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이규식,정호삼,이민형,백두진,기춘석 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1
Prospidin, a new alkylating agent, has antimitotic and anticancer effect. Incubation with prospidin increases the stability of DNA and suppresses the incorporation of uridine into RNA by 15-20 percent. Prospidin is cytostatic for suspension culture and cells are blocked in G₂ phase of the cell cycle. The authors have demonstrated the effect of prospidin on the liver of mice histologically and histochemically and observed the cellular changes, loss of pyroninophilic granules and accumulation of fat in the hepatic parenchymal cells. Sixty-five healthy mice of ICR strain, average weight being 20g, were divided into two groups; control and prospidin-treated groups. All experimental animals were administered foo and water ad libitum. Animals of the prospidin-treated groups were administered prospidine 500mg per kg of body weight intraperitoneally fter dilution in the water for injection. Animals of the control group were administered only water for injection. Prospidin treated animals were sacrificed at intervals of 6, 12, 24, 36 and 48 hours after administration of prospidin. Histological preparations were made by way of hematoxylin and eosin stain for the cellular changes, methyl green-pyronin stain for pyroninophilic granules and oil red O stain for fat accumulation in the mouse liver. The results obtained are as follows. 1. Cellular swelling associated with vesicular formation were observed in the hepatic parenchymal cells of entire hepatic lobule at 24 and 36 hours after administration of prospidin. 2. A marked reduction of the pyroninophilic granules were observed in the hepatocyte of he whole hepatic lobule at 24, 36 and 48 hours following drug administration. 3. Fat deposits in the hepatic lobule were seen at 36 hours after administration of prospidin. It is suggested that prospidin acts as a cytotoxic agent and causes cellular swelling with vesicular formation, loss of pyroninophilic granules, and fat accumulation in the parenchymal cells of the liver.
Propylthiouracil 투여에 의한 갑상선 기능저하 흰쥐 조직에서 알코올 탈수소효소 활성의 변화
백상현,김동선,이창범,박용수,안유헌,김태화,기춘석,강주섭 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2
Background: Thyroid hormone has been known to affect hepatic alcohol dehydrogenase (ADH) activity. Although the liver is the principal site of ethanol metabolism, stomach is also responsible in part for ethanol oxidation. The effects of thyroid hormone on ADH activity in gastric mucosa and other tissues of rats had not been previously examined. Method: The effects of thyroid hormone on liver, stomach, lung, and kidney ADH activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with propylthiouracil (50 mg/kg) for 14 days. Results: Whereas hepatic ADH activities were not changed by treatment with PTU(42.9(8.6 vs 45.2 (10.1), gastric ADH activities in PTU-treated rats increased by 258.8% of control rat (6.3 ( 0.6 vs 2.2 ( 1.2, p〈0.001). In the activities of other tissues, PTU treatment decreased lung ADH activity by 59.7% of control, and increased kidney ADH activities by 247.1% of control rats. Conclusion: These data suggest that hypothyroidism causes an increase of gastric alcohol metabolism, and that the increase of gastric ADH activity can partly restore the first pass metabolism of ethanol in hypothyroid rats.
송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3
Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.
Immunocytochemical Studies on Guinea Pig Liver Infested with Clonorchis Sinensis
Kee, Choon Suhk,Chung, whan Kook CATHOLIC MEDICAL CENTER 1974 Bulletin of the Clinical Research Institute Vol.2 No.1
Immunocytochemistry has recently been applied to the demonstration within liver tissue of both antigen and gamma globulin, the latter probably representing antibody. The nature of the antigen as well as the antibody target has not been established. It appeared intriguing, therefore, to utilize immunocytochemistry in the study of the distribution of a known antigen and of gamma globulin in the livers of guinea pig with experimental clonorchiasis. Specific antibodies in the sera of patients and animals infested with Clonorchis sinensis have been demonstrated serologically. Thus, the purpose of this study is to disclose the localization, fate and pathogenetic implications of the clonorchis antigen in the liver tissue of the host.
이형접합제 PiMZ 및 α1 - Antitrypsin 결핍을 보인 간경변증
기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이민호(Min Ho Lee),안명주(Myung Ju Ahn),고윤석(Youn Suck Koh),함준수(Joon Soo Ham),이종철(Song Chul Lee),강종명(Jong Myung Kang) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
In 1969, Sharp described the first cases of aplhai-antitrypsin deficiency disease in children with juvenile liver cirrhosis. Since then, this inborn error has been recognized as one of the more common factors in cirrhosis of infancy and childhood, especially in Caucasians of Northern Europeans. PiZZ phenotype is the only one associated with liver disease, there have been a few rescent reports of cirrhosis in heterozygous patients. We experienced a case of 24-year-old male patient who was diagnosed as liver cirrhosis by biopsy but had no defintie causes of liver cirrhosis. The laboratory findings were compatible with liver cirrhosis. By biopsy, the liver is composed of variable sized, micro and macronodules. Dense fibrous tissue encase these nodules. The hepatocytes are strongly positive granules and diastase resistant. Pi phenotype was Pi MIZ by IEF (immunoelectric Focusing) method and the plasma alphai- antitrypsin level is lower than normal.
