N-벤조일-이미다졸 유도체의 가수분해반응

성대동,엄태섭,이종팔,박유미,박현석 東亞大學校 1992 東亞論叢 Vol.29 No.1

The pseudo first order rates for hydrolyses of N-benzoyl-(2,4,5-triphenyl)-imidazole and N-benzoyl-(4,5-diphenyl)-imidazole have been measured by means of spectrometry in over all pH range at 30˚C with the ionic strength of 0.5M KC1. In the case of N-benzoyl-(2,4,5-triphenyl)-imidazole, the general acid catalytic reaction was not observed, while the general base catalytic reaction showed in near the range of pH=7. In the case of N-benzoyl-(4,5-diphenyl)-imidazole, the general acid and base catalytic reaction showed at the regions of less than pH=4 and more than pH=10. The rate constants for pH independent reaction of N-benzoyl-(2,4,5,-triphenyl)-imidazole were shown a little bit faster than those of the corresponding to N-benzoyl-(4,5-diphenyl)-imidazole. The reaction mechanism of pH independent reaction was interpreted by means of thermodynamic parameters, and the isotope effect. The magni-tude of ΔH??, ΔS??, ??/?? values indicated that the bond breaking had been progressed more than bond formation in the transition state.

염화나프토일의 親核性置換反應에 미치는 溶媒效果

成大東 東亞大學校 1980 東亞論叢 Vol.17 No.2

1-염화나프토일과 2-염화나프토일의 가매분해반응을 에탄올-아세토니트릴, 2-프로판올-아세토니트릴, 에탄올-아세톤, 2-프로판올-아세톤, 에탄올-물, 2-프로판올-물, 3차 부탄올-물 혼합용매 속에서 전기전도도법으로 측정하였다. 혼합용매의 조성에 관계없이 1-염화나프토일이 2-염화나프토일보다 속도가 크게 나타났다. 이것은 Dewar지수 Nr과 Streiwiesr의 σ+값과도 일치하였다. 1-염화나프토일은 Sn2전이상태에서 반응중심탄소가 sp²에서 sp³로 변하므로 peri-hydrogen effect가 relieve 됨을 알 수 있었으며 또한 모든 반응이 대체로 Sn2 반응메카니즘으로 진행됨을 알 수 있었다. 동일한 반응기질이 에탄올과 2-프로판올 및 공용매인 아세토니트릴의 혼합용매속에서도 메탄올-아세토니트릴 혼합용매에서와 같은 최대속도 현상이 나타났다. 즉 메탄올-아세토니트릴 혼합용매게에서는 메탄올의 물분율 0.85에서 최대치가 나타나는데 비해 등유전성이 아닌 에탄올-아세토니트릴 혼합용매게에서는 에탄올의 물분율 0.78에서 2-프로판올-아세토니트릴 혼합용매계에서는 2-프로판올도의 물분율 0.62에서 각각 최대속도상수를 갖는다. 이것으로 미루어 볼 때 에탄올과 2-프로판올도 메탄올과 같이 수소결합을 형성하여 다량체를 만들고, 가용매분해반응에서 아세토니트릴이 첨가될 때 이들 알코올의 다량체 구조가 파괴됨을 알 수 있었다. 또한 섭동분자이론(PMO)에서 구한 비결합분자궤도함수(NBMO)의 계수와 반응속도의 대수가 거의 직선적으로 비례함을 알 수 있었다. The kinetics for solvolysis of 1-naphthoyl and 2-naphthoyl chlorides have been measured in solvent mixtures, EtOH-Me추, 2-PrOH-MeCN, EtOH-(Me)₂CO, 2-PrOH-Me)₂CO, EtOH-H₂O, 2-PrOH-H₂O and t-BuOH-H₂O. The rate constants of 1-naphthoyl chloride were faster than 2-naphthoyl chloride in all solvent mixtures. This agrees with Dewar number, Nr and Streitwieser's σ+ value. It was concluded that the valence state of carbonyl carbon changed from sp² to sp³ in transition state and peri-hydrogen effect was relieved; the solvolytic reactions proceeded by Sn2 mechanism in all solvent mixtures system. There were maxima in rate of reaction for EtOH-MeCN, 2-PrOH-MeCN mixtures in the same way as for MeOH-MeCN mixture. The maximum rate in EtOH-MeCN mixture was observed at mole fraction of EtOH, 0.85 and in 2-PrOH-MeCN mixture was observed at mole fraction of 2-PrOH, 0.62. This behavior is interpreted as the structure of alcohols also has hydrogen bonding structure, and the polymer structure of alcohols is destroyed by adding aprotic solvent, MeCN. Comparing the perturbation molecular orbital theory in the transition state, the logarithms of solvolytic rate constants have been found to be proportional to the AO coefficient of nonbonding molecular orbital, 2a? in this solvolytic reaction.

