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Determination of bearing capacity of stone column with application of Neuro-fuzzy system
Manita Das,Ashim Kanti Dey 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.5
The neuro-fuzzy controller applies the neural network learning techniques to tune the membership functions and keeps thesemantics of the fuzzy logic controller intact. Hence benefits of both the neural network and fuzzy logic controller are taken intoconsideration. In this study, to predict the bearing capacity of a stone column, application of Adaptive Neuro-fuzzy Inference System(ANFIS) is presented. To train and test the data sets, 105 data pairs are collected from the previous technical literature. These data setsinclude the data of stone and sand columns. The spacing of the columns varies from 1.5 to 10 times the diameter. The undrainedcohesion varies from 7 to 400 kPa. Both experimental and analytical data are included in the collection. To test the trained ANFISmodels, data are collected from physical experiments on plate load test and numerical analysis with PLAXIS-2D. For thecomparative study, ANFIS models combined with plate load test results and analytical results, three ANFIS models are developed. Acomparative study on the accuracy of prediction by these three models is discussed.
( Ajay Duseja ),( Kiran K Thumburu ),( Ashim Das ),( Rk Dhiman ),( Yk Chawla ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: There is no effective non-invasive method to differentiate patients with or without histological NASH among patients with NAFLD. Aim of this study was to determine if presence of metabolic syndrome could be used as a predictor of histological NASH in patients with NAFLD. Methods: Fifty eight patients with NAFLD (July 2001-Jan 2007) (mean age 38.2±8.0 years, M:F=41:17) were histologically classified into Class I-IV as per Matteoni et al (Gastroenterology 1999:116;1413-1419). Those having NASH (Class III&IV) were further graded and staged as per Brunt et al (Am J Gastroenterol 1999:94:2467-2474). Differences in age, gender, BMI, waist, waist-hip ratio, serum insulin, insulin resistance (HOMA-IR), liver enzymes (AST, ALT)and presence of metabolic syndrome were studied between those with and without histological NASH. Metabolic syndrome (≥3 criteria) was defined as per adult treatment panel (ATP) III criteria with modified waist for Asian patients. Results: Twenty nine (50%) patients had class I or II (without histological NASH) disease and other 29 (50%) had class III or IV (histological NASH) disease. Overall metabolic syndrome was present in 25 (45.5%) patients with NAFLD. Fifteen (51.7%) patients in class I or II disease (without histological NASH) had metabolic syndrome in comparison to 10 (38.5%) patients in class III or IV (with histological NASH) (p=0.8). Other studied parameters were not different amongst two groups. Conclusion: Presence of metabolic syndrome can not be used as a predictor of histological NASH in patients with NAFLD.
( Ajay Duseja ),( Kiran K Thumburu ),( Nitin Saini ),( Ashim DAS ),( RK Dhiman ),( YK Chanwla ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Experimental data suggests role of adipokine leptin in hepatic fibrosis. Human data on this issue is controversial. Aim of this study was to measure serum leptin levels in patients with nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) and correlate its levels with hepatic fibrosis. Methods: serum leptin levels were assessed by ELISA (DRG Diagnostics, Germany) in 40 patients with NAFLD (liver biopsy=29)(mean age 39.8±10.8 years, men 29), 23 patients with CHC (liver biopsy=20) (mean age 37.7±6.7, men 22) and 15 healthy controls (normal BMI, LFT and ultrasound abdomen), (mean age 32.2±9.2 years, men 13). Histological analysis was done as per Matteoni et al (Gastroenterology 1999) and Brunt et al (Am J Gastroenterol 1999) in patients with NAFLD and as per Ishak et al (J Hepatol. 1995) in patients with CHC. Correlation of serum leptin was studied with age, gender, BMI, waist, waist-hip ratio, ALT, insulin resistance, class of NAFLD (NASH vs. no NASH) and hepatic necro-inflammation and fibrosis. Results: Patients with CHC had higher serum leptin levels in comparison to healthy controls (12.6±3.4 ng/ml vs. 5.0±5.2 ng/ml, p=0.002) and NAFLD patients (12.6±3.4 ng/ml vs. 5.9±3.3 ng/ml, p=0.05). There was no difference between serum leptin levels of NAFLD patients and healthy controls. Serum leptin showed no correlation with age, gender, BMI, waist, waist hip ratio, ALT and insulin resistance in both the patient groups. There was no correlation of serum leptin with either class of NAFLD (NASH vs. no NASH) (p=0.75) and with grade of the disease and stage of hepatic fibrosis in both NAFLD (p=0.44) and CHC groups (p=0.59). Conclusions: Patients with CHC have higher serum leptin levels in comparison to NAFLD. Serum leptin levels do not correlate with hepatic fibrosis in patients with NAFLD and CHC.