기춘석(Choon Suhk Kee),박동일(Dong Il Park),이오영(Oh Young Lee),한동수(Dong Soo Han),손주현(Joo Hyun Son),윤병철(Byung Chul Yoon),안유헌(Yoo Hern Ahn),함준수(Jun Su Ham),이민호(Min Ho Lee),박경남(Kyung Nam Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A Gynecomastia occurs in about 30% to 50% of patients with cirrhosis of the liver. Since es- trogens stimulate breast tissue whereas androgens antagonize these effects, gynecomastia has long been considered the result of an imbalance between these hormones. Several mechanisms may operate to produce a relative estrogen excess in hepatic disorders, especially alcoholic cir- rhosis. We have studied the prevalence of gynecomastia and measured the estrogen/testoster- one ratio in cirrhotic subjects and control. Twenty male patients with hepatic cirrhosis were identified from the medical inpatient services of our institution and ten nonobese healthy rnedi- cal students with no history or physical findings of liver disease cornposed the noncirrhotic control group. The mean BMI in the control subjects was 21.3 + 0.8kg/m and that in the group with cirrhosis was 22.1 + l.lkg/m. Therefore, no statistical significance was found. Gy- necomastia was present in 30% of the control subjects and 25% of the cirrhotic subject. No significant correlation existed between breast tissue diameter and the BMI in the subjects with cirrhosis. In the control group, TT concentrations were higher and TE concentrations were lower than the cirrhotic groups, therefore the ratio of TE/TT were more decreased compared with the subjects with cirrhosis. In contrast, the mean total and free serum testosterone con- centrations were considerably lower and the mean total estrogen concentrations were higher in cirrhotic patients with gynecomastia compared with those without gynecomastia as were the ratio of TE/FT, E2/FT, TE/TT and E2/TT. In conclusion, the prevalence of gynecomastia in cirrhotic patients was 25%. Total and free serum testosterone concentrations did not differ statistically significant in the cirrhotic men with and without gynecomastia. Neither the TE FT ratio nor the E2 FT ratio was statistically increased in cirrhotic subjents with gynecomastia compared with those without gynecomastia. These findings imply that factors other than the estrogen testosterone ratio may play a role in the development of gynecomastia in both cirrhotic and control subjects. (Korean J Gastroente- rol 1994; 26: 842 849)
기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이민호(Min Ho Lee),이종철(Jong Chul Lee),최호순(Ho Soon Choi),배상철(Sang Cheol Bae),차호진(Ho Jin Cha),함준수(Jun Su Ham) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A The diagnosis of pancreatic cancer is very difficult because the pancreas is located in the retroper- itoneum, symptoms are diverse, and physical findings are not specific. In the USA & western Europe, the incidence of pancreatic cancer has increased since 1930 and is the fourth most common cancer of all sites as a cause of death. Although recently, ERCP ultrasonogra phy (US) & computed tomography (CT) have been widely used for the diagnosis of pancreatic cancer is still difficult. The prognosis of pancreatic cancer is very poor because the retroperitoneal location of the cancer is unsuitable for diret palpation & the profuse lymphatics & venous drainage of the pancreas invite early & widespread dissemination of the tumor cells. In order to evaluate the incidence, epidemiology, clinical manifestations, laboratory findings & ERCP findings, the author analysed 91 cases of pancreatic cancer which were confirmed by surgery 8r ERCP at the Deparment of Internal Medicine, Hanyang University, College of Medicine between January 1972 & September 1986. The results were as follows 1) The pancreatic cancer was most prevalent in 6th & 7th decade (62.7%). Male to female ratio was 1.5:1, with male preponderance. 2) Epigastric pain was most common symptom complained (91%). Weight loss (88%), anorexia (61 %) & vomiting (42%) were also frequently noted in order of frequency. 3) The patient who had under 3 months duration of illness before confirmatory detection was found in 82.4% and those over 1 year duration in 4.4%. 4) The obstructive jaundice (23.1%) was the most common clinical impression of the patients followed by pancreatic cancer (16.4%), peptic ulcer disease (15.4%), pancreatitis (11%) & GB stone (5. Goyo). 5) In physical examination, hepatomegaly was palpable in 52% of patients. Jaundice (37%), abdominal mass (15%) & ascites (10%) were noted in order of frequency. 6) In laboratory findings, the elevated alkaline phophatase was most frequent in 79% of pathients. The elevated SGOT (62%), hyperbilirubinemia (55%) & anemia (32%) were frequently found in order of frequency. 7) In relation with diabetes mellitus, the patient of pancreatic cancer had the DM in 4%. The developmont of diabetes de novo is in 18%. 8) In the 91 patients who were diagnosed, the head of the pancreas was the most common site (68 %) of the tumor following by body (20%) & tail (12%). 9) Regional lymph node metastases were found in 57% & other metastaic sites were liver (53%), abdominal viscera (5%), adrenal (4%) & lung (3%) in order of frequency. 10) According to Fukumotos classification, the most common type was obstructive type (62.5%), followed by the stenosing type (29.1%), narrowing type (5.6%) & abnormal branching type (3.7%) 11) According to Takakis classification, Type 1 (obstruction or stenosis of the main pancreatic ctuct) was the most common (82.7%), followed by Type III (pancreatic dilatation) (9.3%), Type II (obstruction of Wirsung's duct or Santorini's duct) (4%), & Type IV (normal pancreatic duct) (4%).