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Hye Rin Jeong,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was investigated to evaluate a protective effect of ethyl acetate fraction from Cedrela sinensis (EFCS) on H₂O₂ and corticosterone-induced oxidative stress in hippocampal HT22 and human neuroblastoma MC-IXC cells. 40% ethanolic extracts of Cedrela sinensis showed higher total phenolic and total flavonoid contents than other ethanolic extracts. The EFCS showed the significant, 2,2"-azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. The EFCS presented significant antioxidant capacity by evaluating the ferric reducing/antioxidant power (FRAP). The EFCS showed considerable inhibitory effect of malondialdehyde (MDA) levels and acetylcholinesterase (AChE) activity. In addition, the EFCS inhibited ROS production and increased cell viability in H₂O₂ and corticosterone-induced cytotoxicity in HT22 and MC-IXC cells. Main physiologically compounds of EFCS were identified as rutin, isoquercetin, ethyl gallate, quercetin, kampferol-3-O-rhamnose and ethyl digallate using ultrahigh performance liquid chromatography-quadrupole time of flight/mass spectrometer (UPLC-QTOF/MS).
Hye Rin Seo,Hyun Seok Jung,Da Seul Jung,Jeong Won Choi,So Hye Jo 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.9
Objective This study aimed to investigate the changes in interpersonal relationships, behavioral patterns, and emotional states of children and adolescents with psychiatric disorders and their caregivers immediately after the coronavirus disease of 2019 (COVID-19) outbreak in Daegu, South Korea.Methods A total of 147 patients and 147 caregivers participated in the Survey for Outing and Time Usage for Child, Adolescent, and Parents and the COVID-19 Visual Analog Scale for Emotion. We classified the patients and their caregivers into the internalizing disorder (ID) and externalizing disorder (ED) groups and compared the changes.Results Parent–child relationships for adolescent patients and caregivers were interrupted, and friend relationships in all participants were disrupted, while sibling relationships improved in adolescent patients. They experienced negative emotional changes. Time spent outdoor decreased and digital screen time increased for all participants. Friend and parent–child relationships were interrupted in the ED group compared to those in the ID group. ED patients experienced negative changes in emotional states, while ID patients showed no significant changes.Conclusion Results are meaningful as a reference for predicting changes in interpersonal relationships and mental status of pediatric psychiatric patients and for determining healthcare system adaptations to allow mental health support during the COVID-19 outbreak.
Jeong, Hye-Rin,Kim, Ji-Yeon,Kim, Sang-Nyun,Park, Jung-Hwan Elsevier 2018 European journal of pharmaceutics and biopharmaceu Vol.127 No.-
<P><B>Abstract</B></P> <P>Dissolving microneedles (MN) containing cyclosporin A (CyA) were prepared for local delivery of CyA into the dermal layer. The efficacy of using MN to deliver CyA, an insoluble and high molecular weight drug, was observed and compared with oral administration of solubilized CyA.</P> <P>Microneedles containing CyA (CyA MN) were prepared using a closed, low-temperature molding process. The mechanical properties of CyA MN and phase separation were studied regarding the content of CyA. CyA MN were inserted into porcine skin for a predetermined time, and the dissolution and delivered amount of CyA were measured in vitro with an optical microscope and high-performance liquid chromatography (HPLC) analysis of the extracted CyA. A pharmacokinetic study of CyA MN was performed in vivo by administering 10% CyA MN, and the pharmacokinetic profile was compared with that of orally administered CyA.</P> <P>Pyramidal CyA MN (600 μm long, 250 μm wide) were prepared. CyA MN penetrated skin successfully with up to 50% CyA content. When 10% CyA MN were pressed into porcine skin for 60 min, 65% of MN length was dissolved and 34 ± 6.5 μg of CyA in MN was delivered into the skin. Under the same conditions with 10% CyA MN administered to rats, CyA MN showed T<SUB>max</SUB> of 8 h, C<SUB>max</SUB> of 15.9 ng/ml, and area under curve (AUC) of 686, compared to T<SUB>max</SUB> of 2 h, C<SUB>max</SUB> of 18.205 ng/ml, and AUC of 254 for oral administration of solubilized CyA.</P> <P>A therapeutic dose of CyA for treatment of psoriasis was delivered via MN into the skin layer without solubilization of CyA. Due to the hydrophobic properties and high molecular weight of CyA, the safety of CyA delivery was improved using dissolving microneedles because the slow systemic absorption and local treatment enabled CyA to remain in the skin for a longer time. Microneedles are an effective method with high bioavailability for local dermal delivery of insoluble drugs.</P> <P><B>Graphical abstract</B></P> <P>Descriptive figure of a locally dermal delivery of cyclosporin A (CyA) using dissolving microneedles (a) after insertion into skin (b) stay of CyA for a longer time in skin after dissolution of polymer in skin and (c) absorption of CyA into blood capillaries. A predetermined dose of CyA was delivered via dissolving MN into the dermal layer without solubilization of CyA. Due to the hydrophobic properties and high molecular weight of CyA, the safety of CyA delivery was improved using dissolving microneedles because the slow systemic absorption and local treatment enabled CyA to remain in the skin for a longer time.</P> <P>[DISPLAY OMISSION]</P>
