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The International Development Strategy of Les Enphants Roots in China Market
Huang, Shu-Tzu,Cho, Hsin-Ying,Hsu, Yin-Chieh The Korean Society of Costume 2014 International journal of costume and fashion Vol.14 No.1
Facing a mature domestic market and the challenges of the global consumer market, retailers in Taiwan are in pursuit of international development strategies for increasing its market opportunities as one of its key growth strategies. In the global market, the Chinese market becomes Taiwan retailers' main international development milestone due to its similarity of language, culture and historical background with China. Therefore, this research uses case study method based on Eclectic paradigm (Dunning 1981) to explore the various advantages of a Taiwanese children's clothing retailer Les Enphants, which include ownership advantage, internalization advantage, and location advantage. These advantages in turn demonstrate rationales behind Les Enphants' internationalization necessity (Why to Go), selecting China as an expansion target (Where to Go), and management and operation strategies implemented in China (How to Go). Our study highlights a successful entry and expansion model of the Taiwanese children clothing retailer, and may have solid contribution to the practical application of internationalization strategy theory.
( Meng Chieh Wu ),( Hsin Kai Huang ),( Chun Cheng Zhang ),( Li Sheng Chang ),( Yung Ze Cheng ),( Chien Chin Hsu ),( Kao Chang Lin ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Emergency department (ED) overcrowding is a problem in many countries including Taiwan. Access block refers to a situation where patients in the emergency department requiring inpatient care are unable to gain access to appropriate hospital beds within a reasonable time frame (more than 8 hours total time in the emergency department). Access block is one major reason of ED overcrowding. Methods: A new holistic care unit was established in our medical center in Taiwan in July 2012, with the attending physicians including internal medicine physicians and a neurologist. The patients who required hospitalized treatment were referred to internal medicine physicians in the emergency department. The new department was comprised of seven experienced medical attending physician to take care of the patients directly, with 8-hour duty work shifts within 24 hours, in collaboration with emergency physicians, radiologists, nurses, social workers and case managers to form a team. This team had similar three-shift work duty, education and training programs, and they shared medical devices and resources. If beds in the intensive care unit or ward are not available immediately, procedures and treatment can be performed in the holistic care unit. The pediatric patients were excluded from this study. Results: In total, 26,623 patients were admitting to ward from our emergency department from August 2011 to July 2012, and 23,790 patients from August 2012 to July 2013. The rate of access block decreased from 55.29% to 50.01% ( p < 0.01) after holistic care unit was established. The mean time of ED length of stay was also improved from 18.04 hours to 15.43 hours ( p < 0.01). Conclusions: The newly established holistic care unit in our hospital improved the quality of medical care, not only physiologically but also psychologically.
Clinical Features of Patients with Esophageal and Second Primary Cancers
Tsai, Huang-Wen,Chang, Chih-Chun,Sun, Jen-Tang,Liou, Ching-Biau,Lin, Hsiu-Chen,Lin, I-Hsin,Yu, Yun-Chieh,Weng, Wei-Ling,Leong, Ka-I,Yen, Tzung-Hai,Wu, Jiann-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: The prevalence of esophageal cancer (EC) with second primary cancers (SPC) is increasing worldwide. This study was aimed to understand the clinical features of EC patients with SPC in the Taiwanese population. Materials and Methods: Clinical and laboratory data for 180 EC patients with or without SPC were collected between January 2009 and December 2013. Information on treatment approaches, location of SPCs and ABO blood type were also collected and stratified. Results: The most common SPC in EC patients was hypopharyngeal cancer, followed by laryngeal cancer and hepatocellular carcinoma in our study. Malignancies of colon, prostate and lung were also found. There was a significant higher portion of blood type A in the EC patients with SPC compared with those without (42.4% vs 19.5%, P=0.006). Conclusions: The frequency and SPC site distribution and blood type A should be considered in clinical evaluation of EC patients with a high risk of developing SPC in the Taiwanese population.
