폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가

전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.

주문식업체에 따른 연계자격증 개발연구

최계호,정두진,이규희,박영순 대구산업정보대학 2001 논문집 Vol.15 No.-

This paper investigates the educational problems of junior college education linking industries and try to find the method for overcoming the limitations. Therefore, developing the related certificates upon ordering by industries will be a optimum option. Up to date, junior college education under educational-industrial cooperation is not distinguished curriculum from general vocational institute. This phenomenon incurred problems and limitations in developing human resources management fitting ordering education by industries. This study suggests 8 stages for the development of related certificates and provides model certificates which will apply every department. The best policy for a efficient human resources management toward junior college by educational-industrial cooperation will be opening special programs which will help students acquiring certificates.

영어교육의 관점에서 본 미국인의 문화가치 연구

지계순 한국영어교육연구학회 2003 영어교육연구 Vol.- No.26

This paper intends to explore American cultural values and apply them to teaching English. The informants employed in the survey were 73 American adults of English in two universities in America. Each participant was asked to mark the number in the value list. To compare the current values with those of 30 years ago and to investigate dominant cultural values, I used the framework designed by Sitaram and Cogdell(1976). The analyzing procedure was made qualitatively focusing on the more important values for Americans. The findings demonstrate that individualism, human rights, punctuality, equality and efficiency were chosen as primary values and additionally, motherhood, patriotism, peace and collective responsibility were changed into primary values from secondary or tertiary ones. Based on the results, (1) Americans are gradually recognizing the importance of their family and community, (2) the authority and hierarchy from capitalism are becoming more horizontal, (3) the new concept valuing both youth and elderly came out. As a great emphasis is put on a culture education in the 7th national curricula, so I argue the knowledge of cultural values on target language be incorporated into teaching English for Korean learners of English as a foreign language to get more effective communicative competence.

선도농업인의 홈페이지 운영 및 전자상거래 활성화 방안

이순석,윤석규,김용희,이계엽 한국식품유통학회 2004 食品流通硏究 Vol.21 No.1

This study aims to suggest an activating programs through leading farmers' preference analysis for homepage operation and e-commerce using binary logit model. The results showed that leading farmers' preference for homepage operation increased more as the period of internet using and livestock raising was longer, the intention of e-commerce was higher. They also showed that leading farmers' preference for e-commerce increased more as the period of internet using was longer, as age level was higher and non-livestock raising. Therefore the strategies for the activating programs of homepage operation and e-commerce are the strengthening of education about homepage operation and e-commerce for leading farmers, the linkage with a e-commerce, the enlargement of budget for them, the considerations of age level and items of crops or livestock, the support for leading farmers for e-commerce.

貿易賣買에 있어서 危險移轉 時期에 관한 硏究 : F.O.B. 契約과 C.I.F. 契約을 中心으로 under the Contract of F.O.b and C.I.F.

