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RISS 인기검색어
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- 저자 : ( Jeongyeon Won ) (검색결과 6 건)
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S-423 Plasma aldosterone level and its metabolic implications in patients with type 2 diabetes
( Jeongyeon Won ),( Soyeon Yoo ),( Sang Ah Lee ),( Gwanpyo Koh ),( Dae Ho Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Aldosterone is involved in not only the regulation of blood pressure and renal sodium handling, but also the pathogenesis of insulin resistance, suggesting the clinical relevance of the inhibition of renin-angiotensin-aldosterone system (RAAS) in insulin resistant conditions. To better characterize metabolic implication of RAAS, we measured plasma renin activity (PRA) and aldosterone (PA) level in patient with type 2 diabetes. All other treatments and metabolic evaluations were performed at the discretion of the responsible physicians according to local guidelines. In the present study, we analyzed the data of 628 patients aged 18 or more years. Major exclusion criteria included renal failure, severe hepatic dysfunction, the use of spironolactone, and other severe systemic illnesses. Both PRA and PA were correlated with the circulating levels of serum sodium, apolipoprotein B (ApoB), high sensitivity CRP (hsCRP), and ALT. On a multivariate analysis, PA showed a significant association with ApoB (β=0.580, p=<0.001), ALT (β=0.305, p=0.006), and sodium (β=-0.224, p=0.035) after adjusting for multiple factors. In subgroup analyses according to the type of RAAS inhibition, the association of PA with ApoB and hsCRP was markedly attenuated in patient treated with angiotensin-converting enzyme inhibitor (ACEi) (n=53) compared with that in patients treated with angiotensin receptor blocker (n=187) or with no RAAS inhibitor therapy (n=388). Our results show that aldosterone has important implications for the pathophysiology of type 2 diabetes. Further studies are required to determine whether ACEi therapy is a metabolically better RAAS inhibition in patients with type 2 diabetes.
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전보영,Jeongyeon Kwak,Seung-Sub Lee,조상래,Chul Jae Won,김진만,신성재 한국미생물학회 2009 The journal of microbiology Vol.47 No.5
Mycobacterium abscessus has been identified as an emerging pulmonary pathogen in humans. Because little is known regarding immune responses elicited by M. abscessus or its antigens, immunological responses were studied in two murine models subjected to intravenous (high-dose or systemic infection) or pulmonary (low-dose or local infection) inoculation with M. abscessus ATCC 19977. An overall comparison between the two models showed similar patterns of bacterial survival and host immune responses. The colonization of M. abscessus was the highest at 5 days post-infection (dpi) and its elimination was positively correlated with cell-mediated immunity in both challenges. However, an inverse relationship was observed between progressive inflammation and mycobacterial colonization levels in mice infected with a high dose at 14 dpi. Regarding antigens, culture filtrate (CF) of M. abscessus strongly induced IFN-γ secretion, whereas cellular extract (CE) antigen elicited strong antibody responses. The antibody response to M. abscessus antigens in mice subjected to low-dose infection increased when the cellular immune response decreased over 14 dpi. However, the antibody response for the high-dose infection increased promptly after the infection. In comparison of cytokine expression in lung homogenates after M. abscessus infection, Th1 and Th2 cytokines increased simultaneously in the high-dose infection, whereas only cell-mediated immunity developed in the low-dose pulmonary infection. These findings not only enhance our understanding of the immune response to M. abscessus infection according to systemic or pulmonary infection, but may also aid in immunological diagnosis and vaccine development.
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Enzymatic film formation of nature-derived phenolic amines
Kim, Ji Yup,Kim, Won Il,Youn, Wongu,Seo, Jeongyeon,Kim, Beom Jin,Lee, Jungkyu K.,Choi, Insung S. The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.28
<P>An enzyme-instructed method is developed for material-independent, cytocompatible coating of phenolic amines, inspired by melanogenesis found in nature. Tyrosinase-based film formation proceeds smoothly in an aqueous solution at neutral pH, and can use various phenolic amines including catecholamines, such as tyrosine, tyramine, dopamine, norepinephrine, and DOPA, as a coating precursor. Compared with polydopamine coating, the method is fast and efficient, and forms uniform films. Its high cytocompatibility is advantageously applied to cell-surface engineering, where chemically labile Jurkat cells are coated individually without any noticeable decrease in viability. Considering the huge potential of polyphenolic-based coatings, the strategy developed herein will provide an advanced tool for manipulating biological entities, including living cells, in biomedical and medicinal applications.</P>
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Sohee Cha,Kwangheon Park,Jeongyeon Lee,Ranyeong Choi,Seol Kim,Hogyu Yi,Jong-Pil Jung,Jae Hak Cheong,Sangjoon Ahn,Won Pyo Jeong,Seungyeon Choi 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
To address the pressing societal concern in Korea, characterized by the imminent saturation of spent nuclear fuel storage, this study was undertaken to validate the fundamental reprocessing process capable of substantially mitigating the accumulation of spent nuclear fuel. Reprocessing is divided into dry processing (pyro-processing) and wet reprocessing (PUREX). Within this context, the primary focus of this research is to elucidate the foundational principles of PUREX (Plutonium Uranium Redox Extraction). Specifically, the central objective is to elucidate the interaction between uranium (U) and plutonium (Pu) utilizing an organic phase consisting of tributyl phosphate (TBP) and dodecane. The objective was to comprehensively understand the role of HNO3 in the PUREX (Plutonium Uranium Redox Extraction) process by subjecting organic phases mixed with TBPdodecane to various HNO3 concentrations (0.1 M, 1.0 M, 5.0 M). Subsequently, the introduction of Strontium (Sr-85) and Europium (Eu-152) stock solutions was carried out to simulate the presence of fission products typically contented in the spent nuclear fuel. When the operation proceeds, the complex structure takes the following form. ??? ??(??) + 2??? ?(??) + 2???(???) ↔ ???(???)? ? 2???(???) Subsequently, separate samples were gathered from both the organic and aqueous phases for the quantification of gamma-rays and alpha particles. Alpha particle measurements were conducted utilizing the Liquid Scintillation Counter (LSC) system, while gamma-ray measurements were carried out using the High-Purity Germanium Detector (HPGe). The distribution ratio for U, Eu (Eu-152), and Sr (Sr-84) was ascertained by quantifying their activity through LSC and HPGe. Through the experiments conducted within this program, we have gained a comprehensive understanding of the selective solvent extraction of actinides. Specifically, uranium has been effectively separated from the aqueous phase into the organic phase using a combination of tributyl phosphate (TBP) and dodecane. Subsequently, samples containing U(VI), Eu(III), and Sr(II) underwent thorough analysis utilizing LSC and HPGe detectors. Our radiation measurements have firmly established that the concentration of nitric acid enhances the selective separation of uranium within the process.
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