Lin Chih-Hsin,Hsieh Yu-Shao,Sun Ying-Chieh,Huang Wun-Han,Chen Shu-Ling,Weng Zheng-Kui,Lin Te-Hsien,Wu Yih-Ru,Chang Kuo-Hsuan,Huang Hei-Jen,Lee Guan-Chiun,Hsieh-Li Hsiu Mei,Lee-Chen Guey-Jen 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.1
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine’s screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (TauRD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC50 of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 TauRD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 TauRD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 TauRD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.
Lung-Chun Huang,Wen-San Huang,Chung-Ping Lin,Olga M. Nuñeza,Hui-Yun Tseng,Hsin-Chieh Tang 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.4
Endemic species of oceanic islands are vulnerable due to their geographical isolation and small population sizes. For endangered island species, captive breeding program is an important strategy for conservation and sustainable management. Pachyrhynchus sarcitis is a flightless weevil decorated with colourful markings and distributed exclusively on several islets of Southeast Asia including Lanyu, Ludao, and Babuyan Islands. The life history of threatened Pachyrhynchus species of these islands was poorly known. This study reared P. sarcitis from Lanyu and Babuyan Islands for the first time in the laboratory using their host plant (Leea guineensis). The two island populations showed significant differences in instar numbers, in which the weevils from Lanyu Island had a higher instar number regardless the length of developmental duration. The adult body size of both sexes of the Babuyan population became smaller under laboratory condition; whereas Lanyu population in the laboratory did not show this trend. The differences in larval development might suggest local adaptation to the host plants or other life history associated characteristics which requires further research.
The International Development Strategy of Les Enphants Roots in China Market
Shu Tzu Huang,Hsin Ying Cho,Yin Chieh Hsu 한국복식학회 2014 International journal of costume and fashion Vol.14 No.1
Facing a mature domestic market and the challenges of the global consumer market, retailers in Taiwan are in pursuit of international development strategies for increasing its market opportunities as one of its key growth strategies. In the global market, the Chinese market becomes Taiwan retailers’ main international development milestone due to its similarity of language, culture and historical background with China. Therefore, this research uses case study method based on Eclectic paradigm (Dunning 1981) to explore the various advantages of a Taiwanese children’s clothing retailer Les Enphants, which include ownership advantage, internalization advantage, and location advantage. These advantages in turn demonstrate rationales behind Les Enphants’ internationalization necessity (Why to Go), selecting China as an expansion target (Where to Go), and management and operation strategies implemented in China (How to Go). Our study highlights a successful entry and expansion model of the Taiwanese children clothing retailer, and may have solid contribution to the practical application of internationalization strategy theory.
( Po-chih Yang ),( Hsin-chieh Huang ),( Kai-wen Huang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare primary hepatic cancer with poor prognosis. Aggressive surgical planning with complete resection of cHCC-CC plays an important role in treatment. We presented one case of successful resection of huge cHCC-CC after portal vein embolization (PVE). Methods: This is a 46-year-old man with alcoholic liver cirrhosis. CT scan showed one 10cm infiltrative tumor in right liver with right anterior portal venous tumor thrombosis enhanced in arterial phase and washed out in portal venous phase. Regional enlarged lymph nodes is also noted. Under the preoperative diagnosis of HCC, right hepatectomy is planned. CT volumetry showed future liver remnant(FLR) is 480ml, 38.5% of standard liver volume. The ideal percentage of FLR in cirrhotic liver is more than 40% in our institution. Because of tumor thrombosis with total occlusion in right anterior portal pedicle, we performed PVE to right posterior portal vein for inadequate FLR. Two weeks after PVE, left liver enlarged from 480ml(38.5%) to 620ml(49.7%). There was no complication during PVE. Results: Right hepatectomy and regional lymph node dissection were performed two weeks after PVE. The post-operative course was smooth without any evidence of hepatic insufficiency. Pathology reported combined hepatocellular-cholangiocarcinoma but no malignant lymph nodes. There is no evidence of recurrence in follow-up CT scan 17 months after the operation until now. Conclusions: Aggressive surgical planning with PVE is effective for patient with cHCC-CC without adequate FLR even in cirrhotic liver. Complete resection may provide longer overall survival in this disease with dismal prognosis.