尹基官,宋啓儀 충남대학교 경상대학부설 경영경제연구소 1989 경영논집 Vol.5 No.1

흑염소 엑기스 식품의 소비성향

조규석,임병순,김계웅 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

This survey was carried out in order to collect basic data for the promotion of consumption of extracted juice from meat and bone of native goat. Data were gathered from a total of 148 peoples, who composed of 92 male and 56 female. Items investigated were experience and non-experience drunken, the kinds of healthy food , the reason of intake, intake frequency, intake season, the reason of non-intake, and supplementary item of goods at extract-making. The results obtained from answering after this survey were summarized as follows; 1. In answer about the drunken experience and non-experience for the healthy processed foods, the ratio of people surveyed was 85.14% and 15.86%, respectively. Male had tendency to be drunken much more than female with non-significance (P>0.05). And then, the older group showed tendency to be much more the drunken experience than the younger group. 2. The general herb-medicine among healthy foods used was the largest(50.0%), the extracted juice of goat meat and bone was used with the next largest(18.92%). The extracted juice was significantly(P<0.001) drunken much more in female than in male. And than, there was highly significant among age group in various healthy foods(P<0.01). 3. The healthy management among reasons of intake was answered in the largest(65.63%), the next answer was control after sickness(19.19%). There were not significant differences between gender group, and between age group, respectively. 4. The largest group at drinking times was answered to be two times a day(45.31%). There was not significant difference between gendergroup. However, there was highly significant between age group(P<0.001). 5. The drinking season was mostly answered to be in spring(35.94%), the next one was in winter(23.44%). The female group in spring was significantly(P<0.01) drunken much more than male. However, There was not significant between age group. 6. The largest reason for non-intakes of goat extracts was answered to be the decrease of the palatability(36.49%). There were significant differences between gender group, and between age group, respectively. 7. The supplementary item at extract-making was the promotion of palatability (44.95%). There was significant difference between gender group(P<0.05). And then, the group under 30 age answered mostly the promotion of palatability(50.95%), group more than 41 age answered price-down(41.38%). 8. 77.03% of questionnaire about drinking volume(80㎖) answered to be appropriate, 17.57% of those answered to be deficient. There were highly significant differences between gender group(P<0.01), and age group(P<0.01), respectively. 9. In the response after panel test of extract, 43.24% of questionnaire were good, while 10.81% of those were bad and very bad. Therefore, the scoring of sensory examination from 1(very bad) to 5 points(excellent) was 3.32. There was not significant difference between gender group. However, there was highly significant between age group(P<0.01).

韓國産 미꾸리에 關한 育種·繁殖學的 硏究 : Ⅴ. Ultrastructures Changes of Pituitary Gland and Testes in Male Loach Ⅴ. 미꾸리 수컷의 腦下垂體와 精巢의 微細構造

윤종만,노순창,김계웅,박홍양 건국대학교 동물자원연구센터 1993 動物資源硏究誌 Vol.18 No.-

본 연구는 1992년 3월부터 5월까지 자연채광 상태의 건국대학교 양어실습장에서 사육중인 한국산 미꾸리 수컷(Misgurnus anguillicaudatus)의 뇌하수체와 정소의 조직형태학적 변화를 이해하기 위해서 실시되었다. 미성숙 시기인 3월의 뇌하수체와 정소의 미세구조와 5월경의 성숙단계인 각 조직간의 발달상황을 비교 분석하기 위해서 광학 및 투과형 전자현미경을 이용하였다. 뇌하수체의 성선자극 호르몬이 분비되는 부위(GTH)의 발달은 정소의 주기적인 발달단계와 대체로 일치한다. 성성숙 지수(GSI)는 4월부터 5월에 이르는 시기에 증가하다가 정자세포와 정자의 수가 증가되는 5월에 가장 높게 나타났다. 하나의 小葉 속에 발달단계가 다른 nest가 들어있더라도 같은 정자형성 단계에 속한다. 미성숙 단계에서는 이형염색질이 분산되어 있다가 성숙 단계에서는 핵이 진하고 균질한 상태로서 존재한다. 핵막은 분화초기에 나타난다. 제1차 정모세포에는 15개 이상의 작은 미토콘드리아가 두부의 세포질 주변에 있다가 발달함에 따라 2개의 커다란 미토콘드리아로 변화되면서 한쪽으로 튀어나온 부위 주변에 위치하게 된다. 정자 중편부의 주위에는 미토콘드리아초와 외측 섬유소로 둘러싸여져 있다. This study was undertaken to understand the histomorphological changes of pituitary gland and testis of Korea loach(Misgurnus anguillicaudatus) under natural circumstances from March to May 1992. Sexual maturation was studied on 50 males Korean loach(Misgurnus anguillicaudatus). The results obtained in this study were as follows: The ultrastructures of the gonadotrophs largely parallel the cyclical changes in the testes. Gonadosomatic indices(GSI) increased from April to May, and showed the peak in May, coinciding with the increase of spermatids and spermatozoa in male. Each nest of cells belongs to one spermatogenetic stage, although nests at different stages can be found within the one lobule. At first heterochromatin is dispersed and then is condensed. In mature gamete, the nucleus is dense and homogeneous. The nuclear membrane appeared at the beginning of differentiation. In the primary spermatocytes, the small mitochondria are abundant over the outer cytoplasm. In the latter, the two large mitochondria are located over the cytoplasm. During cell differentiation, the cytoplasm decrease and the nucleus increases. Sperm mitochondria are assembled into an organized sheath surrounding the outer dense fibres and axoneme of the flagellar midpiece.

