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Clozapine Induces Apoptosis in HIT-T15 Pancreatic β-Cell Lines
Sheng Yu Jin(김성우),Joo-Ho Chung(정주호),Cheol-Woo Guak(곽철우),Mi-Kyoung Kim(김미경),Jong-Woo Kim(김종우) 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2
목적 : Clozapine의 드문 부작용으로 췌장염이나 고혈당증 등이 보고되고 있지만 아직까지 정확한 기전은 밝혀지지 않고 있다. 본 연구는 이러한 부작용과 관련하여 clozapine이 췌장 조직에 직접적인 세포 독성을 일으킬 것이라는 가설 하에, clozapine이 HIT-T15 췌장 β-세포주에서 세포 사멸 과정인 apoptosis를 유도하는지를 알아보고자 하였다. 방법 : 먼저 MTT assay로 HIT-T15 췌장 β-세포주에서 clozapine의 세포 독성을 알아보고 형태학적 변화를 관찰하였으며 이러한 세포 독성의 형태로 apoptosis가 일어나는지를 DAPI staining TUNEL assay, caspase-3 assay 등의 방법을 사용하여 알아 보았다. 결과 : Clozapine이 HIT-T15 췌장 β-세포주에서 농도와 시간 의존 양상으로 세포 독성을 일으키고, 형태학적 관찰, DAPI staining, TUNEL assay 결과에서 apoptosis의 특징적인 소견을 나타내었다. 그리고 clozapine 처치 시 caspase-3의 활성이 유의하게 증가되어, caspase-3에 의해 매개되어 apoptosis가 유도된다는 것을 알 수 있었다. 결론 : 본 연구결과로 볼 때, HIT-T15 췌장 β-세포주에서 clozapine에 의해 유도되는 apoptosis가 clozapine 에 의해 발생되는 췌장염이나 고혈당증 같은 부작용의 병태생리학적 기전에 관여할 가능성이 있을 것으로 생각한다.
Study on accelerated life tests for main shaft bearings in wind turbines
Sheng Jin,Hanjie Dong,Jie Chen,Xinghui Xie,Mingjun Guo 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3
This paper focused on a 2.1 MW wind turbine main shaft bearing as the research object and analyzed its reliability under actual working conditions for three years. An accelerated life test for the main shaft bearing in a wind turbine with an amplified load was carried out depending on the reference value of the radial dynamic load rating. The test was conducted for 140 days. The bearing did not show any noticeable damage at the end of the test, which shows that the bearing could be reliable for three years. To prove the correctness of the ALT, a finite element model of the main shaft bearing was created in ABAQUS to obtain the contact stress in both the actual working conditions and the accelerated test conditions. The calculation results were transferred to FE-SAFE to calculate the fatigue life. Finally, a comparison between the theoretical and simulation acceleration factors validated the rationality of the experimental design.
Experimental studies of circular composite bridge piersfor seismic loading
Sheng-Jin Chen,Kuo-Chen Yang,K.M. Lin,C.C. Wang 국제구조공학회 2012 Steel and Composite Structures, An International J Vol.12 No.3
This study proposes and examines a circular composite bridge pier for seismic resistance. The axial and flexural strengths of the proposed bridge pier are provided by the longitudinal reinforcing bars and the concrete, while the transverse reinforcements used in the conventional reinforced concrete pier are replaced by the steel tube. The shear strength of this composite pier relies on the steel tube and the concrete. This system is similar to the steel jacketing method which strengthens the existing reinforced concrete bridge piers. However, no transverse shear reinforcing bar is used in the proposed composite bridge pier. A series of experimental studies is conducted to investigate the seismic resistant characteristics of the proposed circular composite pier. The effects of the longitudinal reinforcing bars, the shear span-to-diameter ratio, and the thickness of the steel tube on the performance of strength, ductility, and energy dissipation of the proposed pier are discussed. The experimentalresults show that the strength of the proposed circular composite bridge pier can be predicted accurately by the similar method used in the reinforced concrete piers with minor modification. From these experimental studies, it is found that the proposed circular composite bridge pier not only simplifies the construction work greatly but also provides excellent ductility and energy dissipation capacity under seismic lateral force.
Sheng-Min Wang,Jung-Bum Kim,Jeong Kyu Sakong,Ho-Suk Suh,Kang Seob Oh,Jong-Min Woo,Sang-Woo Yoo,Sang Min Lee,Sang-Yeol Lee,Se-Won Lim,Seong Jin Cho,Ik-Seung Chee,Jeong-Ho Chae,Jin Pyo Hong,Kyoung-Uk Le 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.2
Objective: This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders. Methods: Inclusion criteria were as follows: age >20 years, diagnosis of anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria, taking only one type of antidepressant, and prescribed one of three oral benzodiazepines (alprazolam, clonazepam, or lorazepam). At baseline and week 6, clinical benefit was evaluated using the Clinical Global Impression-Severity Scale (CGI-S), Clinical Global Impression-Anxiety Scale (CGI-anxiety), and Clinical Global Impression-Sleep Scale (CGI-sleep). Results: Among 180 patients, no differences in demographic characteristics among the three benzodiazepine groups were noted. After six weeks of treatment, all benzodiazepine groups showed significant improvements in CGI-S, CGI-anxiety, and CGI-sleep scores ( p <0.001). There were no differences in mean changes in CGI-S, CGI-anxiety and CGI-sleep among the three benzodia-zepine groups. The incidence of side effects was significantly lower in the clonazepam group than with the other benzodiazepines. The incidences of adverse events for the clonazepam, alprazolam, and lorazepam groups were 26.7% (n=20), 48.4% (n=31), and 43.9% (n=18), respectively. Conclusion: The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders. Furthermore, the safety profile of clonazepam was superior to the other benzodiazepines in this study.
Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients
Jin, Sheng-Yu,Park, Hyun-Ho,Li, Guang-Zhe,Lee, Hee Jae,Hong, Mee-Suk,Park, Hae-Jeong,Park, Hun-Kuk,Seo, Jung-Chul,Yim, Sung-Vin,Chung, Joo-Ho,Lee, Mu-Hyoung KYUNG HEE UNIVERSITY MEDICAL CENTER 2005 고황의학상 수상논문집 Vol.Vol.21-22 No.-