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Syringocystadenoma papilliferum of the vulva
( Injae Jeong ),( Seongu Lee ),( Seongrak Seo ),( Dongju Hyun ),( Heejung Lee ),( Donghyun Kim ),( Moonsoo Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Syringocystadnoma papilliferum (SCAP) is an uncommon cutaneous adnexal neoplasm with a predilection for the head and neck region. Most patients present with a solitary lesion in the head and neck at birth or in early childhood. Those arising outside the head and neck region have rarely been reported. A 32-year-old female presented with the progressive enlargement of a skin-colored firm nodule on the left labium majus, which had been found since 1-year ago. Punch-excisional biopsy showed acanthotic and papillomatous epidermis with the ductal invagination extending into the dermis. The dermal cystic neoplasm, which was connected to the epidermal invagination, was lined by the epithelium of double layers. Epithelial cells consisted of outer cuboidal cells and inner columnar cells which showed a decapitation secretion. The fibrous stromal cores were infiltrated by plasma cells. The diagnosis of syringocystadenoma papilliferum was finally made based on the clinicopathologic grounds, and for the past one year no evidence of recurrence has been traced. Authors, herein, present unusual case of syringocystadenoma papilliferum on the vulva.
Subungual congenital melanocytic nevus showing total melanonychia in infant
( Injae Jeong ),( Seongu Lee ),( Seongrak Seo ),( Dongju Hyun ),( Heejung Lee ),( Donghyun Kim ),( Moonsoo Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Melanonychia commonly results from melanin produced by melanocytes in the nail matrix secondary to inflammatory dermatoses or systemic medication in pediatrics. It can also be caused by a benign pigmented nevus in the matrix or malignant melanoma. Especially, subungual congenital melanocytic nevus is considered rare and only a few histologically proven pediatric cases have been reported in the literature. A 10-months-old male presented with total melanonychia and brownish patch on the periunugal area, which had been found at birth. The patient had no history of trauma and medication. A punch biopsy was performed on proximal nail matrix including toenail. The histological finding was epidermal hyperplasia and a proliferation of melanocytes with small nuclei without atypia or pleomorphism. These melanocytes were arranged in nests of different sizes in the epidermis. The diagnosis of congenital melanocytic nevus was finally made based on the clinicopathologic grounds and ongoing observation. We herein report a rare case of subungual congenital melanocytic nevus on the right 2nd toenail, which presented with total melanonychia and periungual pigmentation in infant.
A case of multiple pilomatrocoma in child with anaplastic astroblastoma
( Injae Jeong ),( Seongu Lee ),( Seongrak Seo ),( Dongju Hyun ),( Heejung Lee ),( Donghyun Kim ),( Moonsoo Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Pilomatricoma is a benign tumor most commonly found in children, occurs mostly in solitary and at a multiple of about 3%. Multiple pilomatricoma occur as idiopathic, but there is a mutation in a gene associated with the configuration of β-catenin Wnt signaling pathway in many cases. A malignancy at an early age with characteristic cutaneous manifestations occurring is to be accompanied by an indication of the CMMRD syndrome genetic testing. Because CMMRD syndrome has no specific gene therapy, required for the early diagnosis and treatment of malignancy through continuous observation An 8-years-old female presented with an asymptomatic multiple nodules on the face and trunk which had been recognized 2-years ago. The patient had a history of receiving about four years ago anaplastic astroblastoma surgery. Excisional biopsy was performed on the face. The histological finding was consistent with pilomatricoma. CMMRD syndrome was suspected on clinical findings, the MLH1, MSH2, MSH6, PMS2 immunohistochemical staining was performed in the brain tissue and skin tissue, but a loss of function mutations was not observed. We herein report a case of multiple pilomatricoma with a history of malignant brain tumors, multiple pilomatricoma with another malignant tumor at an early age need an assessment of the genetic defects.
Jeong-Im Han,Tae-Hwan Choi,Injae Lim,Joo-Kyeong Lee 한국음성학회 2011 말소리와 음성과학 Vol.3 No.2
The present work is a follow-up study to that of Han, Choi, Lim and Lee (2011), where an asymmetry in the source segments eliciting the interlanguage speech intelligibility benefit (ISIB) was found such that the vowels which did not match any vowel of the Korean language were likely to elicit more ISIB than matched vowels. In order to identify the source of the stronger ISIB in non-matched vowels, acoustic analyses of the stimuli were performed. Two pairs of English front vowels [i] vs. [?], and [?] vs. [æ] were recorded by English native talkers and two groups of Korean learners according to their English proficiency, and then their vowel duration and the frequencies of the first two formants (F1, F2) were measured. The results demonstrated that the non-matched vowels such as [?], and [æ] produced by Korean talkers seemed to show more deviated acoustic characteristics from those of the natives, with longer duration and with closer formant values to the matched vowels, [i] and [?], than those of the English natives. Combining the results of acoustic measurements in the present study and those of word identification in Han et al. (2011), we suggest that relatively better performance in word identification by Korean talkers/listeners than the native English talkers/listeners is associated with the shared interlanguage of Korean talkers and listeners.
