Time-dependent Absorption of Doxorubicin, Paclitaxel and Cisplatin during Rotational Intraperitoneal Pressurized Aerosol Chemotherapy in a Porcine Model

( Hyunji Lim ),( Whasun Lim ),( Ji Yeon Ahn ),( Gwonhwa Song ),( Byeong-cheol Kang ),( Suk Joon Chang ),( Jung Chan Lee ),( Jeong Mook Lim ),( Hee Seung Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: To improve the drug distribution and penetration depth in pressurized intraperitoneal aerosol chemotherapy (PIPAC), we developed a novel prototype for rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) to improve drug delivery into the peritoneum. In this study, we evaluated time-dependent absorption of doxorubicin, paclitaxel and cisplatin, and their adverse effects for RIPAC in a porcine model. Methods: Doxorubicin 0.04 mg/kg, paclitaxel 0.57 mg/kg, and cisplatin 0.21 mg/kg, corresponding to about 10% dose of intravenous chemotherapy, were sprayed as aerosol during RIPAC, and capnoperitoneum at the abdominal pressure of 12 mmHg was maintained for 30 minutes in each three pigs. To analyze time-dependent absorption of these three drugs in serum, we collected serum samples for each swine at 11 time-dependent points: preoperative, every 15 minutes for two hours postoperatively, postoperative day 1 (POD1) and 2 (POD2). To evaluate tissue concentration of drug, we obtained the peritoneal tissue specimens at 12 different areas of the abdominal cavity. To evaluate adverse events, we also compared serum values of AST, ALT, GGT, bilirubin, ALP, creatinine and CRP at 7 time-dependent points: preoperative, immediately postoperative (30 minutes), POD1 to POD5. Results: The maximum concentrations of doxorubicin in serum was observed at 15 and 40 minutes, after that it decreased gradually, whereas the concentrations of paclitaxel and cisplatin increased with time. However, the concentration in tissues was maximized in central and pelvis for doxorubicin, in left flank and right lower for paclitaxel, and in pelvis for cisplatin. And there were no adverse events among these three drugs after RIPAC. Conclusion: Although the pattern of time-dependent serum levels was different among doxorubicin, paclitaxel and cisplatin, RIPAC improved drug delivery in lower abdominal cavity without adverse events.

Activists and Their Communicative Behaviors for Effective Crisis Communication in the Age of Social Media

Hyunji Lim,Sang-Hwa Oh,Young Kim,Jeong-Nam Kim Korean Academic Society For Public Relations 2019 Asian Journal of Public Relations Vol.3 No.1

The purpose of this study is to identify activists, their communicative behaviors, and the effects of these behaviors on crisis communication in the new media landscape. Adopting a new theoretical framework based on problem-solving characteristics, openness, activeness, and time or history, in the situational theory of problem solving, the current study demonstrates that activists in a crisis situation are more likely to actively engage in information acquisition, selection, and transmission than other publics. In addition, this study finds that activists in a crisis could affect an organization negatively in terms of strong attribution of crisis responsibility to the organization, negative reputation, and less supportive behavioral intentions. Practical and theoretical implications are discussed.

Activists and Their Communicative Behaviors for Effective Crisis Communication in the Age of Social Media

( Hyunji Lim ),( Sang-hwa Oh ),( Young Kim ),( Jeong-nam Kim ) 한국PR학회 2019 AJPR Vol.3 No.1

The purpose of this study is to identify activists, their communicative behaviors, and the effects of these behaviors on crisis communication in the new media landscape. Adopting a new theoretical framework based on problem-solving characteristics, openness, activeness, and time or history, in the situational theory of problem solving, the current study demonstrates that activists in a crisis situation are more likely to actively engage in information acquisition, selection, and transmission than other publics. In addition, this study finds that activists in a crisis could affect an organization negatively in terms of strong attribution of crisis responsibility to the organization, negative reputation, and less supportive behavioral intentions. Practical and theoretical implications are discussed.

