Effects of Intravenous Adminitration of Nimodipine on Cerbal Pial Vessels after Experimental Subarachnoid Hemorrhage in Rabbits

Hwang, Soon Gu,Lee, Young Woo 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.7

가토에서 대조내 자가 신선혈 0.2㎖를 주입 후 6시간에 생리식염수와 여러 농도의 운nimodipine 용액(10, 30 및 60㎍/㎏)을 각각 정맥주사하여 야기되는 뇌연막혈관들의 반응(직경변화)을 연구하였다. 혈관의 측정은 개두술 후 수술현미경 최고 확대(40×)하에서 현미경의 대안렌즈에 Filar micrometer eyepiece(424 and 426, AO)을 부착하여 시행하였다. 이 Filar micrometer eyepiece의 한 눈금은 3.4㎛로 매우 미세한 소혈관까지 직접 측정할 수 있었다. PaO₂, PaCO₂ 및 동맥혈 pH는 대개 전 실험을 통해서 의의있는 변화를 보이지 않았다. 수축기 동맥압은 nimodipine 용액 주입 직후에 다소의 하강을 보였으나(p<0.05) 이러한 변화는 수축기 동맥압의 일시적인 하강현상이고 곧 정상 수준으로 복귀했다. 실험적 뇌지주막하 출혈 6시간 후 nimodipine 용액과 동일한 량의 생리식염수를 주입하였을 때 뇌연막혈관의 반응은 미미하여 그 통계학적 의의는 없었다(p>0.05). 그러나 nimodipine 용액을 정주하였을 때는 Group Ⅰ, Group Ⅱ 그리고 Group Ⅲ 모두에서 뇌연막혈관의 확장을 보였다. 이러한 혈관의 확장은 동맥, 특히 소동맥에서 현저한 양상을 보였으며 대연막동맥에서도 상당히 의의있는 혈관 확장을 보이기는 했으나 소연막동맥에서만큼 현저하지는 않았다. 이러한 뇌 연막동맥의 확장은 약물 주입 후 5, 10분에 가장 뚜렷하였으며 그 후는 시간이 경과함에따라 혈관의 직경이 서서히 감소하는 양상을 보였다. 뇌연막정맥의 경우에도 nimodipine용액의 정주 후 미약한 정도의 혈관확장을 보였으나 그 확장된 정도는 뇌연막동맥에 비해 미미하였으며 통계학적 의의도 적거나 없었다. 뇌연막동맥의 nimodipine에 대한 반응은 10, 30 그리고 60㎍/㎏의 약물 양의 변화에 비교적 민감하여 용량에 비례하는 소견을 보였다. 이상의 결과에서 뇌 지주막하 출혈이 야기된 실험동물에 nimodipine을 정주했을 때 뇌연막동맥의 현저한 확장이 야기되며 특히 소동맥이 민감하게 확장되는 사실은 뇌지주막하출혈에 의한 뇌허혈성 질환에 있어 nimodipine의 치료적 유용성을 입증할 수 있는 좋은 증거가 될 것으로 생각되며 그 효능은 정주된 실험약물의 양에 비례하였다. 이로서 부작용이 허용되는 범위 내에서 다량의 nimodipine을 허혈성 뇌혈관질환에 사용하여 치료적인 효과를 기대할 수 있을 것이라 생각된다. The author have studied effects of intravenous injection of normal saline and nimodipine solution(10, 30 and 60㎍/㎏) on cerebral pial vessels at 6 hours after experimental subarachnoid hemorrhage. Measurement of pial vessels were performed under operation microscope through the bilateral craniectomy area. Filar micrometer eyepiece was attached on the oculus of microscope(40×) to make it easier to measure fine pial vessels directly. Measuring unit of this micrometer eyepiece was 3.4㎛. Physilogic parameters(PaO₂, blood pH) generally did not show significant change all through the experiments except that systolic blood pressure showed temporary decrease immediately after the injection of nimodipine solution, which returned to base level soon. Small pial arteries were by far most effectively dilated by intravenous injection of nimodipine solution especially in 5 minutes. Large arteries also presented significant dilatation after the injection. The arteries were dilated as dose-dependent manner. Veins showed dilatation to the lesser degree than arteries independent of dosage of nimodipine, that was statistically of no significance. Conclusively, nimodipine might be used in treatment of vasospasm in subarachnoid hemorrhage in practice.

