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RISS 인기검색어
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- 저자 : ( Yk Chawla ) (검색결과 1 건)
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( Ajay Duseja ),( Kiran K Thumburu ),( Ashim Das ),( Rk Dhiman ),( Yk Chawla ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: There is no effective non-invasive method to differentiate patients with or without histological NASH among patients with NAFLD. Aim of this study was to determine if presence of metabolic syndrome could be used as a predictor of histological NASH in patients with NAFLD. Methods: Fifty eight patients with NAFLD (July 2001-Jan 2007) (mean age 38.2±8.0 years, M:F=41:17) were histologically classified into Class I-IV as per Matteoni et al (Gastroenterology 1999:116;1413-1419). Those having NASH (Class III&IV) were further graded and staged as per Brunt et al (Am J Gastroenterol 1999:94:2467-2474). Differences in age, gender, BMI, waist, waist-hip ratio, serum insulin, insulin resistance (HOMA-IR), liver enzymes (AST, ALT)and presence of metabolic syndrome were studied between those with and without histological NASH. Metabolic syndrome (≥3 criteria) was defined as per adult treatment panel (ATP) III criteria with modified waist for Asian patients. Results: Twenty nine (50%) patients had class I or II (without histological NASH) disease and other 29 (50%) had class III or IV (histological NASH) disease. Overall metabolic syndrome was present in 25 (45.5%) patients with NAFLD. Fifteen (51.7%) patients in class I or II disease (without histological NASH) had metabolic syndrome in comparison to 10 (38.5%) patients in class III or IV (with histological NASH) (p=0.8). Other studied parameters were not different amongst two groups. Conclusion: Presence of metabolic syndrome can not be used as a predictor of histological NASH in patients with NAFLD.
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