Influence of Ageing on the Intergranular Corrosion of an Al–Mg–Si Alloy
Aluru Praveen Sekhar,Arijit Samaddar,Ashim Bikash Mandal,Debdulal Das 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.12
This report investigates the influence of ageing on the susceptibility to intergranular corrosion (IGC) of an Al–Mg–Si alloy. The selected AA6063 Al-alloy has been exposed to ageing treatments at a predetermine temperature of 423 K for durationsof 1 to 168 h to achieve the wide range of ageing states covering under- to peak- to over-aged. The ageing behaviour of theselected alloy has been determined based on the results of hardness and tensile properties. The susceptibility to IGC has beenevaluated following the British standard (BS ISO-11846) method B and assessed based on the average and maximum corrosiondepths apart from in-depth surface and sub-surface characterizations of corroded specimens. It has been observed thatthe depths of corrosion increase monotonically with increase in ageing time. With progress of artificial ageing, the dominantmode of corrosion gradually changes in the order of minor pitting, moderate pitting, pitting plus localized IGC, localizedIGC and uniform IGC. The phenomenon of preferential dissolution of Mg from the β″ (Mg5Si6) and β (Mg2Si) precipitatesas well as the existence of Fe-rich intermetallic particles at the grain boundaries cause the pitting and intergranular corrosionbecause of the formation of local galvanic cells between the lower corrosion potential of Mg-depleted precipitates orprecipitate free zones and to the adjacent anodic grain boundary precipitates.
Gaurav Garg,Kuruswamy Thurai Prasad,Navneet Singh,Parul Gupta,Valliappan Muthu,Ashim Das,Amanjit Bal 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.6
Background: Data on the prevalence of programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in non–small cell lung cancer (NSCLC) and their clinical significance in Indian patients are limited. Methods: Newly diagnosed NSCLC cases (adenocarcinoma or squamous cell carcinoma [SqCC] histology) were included in the present study. The TILs were evaluated based on morphology on hematoxylin and eosin–stained slides. PD-L1 expression in tumors was assessed using immunohistochemistry with rabbit monoclonal antibody (SP263) on the Ventana automated immunostainer. Tumors with PD-L1 expression > 50% on tumor cells were considered PD-L1–positive. Tumors in which TILs occupy > 25% of stroma were considered to have high TILs. The association of PD-L1 expression and TILs with various clinical parameters including overall survival (OS) was investigated. Results: The present study included 128 cases of NSCLC (67 adenocarcinoma, 61 SqCC). PD-L1 positivity was observed in 17.2% of the patients with NSCLC. Baseline characteristics of PD-L1–positive subjects were similar to PD-L1–negative subjects except for a higher prevalence of liver metastasis (18.2% vs. 2.8%; p = .018) and a higher probability of diagnosis from extrapulmonary biopsies. High TILs were observed in 26.6% of the subjects. However, PD-L1 expression and high TIL did not affect OS. Conclusions: PD-L1 positivity and high TILs were observed in 20% and 25% of the patients with NSCLC, respectively, however, neither were predictors of survival in SqCC.