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Angiotensin 2 수용체 길항제 투여가 Cyclosporine 신독성에 의한 염증반응에 미치는 영향
송준창 ( Joon Chang Song ),신미정 ( Mi Jung Shin ),전연주 ( Yeon Joo Jun ),우성용 ( Seong Yong Woo ),형복진 ( Bok Jin Hyoung ),윤혜은 ( Hye Eun Yoon ),우현영 ( Hyun Young Woo ),최범순 ( Beum Soon Choi ),양철우 ( Chul Woo Yang ) 대한내과학회 2004 대한내과학회지 Vol.67 No.6
목적 : 신장 이식시 투여되는 cyclosporine (CsA)은 우수한 면역 억제제이지만 장기간 투여로 세뇨관 간질 섬유화와 염증반응을 유발한다. 만성 CsA 신독성 병태생리는 다양하게 제시되고 있으며 이중 레닌-안지오텐신계의 활성화가 중요한 역할을 하는 것으로 보고 되고 있다. 이에 본 연구에서는 안지오텐신 Ⅱ 수용체 길항제인 losartan (LSRT) 투여가 CsA에 의한 신장내 염증반응을 억제하는지 세뇨관 간질 섬유화와 대식세포 침윤의 지표인 Background : Long-term treatment of immunosuppresant CsA causes interstitial inflammation and fibrosis in the kidney. Renin-angiotensin system (RAS) plays the most important role in the pathogenesis CsA-induced renal injury. Accordingly we evaluated the a
발열과 요통을 동반한 혈액투석 환자에서 발견된 경막의 농양
송준창 ( Joon Chang Song ),김미경 ( Mee Kyoung Kim ),김윤정 ( Youn Jeong Kim ),김성용 ( Sung Yong Kim ),김영수 ( Young Soo Kim ),유혜영 ( Hye Young You ),양철우 ( Chul Woo Yang ),김용수 ( Yong Soo Kim ),방병기 ( Byung Kee Bang 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.2
Epidural abscess in hemodialysis patient is uncommon diseases, but it causes severe neruological complication if diagnois is delayed. In the clinical practice, because it is difficult to differentiate epidural abscess with simple back pain. Therefore, it is important to make early diagnosis and treatment of epidural abscess to prevent nuurological sequellae. We here report a case of epidural abscess with early diagnosis and successful treatment. A 54-year-old male patient was admitted to back pain and fever. Under the presumptive diagnosis of epidural abscess, MRI was perofrmed, and it revealed epidural abscess. Intravenous antibiotic treatment was started and drain of abscess was subsequently performed since back pain was persisted. He discharged without neurologic sequellae. Our case strongly suggests that epidural abscess should be considered in patients and early radiologic evaluation and treatment are mandatory to prevent neurological complication.
송준창 ( Joon Chang Song ),황현석 ( Hyeon Seok Hwang ),형복진 ( Bok Jin Hyoung ),이소영 ( So Young Lee ),전연주 ( Yeon Joo Jeon ),장세나 ( Se Na Chang ),윤혜은 ( Hye Eun Yoon ),최범순 ( Bum Soon Choi ),김용수 ( Yong Soo Kim ),양 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.1
After renal transplantation, we are more likely to encounter hyperkalemia rather than hypokalemia. We report a case of kidney transplantation recipient with hypokalemia and hypertension secondary to primary aldosteronism. A 48 year-old woman was presented with fatigue and weight loss that had lasted for 3 months. She was diagnosed as autosomal dominant polycystic kidney disease that ultimately progressed to end-stage renal disease. She was operated for renal transplantation before 6 months. She had hypokalemia and hypertension at that time. The ratio of plasma aldosterone over plasma renin activity was 851.7. The computed tomography (CT) revealed 2.4×1.7 cm sized adrenal mass on the right side. The pre-transplantation CT also showed that there had been adrenal mass in the same location even before the transplantation. Right adrenalectomy was performed. After she got discharged, she was again presented with nausea and vomiting. She developed hyperkalemia and was diagnosed as hyporeninemic hypoaldosteronism. She was prescribed with fludrocortisones and recovered from the disease, and resumed the state of normokalemia and normotension.