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Psychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
Hanly, John G.,Li, Qiuju,Su, Li,Urowitz, Murray B.,Gordon, Caroline,Bae, Sang‐,Cheol,Romero‐,Diaz, Juanita,Sanchez‐,Guerrero, Jorge,Bernatsky, Sasha,Clarke, Ann E.,Wallace, Daniel J. Wiley (John WileySons) 2019 Arthritis & rheumatology Vol.71 No.2
Kang, Da Hyun,Chung, Chaeuk,Kim, Ju‐,Ock,Jung, Sung Soo,Park, Hee Sun,Park, Dong Il,Jung, Sun Young,Park, Myoungrin,Lee, Jeong Eun John WileySons Australia, Ltd 2018 Thoracic cancer Vol.9 No.11
<P><B>Background</B></P><P>Immunotherapy is a new paradigm for the treatment of non‐small‐cell lung cancer (NSCLC), and targeting the PD‐1 or PD‐L1 pathway is a promising therapeutic option. Although PD‐1/PD‐L1 inhibitors are more effective than standard chemotherapy in lung cancer, clinicians are afraid to actively use them because of hyperprogression and pseudoprogression. The aim of this study was to investigate the factors associated with tumor response and serious outcomes.</P><P><B>Methods</B></P><P>We retrospectively collected the medical records of 51 patients with advanced NSCLC who received PD‐1/PD‐L1 inhibitors between January 2016 and February 2018.</P><P><B>Results</B></P><P>The mean patient age was 63.9 years, and 72.5% (37/51) were male. Most (92.2%, 47/51) had received previous systemic treatment. The overall response rate was 21.6% (11/51). The response rate was significantly lower in patients with pleural or pericardial metastasis than in patients without pleural or pericardial metastasis (4.3% vs. 35.7%; <I>P</I> = 0.007). Patients with pleural or pericardial metastasis had a significantly higher rate of adverse events of any grade (91.3% vs. 50.0%; <I>P</I> = 0.002) and grade 3–5 adverse events (52.2% vs. 25.0%; <I>P</I> = 0.046).</P><P><B>Conclusion</B></P><P>Pleural or pericardial metastasis is a significant factor affecting the efficacy and rate of adverse events in advanced NSCLC patients treated with PD‐1/PD‐L1 inhibitors. Clinicians should pay attention to the use of immune checkpoint inhibitors in lung cancer patients with pleural or pericardial metastasis.</P>
Hong, Sung‐,Jin,Kim, Byeong‐,Keuk,Kim, Young‐,Joo,Rha, Seung‐,Woon,Lee, Seung‐,Jin,Kim, Hee‐,Yeol,Choi, Jin‐,Ho,Ahn, Chul‐,Min,Kim, Jung‐,Sun,Ko, John WileySons, Inc. 2020 Catheterization and cardiovascular interventions Vol.95 No.1
<P><B>Abstract</B></P><P><B>Objectives</B></P><P>To evaluate the incidence, predictors, and outcomes of distal vessel expansion on intravascular ultrasound (IVUS) after recanalization of chronic total occlusion (CTO) particularly using new‐generation drug‐eluting stent (DES).</P><P><B>Background</B></P><P>The luminal changes of narrowed vessels distal to CTO segments after recanalization using new‐generation DES have rarely been studied.</P><P><B>Methods</B></P><P>This substudy of the CTO‐IVUS (Chronic Total Occlusion InterVention with drUg‐eluting Stents) trial included a total of 69 new‐generation DES‐treated CTOs with serial matched IVUS analyses at index percutaneous coronary intervention (PCI) and at 1‐year follow‐up. The predictors of distal vessel expansion, any increase of lumen area at the distal reference (LA<SUB>distal</SUB>) on 1‐year follow‐up IVUS, were evaluated by multivariable binary logistic analyses.</P><P><B>Results</B></P><P>Distal vessel expansion was identified in 46 (67%). Independent determinants of distal vessel expansion were proximal CTO, a smaller LA<SUB>distal</SUB> at the index PCI, a greater minimal stent area‐to‐LA<SUB>distal</SUB> (MSA‐to‐LA<SUB>distal</SUB>) ratio, and a greater lumen area at the distal stent edge‐to‐LA<SUB>distal</SUB> (LA<SUB>edge</SUB>‐to‐LA<SUB>distal</SUB>) ratio. The cut‐off values of a MSA‐to‐LA<SUB>distal</SUB> ratio and a LA<SUB>edge</SUB>‐to‐LA<SUB>distal</SUB> ratio predicting the distal vessel expansion by receiver operating characteristic curve analysis were 1.0 and 1.1, respectively. During the median 5.1 years, rates of target vessel revascularization, cardiac death, and stent thrombosis were similar in the distal vessel‐expanded and nonexpanded groups.</P><P><B>Conclusion</B></P><P>After opening CTO with new‐generation DES, two‐thirds of patients exhibited distal vessel expansion on 1‐year follow‐up IVUS. Expansion determinants were a proximal CTO, lower LA<SUB>distal</SUB>, and larger stent areas relative to the LA<SUB>distal</SUB> (modifiable procedural predictors).</P>
