Mangosteen Extract Prevents Dextran Sulfate Sodium-Induced Colitis in Mice by Suppressing NF-κB Activation and Inflammation

채희성,유병훈,송지은,고혁완,최영희,진영원 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.8

In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)–induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group. MGE downregulated the NF-κB pathway by inhibiting the phosphorylation of IκB and IKK in a dose-dependent manner. These findings suggest that MGE alleviates ulcerative colitis by modulating the NF-κB pathway.

저가센서를 이용한 EKF 기반 광역공간 측위 시뮬레이션

채희성,최정필 제어로봇시스템학회 2014 제어로봇시스템학회 국내학술대회 논문집 Vol.2014 No.5

서비스 지향적인 효율적인 클러스터 서버 구축 및 관리

채희성,송하윤,김한규,이기철 한국정보처리학회 2007 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.14 No.6

Modern server systems are usually composed in the form of cluster systems in order to serve not only as many users but also as many kinds of applications as possible. The progression of the cluster system architecture leads in a middleware approach based on the Java framework. The middleware approach alleviates the efforts for the construction and the management of a server system but still preserves its performance and applications on the server. In this research, we introduce a new clustering scheme for the easy construction and maintenance of a cluster server system with the Java Management Extensions. We first demonstrate the construction and configuration process. Our experiment sets can verify that it is easy to construct, expand and manage a middleware based cluster system as well as the applications which reside on it. In addition, we can achieve reasonable performance on our service oriented clustered system with the help of state-of-the-art middleware. The experimental results of performance demonstration contain the availability of a server, and the effectiveness of load balancing and scheduling mechanisms. Especially, our service oriented scheduling mechanism was shown to successfully manage load imbalance under the normal load and cope with the overloaded situations, compared with other known scheduling mechanisms. 현대의 서버 시스템은 대부분의 경우 클러스터 시스템으로 이루어지어 가능한 많은 사용자를 지원할 뿐만 아니라 가능한 많은 어플리케이션을 지원하는 것을 목적으로 하는 서비스 지향 클러스터 시스템이다. 클러스터 시스템 아키텍쳐의 발전으로 자바 프레임웍에 기반한 미들웨어 어프로치가 발전하고 있다. 미들웨어에 의한 방법은 서버 시스템의 성능과 어플리케이션의 활용도를 보장하면서도 서버 시스템 구축을 위한 대부분의 노력을 덜어준다. 본 연구에서는 JMX를 이용하여 클러스터 시스템의 손쉬운 구현과 관리를 달성할 수 있는 새로운 클러스터 시스템을 소개한다. 일단 클러스터 시스템의 구축과 구성단계를 보이며, 어플리케이션과 시스템 양자에 걸쳐서 손쉬운 구축과 확장, 그리고 관리가 미들웨어에 기반한 시스템에서 이루어짐을 보인다. 덧붙여 서비스 지향 클러스터 시스템이 미들웨어에 기반하여 우수한 성능을 보임을 성능 평가 실험 결과를 통하여 검증하였다. 기본적인 성능 평가 결과는 서버의 가용성, 그리고 로드 밸런싱과 스케쥴링 알고리즘의 효율성을 검증하였다. 특히, 우리의 서비스기반 스케줄링 방법이 정상부하시 적재불균형문제와 과부하시의 대처능력에서 타 방법에 비해 우수함을 보였다.

'89 식품위생 시책방향

채희성,Chae, Hui-Seong 한국유가공협회 1989 牛乳 Vol.37 No.-

Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK

채희성,김영미,배진경,Sochivak Sorchhann,Sreymom Yim,Ling Han,백진협,최영희,진영원 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.2

This study investigated the effects of mangosteen on metabolic syndromes in high-fat (HF) diet-fed mice and the underlying mechanisms related to adipogenesis. Mangosteen-supplemented mice gained significantly less body weight, compared with the HF group. The levels were markedly elevated in HF mice for serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, glucose, triglyceride, total cholesterol, low-density lipoprotein (LDL) cholesterol, and free fatty acid; whereas these levels were significantly lower in the 200 mg/kg of the mangosteen extract-treated group. The mangosteen extract did not modify high-density lipoprotein (HDL)-cholesterol, however, LDL-cholesterol was lower and HDL/LDL ratio was higher (9.4 vs. 3.7 in HF group). Furthermore, 200 mg/kg of mangosteen treatment activated the hepatic AMP-activated protein kinase and Sirtuin 1 in an in vivo system. Thus, the results of this study suggest that mangosteen extract exerts antiobesity effects by regulating energy metabolism and hepatic lipid homeostasis.

Efficient Cluster Server Construction and Management for Service Orientation

채희성,송하윤,김한규,이기철,Chae, Hee-Seong,Song, Ha-Yoon,Kim, Han-Gyoo,Lee, Kee-Cheol Korea Information Processing Society 2007 정보처리학회논문지 A Vol.14 No.6