21세기 기독교 언어

홍순우 국제기독교언어문화연구원 1999 기독교언어문화논집 Vol.3 No.-

Dr. Soon Woo Hong. 1999. Christian Language in the 21st Century. Collected Papers on Christian Language Culture. This papers aims at discussing the concept of the 21st century we are facing and inquiring into Christian language for its refinement, for humanity and the language are destined in partnership with each other. On the basis of the purpose, this paper puts forward an argument on a definition of language, Biblical language substance, linguistic permanence, and linguistic force in connection with national force. And final)y this paper reaches a conclusion. In conclusion, this paper proposes that in the 21s1 century we human beings should speak in partnership with one anther without any obstacle as the Spirit gives all of us utterance, filled with the Holy Spirit, as found in the Day of Pentecost. (Professor of Hoseo University, Former President of Seoul Theological University)

Virus 에 감염된 대추나무의 이병엽과 (罹炳葉) 건전엽에 (健全葉) 있어서의 유리 (遊離) amino 산의 정성적 비교

홍순우(Soon Woo Hong),하영칠(Yung Chil Hah) 한국식물학회 1961 Journal of Plant Biology Vol.4 No.1

Hong, Soon-Wooe and Yung-Chil, Hah (Dept. of Botany, Seoul National University, Seoul, Kerea.) A compantive investigation of free amino acids in healthy and virus diseased Chinese date tree. Kor. Jour. Bot. 4 (1)9~12 1961 : A comparative investigation of free amino acids content in healthy check and virus diseased leaves of Chinese date tree, Zizyphus jujuqa Mill var. inermis Rhed, was carried out by authors throughout the growing season of 1959 and 1960 from June to October. The methods of qualitative analysis of free amino acids applied in this experiment is followed by Moore and Stein.^(1.2). free amino acids determined in this experiment are shown in Fig. 1 and Table 1. As the figure and the table are shown, three more amino acids such as glutarmine, asparagine and histidine are detected in the diseased material. The additiolal amino acids which are known as diamines in diseased leaves are conspicuous. It is presumed that the diamine might be increased by the self-reproduoion of the virus in cooporation with certain enzymes which are carrying out the protein metabolism in the host protoplast in contrast with the healthy checks which is carrying out normal protein metabolism,^(3.4.5). From the histological point of view, the facts of phloem degeneration or necrosis in diseased leaves, it seems to interrupt to move free amino acids from roots to leaves and it possibly takes place an excessive productitn of NH_3 which is diaminated by the metabolism of nitrogen compounds in such conditioned leaves.^(6.8) Therefore, it is also presumed that additional diamino acids are accumulated in diseased leaves. There are no change of amino acids in both materials of this plant throughout the growing season qualitatively, and this result agrees with the paper of Knight.^9

대추나무 미친병에 관한 연구 (2) - 엽 (葉) 유관속구조에 미치는 해부학적 영향에 대해서 -

홍순우 (Soon Woo Hong) 한국식물학회 1960 Journal of Plant Biology Vol.3 No.2

HOHG, Soon-Woo (Kores U. Seoul. Korea): A study of virus disease on Chinese date tree (Ⅱ) On the anatomical effects of the shoot cluster disease on the vascular structure of the infacted plants. Kor. Jour. Bot. Vol.3 (2) 29-34 1960 From the view point of phytopathological anatomy, the author has tried to study the effect of the shoot cluster disease virus on the internal structure of vascular tissues of chinese date tree (Ziziphus jujuba var. inermis Rehd.) comparing healthy checks and diseased plants. The materials were collected at tht several sites, Kumgock-Ri, Masuc-Ri, Kyungi-Do, and near the campus of Korea University and around the area of Chongam-Dong, Seoul City, from August 15th to September 5th 1959. The leaf materials of healthy and diseased plants are fixed and aspirated in two kinds of killing solutions, formalin-acetic acid alcohol solution and Craf Ⅲ solution. Sections were cut at 5-10 μ thickness and stained with the double staining reagents of safranin and fast green. In this experiment the author has observed that there are marked structural changes in infected plants in contrast of healthy checks. As figures 3-7 show that the following characteric changes have taken place on infected plants: 1) the arrangement of irregularly developed sieve elements in phloem, 2) the degeneration of phloem elements, 3) the irregular arrangement of epidermis in mid-vein, 4) more necrosis is observed among the parenchymatous cells, 5) abundant accumulation of starch grains in parenchymatous cells,. In contrast to the above irregularities caused by the virus disease, the healthy checks appear normal structures as shown iu figures 1 and 2. In adding to the all features noted above, the author could also observe an interesting feature that the xylem elements in mid-vein vascular bundle tissues are considerably disorganized to show the unspecialized vessel elements, the irregularly arranged xylem elements. Hewever, this kind of irregularities which occur in xylem under the virus infection has not been reported previously. The features noted on the internal structure of vascular bundle under the condition of infection by the shoot cluster disease on chinese date trees appear to be more or less closely similar to the symptoms of the bunchy-top of banana and the yellow dwarf disease of barley in respect to the fact that whether phloem necrosis takes place as a primary symptom or a secondary symptom. In all these disease, primary histological changes of hypoplasia and hypertrophy are proceeded by the necrosis of phloem.

