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하부 클러스터링 환경의 Shared Virtual Memory 시스템에 대한 영향 분석
정재웅(JaeWoong Chung),성병학(Byeong Hag Seong),박규호(Kyu Ho Park),박대연(Daeyeon Park) 한국정보과학회 1999 한국정보과학회 학술발표논문집 Vol.26 No.1A
Shared Virtual Memory(SVM)는 NOW 환경에서 비용으로 사용자에게 소프트웨어적으로 공유 메모리 구조를 제공하는 기법 중의 하나이다. SVM 시스템의 성능은 1 차적으로 일관성 유지 프로토콜의 효율성에 의해 결정되지만 하부 클러스터링 환경의 영향 또한 매우 크다. 그러나 기존의 연구들은 프로토콜의 효율성 개선에만 주안점은 두어 하부 클러스터링 환경의 각 요소가 전체 시스템의 성능에 미치는 영향에 대한 분석이 부족하였다. 본 연구는 클러스터링 시스템의 주요 요소인 CPU, 메인 메모리, 네트워크 인터페이스가 전체 시스템의 성능에 미치는 영향을 밝히고자 한다. 이를 위해 SVM 시스템을 구현하여, 실제로 클러스터링 시스템 상에서 각 요소의 변화에 대한 시스템 성능의 변화를 정량적으로 측정하였다. 측정 분석 결과 CPU와 네트워크 인터페이스의 성능 차와 메인 메모리의 크기가 전체성능에 영향을 크게 미침을 밝혔고, 또 사용된 일관성 유지 프로토콜에 따라 영향을 받는 정도가 달라짐도 밝혔다.
Lee, Jaewoong,Park, Yeon-Joon,Park, Dong-Jin,Park, Kang-Gyun,Lee, Hae Kyung The Korean Society for Laboratory Medicine 2017 Annals of Laboratory Medicine Vol.37 No.1
<P><B>Background</B></P><P>We evaluated the performance of the BD MAX StaphSR Assay (SR assay; BD, USA) for direct detection of <I>Staphylococcus aureus</I> and methicillin resistance not only in <I>S. aureus</I> but also in coagulase-negative <I>Staphylococci</I> (CNS) from positive blood cultures.</P><P><B>Methods</B></P><P>From 228 blood culture bottles, 103 <I>S. aureus</I> [45 methicillin-resistant <I>S. aureus</I> (MRSA), 55 methicillin-susceptible <I>S. aureus</I> (MSSA), 3 mixed infections (1 MRSA+<I>Enterococcus faecalis</I>, 1 MSSA+MRCNS, 1 MSSA+MSCNS)], and 125 CNS (102 MRCNS, 23 MSCNS) were identified by Vitek 2. For further analysis, we obtained the cycle threshold (Ct) values from the BD MAX system software to determine an appropriate cutoff value. For discrepancy analysis, conventional mecA/mecC PCR and oxacillin minimum inhibitory concentrations (MICs) were determined.</P><P><B>Results</B></P><P>Compared to Vitek 2, the SR assay identified all 103 <I>S. aureus</I> isolates correctly but failed to detect methicillin resistance in three MRSA isolates. All 55 MSSA isolates were correctly identified by the SR assay. In the concordant cases, the highest Ct values for <I>nuc</I>, <I>mecA</I>, and <I>mec</I> right-extremity junction (MREJ) were 25.6, 22, and 22.2, respectively. Therefore, we selected Ct values from 0-27 as a range of positivity, and applying this cutoff, the sensitivity/specificity of the SR assay were 100%/100% for detecting <I>S. aureus</I>, and 97.9%/98.1% and 99.0%/95.8% for detecting methicillin resistance in <I>S. aureus</I> and CNS, respectively.</P><P><B>Conclusions</B></P><P>We propose a Ct cutoff value for <I>nuc</I>/<I>mec</I> assay without considering MREJ because mixed cultures of MSSA and MRCNS were very rare (0.4%) in the positive blood cultures.</P>
방사선 치료 후 중심경부림프절에서 재발한 조기 성문암 1예
박의현(Euyhyun Park),주영호(Youngho Ju),황재웅(Jaewoong Hwang),박상헌(Sangheon Park),백승국(Seung-Kuk Baek) 대한두경부종양학회 2013 대한두경부 종양학회지 Vol.29 No.2
Early glottic cancer can be effectively treated with surgery or radiotherapy showing the comparable treatment results. Since radiation therapy may be better in terms of voice preservation, it tends to be preferred in early glot-tic cancer. Most common recurrence site is glottis after radiation therapy and complete remission of glottic pri-mary site followed by local recurrence limited to neck is very rare. The authors are reporting a patient with region-al recurrence of central neck lymph nodes after radiation therapy for T1a glottic cancer.
