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돼지사료중 제주 화산암 분말(Scoria)과 Zeolite 가 산육능력에 미치는 영향
한인규,양창범,김진동,조원탁,이지훈 한국동물자원과학회 2000 한국축산학회지 Vol.42 No.4
This study was conducted to investigate the effect of Cheju scoria and zeolite on the growth performance, nutrient digestibility and excretion, carcass characteristics of pigs and to evaluate the value of Cheju scoria as a feed additive to reduce environmental pollutions. A total of 63 weaned piglets [D (♂) × LY (♀)] averaging 8.3±0.31 ㎏ of body weight were assigned to the feeding trial for 150 days and 16 growing barrows (averaging 40.5±0.57; four pigs per treatment) to the metabolic trial. The weaned piglets in the feeding trial were divided into three groups and treated in three replicates of seven pigs (4 gilts and 3 barrows) with one of the three experimental diets; con-soybean meal basal (BD), 3% Cheju scoria (CS), and 3% zedite diets (ZD). The based diets were formulated to contain 3,657 kcal DE/㎏ (CP 18.87%), 3,620 kcal DE/㎏ (CP 16.00%) and 3,473 kcal DE/㎏ (CP 15.97%) for starter, grower and finisher, respectively. 3% of com in basal diets was replaced by Cheju scoria or ziolite. All the pigs were slaughtered for carcass analysis at the end of experiment. During nursery period (0 to 39d), average daily gain (ADG) was significantly higher in CS than in BD and ZD (P$lt;0.05), and feed efficiencies in CS and ZD were better than that in BD. For growing period (40 to 109d), ADG and average daily feed intake (ADFI) were significantly higher in CS and ZD than in BD (P$lt;0.05)$gt; but feed efficiencies were not statistically different among treatments. For finishing period (109 to 150d), ADG was significantly higher in CS and ZD than in BD, and ADFI was not affected by the treatments. However, CS showed better feed efficiency than the others (P$lt;0.05). For the entire experimental period (0 to 150d), CS and ZD tended to be higher in ADG and ADFI compared to that of BD, but no significant differences in feed efficiency were observed among treatments. Dry matter (DM), crude protein (CP) and phosphorus (P) digestibilities were significantly higher in CS than that of BD, and there was no difference in nutrient digestibility between ZD and BD. Nitrogen (N) and P excretion were significantly lower in CS than in BD during the nursery period (P$lt;0.05). For the growing period, BD showed significantly lower N and P excretion compared to the control (P$lt;0.05). N excretion was significantly lower in CS and ZD than in BD, and P excretion was lowest in CS for the finishing period. There were no differences in carcass weight and back fat thickness among the treatment. However, carcass grade was much better in CS than in the others. With regard to meat color, Hunter L value was highest in CS, but there were no differences in Hunter a and b value between CS and BD. The results from the present study suggest that Cheju scoria could be a effective feed additive to reduce N and P excretion and to improve growth performance and meat quality of pigs. However, further research is needed to investigate the exact mode of action of Cheju scoria and optimal level of dietary supplementation.
Lee, S.W.,Yun, M.H.,Jeong, S.W.,In, C.H.,Kim, J.Y.,Seo, M.H.,Pai, C.M.,Kim, S.O. Elsevier Science Publishers 2011 Journal of controlled release Vol.155 No.2
Nanoxel-PM(TM), docetaxel-loaded methoxy-poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLLA) micellar formulation was prepared in an effort to develop alternative, less toxic and efficacious Tween 80-free docetaxel formulation, and its pharmacokinetics, efficacy, and toxicity were evaluated in comparison with Taxotere(R) in preclinical studies. The mean diameter of the Nanoxel-PM(TM) was 10-50nm and the polydispersity of samples exhibited a narrow size distribution and monodisperse unimodal pattern. Pharmacokinetic study in mice, rats and beagle dogs revealed that Nanoxel-PM(TM) exhibited similar pharmacokinetic profiles (C<SUB>max</SUB>, AUC, t<SUB>1/2</SUB>, CL, V<SUB>ss</SUB>) to Taxotere, and the relative mean AUC<SUB>t</SUB> and C<SUB>max</SUB> of Nanoxel-PM(TM) to Taxotere(R) were within 80-120%. Furthermore, excretion study in rats demonstrated that there was no statistically significant difference in the amount excreted in feces or urine as an unmetabolized docetaxel between Nanoxel-PM(TM) and Taxotere(R). Its pharmacokinetic bioequivalence resulted in comparable anti-tumor efficacy to Taxotere(R) in human lung cancer xenografts H-460 in nude mice as well as in lung, ovary and breast cancer cell lines. Several animal toxicity studies on Nanoxel-PM(TM) compared with Taxotere(R) were carried out. In single dose rat and dog model and repeated dose mouse model, both Nanoxel-PM(TM) and Taxotere(R) exhibited similar toxic effects on hematology and body weight gain. On the other hand, vehicle related hypersensitivity reactions and fluid retentions were not observed when Nanoxel-PM(TM) was administered, unlike Taxotere(R), in the beagle dog study. Based on these results, it is expected that Nanoxel-PM(TM) can reduce side effects of hypersensitivity reactions and fluid retention while retaining antitumor efficacy in cancer patients. Currently, Nanoxel-PM(TM) is under evaluation for bioequivalence with Taxotere(R) in a multi-center, open-label, randomized, crossover study.