Treatment of uncontrolled chyloascites by using intraoperative lipiodol lymphangiography and lymphovenous shunt guided by fluorescence laparoscopy

( Hyunji Lim ),( Soo Jin Park ),( Saebeom Hur ),( Ung Sik Jin ),( Hee Seung Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: To suggest the effect of intraoperative mesenteric lipiodol lymphangiography and lymphovenous shunt guided by fluorescence laparoscopy for treating refractory chylous ascites. Methods: A 22-year-old woman visited due to refractory chylous ascites. Chylous ascites developed after laparoscopic left adenexectomy for dermoid cyst three years ago, and it could not be controlled by repetitive treatment such as total parenteral nutrition, multiple lymphatic embolization and several times of multiple lymphatic ligations. For relieving abdominal distention, ascites had been discharged 3 L/day through the pigtail catheter, and her weight was reduced 58 kg to 38kg. Results: On CT or MRI lymphangiography, we found lymphatic reflux through the left ovarian vein with enhanced lymphatic structure with at the presacral area. Thus, we ligated the left ovarian vein and intestinal branches of cisterna chyli guided by intraoperative mesenteric lipiodol lymphangiography. For reducing lymphatic pressure, we performed lymphovenous shunt between the inferior mesenteric vein and left para-aortic enlarged lymphatics. However, chylous ascites developed again seven days after the first surgery. Thus, we performed intraoperative lipiodol lymphangiography for the pelvic lymphatics, and found leakage point of lymphatic fluid in the aortocaval area guided by fluorescence laparoscopy. We conducted lymphovenous shunt between the right ovarian vein and the enlarged lymphatics in the aortocaval area, and repaired multiple and small lymphatic leakage around the shunt. She has shown no recurrence up to now, and germline CELSR1 variants of uncertain significance related with hereditary lymphedema has been detected. Conclusion: Detection of leakage point and decompression by lymphovenous shunt by intraoperative lipiodol lymphangiography and fluorescence laparoscopy can control refractory chylous ascites.

Delayed diagnosis of gestational diabetes mellitus and perinatal outcomes in women with normal routine glucose challenge test and subsequent macrosomia in late pregnancy

( Hyunji Lim ),( Jeenah Sohn ),( Tae Hoon Kim ),( Byoung Jae Kim ),( Kyu Ri Hwang ),( Taek Sang Lee ),( Hye Won Jeon ),( Sun Min Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Gestational diabetes mellitus(GDM) is a leading cause of fetal excessive growth in utero. However, macrosomia is sometimes suspected on ultrasound at late pregnancy in women with normal blood glucose test at 24-28 weeks of gestation. This study was performed to evaluate the incidence of newly diagnosed GDM at late pregnancy and their perinatal outcome in these women. Methods: Retrospective cohort study was performed. Among singleton pregnant women delivered from January 2010 to December 2018, women who were retested for an oral glucose tolerance test(OGTT) because of suspected fetal macrosomia on ultrasound in the 3rd trimester were enrolled. Their results of routine GDM screening had been normal. Results: Of 169 pregnant women who were retested for 100-g OGTT, 13%(23/169) was newly diagnosed of GDM. There were no significant differences in the maternal age, parity, gestational age at OGTT between GDM and non-GDM group. The women in GDM group had higher level of HbA1c(5.8 vs 5.3, p<0.01) and earlier gestational age at delivery than women in non-GDM group(38+1 vs 38+5 weeks of gestation, p=0.003). Cesarean delivery(CD) rate in GDM group was significantly higher than that of non GDM group(73.9%, vs 49.3%, p=0.028). Analyzing the reason of CD, the proportions were similar in both groups except CD on maternal request(CDMR). The rate of CDMR was higher in GDM group than that of non-GDM group(41.2% vs 23.6%), but it could not reach the statistical significance. There were no significant differences in the obstetrical and neonatal complications between the two groups. Conclusion: Showing normal results in routine blood glucose test, 13% of pregnant women with suspected macrosomia on ultrasound in the 3rd trimester of pregnancy were newly diagnosed of GDM. Nonetheless, there were no differences in perinatal outcomes between newly diagnosed GDM group and non-GDM group. However, concerns over shoulder dystocia, appear to increase cesarean delivery in GDM group.

