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Lunn, David J.,Seo, Sungbaek,Lee, Sang‐,Ho,Zerdan, Raghida Bou,Mattson, Kaila M.,Treat, Nicolas J.,McGrath, Alaina J.,Gutekunst, Will R.,Lawrence, Jimmy,Abdilla, Allison,Anastasaki, Athina,Knigh John WileySons, Inc. 2019 Journal of polymer science Part A, Polymer chemist Vol.57 No.6
<P><B>ABSTRACT</B></P><P>The synthesis and systematic comparison of a comprehensive library of well‐defined polymer architectures based on poly(acrylic acid) is reported. Through the development of new synthetic methodologies, linear, single branched, precision‐branched comb, and star polymers were prepared and their performance as dispersants was evaluated. The ability to accurately control chain lengths and branch points allows the subtle interplay between structure and dispersant performance to be defined and affords critical insights into the design of improved polymeric additives for coating formulations. The general industrial relevance of ionic polymers and branched macromolecular architectures supports these design rules for a wide range of other applications and materials, including as additives for personal care products and in water treatment. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. <B>2019</B>, <I>57</I>, 716–725</P>
A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time
Seo, Daeha,Southard, Kaden M.,Kim, Ji-wook,Lee, Hyun Jung,Farlow, Justin,Lee, Jung-uk,Litt, David B.,Haas, Thomas,Alivisatos, A. Paul,Cheon, Jinwoo,Gartner, Zev J.,Jun, Young-wook Cell Press 2016 Cell Vol. No.
<P><B>Summary</B></P> <P>Tools capable of imaging and perturbing mechanical signaling pathways with fine spatiotemporal resolution have been elusive, despite their importance in diverse cellular processes. The challenge in developing a mechanogenetic toolkit (i.e., selective and quantitative activation of genetically encoded mechanoreceptors) stems from the fact that many mechanically activated processes are localized in space and time yet additionally require mechanical loading to become activated. To address this challenge, we synthesized magnetoplasmonic nanoparticles that can image, localize, and mechanically load targeted proteins with high spatiotemporal resolution. We demonstrate their utility by investigating the cell-surface activation of two mechanoreceptors: Notch and vascular endothelial cadherin (VE-cadherin). By measuring cellular responses to a spectrum of spatial, chemical, temporal, and mechanical inputs at the single-molecule and single-cell levels, we reveal how spatial segregation and mechanical force cooperate to direct receptor activation dynamics. This generalizable technique can be used to control and understand diverse mechanosensitive processes in cell signaling.</P> <P><B>Video Abstract</B></P> <P>Display Omitted</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of a mechanogenetic single-cell perturbation approach </LI> <LI> Interrogation of the spatial, chemical, and mechanical responses of Notch receptors </LI> <LI> Identification of the roles of spatial and mechanical cues on VE-cadherin signaling </LI> <LI> Spatiotemporal and quantitative control of single-cell transcription by nanoprobes </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Central Neurocytoma: A Review of Clinical Management and Histopathologic Features
Seung J. Lee,Timothy T. Bui,Cheng Hao Jacky Chen,Carlito Lagman,Lawrance K. Chung,Sabrin Sidhu,David J. Seo,William H. Yong,Todd L. Siegal,김민수,Isaac Yang 대한뇌종양학회 2016 Brain Tumor Research and Treatment Vol. No.
Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy. The radiological features of CN are indistinguishable from those of other brain tumors; therefore, many histological markers, such as synaptophysin, can be very useful for diagnosing CNs. Furthermore, the MIB-1 Labeling Index seems to be correlated with the prognosis of CN. We also discuss oncogenes associated with these elusive tumors. Further studies may improve our ability to accurately diagnose CNs and to design the optimal treatment regimens for patients with CNs.
Kang, David Sung Yong,Lee, Hun,Reinstein, Dan Z.,Roberts, Cynthia J.,Arba-Mosquera, Samuel,Archer, Timothy J.,Kim, Eung Kweon,Seo, Kyoung Yul,Kim, Tae-im SLACK, Inc. 2018 Journal of refractive surgery Vol.34 No.7
<P>CONCLUSIONS: SMILE with the triple marking centration method can yield improved treatment centration and smaller induction of total HOAs, coma, and spherical aberrations.</P>
Central Neurocytoma: A Review of Clinical Management and Histopathologic Features
( Seung J. Lee ),( Timothy T. Bui ),( Cheng Hao Jacky Chen ),( Carlito Lagman ),( Lawrance K. Chung ),( Sabrin Sidhu ),( David J. Seo ),( William H. Yong ),( Todd L. Siegal ),( Minsu Kim ),( Isaac Yan 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.2
Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to im-prove tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy. The radiological features of CN are indistinguishable from those of other brain tumors; therefore, many histological markers, such as synaptophysin, can be very useful for diagnosing CNs. Furthermore, the MIB-1 Labeling Index seems to be correlated with the prognosis of CN. We also discuss oncogenes associated with these elusive tumors. Further studies may improve our ability to accurately diagnose CNs and to design the optimal treatment regimens for patients with CNs.
Different Calcium Binding Affinity of Calmodulin Isoforms and Its Effect on Target Enzyme Activation
Lee, Sang Hyoung,Jonathan Davis,Seo, Hae Young,Heo, Won Do,Lee, Kyoung Joo,J.David Johnson,Cho, Moo Je Gyeongsang National University, Chinju, Korea 1996 Plant molecular biology and biotechnology research Vol.1996 No.