S-208 In-Stent Restenosis-prone Lesion Characteristics

( Duck-jun Seo ),( Yong-kyun Kim ),( Ki-hong Kim ),( Taek-geun Kwon ),( In-geol Song ),( Dong-ju Yang ),( Wan-ho Kim ),( Yo-han Park ),( Hwan-hyi Cho ),( Young-hoon Seo ),( Hyun-woong Park ),( Jang-ho 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Objective: Instent restenosis (ISR) remains still an important issue even in drug-eluting stents era. We hypothesized that higher inflammatory reaction, which is known as an important atherosclerotic process, at the culprit lesion may have higher restenosis. We sought to evaluate the baseline coronary plaque composition in patients with ISR. Methods: Study population consisted of 241 patients with coronary artery disease, who underwent percutaneous coronary intervention with virtual histology- intravascular ultrasound (VH-IVUS) and 9 months follow up coronary angiography. We compared coronary plaque composition between patients with ISR and those without ISR. Results: Patients with ISR (n=27, 11.2%) were likely to be older (66.2±9.5 years vs. 58.7±11.7 years, p=0.002), increased high sensitivity C-reactive protein (hs-CRP, 1.60±3.59 mg/dl vs. 0.31±0.76 mg/dl, p<0.001) than those without ISR (n=214, 88.8%). Baseline angiographic, procedural findings and gray scale IVUS findings showed no significant differences between 2 groups. VH-IVUS examination showed necrotic core volume (22.1±19.9 mm3 vs.14.2±12.7 mm3, p=0.045) and percent necrotic core volume (14.3±8.7% vs. 19.5±9.1%, p=0.005) were higher in those without ISR than those with ISR, whereas percent fibrofatty volume was higher (16.6±9.7% vs. 12.4±8.4%, p=0.018) in those with ISR than those without ISR. The independent predictors for ISR were hs-CRP (Odd ratio=3.334, 95% confidence interval (CI); 1.158~9.596, p=0.026), and age (Odd ratio=3.557, 95% CI; 1.242~10.192, p=0.018). Conclusions: This study suggests that ISR was not associated with baseline coronary plaque composition but old age and an increased inflammatory marker such as hs-CRP. Keywords: Intravascular Ultrasound, Instent Restenosis, Inflammation and restenosis after percutaneous coronary intervention

In-stent restenosis-prone coronary plaque composition: A retrospective virtual histology-intravascular ultrasound study

Seo, Duck-Jun,Kim, Yong-Kyun,Seo, Young-Hoon,Song, In-Geol,Kim, Ki-Hong,Kwon, Taek-Geun,Park, Hyun-Woong,Bae, Jang-Ho VM Media Sp zo.o. - VMGroup SK 2018 Cardiology journal Vol.25 No.1

토양 매질체에서 탄소나노물질의 이동성

이인걸(In Geol Yi),강진규(Jin Kyu Kang),김성배(Song Bae Kim),김현중(Hyun Jung Kim),한요셉(Yo Sep Han),엄익춘(Ig Chun Eom),조은혜(Eun Hye Jo),박선영(Sun Young Park) 大韓環境工學會 2014 대한환경공학회지 Vol.36 No.8

