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건일로딘 정(미결정에토돌락 200 ㎎)에 대한 에토돌 정의 생물학적동등성
이정애,이윤영,조태섭,박영준,문병석,김호현,이예리,이희주,이경률 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
A bioequivalence of Etodol™ tablets (Yuhan corporation) and Kuhnillodine™ tablets (Kuhnil Pharm, Co., Ltd.) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 200 ㎎ dose of etodolac of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a 2×2 cross-over design. Concentrations of etodolac in human plasma were monitored by a high-performance liquid chromatography. AUCt (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed AUCt and C_(max). No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the AUCt ratio and the C_(max) ratio for Etodol™/Kuhnillodine™ were 1.01 - 1.10 and 0.87 - 1.06, respectively. This study demonstrated a bioequivalence of Etodol™ and Kuhnillodine™ with respect to the rate and extent of absorption.
김주필(Joo Pil Kim),최한석(Han Seak Choi),예용택(Yong Taek Ye),예성훈(Seong Hun Ye),김태우(Tae Woo Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),지성현(Sung Hyun Ji),이형민(Hyung Min Lee),변진관(Jin Kwan Byun),조주완(Joo Whan Jo),박솔 한국거미연구소 2017 한국거미 Vol.33 No.2
한국거미연구회 회원들은 2017년 8월 3일부터 4일까지 경기도 안산시 소재 시화호 갈대습지공원을 김주필, 최한석, 예용택, 예성훈, 김태우, 김대희, 지승환, 지성현, 변진관, 이형민, 조주완, 박솔민, 이형진, 이태후, 이승후, 조윤규, 조원규, 이준이, 신정애, 이영경, 최라미, 이윤정, 이용호, 한주연, 윤혜원, 김형주 등 26명이 주야로 채집한 결과 18과 49속 71종을 발표 보고하는 바이다. From August 3 to 4 in 2017. Koran Arachnological Study members investigated the Spiders in the whole area Gyeonggi-do Ansan-si, and reported 18 Families, 49 Genus 71 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.
김주필(Joo-Pil Kim),예용택(Yong-Taek Ye),최한석(Han-Seok Choi),장지현(Jee-Hyeon Jang):예성훈(Seong-Hun Ye),김태우(Tae-Woo Kim),김대희(Dae-Hee Kim),지승환(Seung-Hwan Ji),이형민(Hyung-Min Lee),이형진(Hyung-Jin Lee) 한국거미연구소 2016 한국거미 Vol.32 No.2
2016년 8월 3일부터 5일까지 제주특별자치도 서귀포시 대정읍 마라도 일대를 한국거미연구회 하계 합동채집회에 김주필, 예용택, 최한석, 장지현, 예성훈, 김태우, 김대희, 지승환, 이형민, 이형진, 신정애, 허양미, 이영경, 최라미, 이윤정 등이 채집조사한 결과 15과, 39속, 45종의 거미류가 조사연구되어 이에 보고하는 바이다. The authors investigated the spiders of the Mara Island in Jeju Island. In the present paper 45 species of 39 genera belong to 15 families were identified. These specimens are deposited at the Joo-Pil Spider Museum, Namyangju-Si, Kyunggi-Do.
김주필(Joo Pil Kim),예용택(Yong Taek Ye),신정애(Jeong Ae Sin),예성훈(Seong Hun Ye),성민규(Min Kyu Seong),이정준(Jeong Jun Lee),채준호(Jun Ho Chae) 한국거미연구소 2016 한국거미 Vol.32 No.1
2014년 10월 2일부터 4일까지 강원도 양양군 하조대 일대를 한국거미연구회 회원(김주필, 예용택, 신정애, 예성훈, 성민규, 이정준, 채준호)들이 조사 연구한 결과 11과 18속 20종이 채집되었기에 이에 보고하는 바이다. The authors investigated the spiders of the Hajodae beach (Gangwon-Do, Yangyang-Gun). In the present paper 20 species of 18 genera belong to 11 families were identified. These specimens are deposited at the Joo-Pil Spider Museum, Namyangju-Si, Gyeonggi-Do.
