http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국 정상인에서 연령에 따른 뇌혈류분포와 혈류예비능의 변화 : Tc-99m HMPAO SPECT 에 의한 연구
문대혁,이희경,송호천,이재태,범희승,손혜경,정환정,민정준,김지열 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3
Purpose: The aim of this study was to evaluate the normal values of regional cerebral blood flow (rCBF) and cerebrovascular reserve (CVR) in normal children to aged volunteers using Tc-99m HMPAO. Materials and Methods: Thirty four right-handed normal volunteers (20 males, 14 females, mean age 40.3±24.9 years, range 4 to 82 years) were underwent rest/acetazolamide (ACZ) brain SPECT using Tc-99m HMPAO and the sequential injection and subtraction method. rCBF was estimated on the basis of a semiquantitative approach by means of right/left ratio, region/cerebellum and region to whole brain ratios in frontal, parietal, temporal, and occipital lobes, basal ganglia, thalami, and cerebellum. CVR was measured by means of % perfusion increase calculated as % mean count change compared to rest rCBF in each regions. Results: Mean values of right to left ratios range from 1.004 to 1.018. rCBF was highest in cerebellum and lowest in basal ganglia and thalami. Frontal and temporal rCBF decreased while occipital and thalami rCBF increased according to age. No sexual difference of rCBF was noted. Mean CVR was 29.9±12.9%. Mean CVR significantly increased to late teens, and declined thereafter. After 6th decade, CVR in both frontal lobes, left parietal lobe and right basal ganglia decreased significantly with advancing age. There was no sexual difference of CVR. Conclusion: Quantitative assessment of CVR was possible by ACZ Tc-99m HMPAO brain SPECT. It revealed that rCBF and CVR changed according to age in normal Korean volunteers. There was no sexual difference.
Hyuk-Hwan Song,Doo-Young Kim,Soyeun Woo,Hyeong-Kyu Lee,Sei-Ryang Oh 고려인삼학회 2013 Journal of Ginseng Research Vol.37 No.3
Identification of the origins of Panax ginseng has been issued in Korea scientifically and economically. We describe a metabolomics approach used for discrimination and prediction of ginseng roots from different origins in Korea. The fresh ginseng roots from six ginseng cooperative associations (Gangwon, Gaeseong, Punggi, Chungbuk, Jeonbuk, and Anseong) were analyzed by UPLC-MS-based approach combined with orthogonal projections to latent structure-discriminant analysis multivariate analysis. The ginsengs from Gangwon and Gaeseong were easily differentiated. We further analyzed the metabolomics results in subgroups. Punggi, Chungbuk, Jeonbuk, and Anseong ginseng could be easily differentiated by the first two orthogonal components. As a validation of the discrimination model, we performed blind prediction tests of sample origins using an external test set. Our model predicted their geographical origins as 99.7% probability. The robust discriminatory power and statistical validity of our method suggest its general applicability for determining the origins of P. ginseng samples.
Discrimination of white ginseng origins using multivariate statistical analysis of data sets
Hyuk-Hwan Song,Ji Young Moon,Hyung Won Ryu,노봉수,김정한,Hyeong-Kyu Lee,Sei-Ryang Oh 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
Background: White ginseng (Panax ginseng Meyer) is commonly distributed as a health food in foodmarkets. However, there is no practical method for distinguishing Korean white ginseng (KWG) fromChinese white ginseng (CWG), except for relying on the traceability system in the market. Methods: Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometrycombined with orthogonal partial least squares discrimination analysis (OPLS-DA) was employed todiscriminate between KWG and CWG. Results: The origins of white ginsengs in two test sets (1.0 mL and 0.2 mL injections) could be successfullydiscriminated by the OPLS-DA analysis. From OPLS-DA S-plots, KWG exhibited tentative markers derivedfrom ginsenoside Rf and notoginsenoside R3 isomer, whereas CWG exhibited tentative markers derivedfrom ginsenoside Ro and chikusetsusaponin Iva. Conclusion: Results suggest that ultra-performance liquid chromatography quadrupole time-of-flightmass spectrometry coupled with OPLS-DA is an efficient tool for identifying the difference between thegeographical origins of white ginsengs.
Song, Hyuk-Hwan,Kim, Doo-Young,Woo, Soyeun,Lee, Hyeong-Kyu,Oh, Sei-Ryang The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.3
Identification of the origins of Panax ginseng has been issued in Korea scientifically and economically. We describe a metabolomics approach used for discrimination and prediction of ginseng roots from different origins in Korea. The fresh ginseng roots from six ginseng cooperative associations (Gangwon, Gaeseong, Punggi, Chungbuk, Jeonbuk, and Anseong) were analyzed by UPLC-MS-based approach combined with orthogonal projections to latent structure-discriminant analysis multivariate analysis. The ginsengs from Gangwon and Gaeseong were easily differentiated. We further analyzed the metabolomics results in subgroups. Punggi, Chungbuk, Jeonbuk, and Anseong ginseng could be easily differentiated by the first two orthogonal components. As a validation of the discrimination model, we performed blind prediction tests of sample origins using an external test set. Our model predicted their geographical origins as 99.7% probability. The robust discriminatory power and statistical validity of our method suggest its general applicability for determining the origins of P. ginseng samples.
Flavonoids from Thyrsanthera suborbicularis and Their NO Inhibitory Activity
Hyuk-Hwan Song,Piseth Khiev,채희성,Hyeong-Kyu Lee,Sei-Ryang Oh,최영희,진영원 한국생약학회 2012 Natural Product Sciences Vol.18 No.4
Further phytochemical investigation on the whole plant of Thyrsanthera suborbicularis, collected in Cambodia, led to kaempferol (1), vitexin (2), apigenin-7-O-neohesperidoside (3), chrysoeriol-7-O-b-D-glucopyranoside (4), isorhamnetin 3-O-rutinoside (5), kaempferol-3-O-[a-L-rhamnopyranosyl-(13)-a-L-rhamnopyranosyl-(16)-b-D-galactopyranoside (6), kaempferol-3-O-a-L-rhamnopyranosyl(12)-O-[a-L-rhamnopyranosyl (16)]-b-D-glucopyranoside (7), kaempferol-3-O-[6''-O-(E)-p-coumaroyl]-b-D-glucopyranoside (8), kaempferol-3-O-[6''-O-(E)-p-coumaroyl]-b-D-galactopyranoside (9), and amentoflavone (10). All the structures were confirmed by the interpretation of NMR (1D and 2D) and MS data, and comparison with the published values. Of the isolated compounds 1 - 10, compounds 8 and 10 displayed the inhibitory activity against NO production in LPS-induced Raw 264.7 cells with IC50 values, 3.56 and 15.73 mM, respectively.