탄소나노물질은 대표적인 나노물질로써, 풀러렌, 탄소나노튜브, 그래핀 등을 포함한다. 탄소나노물질은 다양한 분야에서 널리 이용되고 있는데, 생산, 사용, 처리 등의 단계에서 환경에 노출될 수 있고, 일단 노출이 되면 다양한 계로 확산되어 여러 생태학적 수용체에 큰 위협이 될 수 있다. 탄소나노물질이 토양환경에 노출되었을 때, 물의 흐름을 따라 토양을 통과하여 지하수에 노출될 가능성 여부를 판단하기 위하여 연구들이 진행되고 있다. 토양이 탄소나노물질의 이동을 제한하는 역할을 잘하는 것으로 판단될 경우에는, 탄소나노물질의 지하수 노출 가능성이 상당히 낮아질 것이다. 본 논문에서는 최근까지 토양 매질체에서 탄소나노물질의 이동과 관련하여 수행된 연구들을 정리하였다. 또한, 이러한 연구들을 통해 알려진 탄소 나노물질의 이동에 영향을 미치는 인자들을 제시하였다. 그리고, 탄소나노물질의 이동을 모사하는데 이용되는 DLVO이론, 콜로이드 여과이론 그리고 이동모델을 제시하였다. 최근, 국내에서도 탄소나노물질의 생산과 상업적, 환경적 이용이 급속히 증가하고 있다. 따라서, 국내에서 생산되고 유통되는 탄소나노물질의 토양환경에서 이동에 관한 연구들이 향후에도 다양한 토양 환경조건에서 수행되어야 할 것으로 보인다. Carbon nanomaterials such as fullerene, carbon nanotube and graphene are representative nanomaterials and widely used in various fields. Carbon nanomaterials can be exposed to environments during their production, usage and disposal, spreading to different systems and posing a great threat to various ecological receptors. Researches are conducted in order to determine the possibility of groundwater exposure to carbon nanomaterials due to their release and passage through soils. If soils can play a significant role in limiting the transport of carbon nanomaterials, the possibility of groundwater exposure to carbon nanomaterials can be reduced greatly. This review paper presented the research works performed for the mobility of carbon nanomaterials in soil media. Also, the paper provided the factors affecting the transport of carbon nanomaterials in soil media along with the DLVO theory/colloid filtration theory/transport model, which are used to describe the transport of carbon nanomaterials in soil media. Recently, production of carbon nanomaterials and their commercial and environmental applications increase rapidly in Korea. Therefore, researches regarding the fate and transport of domestic carbon nanomaterials in soil environments should be performed in various environmental conditions.

Batch and Flow-Through Column Studies for Cr(VI) Sorption to Activated Carbon Fiber

In Lee,Jeong Ann Park,Jin Kyu Kang,Jae Hyun Kim,Jeong Woo Son,In Geol Yi,Song Bae Kim 대한환경공학회 2014 Environmental Engineering Research Vol.19 No.2

The adsorption of Cr(VI) from aqueous solutions to activated carbon fiber (ACF) was investigated using both batch and flow-through column experiments. The batch experiments (adsorbent dose, 10 g/L; initial Cr(VI) concentration, 5.500 mg/L) showed that the maximum adsorption capacity of Cr(VI) to ACF was determined to 20.54 mg/g. The adsorption of Cr(VI) to ACF was sensitive to solution pH, decreasing from 9.09 to 0.66 mg/g with increasing pH from 2.6 to 9.9; the adsorption capacity was the highest at the highly acidic solution pHs. Kinetic model analysis showed that the Elovich model was the most suitable for describing the kinetic data among three (pseudo-first-order, pseudo-second-order, and Elovich) models. From the nonlinear regression analysis, the Elovich model parameter values were determined to be α = 162.65 mg/g/h and β = 2.10 g/mg. Equilibrium isotherm model analysis demonstrated that among three (Langmuir, Freundlich, Redlich.Peterson) models, both Freundlich and Redlich.Peterson models were suitable for describing the equilibrium data. In the model analysis, the Redlich.Peterson model fit was superimposed on the Freundlich fit. The Freundlich model parameter values were determined to be KF = 0.52 L/g and 1/n = 0.56. The flow-through column experiments showed that the adsorption capacities of ACF in the given experimental conditions (column length, 10 cm; inner diameter, 1.5 cm; flow rate, 0.5 and 1.0 mL/min; influent Cr(VI) concentration, 10 mg/L) were in the range of 2.35.4.20 mg/g. This study demonstrated that activated carbon fiber was effective for the removal of Cr(VI) from aqueous solutions.

Modification of mesenchymal stem cells for cardiac regeneration.