급성 간염 후에 발생된 재생불량빈혈 1례

이대성,이정현,박재선,김미향 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Aplastic anemia following acute hepatitis with or without acute hepatic failure is an uncommon and known to have a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 13 year-old boy. He had been admitted because of jaundice and lethargy for 2 weeks and clinical findings of acute fulminant hepatitis. Serum studies for antibodies and antigens related to hepatitis A, B, C viruses and cytomegalovirus, Ebstein-Barr virus, and, parvovirus B19 were negative. He had been recovered and discharged. He was readmitted because of lethargy and stuporous mentality 5 months later. Laboratory finding showed pancytopenia in peripheral blood smear and hypocellularity of all hematopoietic elements in bone marrow biopsy. Patient had been treated by s teroid and oxymetholone for a month before he died of sepsis

품종 및 성별에 따른 쇠고기의 지방산조성 비교

김대곤,성삼경,정근기,최창본 대구산업정보대학 1995 논문집 Vol.9 No.2

Dae Gon The study was conducted to investigate the effect of breed, sex on fatty acid compostition. Hanwoo and Holstein used, in the study were classified by sex. The results are summarized as follows ; Oleic acid and unsaturated fatty acids(UFA) percentages of total fatty acids in Hanwoo were higher than in Holstein, but palmitic acid and saturated fatty acids(SFA) were lower in Hanwoo. Oleic acid in steers of Hanwoo and Holstein tended to increase compared with bulls. Oleic acid in rib loin and top round were considerably higher in Hanwoo steers than in Holstein steers. In Hanwoosteers, oleic acid and UFA tended to increased while stearic acid and SFA decreased as marbling degree increased.

삼배위 황화합물의 산촉매 가수분해 반응

성대동,이종팔,엄태섭 東亞大學校 大學院 1995 大學院論文集 Vol.20 No.-

The acid catalyzed hydrolysis of N-substituted sulfinamides have been studied in agueous solution of perchloric acid at 25℃ by spectrophotometrically. The pH-rate profile for N-phenylbenzene-sulfinamide(a); N-p-chlorophenybenzenesulfinamide(d), N-phenyl-p-chlorobe enesulfinamide(f) and N-phenyl-o-chlorobenzenesulfinamide (h) shows linearity, while those for N-p-methoxyphenylbenzenesulfin-amide(b), N-p-methylphenylbenzenesulfinamide(c) and N-phenyl-p-ethylbenzenesulfinamide(e) have a break at about pH 3. The break of pH-rate profile is ascribed to a change in the rate-determining step of the reaction involving a hypervalent intermediate.

Drosophila busckii의 韓國集團에서 있어서 同位酵素 多形現象

成耆昌,尙椿植,金彧,金大鎰 성균관대학교 기초과학연구소 1985 論文集 Vol.36 No.1

Genetic structure and variability were investigated in four Korean populations of Drosophila busckii. Eight allozyme loci were analysed by means of starch gel electrophoresis. The proportions of polymorphic loci and loci heterozygous per individual were estimated to be 0.25 and 0.051, respectively. The average genetic similarity between four populations was found to be S―=0.977. This value is similar to the other Drosophila populations reported. However, the gene variation of D. busckii in this study appeared to be the least variable among 28 Drosophila species reported. It is suggested that the low gene variation in D. busckii might be due to adaptation of this species to a narrow niche, but the possibility of occurrence of the random drift cannot be excluded.

Drosophila quinaria Species Group의 遺傳的 近緣關係

成耆昌,金正洙,金大鎰,金彧,金溶聲 성균관대학교 기초과학연구소 1985 論文集 Vol.36 No.2

The genetic relatedness among the Korean Drosophila quinaria species group, including D. nigromaculata, D. unispina, D. brachynephrose, and D. angularis, has been examined by using horizontal starch gel electrophoresis. The results showed that none of the ten isozyme patterns examined for these four species was identical. The average genetic similarity among the four species was found to be 0.440. The similarity among three species. D. unispina, D. brachynephrose, and D. angularis was 0.466. The relatedness was found to be closest between D. nigromaculata and D. unispina, showing 0.640. D. nigromaculata and D. angularis showed relatedness of 0.258. The results suggested that these four species appear to be genetically related at the level of sibling species. The percent polymorphism in D. brachynephrose was found to be 76.9%, showing significant genetic variations.

위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예

김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.

견관절 주위근의 스트레칭후 동통유발점압통역치의 변화

홍대종,최기섭,박시복,이상건 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.6

親核性 置換反應에서 最大速度現象과 Hammett 相關關係

성대동,이종팔,이미정,엄태섭 東亞大學校 大學院 1996 大學院論文集 Vol.21 No.-

The nucleophilic substitution reactions of p-substituted benyl bromide with p-substituted N,N-dimethyl anilines in methanol and acetonitrile binary solvent mixtures which are known as an isodielectric olvent system kinetically and the results are as follows. 1.The postive dharge is developed on the reaction center of the substrate and it means that the bond cleavage is preceded more than bond formation in the transition on the analogy of Hammett ?? values. 2.The bond formation is not progressed in the case of electron donating substituent of substrate. however, the bond formation is much developed in the case of electron withdrawing substituent of substrate on the anlogy of Hammett ?? values. 3.The nucleophilic attacking ability is shown a highest at 80%(V/V) methanol content and the bond formation is well progressed at the same methanol composition on the result of a cross interacton coefficient, ??.