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Takashi Takata,Yasusei Kudo,Hiroko Hatano,kuko Ogawa,Samadarani Siriwardena,Shoïro Kitajima,Masae Kitagawa,Mutsumi Miyauchi 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.2
Oral squamous cel1 carcinoma(OSCC) is the most common malignancy of head neck region. Typically OSCC cells s how persist ent invasion that frequently leads to local recurrence and distant lymphatic metastasls However, molecular mechanisms of invasion of OSCC remain poorly understood. Her e we identifi ed periostin, interferon induced transmembrane protein l (IF1TM1) and wingless-type MMTV integration site family, member 5B(WNT5B) , as invasion promoting molecules in OSCC by comparing gene expression profiles between a parent OSCC cell line(MSCC-l) and its highly invasive clone(MSCC-1nvl). Overexpression of periostin, IFITMl and WNT5B mRNAs were confirmed in MSCC-1nvl by RT-PCR. Transfection of these molecules promoted invasion of OSCC cells Moreover , siRNA t r eatment of these molecules suppressed invasion of cancer cells in vitro I nter estingly, Periostin, 1F1TMl and WNT5B were highly expressed in OSCCs in comparison with nonnal tissues. 1n an orthotopic mouse model of OSCC, periostin-overexpressing cells metas tasized spontaneously to cervical lymph nodes and t o t he lung through their aggressive invasiveness. These findings suggest that peri ostin, IFITMl and WNT5B play important roles for invasion and of OSCC and can be prognostic markers and therapeutic t argets of OSCC.
Numerical Analysis of Drag and Heating Reduction by Directed Energy Air Spike
Sho Sasamoto,Etsuo Morishita 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
It is well known to the aerospace engineering community that aerodynamic drag and heating are extremely critical issues at hyper velocities. Directed Energy Air Spike (DEAS) is a method to deposit a small amount of energy in the flow ahead of a blunt body and to reduce the drag and the heating. The hypersonic flow at M=7 past the blunt body is investigated numerically. The axis-symmetric bodies are studied. The compressible Navier-Stokes Equations are solved by the AUSM-DV scheme. The effects of heat addition and its location are of a particular interest in the present calculation. And the computational results show that optimum amount and location of the heat addition could be determined aerodynamically. The present calculations also confirm that DEAS is a very effective method for the drag and heat transfer reduction at hypersonic speeds.
Highly Accurate Analysis of the Cervical Neural Tract of the Elderly Using ZOOM DTI
Sho Furuya,Motoyuki Iwasaki,Takumi Yokohama,Daisuke Ohura,Tomoyuki Okuaki 대한척추신경외과학회 2018 Neurospine Vol.15 No.2
Objective: To investigate the fractional anisotropy (FA) values of the cervical spinal cord in elderly individuals using zonally magnified oblique multislice (ZOOM) diffusion tensor imaging (DTI). Methods: Fourteen healthy elderly volunteers (group E) and 10 young volunteers (group Y) were enrolled. We assessed the FA, apparent diffusion coefficient (ADC), and λ1–λ3 values using 3-T magnetic resonance imaging. The region of interest was contoured entirely inside the spinal cord, with no gray/white matter distinction, in order to avoid including the cerebrospinal fluid. Results: As lower cervical levels were approached, the FA values gradually decreased, while the ADC values increased. The mean FA values at each cervical level were as follows in groups E and Y: 0.71 and 0.70 at the C2/3 level, 0.66 and 0.66 at the C3/4 level, 0.63 and 0.62 at the C4/5 level, 0.57 and 0.57 at the C5/6 level, and 0.58 and 0.57 at the C6/7 level, respectively. The mean ADC values in groups E and Y were 1.06 and 0.99 at the C2/3 level, 1.05 and 1.06 at the C3/4 level, 1.14 and 1.06 at the C4/5 level, 1.18 and 1.21 at the C5/6 level, and 1.39 and 1.46 at the C6/7 level, respectively. There were no significant differences between the elderly and young participants. Conclusion: In both asymptomatic elderly and young individuals, the FA values gradually decreased and the ADC values increased moving towards lower cervical levels. Age did not affect the FA values, even though mild cord compression was evident due to spondylotic changes. ZOOM DTI has the potential to provide more information than conventional DTI.
Sho Takeshita,Yukiharu Todo,Kazuhira Okamoto,Satoko Sudo,Katsushige Yamashiro,Hidenori Kato 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.4
Objective: A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. Methods: A retrospective chart review was carried out for 531 patients with cervical cancer who underwent lymph node dissection between 1993 and 2014. CINDEIN metastasis was pathologically identified by microscopic investigation. After 2007, sentinel lymph node biopsy was performed selectively in patients with non-bulky cervical cancer. The sentinel node was identified using 99mTc-phytate and by scanning the pelvic cavity with a γ probe. Results: Two hundred and ninety-seven patients (55.9%) underwent CINDEIN dissection and 234 (44.1%) did not. The percentage of International Federation of Gynecology and Obstetrics stage IIb to IV (42.4% vs. 23.5%, p<0.001) was significantly higher in patients who underwent CINDEIN dissection than those who did not. CINDEIN metastasis was identified in 1.9% overall and in 3.4% of patients who underwent CINDEIN dissection. For patients with stage Ia to IIa disease, CINDEIN metastasis was identified in 0.6% overall and in 1.2% of patients who underwent CINDEIN dissection. Of 115 patients with sentinel node mapping, only one (0.9%) had CINDEIN detected as a sentinel node. In this case, the other three lymph nodes were concurrently detected as sentinel lymph nodes. Conclusion: CINDEIN dissection can be eliminated in patients with stage Ia to IIa disease. CINDEIN might not be regional lymph nodes in cervical cancer.
( Sho Igarashi ),( Yutaka Kaizu ),( Kenji Imou ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
In recent years, robotic technology has been adopted in agriculture to improve productivity and competitiveness. Precise and robust environmental perception is an important requirement to resolve issues such as safe interaction with obstacle and localization for autonomous robot vehicle. Accordingly, we propose the use of a Simultaneous Localization and Mapping algorithm, to generate local maps of agricultural fields. In our study, the 3D data required for the mapping process were collected using 3D LiDAR(Velodyne VLP-16). The resulting 3D map is formed by a 3D point cloud data, and its distance accuracy was evaluated. Evaluation of distance accuracy was made by comparing with positioning data with absolute coordinates measuring by dual-frequency Global Navigation Satellite System(GNSS). The results show that the mean deviation error and RMSE are approximately 0.03 m and 0.13 m, respectively. We conclude that our 3D point clouds maps have acceptable quality and can support process automation of fields by autonomous robot vehicle.