대추나무 미친병에 관한 연구 (1) - 이병식물의 (罹炳植物) 내외형태학적 특징 및 그 명명에 대해서 -

홍순우(Soon Woo Hong),김종진(Chong Chin Kim) 한국식물학회 1960 Journal of Plant Biology Vol.3 No.1

HONG, Soon-Woo, & KIM, Chong-Chin: A study of virus disease on chinese date tree (I). On the external and the internal morphogical characteristics of disease inrected plants. Kor. Jour. Bot. 3 (1). 32-38. 1960 Since the peeuliar virus disease of chinese date tree (Zizyphus jujuba Mill. var. inermis Rehd.) has been noted in South Korea around 1950, 70% to 80% of the economically important trees have been either completely destroyed or infected with the virus, severe damage has been noted, particularly, across the area ranged from middle east to the middle part of Korea, including Seoul area. Yoon,-Koock-Byung in 1958 first reported the disease and described it might be caused by a kind of yellows. But he did not conform in his paper that the disease is pecisely caused by yellows virus. The authors, hereby intend to identify the true cause of the disease of the chinese date tree by studying the external symptoms of the disease and the internal morphological characteristics of the diseaset plant which shows various abnormalities in contrast to the healthy checks. In view of fact that the leaves of the infected plants become yellowish in color similar to the peach yellows, aster yellows, it is likely to be identifiable as the common yellows. Furthermore, the abnormal characteristics observed by the authors are as follow: The floral organs such as petals, sepald, stamens, and pistil turn into vegetative leaves, the leaves on heavily infected plant appear as small sized one and also showing as a common witch`s broom like symptom. There are also an occuring of numerous advantitious shoots developed from both of stems and roots. The amount of photosynthetc starch grains increses iIn parenchymatous cells, necrosis takes place in mesophyll, Partlcularly, Palisade Parenchyma in the leaves of infected plants are distinguished in contrast to the healthy checks. From the symptoms and the present experiments described above, the authors are belived that the disease of chinese date tree is not caused by the yellows. It appears the disease is rather similar to the symptoms of sandal spike virus which was noted in India early in this centry. But the host plant of sandal disease, Santalum album L. and the insect vector, Jassus indicus Wal., have never been reported in Korean flora and the founa. The temperature and the other environmental factors is auite different Korea ard India. Thus the authors believe that the peculiar disease must be an endemic new virus origin in Korea and must be called as shoot cluster disease of chinese date tree.

Clear cell sarcoma of the kidney : Immunohistochemical study and flow cytometric DNA analysis of 7 cases

Choi, Yoon-Jung,Jung, Woo-Hee,Jung, Soon-Hee,Park, Chanil Yonsei University, College of Medicine 1994 Yonsei medical journal Vol.35 No.3

수군 녹조류 (數群 綠藻類) 의 유리 아미노산 분포에 따른 계통학적 연구 조류의 화학성분과 계통학적 상관성에 대하여 (3)

이민재(Min Jai Lee),홍순우(Soon Woo Hong),이인규(In Kyu Lee) 한국식물학회 1962 Journal of Plant Biology Vol.5 No.3

LEE, Min-Jai, HONG, Soon-Woo & LEE, In-Kyu, (Dept. of Botany, Seoul National Univ.) An analytical studies of free amino acid and its relationship among the main groups of green algae (Ⅲ). Kor. Jour. Bot. V (3) : 25-29, 1962. Succeeding the previous papers, nineteen species of marine green algae and three species of fresh water green algae are analyzed to the free amino acid patterns by paper chromatogram, and it has been described as containing significant qualities of the pattern in relation to phylogenetic studies. Those seem to have a tendency of recognizable pattern on inter-Orders and inter-Phyla of marine algae. And the patterns of fresh water and marine green algae are also carried out referring to these studies.

