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Lee, Ho Sup,Kim, Kihyun,Yoon, Dok Hyun,Kim, Jin Seok,Bang, Soo-Mee,Lee, Jeong-Ok,Eom, Hyeon Seok,Lee, Hyewon,Kim, Inho,Lee, Won Sik,Bae, Sung Hwa,Kim, Se Hyung,Lee, Mark Hong,Do, Young Rok,Lee, Jae Ho Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-
<P>Waldenström's macroglobulinemia (WM) is a B-cell proliferative malignancy characterized by immunoglobulin M monoclonal gammopathy and bone marrow infiltration by lymphoplasmacytic cells. Clinical features and cytogenetics of WM in Asia including Republic of Korea remain unclear. Moreover, no study has reported treatment outcomes in patients with WM treated with novel agent combined with conventional chemotherapy. This study investigated clinical features and assessed treatment outcomes with novel agent and conventional chemotherapy in Republic of Korea. Data from all (<I>n</I> = 71) patients with newly diagnosed WM at 17 hospitals who received chemotherapy between January 2005 and December 2012 were collected retrospectively. The median age of patients was 66 years (range: 37–92 years) and male to female ratio was 5 : 1. Patients treated with novel agent combined chemotherapy displayed higher overall response rate (ORR) compared to conventional chemotherapy alone (92.9% versus 52.6%, <I>P</I> = 0.006). The 5-year overall survival rate was 62.6% (95% confidence interval: 34.73–111.07). Use of novel agents produced higher ORR but survival benefit was not apparent due to the small number of patients and short follow-up duration. Further studies are needed to confirm the efficacy of novel agents in patients with WM.</P>
The Outcomes of Hypertransfusion in Major ABO Incompatible Allogeneic Stem Cell Transplantation
Lee Se Hoon,Park Joon Oh,Jung Chul Won,Park Keunchil,Lee Kyoo Hyung,Lee Mark Hong,Lee Kyung Eun,Park Jinny,Kim Kihyun,Kim Won Seog,Im Young Hyuk,Kang Won Ki,Kim Seon Woo,Lee Je Hwan,Park Se Hoon 대한의학회 2004 Journal of Korean medical science Vol.19 No.1
Eui-Seon Lee,Tae-Young Kim,Yam Prasad Aryal,Kihyun Kim,Seongsoo Byun,Dongju Song,Yejin Shin,Dany Lee,Jooheon Lee,Gilyoung Jung,Seunghoon Chi,Yoolim Choi,Youngkyun Lee,Chang-Hyeon An,Jae-Young Kim 대한구강생물학회 2021 International Journal of Oral Biology Vol.46 No.2
This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.
Loss Analysis and Comparison of High Power Semiconductor Devices in 5MW PMSG MV Wind Turbine Systems
Lee, Kihyun,Suh, Yongsug,Kang, Yongcheol The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.5
This paper provides a loss analysis and comparison of high power semiconductor devices in 5MW Permanent Magnet Synchronous Generator (PMSG) Medium Voltage (MV) Wind Turbine Systems (WTSs). High power semiconductor devices of the press-pack type IGCT, module type IGBT, press-pack type IGBT, and press-pack type IEGT of both 4.5kV and 6.5kV are considered in this paper. Benchmarking is performed based on the back-to-back type 3-level Neutral Point Clamped Voltage Source Converters (3L-NPC VSCs) supplied from a grid voltage of 4160V. The feasible number of semiconductor devices in parallel is designed through a loss analysis considering both the conduction and switching losses under the operating conditions of 5MW PMSG wind turbines, particularly for application in offshore wind farms. This paper investigates the loss analysis and thermal performance of 5MW 3L-NPC wind power inverters under the operating conditions of various power factors. The loss analysis and thermal analysis are confirmed through PLECS Blockset simulations with Matlab Simulink. The comparison results show that the press-pack type IGCT has the highest efficiency including the snubber loss factor.
Loss Analysis and Comparison of High Power Semiconductor Devices in 5MW PMSG MV Wind Turbine Systems
Kihyun Lee,Yongsug Suh,Yongcheol Kang 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.5
This paper provides a loss analysis and comparison of high power semiconductor devices in 5MW Permanent Magnet Synchronous Generator (PMSG) Medium Voltage (MV) Wind Turbine Systems (WTSs). High power semiconductor devices of the press-pack type IGCT, module type IGBT, press-pack type IGBT, and press-pack type IEGT of both 4.5kV and 6.5kV are considered in this paper. Benchmarking is performed based on the back-to-back type 3-level Neutral Point Clamped Voltage Source Converters (3L-NPC VSCs) supplied from a grid voltage of 4160V. The feasible number of semiconductor devices in parallel is designed through a loss analysis considering both the conduction and switching losses under the operating conditions of 5MW PMSG wind turbines, particularly for application in offshore wind farms. This paper investigates the loss analysis and thermal performance of 5MW 3L-NPC wind power inverters under the operating conditions of various power factors. The loss analysis and thermal analysis are confirmed through PLECS Blockset simulations with Matlab Simulink. The comparison results show that the press-pack type IGCT has the highest efficiency including the snubber loss factor.
Lee, Changsoo,Shin, Kihyun,Lee, Yung Jong,Jung, Chanwon,Lee, Hyuck Mo Elsevier 2018 CATALYSIS TODAY - Vol.303 No.-
<P><B>Abstract</B></P> <P>Here we examine Ag-Cu<SUB>2</SUB>O core-shell nanoparticles with bumpy structures for use in plasmonic photocatalysts. We synthesized the nanoparticles using a very simple co-reduction process. The shell thickness of the nanoparticles was controlled in order to investigate the effects of shell thickness on photocatalytic activity and stability. With increasing shell thickness, it was be observed that the activity and the stability were simultaneously improved. A thin shell lead to de-wetting of Cu<SUB>2</SUB>O from the Ag core and considerable oxidation of Cu<SUB>2</SUB>O to CuO. The high activity could be due to the unique structure of Ag-Cu<SUB>2</SUB>O, which has a high surface area and plasmonic charge transfer from the Ag core. In addition, we elucidated the stability tendency using conducted density functional theory (DFT) calculation. Strain induced between the Ag core and shell is critical to the stability, leading to de-wetting and oxidation of Cu<SUB>2</SUB>O.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We synthesized Ag-Cu<SUB>2</SUB>O core-shell NPs with bumpy structure. </LI> <LI> The Ag-Cu<SUB>2</SUB>O core-shell NPs have high surface area and broad range of UV–vis absorption. </LI> <LI> Shell thickness of Ag-Cu<SUB>2</SUB>O NPs play a key role for activity and stability of the photocatalysts. </LI> <LI> Combined experimental and theoretical study was conducted. </LI> <LI> High strain between core and shell of thin core-shell NPs induce de-wetting and oxidation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Investigation of the effect of pre-fill gas in VEST discharges by predictive transport simulations
Lee Chanyoung,Kim SeongCheol,Kim Young-Gi,Kim YooSung,Lee Kihyun,Hwang Y. S.,나용수 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.2
The predictive modeling of the VEST (Chung et al. in Plasma Sci Technol 15(3):244, 2013) device is presented. The integrated simulation tool was organized to conduct the 1D transport simulation considering neoclassical and turbulent transport, and pre-fll gas neutrals. The 1D transport equation and a detailed setup for the predictive analysis were addressed. By varying pre-fll gas levels, a set of predictive simulations was conducted. The electron density, electron and ion temperatures from Thomson scattering, and ion Doppler spectroscopy diagnostics were compared with the predictive simulation results. The discrepancies upon comparing the measurements with the simulations and further required eforts were discussed.