美國의 邊境精神과 韓國의 새마을運動精神과의 比較硏究

郭東憲,李瑛雨,李廷彬,申址湜 경북대학교 1988 새마을 硏究論叢 Vol.9 No.-

여자 축구 선수들의 양발 길이 차이와 부상과의 상관

장지훈,이명국 한국유산소운동과학회 2002 대한스포츠융합학회지 (jcses) Vol.6 No.1

The purpose of this study was to develop injury prevention program for women soccer players. Subject were all the members of korean national women youth soccer team (U-19). The length of both feet was measured, and 24 female soccer players were divided into 3 groups according to her length difference between both feet. In A group, the length of right foot was equal to that of left. In B group, the difference between both feet length was under 2mm. In C group, the difference between both feet length was above 3mm. Injury score was awarded by medical doctor and team doctor to each person after interview. Ball speed of both leg was measured by speed gun, balance was by stork stand As a result, about 80% of subjects were included in B and C group. Pearson's r was .590 between the foot length difference and injury score (p<.01), especially the highest 'r' was shown between the foot length difference and ankle injury score (r=.745, p<.01). No significance was shown between the foot length difference and ball speed, but significant difference was shown between the foot length difference and balance (p<.05).

15주간의 신체 활동 증진 프로그램이 여자 대학생의 신체 조성 및 혈중 지질 농도에 미치는 영향

장지훈,성기홍,김남익,조국래,이동수 한국유산소운동과학회 2002 대한스포츠융합학회지 (jcses) Vol.6 No.1

The purpose of this study was to develop the lecture model as liberal arts which have the positive effects to promote physical activity and to decrease obesity-dated variables. Subjects in this study were women university students, and they were divided into two groups to voluntary applying; one was tennis group (n=10), the other table tennis group (n=10). Physical activity promotion program in this study was practiced one time a week, 130 min. one time with the intensity under 83% predicted HR max for 15 weeks. Anthropometrics, body fat(%), blood lipid profile were measured before and after attending the program, respectively. After 15-week-physical activity promotion program, body weight, BMI, WHR, body fat(%), total cholesterol concentration, triacylglyceride concentration were decreased significantly in both groups (p<.5). Resting heart rate was decreased significantly only in tennis group (p<.5). No significance was shown in systolic and diastolic blood pressure to both groups.

소아 IgA 신병증의 예후와 관련한 임상병리학적 고찰

권재훈,최은나,박지민,정현주,이재승,Kwon Jae-Hun,Choi Eun-Na,Park Jee-Min,Jeung Hyeun-Joo,Lee Jae-Seung 대한소아신장학회 2003 Childhood kidney diseases Vol.7 No.1

