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Role of Th2 cytokines on the onset of asthma induced by <i>meta</i>‐xylene in mice
Hong, Seong‐,Gyeol,Hwang, Yun‐,Ho,Mun, Seul‐,Ki,Kim, Su‐,Jin,Jang, Ho‐,Yeol,Kim, Hangun,Paik, Man‐,Jeong,Yee, Sung‐,Tae John Wiley Sons, Inc. 2019 Environmental toxicology Vol.34 No.10
<P><B>Abstract</B></P><P><I>meta</I>‐Xylene (<I>m</I>‐xylene) is one of three isomers of xylene, which is widely used as a solvent and detergent in various industries and medical technology. Exposure to volatile organic compounds, such as <I>m</I>‐xylene, causes pulmonary inflammation and airway inflammation, thereby contributing to the onset of asthma. Exposure to <I>m</I>‐xylene increases acute wheezing and intensity of asthma symptom. However, the mechanism of the onset of asthma by <I>m</I>‐xylene has not been studied yet. C57BL/6 mice were sensitized and challenged by <I>m</I>‐xylene at 100 or 300 mg/kg. The mice were then sacrificed after the last challenge. Exposure to <I>m</I>‐xylene increased the total number of inflammatory cells and the production of interleukin (IL)‐4, IL‐5, IL‐13, and immunoglobulin E related to the Th2 immune response. In contrast, the production of interferon‐γ related to the Th1 immune response was decreased. In addition, the airway resistance increased according to the airway hyper‐responsiveness measurements. Finally, a histological analysis revealed infiltration of inflammatory cells, mucus production, and lung fibrosis. These results suggest that <I>m</I>‐xylene is a potential risk factor for asthma and the onset of asthma is caused by TH2 cytokines.</P>
우리나라 자동차 정비사의 안전사고 개선 방안에 대한 조사연구
조홍성(Hongseong Jo),강호인(Hoin Kang) 한국자동차공학회 2023 한국자동차공학회 부문종합 학술대회 Vol.2023 No.5
This study aims to investigate for preventing safety accidents of automobile mechanics in Korea. With the increasing cars, the role and importance of automobile mechanics are also expanding; however, safety accidents occur due to various factors during working. Therefore, Investigation for preventing safety accidents among automobile mechanics are required. To achieve this, a survey was conducted on automobile mechanics currently employed, covering safety accident experience, types, causes, and improvement measures. The survey showed that some 53.7% of mechanics experienced safety accidents during working, with cutting and puncture being the most common accident types. Furthermore, it was confirmed that most of safety accidents were caused by human factors, and strengthening safety education was suggested as the best solution. Based on this investigation, it is necessary for both individuals and companies to continuously make efforts to prevent safety accidents among automobile mechanics.
모듈 기반 퍼스널 로봇의 결함 허용 지원을 위한 네트워크 연결 유지 관리 기법
최동희(Donghee Choi),박홍성(Hongseong Park) 대한전기학회 2006 정보 및 제어 심포지엄 논문집 Vol.2006 No.1
Middleware offers function that user application program can transmit data independently of network device. Connection management about network connection of module is important for normal service of module base personal robot. Unpredictable network disconnection is influenced to whole robot performance in module base personal robot. For this, Middleware must be offer two important function. The first is function of error detection and reporting about abnormal network disconnection. Therefore, middleware need method for network error detection and module management to consider special quality that each network device has. The second is the function recovering that makes the regular service possible. When the module closed from connection reconnects, as this service reports connection state of the corresponding module, the personal robot resumes the existing service. In this paper proposed method of network connection management for to support fault tolerant about network error of network module based personal robot.
창의적 공학교육을 위한 Chem-E-Car 강의안 개발
김지용(Jiyong Kim),김홍성(Hongseong Kim),임종구(Jongkoo Lim),문일(Il Moon) 한국공학교육학회 2006 공학교육연구 Vol.9 No.3
he engineer s creativity is becoming more important as high value - added products are required . In this paper , a new curriculum model for creative engineering education has been developed . This study proposes the method of applying Chem - E - Car to the chemical engineering education for students to develop creativity . The Chem - E - Car is used as a given problem to students for developing safety study , teamwork , communication skill and creativity . The PBL ( problem based Learning ) is used in the class . The problem in this case is to make the Chem - E - Car , a shoebox sized car powered only by chemical reactions . Four types of Chem - E - Car such as turbine , rocket , voltaic cell and fuel cell are developed through out this program . The fuel cell powered Chem - E - Car is emphasized to students as new problems with constraints . This paper shows how the students solved the problems with creativity . 본 연구에서는 창의적 문제 해결능력 향상에 필요한 기초 이론과 이를 응용하고 실습하기 위한 Chem-E-Car 교육 강의 모델을 개발하였다. 개발된 강의 모델은 창의 설계 및 제어 라는 과목을 통하여 강의되었으며, 구체적 강의 내용은 학생들의 창의력을 향상시키기 위한 TRIZ 강의, Chem-E-Car 제작에 필요한 기초 지식인 공정제어 강의 그리고 실제 Chem-E-Car 제작 및 경연대회 등으로 구성 되었다. 특히 Chem-E-Car제작을 위한 주요 장치인 연료 전지의 유로를 직접 설계 및 공정모사를 수행하였으며, 이를 바탕으로 Chem-E-Car 경연대회를 개최하여 학생들의 창의력 증진을 위한 의욕을 고취시켰다. 또한 Chem-E-Car대회의 수상자는 한국화학공학회에서 개최한 전국 학생 창의설계 경진 대회 에 참가하여 수상하였으며, 이는 한국공학교육인증(ABEEK) 프로그램을 준비하거나 운영하고 있는 여러 대학의 창의설계 과목에 대한 이해를 증진 시켰다. 또한 무공해 연료전지 자동차 개발의 기본 지식을 습득하고, 연료전지에 관한 저변 연구 인력 확보에 기여하였다.