Park Kuenyoul,Lee Jaewoong,Lee Kihyun,Jung Jiwon,Kim Sung-Han,Lee Jina,Chalita Mauricio,Yoon Seok-Hwan,Chun Jongsik,Hur Kyu-Hwa,Sung Heungsup,Kim Mi-Na,Lee Hae Kyung 대한의학회 2021 Journal of Korean medical science Vol.36 No.4
Background: Coronavirus disease 2019 (COVID-19) outbreaks emerged at two university- affiliated hospitals in Seoul (hospital A) and Uijeongbu City (hospital S) in the metropolitan Seoul area in March 2020. The aim of this study was to investigate epidemiological links between the outbreaks using whole genome sequencing (WGS) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: Fifteen patients were enrolled in the study, including four non-outbreak (A1–A4) and three outbreak cases (A5–A7) in hospital A and eight cases (S1–S8) in hospital S. Patients' hospital stays, COVID-19 symptoms, and transfer history were reviewed. RNA samples were submitted for WGS and genome-wide single nucleotide variants and phylogenetic relationships were analyzed. Results: The index patient (A5) in hospital A was transferred from hospital S on 26 March. Patients A6 and A7 were the family caregiver and sister, respectively, of the patient who shared a room with A5 for 4 days. Prior to transfer, A5 was at the next bed to S8 in the emergency room on 25 March. Patient S6, a professional caregiver, took care of the patient in the room next to S8's room for 5 days until 22 March and then S5 for another 3 days. WGS revealed that SARS-CoV-2 in A2, A3, and A4 belong to clades V/B.2, S/A, and G/B.1, respectively, whereas that of A5–A7 and S1-S5 are of the V/B.2.1 clade and closely clustered. In particular, SARS-CoV-2 in patients A5 and S5 showed perfect identity. Conclusion: WGS is a useful tool to understand epidemiology of SARS-CoV-2. It is the first study to elucidate the role of patient transfer and caregivers as links of nosocomial outbreaks of COVID-19 in multiple hospitals.
Inhibition of Various K⁺ Current by Ofloxacin in Neonatal rat Ventricular Myocytes
Park Sang Woong(박상웅),Oh Seung Bum(오승범),Gu Jaewoong(구재웅),Sung Dong Jun(성동준) 한국웰니스학회 2018 한국웰니스학회지 Vol.13 No.3
플루오로 퀴놀론은 광범위하게 사용되는 항생제 중 하나이다. Ofloxacin은 상대적으로 안전하다고 여겨지지만 심장에 부작용이 있는지 여부는 불분명하다. 이 파일럿 연구는 ofloxacin이 L-typeCa<SUP>2+</SUP> 채널 전류뿐만 아니라 다양한 K⁺ 채널 전류에 미치는 영향을 연구했다. 다양한 K⁺ 전류는 다단계 펄스를 사용하는 전압 펄스 프로토콜로 검사되었으며, 단계 -120mV에서 +50mV까지의 탈분극 단계,-80mV의 유지력에서 -40mV까지 진행되었다.L-typeCa<SUP>2+</SUP> 전류는 prepulse후 -40mV에서 0mV에서 측정되었다. Ofloxacin은 IKir의 경우 850μM, IK의 경우 6.8μM 및 IKr의 경우 0.4μM의 IC50값으로 다양한 K⁺ 전류를 억제하였다. 그러나 Ofloxacin은 L-typeCa<SUP>2+</SUP> 전류에 영향을 미치지 않았다. 이 결과를 통해 잠재적인 심장 부작용, 예를 들어 활동 전위의 연장과 부정맥이 ofloxacin에 의해 유발 될 수 있다고 제안한다. Fluoroquinolones are among the most widely used broad-spectrum antibiotics. Although ofloxacin is deemed to be relatively safe, whether side effects occur in the heart is unclear. This pilot study investigated the effect of ofloxacin on various K+ channel currents as well as L-type Ca2+ channel currents. The various K+ currents were examined with a voltage pulse protocol using multi-step pulses, with a step to-120mV followed by a depolarizing step to +50mV and then to–40mV from holding potential of-80mV. L-type Ca2+ currents were measured at 0mV after prepulse to-40mV. Ofloxacin inhibited the various K+ currents, with IC50 values of 850μM for IKir, 6.8μM for IKs, and 0.4μM for IKr. Ofloxacin did not affect the L-type Ca2+ currents. We suggest that potential cardiac side effects, such as action potential prolongation and arrhythmia, maybe induced by ofloxacin.
정재웅,박주희,정양훈,원석채 순천향대학교 순천향의학연구소 2021 Journal of Soonchunhyang Medical Science Vol.27 No.2
Magnetic resonance imaging (MRI) is a useful and safe imaging modality for examining preterm infants. However, MRI examination requires careful precautions, and infants and children are likely to require deep sedation or anesthesia to keep them still during the examination. Sedation has various risks and the greatest concern of sedation is cardiorespiratory events. In addition, delicate titration is also necessary for preterm infants because propofol pharmacokinetics is different from those in older children. We successfully completed sedation of a preterm neonate (gestational age, 32+1 weeks; birth weight, 1,970 g) with a history of frequent apnea through careful assessment and continuous monitoring. We want to suggest alternative options for airway management of the high risk of respiratory complications.