http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Disintegrating Behavior of A Rapidly Disintegrating Famotidine Tablet Formulation
Park, Jeong-Sook,Shin, Kwang-Hyun,Park, Jong-Bum,Lee, Si-Beum,Hwang, Sung-Joo The Korean Society of Pharmaceutical Sciences and 2007 Journal of Pharmaceutical Investigation Vol.37 No.5
A rapidly disintegration famotidine tablet formulation in the oral cavity was developed using microcrystalline cellulose (MCC) and low-substituted hydroxypropyl cellulose (L-HPC), or additionally cropovidone as an internal disintegrant. Effects of disintegrants on the disintegration time in vitro and hardness were evaluated. Average wetting time of the tablets prepared in scale-up manufacturing process was less than 15 sec. Among the formulations tested, the tablet prepared with crospovidone as an internal disintegrant and Emcocel $90M^{(R)}$ as an external disintegrant showed fastest disintegration. These results may suggest that crospovidone and Emcocel $90M^{(R)}$ possessed excellent wetting nature, which result in the rapid disintegration of tablet.
( Jae-hyung Kim ),( Beum-joo Shin ),( Seung-wan Baik ),( Gye-rok Jeon ) 한국센서학회 2017 센서학회지 Vol.26 No.1
In this study, bioelectrical impedance analysis, which has been used to assess an alteration in intracellular fluid (ICF) of the body, was applied to detect intravenous infiltration. The experimental results are described as follows. Firstly, when infiltration occurred, the resistance gradually decreased with time and frequency i.e., the resistance decreased with increasing time, proportional to the amount of infiltrated intravenous (IV) solution. At each frequency, the resistance gradually decreased with time, indicating the IV solution (also blood) accumulated in the extracellular fluid (ECF) (including interstitial fluid). Secondly, the resistance ratio started to increase at infiltration, showing the highest value after 1.4 min of infiltration, and gradually decreased thereafter. Thirdly, the impedance (Z<sub>C</sub>) of cell membrane decreased significantly (especially at 50 kHz) during infiltration and gradually decreased thereafter. Fourthly, Cole-Cole plot indicated that the positions of (R, X<sub>C</sub>) shifted toward left owing to infiltration, reflecting the IV solution accumulated in the ECF. The resistance (R<sub>0</sub>) at zero frequency decreased continuously over time, indicating that it is a vital impedance parameter capable of detecting early infiltration during IV infusion. Finally, the mechanism of the current flowing through the ECF, cell membrane, and ICF in the subcutaneous tissues was analyzed as a function of time before and after infiltration, using an equivalent circuit model of the human cell. In conclusion, it was confirmed that the infiltration could be detected early using these impedance parameters during the infusion of IV solution.
Angiotensin 2 수용체 길항제 투여가 Cyclosporine 신독성에 의한 염증반응에 미치는 영향
송준창 ( Joon Chang Song ),신미정 ( Mi Jung Shin ),전연주 ( Yeon Joo Jun ),우성용 ( Seong Yong Woo ),형복진 ( Bok Jin Hyoung ),윤혜은 ( Hye Eun Yoon ),우현영 ( Hyun Young Woo ),최범순 ( Beum Soon Choi ),양철우 ( Chul Woo Yang ) 대한내과학회 2004 대한내과학회지 Vol.67 No.6
목적 : 신장 이식시 투여되는 cyclosporine (CsA)은 우수한 면역 억제제이지만 장기간 투여로 세뇨관 간질 섬유화와 염증반응을 유발한다. 만성 CsA 신독성 병태생리는 다양하게 제시되고 있으며 이중 레닌-안지오텐신계의 활성화가 중요한 역할을 하는 것으로 보고 되고 있다. 이에 본 연구에서는 안지오텐신 Ⅱ 수용체 길항제인 losartan (LSRT) 투여가 CsA에 의한 신장내 염증반응을 억제하는지 세뇨관 간질 섬유화와 대식세포 침윤의 지표인 Background : Long-term treatment of immunosuppresant CsA causes interstitial inflammation and fibrosis in the kidney. Renin-angiotensin system (RAS) plays the most important role in the pathogenesis CsA-induced renal injury. Accordingly we evaluated the a
Segmental Prevalence and Extraction Rate of Retained Intrahepatic Stone
Kwak, Byung Kook,Lee, Jong Beum,Joo, Sang Shin,Lee, Hwa Yeon,Shim, Hyung Jin,Kim, Kun Sang,Lee, Yong Chul 중앙대학교 의과대학 의과학연구소 1996 中央醫大誌 Vol.21 No.2