Original Articlet:Augmentation of Filtering Blebs with Viscoelastics in Trabeculectomy
( Hye Rin Jeong ),( Kyung Rim Sung ) 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.5
Purpose: To evaluate the clinical outcome of viscoelastics (VE, sodium hyaluronate)-augmented trabeculectomy (VAT, 66 eyes) and conventional trabeculectomy (CT, 57 eyes) for glaucomatous eyes. Methods: In the VAT group, half of the anterior chamber space was filled with VE via the paracentesis site at the end of CT and a balanced salt solution was injected into the anterior chamber. This procedure induced migration of VE from the anterior chamber into the bleb space; thus the bleb was elevated with underlying VE. Follow-up examinations were performed until 1 year after surgery. Success was defined as the attainment of an intraocular pressure (IOP) greater than 5 mmHg and less than 22 mmHg. If IOP was in the range of success without antiglaucoma medication, it was regarded as a complete success. Results: The mean postoperative IOP was significantly lower in the VAT group at postoperative 1 day, 1 week, and 1 month. The complete success rate was significantly higher in the VAT group (89%) than in the CT group (75%), though the qualified success rate was not different between the two groups. The number of IOP-lowering medications at postoperative 1 year was significantly higher in the CT group (1.30 ± 1.08 vs. 0.73 ± 0.98, p = 0.003). Among postoperative procedures, laser suture lysis was required less frequently in the VAT group (p < 0.001). Conclusions: Placing VE within the bleb at the end of surgery may result in better IOP control and less need for IOP-lowering medication without any additional materials, cost, or time.
미니피그에서 자가치아뼈 이식의 골형성 효과에 대한 연구
정혜린(Hye Rin Jeong),황주홍(Ju Hong Hwang),이정근(Jeong Keun Lee) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.5
Introduction: This study examined the effect of autogenous tooth bone used as a graft material for bone regeneration in an artificial bony defect of minipigs. Materials and Methods: Four healthy minipigs, weighing approximately 35-40 kg, were used. Four standardized artificial two-walled bony defects, 5 mm in length and depth, were made on the bilateral partial edentulous alveolar ridge on the mandible of minipigs, and autogenous tooth bone was augmented in the right side as the experimental group. On the other hand, only alloplastic bone graft material HA was grafted with the same size and manner in the left side as the control group. All minipigs were sacrificed at 4 weeks after a bone graft and evaluated histologically by Haematoxylin-eosin staining. The specimens were also evaluated semi-quantitatively via a histomorphometric study. The percentage of new bone over the total area was evaluated using digital software for an area calculation. Results: All specimens were available but one in the left side (control group) and two in the right side (experimental group) were missing during specimen preparation. The amount of bone formation and remodeling were higher in all experimental groups than the control. The mean percentage area for new bone in the experimental and control groups was 43.74±11.96% and 30.79±2.93%, respectively. Conclusion: Autogenous tooth bone is a good alternative to autogenous bone with the possible clinical feasibility of an autogenous tooth bone graft in the reconstruction of bony defects.
진혜정 ( Hye Jung Jin ),김백일 ( Beak Il Kim ),박덕영 ( Deok Young Park ),정성화 ( Seong Hwa Jeong ),배광학 ( Kwang Hak Bae ),김진범 ( Jin Bom Kim ),정승화 ( Seung Hwa Jeong ),이혜린 ( Hye Rin Lee ),우경지 ( Gyeong Ji Woo ),최연희 대한예방치과·구강보건학회 2015 大韓口腔保健學會誌 Vol.39 No.1
Objectives: The present study aimed to evaluate the validity of a set of self-reported questionnaires for periodontitis for estimating the prevalence of chronic adult periodontitis in the Korean population. Methods: The questionnaire is comprised of a total of 14 questions with four summarized concepts including self-diagnosis of oral status, subjective signs related to oral health, smoking and drinking status, and use of auxiliary oral hygiene devices including scaling. The predictiveness of the measures from these self-reported questions was assessed by logistic regression modeling using receiver operating characteristic (ROC) statistics, sensitivity, and specificity. Results: The sensitivity, specificity, and AUC including all questions were 0.571, 0.768, and 0.781, respectively; the sum of sensitivity and specificity was 1.34. To gain robustness, a simplified predictive model was built with six questions. Its results were 0.536, 0.817, and 0.762 for sensitivity, specificity, and AUC, respectively. The sum of sensitivity and specificity was found to be 1.35. Conclusions: The self-reported questionnaire for periodontitis showed considerable validity, but further study is required to provide optimal validity and predictability.