현대의 서버 시스템은 대부분의 경우 클러스터 시스템으로 이루어지어 가능한 많은 사용자를 지원할 뿐만 아니라 가능한 많은 어플리케이션을 지원하는 것을 목적으로 하는 서비스 지향 클러스터 시스템이다. 클러스터 시스템 아키텍쳐의 발전으로 자바 프레임웍에 기반한 미들웨어 어프로치가 발전하고 있다. 미들웨어에 의한 방법은 서버 시스템의 성능과 어플리케이션의 활용도를 보장하면서도 서버 시스템 구축을 위한 대부분의 노력을 덜어준다. 본 연구에서는 JMX를 이용하여 클러스터 시스템의 손쉬운 구현과 관리를 달성할 수 있는 새로운 클러스터 시스템을 소개한다. 일단 클러스터 시스템의 구축과 구성단계를 보이며, 어플리케이션과 시스템 양자에 걸쳐서 손쉬운 구축과 확장, 그리고 관리가 미들웨어에 기반한 시스템에서 이루어짐을 보인다. 덧붙여 서비스 지향 클러스터 시스템이 미들웨어에 기반하여 우수한 성능을 보임을 성능 평가 실험 결과를 통하여 검증하였다. 기본적인 성능 평가 결과는 서버의 가용성, 그리고 로드 밸런싱과 스케쥴링 알고리즘의 효율성을 검증하였다. 특히, 우리의 서비스기반 스케줄링 방법이 정상부하시 적재불균형문제와 과부하시의 대처능력에서 타 방법에 비해 우수함을 보였다. Modern server systems are usually composed in the form of cluster systems in order to serve not only as many users but also as many kinds of applications as possible. The progression of the cluster system architecture leads in a middleware approach based on the Java framework. The middleware approach alleviates the efforts for the construction and the management of a server system but still preserves its performance and applications on the server. In this research, we introduce a new clustering scheme for the easy construction and maintenance of a cluster server system with the Java Management Extensions. We first demonstrate the construction and configuration process. Our experiment sets can verify that it is easy to construct, expand and manage a middleware based cluster system as well as the applications which reside on it. In addition, we can achieve reasonable performance on our service oriented clustered system with the help of state-of-the-art middleware. The experimental results of performance demonstration contain the availability of a server, and the effectiveness of load balancing and scheduling mechanisms. Especially, our service oriented scheduling mechanism was shown to successfully manage load imbalance under the normal load and cope with the overloaded situations, compared with other known scheduling mechanisms.

구면기하학 기반 GPS 측위 알고리즘

채희성 제어로봇시스템학회 2009 제어로봇시스템학회 합동학술대회 논문집 Vol.2009 No.12

Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-kB) Pathways

채희성,김영미,진영원 한국생약학회 2017 Natural Product Sciences Vol.23 No.1

Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism remain unknown. To explore the mediator and cellular inflammatory response of sinensetin, we examined its influence on phorbol 12-myristate 13-acetate (PMA) plus A23187 induced inflammatory mediator production in a human mast cell line. In this study, interleukin (IL)-6 production was measured using the enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction. Sinensetin inhibited PMA plus A23187 induced IL-6 production in a dose-dependent manner as well as IL-4, IL-5 and IL-8 mRNA expression. Furthermore, sinensetin inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation, suggesting that sinensetin inhibits the production of inflammatory mediators by blocking STAT3 phosphorylation. Moreover, sinensetin was found to inhibit nuclear factor kappa B activation. These findings suggest that sinensetin may be involved in the regulation of mast cell-mediated inflammatory responses.

Pyoderma Gangrenosum of the Preauricular Area with Ulcerative Colitis: A Case Report and Review

채희성,한성민,이하늘,전현종,서영준 대한청각학회 2018 Journal of Audiology & Otology Vol.22 No.4

Pyoderma gangrenosum (PG) is primarily, a sterile, inflammatory, neutrophilic dermatosis, characterized by recurrent cutaneous ulceration with mucopurulent or hemorrhagic exudate. The incidence of PG is uncertain, but it is estimated to be about 3-10 patients per million per year. It occurs most commonly on the lower legs, but has been reported at other sites of the body as well. The causes of PG are unknown, but about 50-70% of cases are associated with other diseases, mainly inflammatory bowel disease. We hereby report a case of PG in a 21-year-old male, with a history of ulcerative colitis (UC). After appropriate diagnostic methods including biopsy for pathologic confirmation, sigmoidoscopy and computed tomography, we excluded other diseases and the lesion was diagnosed as PG. We then carried out regular dressing of the wound, while UC was treated with steroid and immunosuppressant medication, with inputs from the department of gastroenterology during the hospital stay. There occurred recurrence of the skin lesion, 7 months after discharge, after which they improved. UC has been in the remission state as per the follow-up, since 2 years.

Mediating Effect of Meta-cognition between Locus of Control and Self-efficacy

채희성,함상우 국제문화기술진흥원 2018 International Journal of Advanced Culture Technolo Vol.6 No.1

Meta-cognition is the knowledge and cognition of cognitive phenomena, including the control of ones own memory, comprehension, and thought processes. Meta-cognition is similar to self-awareness, which is the understanding of oneself, and affects people’s attitudes and behaviors. This study demonstrated the mediating effect of meta-cognition between internal locus of control and self-efficacy. Internal locus of control refers to the steady faith that any outcome is related to one's own efforts. Self-efficacy is a collection of personal strong belief that one individual can achieve his or her own goals. In this study, if a person has a tendency to adopt an internal locus of control, meta-cognition is improved, and self-efficacy can in turn be increased if meta-cognition is improved. This study conducted an empirical analysis through questionnaires conducted on 260 university students. The results of the research demonstrated that there is a highly positive correlation between metacognition, control position, and self-efficacy. In addition, this study emphasized that positive meta-cognition with internal locus of control can lead to positive attitudes and behaviors, and positive results.