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Na, Ann-Yae,Jo, Jung Jae,Kwon, Oh Kwang,Shrestha, Riya,Cho, Pil Joung,Kim, Kyu Min,Ki, Sung Hwan,Lee, Tae Hee,Jeon, Tae Won,Jeong, Tae Cheon,Lee, Sangkyu Elsevier 2018 Toxicology and applied pharmacology Vol.352 No.-
<P><B>Abstract</B></P> <P>Non-alcoholic fatty liver disease (NAFLD) includes conditions such as steatosis, non-alcoholic steatohepatitis, and ultimately hepatocellular carcinoma. Although the pathology of NAFLD is well-established, NAFLD-induced drug metabolism mediated by cytochrome P450 (CYP) in the liver has remained largely unexplored. Therefore, we investigated NAFLD-induced drug metabolism mediated by CYP by quantitative toxicoproteomics analysis. After administration of a methionine-choline deficient (MCD) diet to induce development of NAFLD, tandem mass tags-based liquid chromatography-tandem mass spectrometry analysis was conducted to investigate the dynamics of hepatic proteins. A total of 1295 proteins were identified, of which 934 were quantified by proteomic analysis. Among these proteins, 21 proteins were up-regulated and 51 proteins were down-regulated by the MCD diet. Notably, domain annotation enrichment using InterPro indicated that proteins related to CYPs were significantly decreased. When we investigated CYP activity using <I>in vivo</I> and <I>in vitro</I> CYP cocktail assays, most CYPs were significantly decreased, whereas CYP2D was not changed after administration of the MCD diet. In conclusion, we identified significantly altered levels of CYPs and their activities induced by the MCD diet and confirmed the NAFLD-induced drug metabolism by pharmacokinetic analysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NAFLD-induced drug metabolism was investigated by comparative toxicoproteomics. </LI> <LI> Among 934 quantified proteins, 21 were up-regulated, and 51 were down-regulated. </LI> <LI> Domain annotation enrichment indicated CYPs were significantly decreased. </LI> <LI> The decreased CYP activities were confirmed by <I>in vivo</I> and <I>in vitro</I> assays. </LI> <LI> Our data provides understanding of the drug-interaction in NAFLD patients. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
유방 방사선 검사를 위한 압박 패드의 제작 및 유방 압박 통증에 영향을 주는 요인 분석
김도희(Do-Hee Kim),이안(Ann Yi),권보라(Bo-Ra Kwon),구홍욱(Hong-Uk Ku),방용식(Yong-Sik Bang),조명주(Myeong-Ju Cho) 한국방사선학회 2021 한국방사선학회 논문지 Vol.15 No.5
본 연구는 여러 재질의 맘모 패드를 제작함으로써 환자의 압박 통증 및 불편함 감소 효과와 단일 패드의 대체 가능성을 살펴보고 유방촬영 시 환자의 압박 통증변화와 다양한 요인에 대하여 알아보고자 하였다. 이를 위해 기존의 H사의 맘모 패드를 대체할 수 있는 고경도, 고탄성의 맘모 패드를 제작하였고 제작된 패드의 유용성을 평가하기 위하여 각각의 화질을 비교 평가하였다. 또한 유방촬영 시 통증 관련 요소를 파악하기 위해 2018년 12월부터 2020년 3월까지 서울의 일 종합병원 내원자 중 유방검사를 실시한 환자를 대상으로 설문 조사하여 총 200명의 데이터를 비교 분석하였다. 영상평가 결과, 기존 패드와 신규 제작 패드 모두 화질평가와 임상영상평가의 기준 내 적합치를 나타내었다. 또한 유방촬영 시 압박 통증의 변화와 관련된 요인들을 분석한 결과 일반적 분석항목 요인으로 나이, 키, BMI수치로 나타났으며 여성적·경험적 분석항목 요인으로 생리여부, 출산 경험, 모유 수유 경험, 폐경여부, 유방 GRADE, 유방 형태, 유방촬영 경험으로 나타났다. 결과적으로 나이, 모유 수유 경험, 유방촬영 경험, 폐경여부는 유방촬영 시 통증 변화 정도의 54.0%의 설명력을 나타내었고 유방촬영 시 통증의 변화는 중간 통증에서 유방촬영 경험이 증가할수록 약 0.26배, 심한 통증 이상에서 유방촬영 경험이 증가할수록 약 0.14배씩의 차이를 나타내었다. The purpose of this study was to identify the effects of mammo pad made of different kinds of materials on the reduced inconvenience and compression pains of patients to examine plausible interchangeability of existing pads made of single kind of material, and to examine the changes in pains of patients taking mammography and various factors therein. The high-hardness and highly-elastic mammo pressure pads, capable of