Hollow fiber membrane process for SO<sub>2</sub> removal from flue gas
Kim, KeeHong,Kim, JongHak,Lee, HyungKeun John WileySons, Ltd 2015 Journal of chemical technology and biotechnology Vol.90 No.3
<P><B>Abstract</B></P><P><B>BACKGROUND</B></P><P>In this study, a polymeric membrane process was investigated to avoid the poisoning of CO<SUB>2</SUB> sorbents with SO<SUB>2</SUB> during the carbon capture and separation (CCS) process. Two types of hollow fiber composite membranes were prepared using poly(ether‐<I>b</I>‐amide) (PEBAX) and cellulose acetate (CA) as composite materials.</P><P><B>RESULTS</B></P><P>Both of the composite membranes exhibit a trade‐off between the pure gas permeance and the ideal selectivity. The PEBAX1657/PEI exhibited higher permeance than CA/PES due to the morphology of the substrate and the effects of the coating material. A mixed‐gas separation experiment investigated the SO<SUB>2</SUB> removal efficiency and the CO<SUB>2</SUB> loss ratio. The SO<SUB>2</SUB> removal efficiency and CO<SUB>2</SUB> loss ratio were found to be positively correlated with the permeance of the gas components. A multi‐stage membrane process was designed to reduce the CO<SUB>2</SUB> loss ratio with a 90% removal efficiency of SO<SUB>2</SUB>. Compared with a single‐stage process, the CO<SUB>2</SUB> loss ratio was decreased by up to 16.1%, and the membrane area was estimated at 18.1 m<SUP>2</SUP> for the multi‐stage process.</P><P><B>CONCLUSION</B></P><P>A multi‐stage membrane process was designed using different types of membrane modules to decrease CO<SUB>2</SUB> loss ratio without sacrificing SO<SUB>2</SUB> removal efficiency. © 2014 Society of Chemical Industry</P>
Oh, Jungju,Lee, Min Sang,Jeong, Ji Hoon,Lee, Minhyung John WileySons, Ltd 2017 Journal of Pharmaceutical Sciences Vol.106 No.12
<P>An efficient gene carrier to the brain is required for successful gene therapy of ischemic stroke. In this study, deoxycholic acid-conjugated polyethylenimine (DA-PEI) was synthesized and evaluated as a heme oxygenase-1 (HO-1) gene carrier for ischemic stroke gene therapy. Gel retardation assay and heparin competition assay showed that DA-PEI formed a stable complex with plasmid DNA. In vitro transfection assays with the luciferase gene showed that DA-PEI had higher transfection efficiency than polyethylenimine (25 kDa, PEI25k) and lipofectamine in Neuro2A cells. Furthermore, DA-PEI had less toxicity than lipofectamine. To evaluate the therapeutic effects of the pb-HO-1/DA-PEI complex, the complex was injected locally in the brain of the transient middle cerebral artery occlusion animal model. In in vivo studies, DA-PEI was more effective than PEI25k in delivering pb-HO-1 to the ischemic brain and achieved higher HO-1 expression. As a result, the pb-HO-1/DA-PEI complexes more effectively reduced infarct volume and the number of apoptotic cells compared with the pb-HO-1/PEI25k complex. The results suggest that DA-PEI will be useful for HO-1 gene therapy of ischemic stroke. (C) 2017 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.</P>
Kim, Dongchan,Chae, Jong‐,Hee,Han, Yeji John WileySons, Inc. 2019 International Journal of Imaging Systems and Techn Vol.29 No.4
<P><B>Abstract</B></P><P>Accurate extraction of brain tissues from magnetic resonance (MR) images is important in neuroradiology. However, brain extraction is more difficult for pediatric brains than for adult brains due to several factors including smaller brain sizes and lower tissue contrasts. In this work, we propose a brain extraction technique that utilizes dual frame (DF) 3D U‐net deep learning architecture and the human connectome project (HCP) database for multislice 2D pediatric T2‐weighted MR images with diseases. To improve segmentation accuracy in small pediatric brains with detailed boundary regions, DF 3D U‐net architecture was used. We pretrained networks with the HCP database to compensate for the limited amount of MR images and manual segmentation masks