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Shuaiqi Dong,Dong Zhao,Lei Li,Xiaowei Li,Tao Chen 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.1
CBM (Coalbed methane) belongs to unconventional natural gas mineral resources. The development and utilization of CBM can greatly reduce the occurrence of mine gas accidents, and how to improve the desorption capacity of CBM has always been a hot issue for researchers. Liquid nitrogen has obvious effect on coal seam cracking and permeability improvement. The purpose of this paper is to study the cracking mechanism of liquid nitrogen on coal, and provide a theoretical basis for using liquid nitrogen freezing and thawing to treat coal so as to improve the production of coalbed methane. Coal samples from Yangquan County, Shanxi Province were pretreated. The pore structure test, microscopic observation test and methane isothermal adsorption test were carried out after the coal samples with different particle sizes were treated with different liquid nitrogen freeze-thaw cycles. According to the experimental data, the evolution law of pores of coal before and after freezing and thawing with liquid nitrogen, the cracking mechanism of coal treated with freezing and thawing with liquid nitrogen, and the optimal number of freezing and thawing cycles with liquid nitrogen are analyzed. The results show that: 1) the evolution characteristics of pore structure of lower coal after liquid nitrogen freezing and thawing are that micropores in coal are promoted to develop into transition pores and mesopores, and mesopores and transition pores develop into macropores and fractures. 2) Through the observation of a metallographic microscope, the expansion degree of coal surface crack is positively correlated with the times of liquid nitrogen freeze-thaw. 3) Liquid nitrogen freeze-thaw treatment has an optimal number of cycles for the cracking degree of coal. With the increase of freeze-thaw cycles, the final adsorption capacity of coal pillar increases first and then decreases; The adsorption capacity of granular coal first increases and then decreases. After reaching freeze-thaw saturation, continued freeze-thaw is not conducive to the increase of adsorption capacity. These research results provide theoretical support for the implementation of liquid nitrogen fracturing and permeability enhancement technology in coal reservoirs.
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Liu Shuaiqi,Zhu Zhihui,Li Huiya,Zhao Jie,Wen Xin 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.1
Combined with the shared similarity among multiple source images and depth of field in a camera, a new image fusion algorithm based on nonsubsampled shearlet transform (NSST) domain is proposed. First, NSST is utilized for decomposition of the source images, the low frequency coefficients is fused by weight votes in the structure-driven regions by using shared similarity and depth of field (SSSID), and then apply larger sum-modified-Laplacian (SML) with depth of field to the high frequency coefficients, finally the fusion image is gained after we do the inverse NSST to the fused coefficients. The algorithm can not only preserve the information of the source images well, but also suppress pixel distortion due to nonlinear operations in transform domain. Experimental results demonstrate that the proposed method outperforms the state-of-the-art transform domain fusion methods on image quality and objective fusion criteria.
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박선주 ( Sun Joo Park ),타이슈아이치 ( Shuaiqi Tai ),이연지 ( Yeon Ji Lee ),전유진 ( You Jin Jeon ),김용태 ( Yong Tae Kim ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.4
BACE2 is a membrane-bound aspartic protease that is highly homologous with BACE1. While BACE1 processes the amyloid precursor protein (APP) at a key step in generating β-amyloid peptide and presumably causes Alzheimer’s disease (AD), BACE2 has not been demonstrated to be involved in APP processing directly, and its physiological functions are unknown. To determine its function and to develop inhibitors from marine sources, we constructed an overexpression vector for producing BACE2. The gene encoding human BACE2 protease was amplified using the polymerase chain reaction and cloned into the pET11a expression vector, resulting in pET11a/BACE2. Recombinant BACE2 protease was overexpressed successfully in E. coli as inclusion bodies, refolded using the rapid-dilution method, and purified via two-step fast protein liquid chromatography using Sephacryl S-300 gel filtration and Re- source-Q column chromatography. The BACE2 protease produced was an active form. This study provides an ef- ficient method not only for studying the basic properties of BACE2, but also for developing inhibitors from natural marine sources.
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Anti-glioma Effect and Safety of Docetaxel-loaded Nanoemulsion
Huil Gaoe,Xinguo Jiang,Zhiqing Pang,Shuaiqi Pan,Shijie Cao,Zhi Yang,Chen Chen 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2
Docetaxel, an inhibitor of microtubule depolymerization, has been used for many malignancies. Due to its toxicity and the non-selective distribution of its commercial formulation, Taxotere®, new formulations with less toxicity and tumor targeting need to be explored. For its safety and ease of factory scale production, nanoemulsion, was selected to encapsulate docetaxel. The particle size of docetaxel loaded nanoemulsion (DNE) was 72.3 nm, the average zeta potential was −6.38 mV, the encapsulation efficiency was 93.1% and the drug loading capacity was 2.87%. Although DNE presented similar antiproliferation effects on both U87 cells and bEnd.3 cells, its in vivo toxicity was significantly lower than Taxotere®. In vivo fluorescent imaging suggested nanoemulsions loaded with a fluorescent probe could distribute to the brain and accumulate at the glioma site. The pharmacological experiments also confirmed that the DNE could target glioma sites and prolong the median survival time of mice with gliomas. In conclusion, DNE is a new, less toxic, drug formulation that is effective for brain glioma therapy.
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Regeneration mechanism of CeO2-TiO2 sorbents for elemental mercury capture from syngas
Jinsong Zhou,Kunzan Qiu,Wenhui Hou,Shuaiqi Meng,Xiang Gao 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.3
The characteristics of mercury desorption on spent CeO2-TiO2 (CeTi) sorbents were investigated to improve the cyclic regeneration removal activity. Mercury was significantly released in the form of elemental mercury at temperatures ranging from 250 to 280 oC. Mercury desorption had a significant correlation with regeneration temperature, but was independent of the heating rate and regeneration conditions. The optimal regeneration temperature was 500 oC. The CeTi sorbents could be easily restored by simple heating and exhibited superior activity over several capture- regeneration cycles. The amount of released mercury almost equaled the adsorbed mercury on the surface of the CeTi sorbent, indicating that most of the adsorbed mercury was released during the heating process.
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