Song, Heesang,Song, Byeong-Wook,Cha, Min-Ji,Choi, In-Geol,Hwang, Ki-Chul Ashley Publications Ltd 2010 Expert opinion on biological therapy Vol.10 No.3

<P>Mesenchymal stem cells (MSCs) have the greatest potential for use in cell-based therapy of human heart diseases, especially in myocardial infarcts. The therapeutic potential of MSCs in myocardial repair is based on the ability of MSCs to directly differentiate into cardiac tissue and on the paracrine actions of factors released from MSCs. However, the major obstacle in the clinical application of MSC-based therapy is the poor viability of the transplanted cells due to harsh microenvironments like ischemia, inflammation and/or anoikis in the infarcted myocardium. Recently, various approaches have been implemented in an effort to improve the survival of implanted MSCs through ex vivo manipulation of MSCs.</P>

급성 A형 간염 이환 후에 만성신장병이 합병된 1예와 막사구체신염이 합병된 1예

송인걸 ( In Geol Song ),강민규 ( Min Gyu Kang ),나운태 ( Woon Tae Na ),김성태 ( Sung Tae Kim ),박문일 ( Moon Il Park ),윤세희 ( Se Hei Yun ),윤성로 ( Sung Ro Yun ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.4

Acute A viral hepatitis is a mild, self-limiting disease of liver and acute renal failure (ARF) is a rare complication. We report two cases of chronic renal failure (CRF) in nonfulminant acute A viral hepatitis and ARF. A 40-year-old man was admitted with ARF and acute A viral hepatitis, and underwent temporary hemodialysis therapy. The renal biopsy showed acute tubular necrosis with tubulointerstitial nephritis. At 13 months after discharge serum creatinine was 1.33 mg/dL and protein-creatinine ratio of spot urine was 0.47 (mg/mg Cr). The second case was a 28-year-old man and was managed conservatively. At discharge the serum creatinine was 3.14 mg/dL and the urinalysis showed hematuria, and protein-creatinine ratio 0.56 (mg/mg Cr). Thirty-nine months after discharge, the creatinine was 1.23 mg/dL, the urinalysis showed persistent nephritis findings and the protein-creatinine ratio 1.28. Kidney biopsy revealed the membranous glomerulopathy with mild tubulointerstitial nephritis, and all of findings suggested the systemic disease-associated secondary glomerulopathy. To our knowledge our case is the first one of chronic glomerulapathy that is confirmed by kidney biopsy.

Characterization of Quintinite Particles in Fluoride Removal from Aqueous Solutions

Jae Hyun Kim,Jeong Ann Park,Jin Kyu Kang,Jeong Woo Son,In Geol Yi,Song Bae Kim 대한환경공학회 2014 Environmental Engineering Research Vol.19 No.3

The aim of this study was to characterize quintinite in fluoride removal from aqueous solutions, using batch experiments. Experimental results showed that the maximum adsorption capacity of fluoride to quintinite was 7.71 mg/g. The adsorption of fluoride to quintinite was not changed at pH 5?9, but decreased considerably in highly acidic (pH < 3) and alkaline (pH > 11) solution conditions. Kinetic model analysis showed that among the three models (pseudo-first-order, pseudo-second-order, and Elovich), the pseudo-second-order model was the most suitable for describing the kinetic data. From the nonlinear regression analysis, the pseudo-second-order parameter values were determined to be qe=0.18 mg/g and k2=28.80 g/mg/hr. Equilibrium isotherm model analysis demonstrated that among the three models (Langmuir, Freundlich, and Redlich-Peterson), both the Freundlich and Redlich-Peterson models were suitable for describing the equilibrium data. The model analysis superimposed the Redlich-Peterson model fit on the Freundlich fit. The Freundlich model parameter values were determined from the nonlinear regression to be KF=0.20 L/g and 1/n=0.51. This study demonstrated that quintinite could be used as an adsorbent for the removal of fluoride from aqueous solutions.