목적 : IgA 신병증으로 진단된 소아환자를 대상으로 질병의 예후와 관련된 연구는 부족한 상태이다. 이에 저자들은 조직생검을 통해 확진된 IgA 신병증 환아의 임상경과를 관찰함으로써 소아들에서 장기 예후에 영향을 줄 수 있는 인자들의 특성을 알아보고자 하였다. 대상 및 방법 : 1981년부터 2000년까지 연세의료원에서 신생검을 시행하여 병리 소견상 IgA 신병증으로 확진된 15세 이하의 57명 환아에서 후향적 방법으로 자료 분석을 시행하였다. 모든 환아들은 조직 생검 당시 혈뇨나 무증후성 단백뇨($<40\;mg/m^2/day$)를 보였으며 정상 신기능 및 혈압을 유지하였다. 진단 당시의 임상검사소견, 병리소견 등을 바탕으로 IgA 신병증의 합병증인 심한 단백뇨(${\ge}40\;mg/m^2/day$), 약물복용을 요하는 고혈압. 만성 신부전 등의 발생에 대해 관찰하였다. 결과 : 대상 환아들의 진단 시 평균 연령은 4세에서 15세까지 $9.5{\pm}2.8$세였으며 42명(74%)이 남자였다. 단독 육안적 혈뇨는 20명(35%), 단독 현미경적 혈뇨는 3명(5%)이며 단독 단백뇨는 15(26%)이었다. 육안적 혈뇨와 단백뇨를 같이 동반한 경우는 15명(26%)이며 현미경적 혈뇨와 단백뇨는 15명(26%)에서 보였다. $7.0{\pm}3.5$년의 평균추적 관찰 기간동안 전체 57명의 환아 중 단백뇨 및 혈뇨가 완전히 소실된 경우는 38명(67%)이었고 진단 당시처럼 혈뇨나 단백뇨가 지속되나 IgA 신병증의 부작용은 발생하지 않은 경우는 12명(21%)이었다. 반면, 단지 7명(12%)의 환아에게서 IgA 신병증의 합병증이 발생하였는데 이 중에서 신증후군 정도의 단백뇨는 4명(7%), 약물복용을 요하는 고혈압은 1명(2%)이었고 2명(4%)의 환아는 말기 신부전으로 이행하였다. 발병 연령을10세 전후로 나누었을 때(P<0.01)와 Lee와 Haas의 병리조직학적인 분류(P<0.05)는 IgA 신병증의 합병증 발생과 밀접한 연관을 보인 반면, 진단당시 증상이나 성별은 통계적 유의성을 보이지 않았다. 57명 중 7명의 환아에서 평균 $3.4{\pm}3.5$년후에 신조직검사를 재실시하였다. 이 중 3명의 환아는 처음 class와 같았으며, 1명의 환아는 class III에서 class IV로 진행된 반면, 3명의 환아는 class IV에서 각각 class I, class II 및 class III로 변하였다. 결론 : 본 연구를 통해 소아의 IgA 신병증은 더 이른 시기에 진단 받았을 때 합병증의 발생 및 궁극적인 신부전으로의 이행이 적게 나타났다. 또한 추적 신조직 검사상 조직의 변화소견을 볼 때, 소아 IgA 신병증이 성인에서의 것보다 더 좋은 예후를 보이는 근거가 될 수 있다. Purpose : This study was performed to determine the natural history of histologically confirmed IgA nephropathy in pediatric patients who presented with hematuria and proteinuria. Patients and Methods : We reviewed the clinical course of 57 patients diagnosed with IgA nephropathy at the age of 15 years or younger from 1981 to 2000. All patients presented with hematuria or minimal proteinuria($<40\;mg/m^2/day$) and had normal renal function and blood pressure at the time of renal biopsy. Based on the clinical and pathological findings at the time of diagnosis, we sought for complications of IgA nephropathy such as heavy proteinuria(${\ge}40\;mg/m^2/day$), hypertension, and chronic renal failure. Results : The mean age at presentation was $9.5{\pm}2.8$ years(4 to 15 years) and 42(74%) were male. Isolated gross hematuria was observed in 20 patients(35%), microscopic hematuria in 3(5%), minimal proteinuria in 4(7%), both gross hematuria and minimal proteinuria in 15(26%), and both microscopic hematuria and minimal proteinuria in 15(26%). During a median follow-up of $7.0{\pm}3.5$ years, 38(67%) had complete resolution of hematuria and proteinuria, 12(21%) had persistently abnormal urinalysis without development of adverse events. Only 7(12%) developed adverse events : 4(7%) developed severe proteinuria, 1(2%) became hypertensive, and 2(3%) developed Impaired renal function. By univariate analysis using the chisquare test, the age at presentation(>10 years)(P<0.01) and poor histological classes of the Lee or Haas classification at onset(P<0.05) were significantly correlated with adverse events, whereas sex and clinical signs at onset were less concordant. Conclusion : We can conclude that the prognosis of IgA nephropathy diagnosed in early childhood is better and a good correlation exists between the clinical manifestations of this disease and the histological classes.

Brain abscess in Korean children: A 15-year single center study

Lee, Cha-Gon,Kang, Seong-Hun,Kim, Yae-Jean,Shin, Hyung-Jin,Choi, Hyun-Shin,Lee, Jee-Hun,Lee, Mun-Hyang The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.5

Purpose: A brain abscess is a serious disease of the central nerve system. We conducted this study to summarize the clinical manifestations and outcomes of brain abscesses. Methods: A retrospective chart review of pediatric patients diagnosed with brain abscesses from November 1994 to June 2009 was performed at Samsung Medical Center, Seoul, Korea. Results: Twenty-five patients were included in this study. On average, 1.67 cases per year were identified and the median age was 4.3 years. The common presenting clinical manifestations were fever (18/25, 72%), seizure (12/25, 48%), altered mental status (11/25, 44%), and signs of increased intracranial pressure (9/25, 36%). A total of 14 (56%) patients had underlying illnesses, with congenital heart disease (8/25, 32%) as the most common cause. Predisposing factors were identified in 15 patients (60%). The common predisposing factors were otogenic infection (3/25, 12%) and penetrating head trauma (3/25, 12%). Causative organisms were identified in 64% of patients (16/25). The causative agents were $S$ $intermedius$ (n=3), $S$ $aureus$ (n=3), $S$ $pneumoniae$ (n=1), Group B streptococcus (n=2), $E.$ $coli$ (n=1), $P.$ $aeruginosa$ (n=1), and suspected fungal infection (n=5). Seven patients received medical treatment only while the other 18 patients also required surgical intervention. The overall fatality rate was 16% and 20% of patients had neurologic sequelae. There was no statistical association between outcomes and the factors studied. Conclusion: Although uncommon, a brain abscess is a serious disease. A high level of suspicion is very important for early diagnosis and to prevent serious consequences.

Expression of beta-catenin and its mechanism of delocalization in intestinal-type early gastric cancer based on mucin expression.

