diastolic pressure(43±24 vs 17±10 ㎜ Hg), coronary perfusion pressure(35±25 vs 13±9㎜ Hg), and end tidal CO2 tension(9±4 vs 3±2 ㎜ Hg). Two of 13 animals(15 %) resuscitated with S-CPR and six of 12 animals(50%) resuscitated with SST-CPR survived until 12 hours after cardiac arrest(p<0.05). Donclusion: SST-CPR, compared with S-CPR, improves the short-term survival rate in canine cardiac arrest.

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.

생쥐 정소 발달과정에 대한 미세구조적 연구

안영모,오승한,이정환,김완종 순천향대학교 기초과학연구소 2001 순천향자연과학연구 논문집 Vol.7 No.2

Differentiation and development of the mouse testis were studied by light and electron microscopes from the newborn up to the adult stage. The purpose of the present study was to investigate the morphological changes of developing germ cells in seminiferous tubule and Leydig cells in interstitial tissue during the developmental process of mouse testis. The results were as follows: the seminiferous tubule diameter began to increase from 1 day and was fully developed at the 30th day after birth, particularly, the seminiferous tubule diameter was rapidly increased between 15 days and 30 days of age. Germ cells of various stages were embedded in cytoplasm of the Sertoli cell. Leydig cell contained numerous mitochondria with tubular cristae and well developed smooth endoplasmic reticulum. Spermatogonia were located close to the basal layer. Spermatocytes were connected to each other by the intercellular bridge until the late spermatid stage. An acrosome located to the head apex and the microtubule arrangement of flagellum shown the typical "9+2" pattern. At the newborn stage, the Sertoli cell and germ cells started to be already differentiated. Spermatids and immature spermatozoa were appeared at 30 days of age, and thereafter, spermatogenesis occurred actively. In conclusion, the development of mouse testis was completed after 30 days of age at which the secondary sexual characteristics and the spermatogenesis began to occur. These results suggest that ultrastructural features of developing germ cells and Leydig cell were thought to have close interrelationship with their functional accomplishment.

대량의 Phenothiazine게 향정신약물 투여로 유발된 간질양 경련으로 보인 3례

김영훈,이정호,오석환 인제대학교 1981 仁濟醫學 Vol.2 No.1

Phenothiazine계 향정신약물의 투여로 인해 유발되는 경련은 임상에서 흔히 볼 수 있는것은 아니다. 경련이 있을 경우에는 단 일회에 그치는 경우가 대부분이며 적절한 감량이나 항경련제의 병용으로 이후의 경련에 대비할 수 있기 때문에, 이것이 치명적인 부작용은 될 수 없다는 것이 일반적인 견해이다. 외국에서는 이에 선행하는 요인의 분석 및 그 원인의 규명을 위해 많은 조사가 있었지만, 국내에서는 아직 이에 대한 지상보고가 없었기 때문에 저자들이 경험한 Phenothiazine계 향정신약물의 투여로 인하여 경련을 일으킨 3례를 문헌고찰과 함께 보고하는 바이다. It has been reported that all neuroleptic agents may cause convulsive seizures, but the incidence is thought to be rather low. Generally they were found single, isolated and occured during intensive phenothiazine treatment. We observed three cases that had tonic, clonic and generalized convulsive seizures following intensive phenothiazine treatment. Facing the fact that any special paper has not been reported in Korea about convulsive seizures induced by intensive phenothiazine medication, we report here those three cases with a brief review of literatures.

정신분열증과 대뇌 비대칭

이영주,이정호,오석환 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.1

Until recently, many investigators have studied on cerebral laterality and psychiatric illness. It was already reported that normal right-handed individuals often show neuroanatomical asymmetries of the brain on computerized tomography scan, with wider right frontal and left occipital lobes. There fore, the authors attempted to know of the pattern of cerebral asymmetries in schizophrenics and controls through computerized tomography on the notice that many inverstigators had attempted to classify schizophrenia by neuroanatomical findings of the brain. We examined the frequency of reversale of narmal asymmetries, in one group of 30 right-handed schizophrenies and the other group of 30 right-handed control subjects. Statistics were done by the Chi square method. Compared to 30 right-handed control group, the schizophrenic group had an significantly increased frequency of front and occipital reversals. This result suggests that reversals of neuroanatomical asymmetries, and by implication abnormalities of lateralization, are relevant to some schizophrenics. But larger samples are consider to be needed for further evaluation.

Disulfiram으로 인한 급성 뇌증후군 2예

최성학,이정호,오석환 인제대학교 1985 仁濟醫學 Vol.6 No.1

만성 알코올리즘 환자의 치료 방법 중 혐기요법의 하나로 Disulfiram요법을 시행하여 뇌증후군 및 정신병적인 증상을 일으킨 1예와, 금주 목적으로 의사의 지시없이 Disulfiram만을 복용하여 급성 정신증상을 유발한 1예를 치험하였기에 보고한다. It is well known that disulfiram therapy may result in psychosis, organic brain syndrome, and peripheral neuropathy, additional to the wanted effects of the drug. We experienced two cases of psychoses in chronic alcoholisms who had no past history of psychosis: one; organic brain syndrome and psychotic symptoms resulted from the therapy, the other, acute psychotic symptoms resulted from arbitral taking of disulfiram only, aimed to stop drinking. It is said that the symptoms will disappear only by stopping the medication. Therefore, we assume that disulfiram therapy can be effective as the adjunctive therapy only when it is tried by physicians, and that arbitual usage by general population should be restrained.