종설 : 급성관동맥 증후군과 취약성 경화반

배장호 ( Jang Ho Bae ),송인걸 ( In Geol Song ) 대한내과학회 2010 대한내과학회지 Vol.79 No.3

Acute coronary syndrome (ACS) consists of unstable angina, non-ST segment elevation myocardial infarction (NSTEMI), and STEMI. The pathology underlying ACS is acute thrombosis in a coronary artery, which is usually caused by plaque rupture in a mild stenotic lesion. A rupture-prone plaque is known as a vulnerable plaque (VP), although recently the definition of VP has been expanded to include rapidly progressive plaque. Although no single method can predict future cardiac events in mild stenotic lesions, there have been big advances in detecting VP, such as virtual histology-intravascular ultrasound and optical coherence tomography. These techniques look for thin cap fibroatheromas, which is the most common type of VP, characterized by a thin fibrous cap <65 μm, a large necrotic core, and marked macrophage infiltration of the fibrous cap. The recent concept of VP, the methods for detecting VP, and the treatment of VP are discussed. (Korean J Med 79:241-249, 2010)

Increased risk of chronic urticaria in patients with autoimmune thyroid diseases: A nationwide population- based study

( Yoon Seob Kim ),( Kyung Do Han ),( Ji Hyun Lee ),( Nack In Kim ),( Joo Young Roh ),( Seong Jun Seo ),( Hae Jun Song ),( Min Geol Lee ),( Jee Ho Choi ),( Young Min Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: To our knowledge, there have been no previous reports regarding the association between chronic urticaria (CU) and autoimmune thyroid diseases (AITD) in a nationwide population based study. Objectives: The aim of this study is to evaluate the risk of CU development after diagnosis with AITD including Grave’s disease and Hashimoto’s thyroiditis. Methods: National registry data which were collected fromthe Korean National Health Insurance Research Database from 2002 to 2013, comprising 1,025,340 (2.2%) randomly selected subjects were used. We compromised AITD cohort (N= 2,473) who had been diagnosed in 2003. The comparison cohort which was composed of randomly selected patients (N= 12,365) who were matched to the AITD group according to age and sex based on a 1:5 ratio. Each sampled patient was tracked whether CU occurs until 2013 or not. The risk of CU development was estimated using the Cox proportional hazards model and Cox proportional hazard regressions. Results: After adjusting for age, sex and co-morbidities,the people with AITD had a 1.648-fold greater risk of developing CU compared to comparison cohort (HR 1.648, 95% CI 1.417-1.918, P < 0.0001). In particular, Grave’s disease group had a more significantly increased risk of developing CU (HR 1.622) than Hashimoto’s thyroiditis one (HR 1.432). Conclusion: This study demonstrates that the presence of AITD is significantly associated with an increased risk of the future development of CU.

Increased risk of chronic urticaria in patients with anxiety and/or depressive disorders

( Yoon Seob Kim ),( Kyung Do Han ),( Ji Hyun Lee ),( Nack In Kim ),( Joo Young Roh ),( Seong Jun Seo ),( Hae Jun Song ),( Min Geol Lee ),( Jee Ho Choi ),( Young Min Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Chronic urticaria (CU) has been reported tobe associated with a number of psychological factors. However, there have been no studies regarding whether psychiatric disorders contribute to the development of CU. Objective: The aim of this study is to evaluate the risk of CU development after diagnosis with anxiety and depressive disorders. Methods: National registry data which were collected fromthe Korean National Health Insurance Research Database from 2002 to 2013, comprising 1,025,340 (2.2%) randomly selected subjects were used. We compromised anxiety disorder cohort (N=115,573), depressive disordercohort (N=41,797), coexisting both anxiety and depressive disorder cohort (N=64,002), based on disease code registered in 2003. The comparison cohort was composed of rest subjects (N= 483,947). Each sampled patient wastracked whether CU occurs until 2013 or not. The risk of CU development was estimated using the Cox proportional hazards model and Cox proportional hazard regressions. Results: People with anxiety disorder and depressive disorder had a higher risk (Crude HR 2.788 and 2.353,respectively) of developing CU compared to comparison cohort. Coexisting both anxiety and depressive disorder cohort had much higher risk than comparison cohort (Crude HR 3.875). Conclusion: This study demonstrates that the presence of anxiety and depressive disorders are significantly associated with an increased risk of the future development of CU.