김주필(Joo Pil Kim),예용택(Yong Taek Ye),예성훈(Seong Hun Ye),유혜성(Hye Seong Yeu),장지현(Jee Hyeon Jang),오종화(Jong Hwa Oh),채준호(Jun Ho Chae),김태우(Tae Woo Kim),김민섭(Min Seob Kim),변진관(Jin Gwan Byun),이형민(Hyung Min Lee),김 한국거미연구소 2015 한국거미 Vol.31 No.2
2014년 8월 5일부터 7일까지 경상남도 창녕군 일대에 위치한 대한민국 최대의 내륙 습지인 우포늪 일대를 한국거미연구회 회원(김주필, 예용택, 장지현, 오종화, 예성훈, 유혜성, 채준호, 김태우, 김민섭, 변진관, 성민규, 김지후, 김대희, 김녕, 이정준, 이형민 등 16명)들이 채집 조사한 결과 16과 48속 69종의 거미가 조사 연구되어 이에 보고하는 바이다. The authors investigated the spiders of the Upo wetland from 5th August to 7th August, 2014. In the present paper 69 species of 48 genera belong to 16 families were identified. These specimens are deposited at the Joo-Pil Spider Museum, Namyangju-Si, Kyunggi-Do.
김주필(Joo Pil Kim),예용택(Yong Taek Ye),오종화(Jong Hwa Oh),예성훈(Seong Hun Ye),성민규(Min Gyu Seong),이정준(Jeong Jun Lee),김태우(Tae Woo Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),이형민(Hyeong Min Lee) 한국거미연구소 2016 한국거미 Vol.32 No.1
2015년 8월 3일부터 5일까지 한국거미연구회 회원들은 강원도 삼척시 육백산을 채집 조사한 결과 22과 49속 63종이 채집 조사되어 이에 보고하는 바이다. The authors investigated the spiders of the Mt. Yukbaek from August 3th to August 5th, 2015. In the present paper 63 species of 49 genera belong to 22 families were identified. These specimens are deposited at the Joo-Pil Spider Museum, Namyangju-Si, Gyeonggi-Do.
김주필(Joo Pil Kim),최한석(Han Seak Choi),예용택(Yong Taek Ye),예성훈(Seong Hun Ye),김태우(Tae Woo Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),지성현(Sung Hyun Ji),이형민(Hyung Min Lee),변진관(Jin Kwan Byun),조주완(Joo Whan Jo),박솔 한국거미연구소 2017 한국거미 Vol.33 No.2
한국거미연구회 회원들은 2017 년 8월 2일부터 3일까지 인천광역시 남동구 소재 소래습지생태공원을 김주필, 최한석, 예용택, 예성훈, 김태우, 김대희, 지승환, 지성현, 변진관, 이형민, 조주완, 박솔민, 이형진, 이태후, 이승후, 조윤규, 조원규, 이준이, 신정애, 이영경, 최라미, 이윤정, 이용화, 한주연, 윤혜원, 김형주 등 26명이 주야로 채집한 결과 14과 38속 50종을 발표 보고하는 바이다. From August 2 to 3 in 2017. Koran Arachnological Study members investigated the Spiders in the whole area Incheon Namdong-gu, and reported 14 Families, 38 Genus 50 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.
루리드 정(록시스로마이신 150㎎)에 대한 록시스린 정의 생물학적동등성
정선경,이윤영,조태섭,김호현,이예리,이경률,이희주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3
A bioequivalence study of Roxithrin™ tablet (Kukje Pharma. Ind. Co., Ltd.) to Rulid™ tablet (Han Dok Pharma. Ind. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the roxithromycin dose of 300 mg in a 2×2 crossover study. There was a one-week wash-out period between the doses. Plasma concentrations of roxithromycin were monitored by a high-performance liquid chromatography for over a period of 36 hours after drug administration. AUC, (the area under the plasma concentration-time curve from time zero to 36 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach C_(max)) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed AUC, and C_(max). No significant sequence effect was found for all of the bioavailability parameters indicating that the cross-over design was properly performed. The 90% confidence intervals of the AUC, ratio and the C_(max) ratio for Roxithrin™/Rulid™ were 1.00 - 1.13 and 0.98 - 1.10, respectively. These values were within the acceptable bioequivalence intervals of 0.80 - 1.25. Thus, our study demonstrated the bioequivalence of Roxithrin™ and Rulid™ with respect to the rate and extent of absorption.
마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구
김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.
모빅 캡슐(멜록시캄 7.5㎎)에 대한 멜락스 캡슐의 생물학적동등성
이예리,염승복,고연정,고정길,김호현,이희주,이경률 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5
A bioequivalence of Melax capsules (Chong Kun Dang Pharm., Korea) and Mobic™ capsules (Boehringer Ingelheim Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 15 mg dose of meloxicam of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a 2 x 2 crossover design. Concentrations of meloxicam in human plasma were monitored by a high-performance liquid chromatography. AUC, (the area under the plasma concentration-time curve from time zero to 72 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach Cma,.) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed AUC, and C_(max). No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the AUCt ratio and the C_(max) ratio for Melax™/Mobic™ were 0.95 - 1.04 and 0.98 - 1.14, respectively. This study demonstrated a bioequivalence of Melax™ and Mobic™ with respect to the rate and extent of absorption.