of pediatric patients. For quantitative analysis, we compared the brain extraction results of brain extraction tool, DF, and conventional 3D U‐net using the dice similarity coefficient (DSC), intersection of union (IoU), and boundary F1 (BF) scores; each deep learning architecture was evaluated with and without pretraining using the HCP. This study included 10 patients with diseases and all images were acquired using a PROPELLER MR sequence. Pretraining using the HCP database enhanced segmentation performance of the network, and the skip connections in the DF 3D U‐net could enhance the contour similarity of segmentation results. Experimental results showed that the proposed method increased the DSC, IoU, and BF scores by 0.8%, 1.6%, and 1.5%, respectively, compared with those of the conventional 3D U‐net without pretraining.</P>
Na, Tae‐,Young,Han, Young‐,Hyun,Ka, Na‐,Lee,Park, Han‐,Su,Kang, Yun Pyo,Kwon, Sung Won,Lee, Byung‐,Hoon,Lee, Mi‐,Ock John WileySons, Ltd 2015 The Journal of pathology Vol.235 No.5
<P><B>Abstract</B></P><P>Chronic ethanol consumption causes hepatic steatosis and inflammation, which are associated with liver hypoxia. Monocyte chemoattractant protein‐1 (MCP‐1) is a hypoxia response factor that determines recruitment and activation of monocytes to the site of tissue injury. The level of MCP‐1 is elevated in the serum and liver of patients with alcoholic liver disease (ALD); however, the molecular details regarding the regulation of MCP‐1 expression are not yet understood completely. Here, we show the role of liver X receptor α (LXRα) in the regulation of MCP‐1 expression during the development of ethanol‐induced fatty liver injury, using an antagonist, 22‐S‐hydroxycholesterol (22‐S‐HC). First, administration of 22‐S‐HC attenuated the signs of liver injury with decreased levels of MCP‐1 and its receptor CCR2 in ethanol‐fed mice. Second, hypoxic conditions or treatment with the LXRα agonist GW3965 significantly induced the expression of MCP‐1, which was completely blocked by treatment with 22‐S‐HC or infection by shLXRα lentivirus in the primary hepatocytes. Third, over‐expression of LXRα or GW3965 treatment increased MCP‐1 promoter activity by increasing the binding of hypoxia‐inducible factor‐1α to the hypoxia response elements, together with LXRα. Finally, treatment with recombinant MCP‐1 increased the level of expression of LXRα and LXRα‐dependent lipid droplet accumulation in both hepatocytes and Kupffer cells. These data show that LXRα and its ligand‐induced up‐regulation of MCP‐1 and MCP‐1‐induced LXRα‐dependent lipogenesis play a key role in the autocrine and paracrine activation of MCP‐1 in the pathogenesis of alcoholic fatty liver disease, and that this activation may provide a promising new target for ALD therapy.Copyright © 2014 The Authors. <I>The Journal of Pathology</I> published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</P>
Ha, Seon-Ah,Shin, Seung Min,Kim, Hyun Kee,Kim, Sanghee,Namkoong, Hong,Lee, Youn Soo,Kim, Hae Joo,Jung, Sang Min,Lee, Yu Sun,Chung, Yeun Jun,Park, Yong Gyu,Jung, Sang Seol,Kim, Jin Woo John WileySons, Ltd 2009 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol. No.
<P>Obese women have an increased risk for post-menopausal breast cancer. The physiological mechanism by which obesity contributes to breast tumourigenesis is not understood. We previously showed that <I>HCCR-1</I> oncogene contributes to breast tumourigenesis as a negative regulator of p53 and detection of HCCR-1 serological level was useful for the diagnosis of breast cancer<SUB>.</SUB> In this study, we found that the HCCR-1 level is elevated in breast cancer tissues and cell lines compared to normal breast tissues. We identified apolipoprotein E (ApoE) interacting with HCCR-1. Our data show that HCCR-1 inhibits anti-proliferative effect of ApoE, which was mediated by diminishing ApoE secretion of breast cancer cells. Finally, HCCR-1 induced the severe obesity in transgenic mice. Those obese mice showed severe hyperlipidaemia. In conclusion, our results suggest that HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE. Therefore, HCCR-1 seems to provide the molecular link between the obesity and the breast cancer risk.</P>