Jeong, Kyoung Hoon,Kim, Se Hoon,Choi, Yun Ho,Cho, Inja,Kim, Won-Joo Elsevier 2018 Epilepsy research Vol.147 No.-
<P><B>Abstract</B></P> <P>Granule cell dispersion (GCD) is a common neuropathological feature of hippocampal sclerosis (HS) in patients with temporal lobe epilepsy (TLE). However, the underlying molecular mechanism of GCD formation remains unclear. The present study aimed to investigate the expressional changes of With No Lysine protein kinase subtype 3 (WNK3), a molecule upstream of cation-chloride cotransporters with reciprocal expression in sclerosed hippocampus of TLE patients. Using immunofluorescence staining, we analyzed WNK3 immunoreactivity in hippocampal specimens from histologically normal controls and TLE patients with HS. Our results showed that WNK3 expression was significantly increased in dispersed granule neurons in hippocampal tissues from patients with TLE compared with histologically normal hippocampus. These findings demonstrate a potential association between an increased expression of WNK3 and GCD formation during the chronic phase of epilepsy. Controlling WNK3 expression may thus be a novel therapeutic target in epileptogenesis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We examined the expressional change of WNK3 on GCD of TLE patients with HS. </LI> <LI> WNK3 expression significantly enhanced in dispersed dentate granule neurons. </LI> <LI> The control of WNK3 may be a novel therapeutic target against epileptic processes. </LI> </UL> </P>
Speech Intelligibility of Korean EFL Learners : Role of Proficiency, Text Type and Text Length
Injae Lim,Jeong-Im Han,Taehwan Choi,Joo-Kyeong Lee 아시아영어교육학회 2016 The Journal of Asia TEFL Vol.13 No.4
The purpose of this study was to investigate whether and to what extent the intelligibility of Korean EFL learners’ speech at the text level is affected by their English proficiency, text type, and text length. Various speech materials produced by native English speakers and two Korean EFL speaker groups (high vs. low proficiency) were presented to native English listeners and two Korean EFL listener groups, respectively, for comparison of intelligibility scores. The results showed that the listeners’ overall proficiency played the most critical role in determining the level of speech intelligibility for all speaker groups, regardless of the type and length of speech materials. The speakers’ proficiency level in terms of pronunciation, however, had no significant effect. As for the text type, dialogue texts were consistently more intelligible than monologues to all listener groups while the effect of text length varied depending on the text type. These results suggest that L2 learners’ speech intelligibility needs to be examined within the context of natural L2 text beyond word- and sentence-level utterances in consideration of the interaction of text-related features and other learner variables. Some pedagogical implications are also discussed.
동기식 IR-UWB 시스템에서 불완전 동기 환경에 강인한 채널 추정 기법
황인재(Injae Hwang),김정빈(Jeong-been Kim),오왕록(Wangrok Oh),안재민(Jaemin Ahn) 한국통신학회 2009 韓國通信學會論文誌 Vol.34 No.3
본 논문에서는 IEEE 802.15.4a를 기반으로 한 IR-UWB (Impulse Radio ? Ultra-wideband) 시스템에서 잔여 주파수 오프셋의 영향을 줄이는 채널 추정 기법을 제안한다. 실제로 IR-UWB 수신기는 제한된 프리앰블 심볼의 개수 때문에 주파수 동기를 완벽하게 수행할 수 없다. 따라서 잔여 주파수 오프셋이 존재하고 이 영향으로 채널 추정 과정에서 상당한 오류가 발생하게 된다. 제안된 채널 추정 기법은 채널 추정과정에서 얻어낸 다중경로 프로파일을 이용하여 주파수 동기에 대한 정보를 획득하고 그것을 이용함으로써 제한된 수의 프리앰블 심볼을 가지고도 잔여 주파수 오프셋을 보상하고 잔여 주파수 오프셋에 의한 채널 추정 오류를 수정하여 정확한 채널 상태 정보를 추정하는 기법이다. 제안된 알고리즘을 IEEE 802.15.4a에서 제시한 채널 모델에 적용하여 모의실험 하였으며 제안된 채널 추정 알고리즘과 기존의 채널 주정 알고리즘을 비교 분석하여 성능이 개선됨을 확인하였다. A novel channel estimation scheme is proposed for coherent Impulse Radio Ultra Wideband (IR-UWB) system based on IEEE 802.15.4a specification. By extracting and utilizing the information on the frequency synchronization, the proposed channel estimation algorithm improves the receiver performance even under the restricted number of preamble symbols in IEEE 802.15.4a signal format. Simulation results over the IEEE 802.15.4a channel models show the performance gain with the proposed algorithm compared to ordinary channel estimation method.