replacing existing mammo pad of “H” company, were manufactured, and the display quality of mammography obtained from respective mammo pad were compared to each other to appraise the availability of manufactured mammo pad. In addition, 200 patients, who came to a general hospital in Seoul, were selected as subjects for the survey employing a questionnaire which was distributed to the subjects from December 2018 to March 2020 to identify the factors involved with the mammo pad of patients while taking mammography. The results of mammography obtained from both of the existing and newly manufactured mammo pad revealed appropriate display qualities fell within the range of clinical criteria. Besides, the factors associated with changing compression pains of patients taking mammography were analyzed wherefrom the general factors in the following order of age, height, and BMI index appeared, while the experiential and female factors appeared as in the following order: presence of menstruation, experience of child-birth, experience of breast feeding, menopause, grade of breast, shape of breast, and experience of mammography. In conclusion, the following factors comprising the age, experience of breast feeding, experience of mammography, and menopause rendered approximately 54% of power of explaining the degree of changing pains during mammography. Regarding the changes in compression pains while taking mammography, the increasing experience of mammography of patients rendered approximately 0.26 times more at the intermediate range of compression pains and approximately 0.14 times more at the range of severe pains.
해양부산물 아미노산액비 및 유용미생물(KEM) 시용이 들깻잎의 품질에 미치는 영향
조전권 ( Jeon Kwon Cho ),안승원 ( Seoung Won Ann ),김영칠 ( Young Chil Kim ),황인수 ( In Su Hwang ),김명선 ( Myoung Seon Kim ),이정관 ( Jung Kwan Lee ),노희영 ( Hee Young No ) 한국환경과학회 2010 한국환경과학회지 Vol.19 No.10
This study was carried out to investigate the effect of KEM and SAF appication on contents change of fatty acids and organic acid of perilla(Perilla Frutescens Britton). Contenst of squalene in perilla leaves on control and KEM/SAF treated were 3.39 mg and 4.22 mg, respectively. Therefore the squalene quantity of KEM/SAF treated leaves was 24.2% more than that of control. A total 6 fatty acids in perilla leaves were analyzed in this study. Percentage of the saturated and unsaturated fatty acid in perilla leaves were 20 and 80%, respectively. Contents of phytosterols in perilla leaf such as campesterol and sitosterol were 2.0 and 20.0 mg, respectively. Therefore sitosterol content was 10 fold more than that of campesterol. The KEM/SAF application on perilla leaf was effective on the change of squalene or phytosterol contents. However effect of that was negligible on the change of fatty acid content.
Huge Goiter로 기도협착이 있는 환자에서 Awake Bronchoscopic Intubation을 통한 기도 관리 - 증례보고 -
권태완 ( Taewan Kwon ),강화자 ( Wha-ja Kang ),유안희 ( Ann Hee You ) 경희대학교 경희의료원 2019 慶熙醫學 Vol.34 No.1
The huge thyroid goiter is one of the risk factors of difficult airway. We report the anesthetic management of compromised airway with tracheal narrowing due to a huge goiter. After applying lidocaine spray, awake oral fiberoptic intubation was perfomed and intubation was done with 6.0mm reinforced armored tube. After successful total thyroidectomy, neuromuscular blockade was completely reversed by sugammadex and extubation was uneventful. No respiratory compromise was noted after extubation and the patient was discharged in 3 days after the surgery without any complications.