Inés C. Oría,Juan E. Pizzala,Augusto M. Villaverde,Juan C. Spina,Analía V. Pasqua,Julio C. Lazarte,Oscar M. Mazza,Mariano M. Marcolongo 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.2
The pancreatoduodenal groove is a small area where pathologic processes involving the distal bile duct, duodenum, pancreatic head,ampulla of Vater, and retroperitoneum converge. Despite great advances in imaging techniques, a definitive preoperative diagnosis ischallenging because of the complex anatomy of this area. Therefore, surgical intervention is frequently required because of the inabilityto completely exclude malignancy. We report 3 cases of patients with different groove pathologies but similar clinical and imaging presentation, and show the essential roleof endoscopic ultrasound (EUS) in making a specific preoperative diagnosis, excluding malignancy in the first case, changing diagnosisin the second case, and confirming malignancy in the third case. EUS was a fundamental tool in this cohort of patients, not onlybecause of its ability to provide superior visualization of a diffcult anatomical region, but because of the ability to guide precise, realtimeprocedures, such as fine-needle aspiration.
Optimum Lactose: Sucrose Ratio for the Pigs Weaned at 21 Days of Age
Jin, C.F.,Kim, J.H.,Han, In K.,Yeon, J.U. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.2
A total of 240 weaned pigs (BW 5.4 kg) were allotted in a completely randomized block design to find out the optimum lactose : sucrose ratio for the weaned pigs. Treatments were 100:0 (A), 75:25 (B), 50:50 (C), 25:75 (D) and 0:100 (E) in lactose : sucrose ratio. For the first week after weaning, average daily gain (ADG) and feed/gain (F/G) were improved (p < 0.05) for pigs fed A, B and C diets compared to pigs fed diets D and E, but the average daily feed intakes (ADFI) of the pigs were not different. From d 7 to 14, no significant differences was found in ADG and ADFI among the treatments, but pigs fed the diets A, B and C had improved F/G compared with the pigs fed diets D and E (p < 0.05). From d 15 to 21, no significant differences were found in ADG, ADFI and F/G among the treatments. The digestibility of nutrients was not influenced by the lactose : sucrose ratio except nitrogen. Nitrogen digestibility of A diet was significantly higher than D and E diets (p < 0.05) but no significant differences were found among diets A, B and C. Dry matter and phosphorus excretions were not influenced by the treatments. The pigs fed diets A, B and C excreted significantly less nitrogen than the pigs fed diets D and E. In conclusion, the results suggest that sucrose can effectively replace up to 50% lactose in starter diets.
Kim, Cha-Young,Koo, Yoon-Duck,Jin, Jing-Bo,Moon, Byeong-Cheol,Kang, Chang-Ho,Kim, Sun-Tae,Park, Byung-Ouk,Lee, So-Young,Kim, Man-Lyang,Hwang, In-Hwan,Kang, Kyu-Young,Bahk, Jeong-Dong,Lee, Sang-Yeol,,C Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-
ABSTRACT: Hundreds of proteins involved in signaling pathways contain a Ca^(2+)-dependent membrane-binding motif called the C2-domain. However, no small C2-domain proteins consisting of a single C2-domain have been reported in animal cells. We have isolated two cDNA clones, OsERG1a and OsERGIb, that encode two small C2-domain proteins of 156 and 159 amino acids, respectively, from a fungal elicitor-treated rice cDNA library. The clones are believed to have originated from a single gene by alternative splicing. Transcript levels of the OsERG1 gene are dramatically elvated by a fungal elicitor prepared from Magnaporthe grisea or by Ca^(2+) ions. The OsERG1 protein produced in Escherichia coli binds to phospholipid vesicles in a Ca^(2+)-dependent manner and is translocated to the plasma membrane of plant cells by treatment with either a fungal elicitor of a Ca^(2+)-ionophore. These results suggest that OsERG1 proteins containing a single C2-domain are involved in plant defense signaling systems.
溫度 및 生長調節劑 處理가 Dendrobium의 花芽形成과 開花에 미치는 影響
金榮七,印致鍾,鄭載薰,蔡洙天,李春容,李武鉉 公州大學校 産業開發硏究所 1996 産業開發硏究 Vol.4 No.-
According to the effect of temperature on the visible flower bud formation and flowering, they were promoted as ADT decreased: none of four cultivars differentiated flower bud at higher temperature such as 25C and 30C ADT. At 20C, days to flower bud formation in Snowflake 'Red Star', Malones 'Fantasy' and Yukidaruma 'King' was quitely delayed wheres days to flower bud formation at 15C was a little bit more advanced than those at 20C and more advanced in Yukidaruma 'King' and Snowflake 'Red Star' than in Golden Blossom 'Kogane' and Malones 'Fantasy'. On the basis of these results, it was found that flower bud formation of Dendrobium was accomplished by low temperature(below 15C) and the flowering and ripening of stem after occurrence of flag leaf were accelerated by high temperature. In addition, flower bud formation and flowering were markedly stimulated by BA 200ppm application, showing the additive effect with low temperature.
박병권(Byung-Kwon Park),임종환(Jong-Hwan Lim),황윤환(Youn-Hwan Hwang),김명석(Myung-Seok Kim),송인배(In-Bae Song),이홍기(Hong-Gee Lee),한성진(Sung-Jin Han),황미현(Mi-Hyun Hwang),김종우(Jong-Woo Kim),이만휘(Man-Hee Rhee),박승춘(Seong-C 한국독성학회 2006 Toxicological Research Vol.22 No.4
This study was carried out to investigate the acute toxicity of surfactin C in mice. Surfactin C was administered orally at does of 0, 381, 610, 977, 1562 and 2500 ㎎/㎏. Number of deaths, clinical signs, body weights, feed and water consumptions, and biochemical examinations were investigated for 14 days after single oral administration of surfactin C. LD?? value was over 2500 ㎎/㎏ in mice. In addition, no differences were found between control and treated groups in clinical signs, body weight gains, hematology, serum chemistry, feed and water consumptions. The results indicate that surfactin C did not show any toxic effects at 2500 ㎎/㎏ in mice.