간내 잔류담석의 간 구역별 빈도와 제거율과 실패원일을 알고자 한다. 담석증으로 수술을 받고 T자관을 통하여 잔류담석 제거술을 시행 받은 환자중 간내담도에 잔류담석이 있던 126명을 후향적으로 담도조영사진을 분석하였다. 간내담도별 잔류 단석의 빈도와 제거율은 좌외측(left lateral)이 각각 54.0%, 91.1% ; 우후(right posterior)가 38.1%, 81.2% ; 우전(right anterion)이 26.2%, 93.8% ; 좌 내측(left medial)이 14.3%, 77.7%를 보였다. 전체 제거율은 85.6%이었다. 미상엽은 모든 예에서 간내 담석이 없었다. 제거 실패의 주된 원인은 담도 협착과 매복된 담석이었다. 우후와 좌내측 간내담도에서는 고유한 담도의 굴곡이 또 하나의 실패의 주된 원인이었다. 결론적으로 좌외측 간내담도가 담석의 빈도가 가장 높고 우후, 우전, 좌내측 간내담도의 순서로 높았다. 우후와 좌내측 간내담도의 담석제거율이 우전, 좌외측 보다 낮았으며, 이것은 고유한 굴곡 대문으로 설명된다. To evaluate the hepatic segmental prevalence and the extraction rate of the retained intrahepatic stones on cholangiogram and the cause of failure of percutaneous stone removal through a T-tube tract. One hundred and twenty-six patients who had undergone the extraction of the retained intrahepatic stones were evaluated. Selective segmental cholangiogrmas were obtained for each segmental prevalence by using a pre-shaped 10F catheter. The results of the segmental extraction rate and the cause of failure were also evaluated after completing the stone removal session. The segmental prevalence and the extraction rate were 54.0% and 91.1% in the left lateral(LL), 38.1% and 81.2% in the right posterior(RP), 26.2% and 93.8% in the right anterior(RA), 14.3% and 77.7% in the left medial(LM) segmental duct, respectively. The total extraction rate was 85.6%. The caudate lobe had no stone in all cases. The main causes of extraction failure were stricture and stone impaction. In the RP and the LM segmental duct, duct angulation was another amin cause of failure. The prevalence of retained stones is highest in the LL segmental duct, the RP, the RA and the LM segmental duct, in descending order. There was no stone in the caudate lobe. The extraction in the RP and LM segmental ducts is more difficult than in the RA and LL segmental ducts. This result can be explained by the natural anatomical angulation of these ducts.
( Geun Chul Park ),( Soo Hong Kim ),( Jae Hyung Kim ),( Beum Joo Shin ),( Gye Rok Jeon ) 한국센서학회 2016 센서학회지 Vol.25 No.2
This paper proposes a threshold-based fall recognition algorithm to discriminate between falls and activities of daily living (ADL) using a tri-axial accelerometer and a bi-axial gyroscope sensor mounted on the upper sternum. The experiment was executed ten times according to the proposed experimental protocol. The output signals of the tri-axial accelerometer and the bi-axial gyroscope were measured during eight falls and eleven ADL action sequences. The threshold values of the signal vector magnitude (SVM_Acc), angular velocity (ωres), and angular variation (θres) parameter were calculated using MATLAB. From the preliminary study, three thresholds (TH1, TH2, and TH3) were set so that the falls could be distinguished from ADL. When the parameter SVM_Acc is greater than 2.5 g (TH1), ωres is greater than 1.75 rad/s (TH2), and θres is greater than 0.385 rad (TH3), these action sequences are recognized as falls. If at least one or more of these conditions is not satisfied, the sequence is classified as ADL.
Kim, Jae-Hyung,Hwang, Young-Jun,Kim, Gun-Ho,Shin, Beum-Joo,Kim, Yong-Jin,Lee, Eun-Joo,Jeon, Gye-Rok The Korean Sensors Society 2017 센서학회지 Vol.26 No.5
An early detection of infiltration in veins is essential to minimize the injuries caused during infusion therapy, which is one of the most important tasks for nurses in clinical settings. We report that bioelectrical impedance analysis is useful in the early detection of infiltration at puncture sites. When infiltration was intentionally induced in the vein of a rabbit's ear, impedance parameters showed significant difference before and after infiltration. In particular, the relative resistance at 20 kHz in the vein of rabbit's ear reduced largely at infiltration, decreased slowly, and then stayed at a constant value. This indicates that the vein in the ear of the rabbit is small, and hence the infiltrated intravenous (IV) solution no longer accumulates after 3 minutes of infiltration. However, when infiltration was induced in the vein of a human's forearm, the relative resistance at 20 kHz decreased gradually over time. In the $R-X_c$ graph, the positions in infiltration induced in the rabbit's ear rapidly shifted before and after infiltration whereas the positions in infiltration induced in the human's forearm changed gradually during infiltration. Our findings suggest that bioelectrical impedance analysis is an effective method to detect the infiltration early in a noninvasive and quantitative manners.
첨단 과학수사 정책 및 포렌식 기법 종합발전방안 연구(Ⅳ) - 국가안보·국민안전 증진을 위한 유관 법제도 및 정책 평가
김한균(Kim, Han-Kyun),이승현(Lee, Seung-Hyun),이경렬(Lee, Kyung-Lyul),김대원(Kim, Dae-Won),박웅신(Park, Woong-Shin),김기범(Kim, Ki-Beum),권양섭(Kwon, Yangsub),주문호(Joo, Moon-Ho),신수민(Shin, Soo-Min),김면기(Kim, Myeonki),박원규(Par 한국형사법무정책연구원 2021 형사정책연구원 연구총서 Vol.- No.-