세무상 이월결손금이 감사시간과 감사보수에 미치는 영향

임현지 ( Hyunji Lim ),우소희 ( Sohee Woo ) 한국회계학회 2017 회계저널 Vol.26 No.1

본 연구는 감사인이 재무제표 감사시에 피감사기업의 세무상 이월결손금에 대한 정보를 사용하는지를 알아보고자 한다. 감사인은 감사위험수준을 결정할 때 재무제표가 왜곡표시 될 가능성에 영향을 미치는 여러 요소들을 고려한다. 세무상 이월결손금은 경영자의 이익조정 동기에 영향을 미칠 수 있으며 이에 감사위험을 높이는 요인이 된다. 따라서 감사인은 감사위험을 낮추기 위해 더 많은 감사노력을 투입할 것이고 이는 감사시간과 감사보수의 증가로 이어질 것이다. 따라서 본 연구는 세무상 이월결손금의 유무가 감사시간 및 보수에 영향을 미치는 지를 검증하였다. 실증분석 결과, 세무상 이월결손금이 존재하는 기업은 그렇지 않은 기업에 비해 감사시간과 감사보수가 높은 것으로 나타났다. 이러한 결과는 감사인이 세무상 이월결손금이 있는 기업에서 경영자의 이익조정의 유인이 높다는 것을 인지하고 있으며, 이에 세무상 이월결손금의 정보를 감사위험수준 결정에 반영하는 것으로 해석된다. 추가분석에서는 세무상 이월결손금이 존재하는 기업 중 결손금의 공제기간의 만료가 임박한 기업이 그렇지 않은 기업에 비해 감사시간과 감사보수가 높게 나타나는지를 분석하였다. 분석결과, 이월공제기간의 만료가 임박한 결손금이 있는 기업과 그렇지 않은 기업의 감사시간과 감사보수는 통계적으로 유의한 차이를 보이지 않았다. 이는 세무상 이월결손금의 공제기한이 당기에 만료되는 기업에서 이익조정의 동기가 더욱 커짐에 따라 감사위험이 증가함에도 불구하고 감사인이 이러한 위험을 차별적으로 감사시간과 보수에 반영하지는 못하고 있는 것으로 해석된다. 본 연구는 다음과 같은 의의가 있다. 첫째, 선행연구에서는 세무상 이월결손금의 유무가 경영자의 이익조정 동기에 미치는 영향에 초점을 맞추고 있는 반면, 본 연구는 세무상 이월결손금으로 인해 예상되는 이익조정의 위험을 감사인이 인지하고 있는가를 실증적으로 검증하였다. 둘째, 감사인이 감사위험 측정시, 결손금의 공제기한의 만료가 임박했는지 여부를 차등적으로 반영하지 않고 있음을 확인하였다. 따라서 감사인이 감사위험 평가시 이월결손금의 유무뿐만 아니라 이월결손금의 크기 및 잔여 공제기간 등도 고려할 필요가 있다는 점을 시사하고 있다. 마지막으로 세무상 이월결손금이 경영자의 이익조정 가능성을 증가시킨다는 기존의 선행연구를 감사인의 입장에서 검증함으로써 기존 연구의 결과를 뒷받침하는 추가적 증거를 제시하였다. This study investigates association between tax carryforward and audit efforts. Managers have incentive to upward reported income but limitation exists because of tax problems. Companies with net operating loss (hereafter, NOL) carryforward are more free from tax problems. Therefore, those companies have more incentive to upward reported income and that means they have high audit risk. This study finds that NOL carryforward strongly affect audit hours and fees. It means auditors input higher efforts to companies with NOL carryforward than companies without it by recognizing NOL carryforward as an audit risk. This study contributes to provide evidence that auditors adjust their efforts when they provide auditing service to companies with NOL carryforward. Auditors consider NOL carryforward as an audit risk. In addition, we provide evidence that auditors do not consider residual deduction period of NOL carryforward, even though companies with NOL carryforward expire in current year have the highest incentive to manage earnings that affect audit risk. We provide implication that auditors need to consider deduction period of NOL carryforward as an audit risk and adjust accordingly.

기-액 막접촉기에 이산화탄소 흡수제를 적용한 공정 운전 연구

임현지(Hyunji Lim),김광휘(Kwanghwi Kim),오진명(JIn-Myeong Oh),박현식(Hyun Sic Park),강조홍(Jo Hong Kang),박진원(Jinwon Park),송호준(Hojun Song) 한국에너지기후변화학회 2023 한국에너지기후변화학회 학술대회 Vol.2023 No.11

누가 더 보호받는가? - 국가복지의 이원성과 노년의 건강 불평등 -

임현지(Hyunji Lim),황인혜(In Hyee Hwang),이철승(Cheol Sung Lee) 한국사회복지학회 2021 한국사회복지학 Vol.73 No.1