우리나라 長壽者의 生活 및 意識調査에 관한 硏究 - Ⅴ. 過去의 健康疾病 및 苦痛에 대한 態度 -

최진호(Jin-Ho Choi),변재형(Jae-Hyeung Pyeun),임채환(Chae-Hwan Rhim),양종순(Jong-Soon Yang),김수현(Soo-Hyun Kim),김정한(Jeung-Han Kim),이병호(Byeong-Ho Lee),우순임(Soon-Im Woo),최선남(Sun-Nam Choe),변대석(Dae-Seok Byun),김무남(Mu-Nam 군산대학교 수산과학연구소 1994 군산대학교 수산과학연구소 연구논문집 Vol.1 No.-

The present study was designed to be link a part of the research on the investigation on daily life and consciousness of the longevous people in Korea, and to investigate the health conditions, and the attitude on disease and suffering of longevous people in the past. 1. By the health conditions of longevous people between 40 and 60 years, ""very good"" showed the highest figure of 71.0%, followed by ""ordinary"" (21.6%). Consequently it is found that 92.6% of total longevous people surveyed maintained the good health conditions above ordinary. 2. Of the experiences of disease and/or injury after 60 years of longevous people, ""never"" showed the highest figure of 74.7%, while ""had"" showed the only 22.6% of total longevous people surveyed. 3. Of the details of disease and/or injury after 60 years of longevous people. ""digestive disease"" showed the highest figure of 32.6%. followed by ""apoplexia cerebri & hypertensions""(14.0%) and ""heart disease""(14.0%), and followed by ""respiratory disease""(12.3%). 4. Of the experiences of suffering between 40 and 60 years of longevous people, ""never"" showed 53.7% of total longevous people surveyed, while the frequency of suffering decreased in the order of ""once""(22.7%), ""2 times""(15.8%) and ""3 times""(4.7%). By the details of suffering between 40 and 60 years of longevous people. ""family life"" showed the highest figure of 85.1%, followed by ""business""(10.1%). 5. By the attitude on suffering of longevous people, ""tried to forget soon"" showed the highest figure of 54.2%, followed by ""continuous worried""(23.3%), and followed by ""not worried""(7.2%).

구개 접근법에 의한 협골 축소 성형술

우순섭,민병일,김명진 大韓顎顔面成形再建外科學會 1993 Maxillofacial Plastic Reconstructive Surgery Vol.15 No.3

The prominent malar region has been recognized a sign of youth and beauty in caucasian who generally have a dolichocephalic and long face. But in the orients, especially Koreans who generally have a mesocephalic or brachycephalic face, it is considered an agressive, unesthetic facial appearance. So many patients require the shaving of prominent malar eminence and arch, and many methods of its reduction have been devised. For the exposure of malar complex, infraorbital skin incision, intraoral approach, preauricular approach, supraauricular scalp incision, and coronal approach have been used. And for the reduction of bony structure, direct shaving, contouring and repositioning of the malar complex after extirpation, and medially fracture of zygomatic arch have been used with its own merits. We performed the reduction malarplasty through intraoral approach. After two parallel oeteotomy at medial part of the zygomatic bone, the midsegment is removed. The posterior arch of zygoma was bended or green stick fractured. When more correction was required, the posterior arch was fractured medially through the step incision at skin. This method has a some advantages. Compared with the method for extirpation of malar complex, the infection rate is diminished, the resorption is small because of no free bone graft. And cheek drooping is prevented. Compared with the method of coronal approach, the surgical trauma is minimal. Now we report some cases of reduction malarplasty performed through intraoral approach and disscus the surgical technique and results.

한국 일부 여성의 혈청내 지질함량에 관한 연구 : 가임여성, 임신부, 폐경기 여성을 대상으로

우순임,안병숙 서울여자대학교 여성연구소 1989 여성연구논총 Vol.5 No.-