이동형 생체계측을 위한 임베디드 컴퓨팅

홍주현,진계환,박경순,조명찬,박길선,차은종,이태수 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

연구목적: 초소형 정밀 기계 기술로 제작된 2차원 가속도 센서와 916 MH2 단거리 고주파 데이터 통신 기술을 응용하여 인체의 운동상태를 자동으로 감지하고 분류하는 기법을 제안 하고자 하였다. 재료 및 방법: 인체의 신호를 획득하기 위하여 미국 버클리대에서 제작한 무선 센서를 등 산용 조끼의 전면상단에 부착해서, 대상자의 흉골 부위에 위치하도록 하고, 앉은 상태에서 일어서거나 눕거나 하는 동작 및 그 역동작이 일어날 때, 가속도 센서에서 감지되는 4가지 종류의 파형 현화에 해당되는 데이터를 무선센서 네트웍을 통해 획득하였다. 결과: 획득한 신호를 주성분분석(Principal Component Analysis)과 지원벡터머신(Support Vector Machine)을 사용하여, 2차주성분까지를 도표화하고 클러스터링 함으로써, 4개의 영역으로 분할하는 것이 가능함을 말 수 있었다 결론: 소형 센서들이 작동되는 임베디드 컴퓨팅 환경에서 일상생활 중에 발생하는 인체의 4가지 동작을 자동으로 감지하고 분류하는 것이 가능함을 보였다. Purpose: New monitoring and classifying method of human motion contort was pro- posed by using 2-axial MEMS accelerometer and 916 MHz short-range data communica-tion technology. Materials and Methods: The wireless sensor of MICA mote was attached to a woman mountain vest and located close to the subject's sternum. During four types of sub-ject's motion, that is, sit-to-stand, stand-to-sit, sit-to-tying, and tying-to-sit, waveform changes of the accelerometer data were acquired by wireless sensor network. Results: The acquired signal was analyzed by Principal Component Analysis(PCA) and Support Vector Machine(SVM) technique. By clustering the first and second principal components, four regions corresponding to the four types of motion, were clearly segment-ed. Conclusion: Human motion context during daily life could be monitored and classified automatically by using small sensors in embedded computing environment

Hydrochlorothiazide의 microcapsule 제조와 평가

남상철,박목순,나성범,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 1990 藥學論文集 Vol.6 No.-

The microcapsules of hydrochlorothiazide using Eudragit RL were prepared by the solvent evaporation process in liquid paraffin phase, and the microcapsules of hydrochlorothiazide using Ethylcellulose were prepared by the solvent evaporation process in water phases. The size distribution, drug content, interaction between the drug and the polymer, dissolution test, observation of SEM were investigated. The results are summarized as belows. The Eudragit RL microcapsules and Ethylcellulose microcapsules obtained were spherical, uniform and free flowing particles. As the dispersing agents (Eudragit RL-magnesium stearate, Ethylcellulose-sod, lauryl sulfate) were fixed, the preparation of microcapsules showed constant in particle size distribution. The actual drug contents of the Eudragit RL microcpasules were lower than theoretical drug contents, but the actural drug contents of the Ethylcellulose were higher than those. No interaction between the polymer and the drug was observed from the results of TLC, UV, IR, DSC. The release of hydrochlorothiazide from the Eudragit RL microcapsules except for the release in pH 8.0 phosphate buffer solution was not increased when the drug: polymer ratio was increased. The dissolution rate of hydrochlorothiazide from Ethylcellulose microcapsules increased with increasing drug: polymer ratio. Scanning electron micrograph study revealed that microcapsules prepared by this method showed comparatively rough surface when drug: polymer ratio was decreased.

告知義務 違反과 錯誤ㆍ詐欺의 關系

沈相武,鄭淳計 동의대학교 법정연구소 2001 공공정책연구 Vol.17 No.-