본 연구는 복지이원주의에 따른 노년기 건강 불평등을 살펴본다. 한국 복지제도가 내부자와 외부자에게 서로 다른 수준의 보호를 제공한다면, 공적 보호 수준에 따른 내부자와 외부자 간 건강 격차는 존재할 것인가? 만일 그렇다면, 공적 보호 외부자의 건강은 사적 자산에 더욱 의존하겠는가? 우리는 이러한 질문들에 답하기 위하여 ‘연금의 3층 체계’와 ‘복지체계의 공사 분리구조’라는 이론틀을 제시하고, 65세이상 노인층에게서 이러한 제도와 구조로 인한 건강 불평등이 출현하고 있는지를 검증한다. 본 연구가 한국복지패널 4차-14차 조사의 65세 이상 노인 인구를 대상으로 분석한 결과, 가장 높은 수준의 보호를 받는 특수직역연금 수급집단의 주관적 신체적, 정신적 건강 위험이 일반 국민연금 수급집단 및 미수급집단 대비 낮은 것으로 나타났다. 나아가 우리는 민간연금과 가구자산이 65세 이상 인구의 주관적, 정신적 건강에 미치는 영향을 살펴보았다. 민간연금의 영향력은 통계적으로 유의하지 않았으나, 가구자산의 영향력은 유의했다. 연금 지위와 가구자산의 상호작용항을 테스트한 결과, 연금 지위가 높은 내부자일수록 적은 자산이 초래하는 노년의 건강 위험으로부터 자유로운 것으로 나타났다. 반면 자산수준이 높은 경우 연금 수준에 따른 건강 격차는 나타나지 않았다. 본 연구 결과는 복지이원주의에 기반한 연금과 자산의 불평등한 분배가 노인층 내부의 건강 불평등을 악화시킬 수 있음을 시사한다. This paper studies the effects of welfare dualism on health outcomes of the elderly in South Korea. Based on the Korean welfare system that provides different levels of social protection to labor market insiders and outsiders, can we observe health inequalities between the two groups? What is the role of assets in the relationship between individuals without public social insurance and their health outcomes? In order to address these questions, this study proposes a theoretical framework based on what we call the "three tiers of the pension system" and "public-private divide of the welfare system." Analyzing 10 waves of the Korean Welfare Panel Data (2009-2019), we find that among the elderly (65 years old and above), subjective physical and mental health risks of individuals receiving special occupational pensions are lower that that of individuals receiving public pensions or no pensions at all. This study also examines the effects of private pension and household assets on the subjective physical and mental health of the elderly. We find that public pension has no significant effect on our outcome of interest; however, household assets had a significant effect on health outcomes. By interacting pension status and household assets, we find that individuals who had higher levels of pension protection (i.e., pension insiders) are less vulnerable to the health risks that are associated with low assets. Moreover, there is no significant difference in health outcomes depending on pension status for individuals who have high levels of private assets. This suggests that inequalities in pension protection and private assets may lead to health inequalities of the elderly.

Impact of coronavirus disease 2019 on patients with chronic pain: multicenter study in Korea

( Hyunji John ),( Yun Hee Lim ),( Sung Jun Hong ),( Jae Hun Jeong ),( Hey Ran Choi ),( Sun Kyung Park ),( Jung Eun Kim ),( Byung-soo Kim ),( Jae Hun Kim ) 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.2

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused significant changes. This study aimed to investigate the impact of COVID-19 on patients with chronic pain. Methods: Patients with chronic pain from 23 university hospitals in South Korea participated in this study. The anonymous survey questionnaire consisted of 25 questions regarding the following: demographic data, diagnosis, hospital visit frequency, exercise duration, time outside, sleep duration, weight change, nervousness and anxiety, depression, interest or pleasure, fatigue, daily life difficulties, and self-harm thoughts. Depression severity was evaluated using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression analysis was used to investigate the relationship between increased pain and patient factors. Results: A total of 914 patients completed the survey, 35.9% of whom had decreased their number of visits to the hospital, mostly due to COVID-19. The pain level of 200 patients has worsened since the COVID-19 outbreak, which was more prominent in complex regional pain syndrome (CRPS). Noticeable post-COVID-19 changes such as exercise duration, time spent outside, sleep patterns, mood, and weight affected patients with chronic pain. Depression severity was more significant in patients with CRPS. The total PHQ-9 average score of patients with CRPS was 15.5, corresponding to major depressive orders. The patients’ decreased exercise duration, decreased sleep duration, and increased depression were significantly associated with increased pain. Conclusions: COVID-19 has caused several changes in patients with chronic pain. During the pandemic, decreased exercise and sleep duration and increased depression were associated with patients’ increasing pain.

Precise Construction of Heteroprotein Complexes via Intracellular Self-Directed Disulfide Bonding

Hyunji KIM,Sung In LIM 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10