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Kim, Byung Chan,Kim, Hyerim,Lee, Hye Soo,Kim, Su Hyun,Cho, Do-Hyun,Jung, Hee Ju,Bhatia, Shashi Kant,Yune, Philip S.,Joo, Hwang-Soo,Kim, Jae-Seok,Kim, Wooseong,Yang, Yung-Hun The Korean Society for Microbiology and Biotechnol 2022 Journal of microbiology and biotechnology Vol.32 No.6
Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections and poses a global healthcare challenge. The utilization of novel molecules which confer synergistical effects to existing MRSA-directed antibiotics is one of the well-accepted strategies in lieu of de novo development of new antibiotics. Thymol is a key component of the essential oil of plants in the Thymus and Origanum genera. Despite the absence of antimicrobial potency, thymol is known to inhibit MRSA biofilm formation. However, the anti-MRSA activity of thymol analogs is not well characterized. Here, we assessed the antimicrobial activity of several thymol derivatives and found that 4-chloro-2-isopropyl-5-methylphenol (chlorothymol) has antimicrobial activity against MRSA and in addition it also prevents biofilm formation. Chlorothymol inhibited staphyloxanthin production, slowed MRSA motility, and altered bacterial cell density and size. This compound also showed a synergistic antimicrobial activity with oxacillin against highly resistant S. aureus clinical isolates and biofilms associated with these isolates. Our results demonstrate that chlorinated thymol derivatives should be considered as a new lead compound in anti-MRSA therapeutics.
Kim, Eun-Shik,Lee, So-Hee,Kim, Joon-Bum,Kim, Chan-Soo,Yoon, Bong-Taek,Lee, Sung-Hoon,Lim, Wontaek,Kim, Hyojung,Choi, Junghwan,Han, Hyerim The Ecological Society of Korea 2015 Journal of Ecology and Environment Vol.38 No.1
In 2013, the epidemics of pine wilt disease caused by the pine wood nematodes (Bursaphelenchus xylophilus) resulted in damages to the forests of black pine (Pinus thunbergii Parl.) trees in Jeju Island, Korea. Among the affected trees, an old black pine tree at Cave Temple on Mt. Sanbangsan was included and died due to the prevalence of pine wilt disease. The tree was on Mt. Sanbangsan, which was designated as a National Scenic Place with the Number 77 and was believed to be more than 400 years old in age. By examining the disc of the tree stem obtained from the height of 2 m, we counted the tree rings from 4 different directions and cross-dated the readings by comparing the records of drought simulated from the BROOK Model. Our analysis indicates that the tree seems to have grown since late 1860s. Contrary to the belief of the general public, we can conclude that the age of the tree was estimated to be at maximum 150 years, which means that it was not the same old tree as was shown in the painting of the Tam-Ra-Sun-Ryeok-Do (an old painting book for the Inspection Tour of Jeju Island) published in 1702. Discussion was extended to the life history of the tree in growth and leaning and the measures to protect the tree species from the damages of the pine wilt disease caused by pine wood nematodes.
종합병원 입원 환자의 간호대학생 실습허용에 대한 견해 및 인식
김영진 ( Kim Youngjin ),김지선 ( Kim Jeesun ),김혜림 ( Kim Hyerim ),박수비 ( Park Subi ),소샛별 ( So Saetbyul ),정보성 ( Jung Bosung ),조은애 ( Choh Eunae ),이선영 ( Lee Seonyoung ),김정은 ( Kim Jeongeun ) 서울대학교 간호과학연구소 2017 간호학의 지평 Vol.14 No.1
Purpose: The aim of this study was to explore the patients` perspectives on nursing students` clinical practices in the wards, and to investigate their willingness for allowing students to practice on them. Methods: This was a descriptive study. 116 inpatients were recruited from the S University Hospital. A 60-item questionnaire was applied to collect the data. The participants were 19 years and older with sound judgement, and were not in special or intensive care units. Data analysis was done in SPSS/WIN 22.0 using descriptive statistics, Fishers exact test, and the ANOVA test. the participant answered to questionnaire from April 29th 2016 to May 10th. Results: 40 participants (34.5%) stated they would allow students` practice, while 72 (61.2%) said they would allow only under staff supervision. 5 participants (4.3%) stated they would not allow whatsoever. The 3 most allowed were emotional support, oral care, and vital signs measurement while the 3 least allowed were gastric feeding, intravenous catheterization, and urinary catheterization. Conclusion: Patients were more inclined to allow students to practice on them when a member of the medical team was present. A fair number of participants said they would be more inclined to allow students` practice if they felt the student was competent; hence, reinforcing simulation sessions is vital in enhancing students` competency and ultimately practice allowance.
Optogenetic control of endogenous Ca<sup>2+</sup> channels in vivo
Kyung, Taeyoon,Lee, Sangkyu,Kim, Jung Eun,Cho, Taesup,Park, Hyerim,Jeong, Yun-Mi,Kim, Dongkyu,Shin, Anna,Kim, Sungsoo,Baek, Jinhee,Kim, Jihoon,Kim, Na Yeon,Woo, Doyeon,Chae, Sujin,Kim, Cheol-Hee,Shin, Nature Publishing Group, a division of Macmillan P 2015 Nature biotechnology Vol.33 No.10
Calcium (Ca<SUP>2+</SUP>) signals that are precisely modulated in space and time mediate a myriad of cellular processes, including contraction, excitation, growth, differentiation and apoptosis. However, study of Ca<SUP>2+</SUP> responses has been hampered by technological limitations of existing Ca<SUP>2+</SUP>-modulating tools. Here we present OptoSTIM1, an optogenetic tool for manipulating intracellular Ca<SUP>2+</SUP> levels through activation of Ca<SUP>2+</SUP>-selective endogenous Ca<SUP>2+</SUP> release−activated Ca<SUP>2+</SUP> (CRAC) channels. Using OptoSTIM1, which combines a plant photoreceptor and the CRAC channel regulator STIM1 (ref. 4), we quantitatively and qualitatively controlled intracellular Ca<SUP>2+</SUP> levels in various biological systems, including zebrafish embryos and human embryonic stem cells. We demonstrate that activating OptoSTIM1 in the CA1 hippocampal region of mice selectively reinforced contextual memory formation. The broad utility of OptoSTIM1 will expand our mechanistic understanding of numerous Ca<SUP>2+</SUP>-associated processes and facilitate screening for drug candidates that antagonize Ca<SUP>2+</SUP> signals.
PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator
Kim, Yoosik,Lee, Jung Hyun,Park, Jong-Eun,Cho, Jun,Yi, Hyerim,Kim, V. Narry Cold Spring Harbor Laboratory Press 2014 Genes & development Vol.28 No.12
<P>dsRNA-dependent protein kinase R (PKR) plays a key role in innate immunity. PKR binds viral dsRNA and undergoes autophosphorylation, which leads to translational repression and signaling pathway modulation in infected cells. Kim et al. now show that PKR is activated during mitosis in uninfected cells. PKR interacts with dsRNAs formed by inverted Alu repeats, which become accessible to PKR during mitosis. Phosphorylated PKR then suppresses translation and coordinates mitosis. This study unveils a novel function of PKR and endogenous dsRNA mitosis in uninfected cells.</P>