Lee, Soo Han,Kang, Hyun Jeong,Shin, Dong-Hun,Cho, Duk-Yeon,Song, Jin Mi,Lee, Han Cheol,Kim, Gwang Ha,Song, Geun Am,Sol, Mee Young,Kim, Jee Yeon,Choi, Kyung Un,Lee, Chang Hun,Huh, Gi Young,Park, Do You Gutenberg 2009 HISTOLOGY AND HISTOPATHOLOGY Vol.24 No.7

<P>The biological characteristics of intestinal-type early gastric cancers (ICs) differ based on mucin phenotypes. Beta-catenin delocalization is a predictive marker of aggressive biological behavior (submucosal invasion and lymph node metastasis) of ICs. The presumptive causative genetic alterations leading to delocalization of beta-catenin in ICs are still controversial, and there are only a few reports regarding beta-catenin expression in gastric cancer based on mucin phenotypes. Therefore, in the current study, the expression and mechanisms of delocalization of beta-catenin were elucidated on the basis of mucin phenotypes in 109 cases of ICs. There was increased cytoplasmic and nuclear beta-catenin expression (delocalization) in ICs with a predominant intestinal mucin phenotype (ICIP; 46.3% [25/54 cases]) compared to ICs with a predominant gastric mucin phenotype (ICGP; 20% [11/55 cases]). There were no beta-catenin or APC mutations in ICs. APC promoter hypermethylation was present in 49 of 105 (46.7%) cases of ICs. There was a significant relationship between APC promoter hypermethylation and beta-catenin delocalization in ICs, especially in ICIPs. There was no relationship between beta-catenin delocalization and APC gene loss of heterozygosity in ICs. In conclusion, we showed that beta-catenin delocalization was more evident in ICIPs, and APC promoter hypermethylation might play a role in delocalization of beta-catenin, especially in ICIPs.</P>

Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer.

Lee, Kyung-Hun,Chang, Hye Jung,Han, Sae-Won,Oh, Do-Youn,Im, Seock-Ah,Bang, Yung-Jue,Kim, Sun Young,Lee, Keun-Wook,Kim, Jee Hyun,Hong, Yong Sang,Kim, Tae Won,Park, Young Suk,Kang, Won Ki,Shin, Sang Joo Springer 2013 Cancer chemotherapy and pharmacology Vol.71 No.4

<P>Ethnic diversity of genetic polymorphism can result in individual differences in the efficacy and toxicity of cancer chemotherapy.</P>

Treatment of Melasma in Asian Skin Using a Fractional 1,550-nm Laser: An Open Clinical Study

LEE, HYOUN SEUNG,WON, CHONG HYUN,LEE, DONG HUN,AN, JEE SOO,CHANG, HANG WOOK,LEE, JONG HEE,KIM, KYU HAN,CHO, SOYUN,CHUNG, JIN HO Blackwell Publishing Inc 2009 Dermatologic surgery Vol.35 No.10

<P>BACKGROUND</P><P>Melasma is a common hyperpigmentation disorder that can cause refractory cosmetic disfigurement, especially in Asians. Fractional photothermolysis (FP) has been reported to be effective for the treatment of melasma, despite small study populations and short follow-up periods.</P><P>OBJECTIVE</P><P>To evaluate the efficacy and safety of FP for the treatment of melasma in Asians.</P><P>PATIENTS AND METHODS</P><P>Twenty-five patients with melasma received four monthly FP sessions and were followed up to 24 weeks after treatment completion. Efficacy was evaluated using objective and subjective ratings, Melasma Area and Severity Index (MASI), melanin index tracking, and skin elasticity measurements.</P><P>RESULTS</P><P>Investigators observed clinical improvements in 60% and patients in 44% at 4 weeks after treatment, but the figures decreased to 52% and 35%, respectively, at 24 weeks after treatment. Mean MASI scores decreased significantly from 7.6 to 6.2. Mean melanin index decreased significantly after the first two sessions, but it relapsed slightly in subsequent follow-ups. The treatment did not alter skin elasticity. Hyperpigmentation was observed in three of 23 subjects (13%).</P><P>CONCLUSION</P><P>Treatment of melasma with FP led to some clinical improvements, but it was not as efficacious as previously reported at 6-month follow-up. We recommend judicious use of FP for the treatment of melasma in Asian skin because of its limited efficacy.</P>

난치성의 급성 췌장염으로 발현한 췌장의 Intraductal Papillary Mucinous Tumor 1예

이상인,지상원,이세준,박영년,이관식,문병수,송시영,정준표,정재복,강진경,김기황,지훈상 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.2

Development of Vision based Control Smart Windwhield Wiper System for Intelligent Vehicle

Jee-Hun Park,Man-Ho Kim,Hong-Jun Im,Kyung-Chang Lee,Suk Lee 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10