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Standardized Ecklonia Stolonifera Extract attenuates Lipid Accumulation in High-Fat Diet-Fed Mice
Xionggao Han,Sun Il Choi,Xiao Men,Se Jeong Lee,Uhyeok Kim,Heegu Jin,Hyun Ji Oh,Dahye Kang,Hyung Bin Kim,Boo Yong Lee,Ok Hwan Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Obesity develops due to an energy imbalance and manifests as the storage of excess triglyceride (TG) in white adipose tissue (WAT). The purpose of this study was to evaluate the anti-obesity activity of Ecklonia stolonifera extracts test material (ESETM) in obese ICR mice fed with a high-fat diet using obesity-related in vivo experiments. We report that ESETM-treated groups of ICR mice showed reduced body weights and adipose tissue weight with improving plasma lipid profiles in obese ICR mice fed with a high-fat diet. ESETM inhibits body mass gain by regulating the expression of proteins involved in adipogenesis and lipogenesis. In addition, ESETM activates protein kinase A (PKA) and increases the expression of lipolytic enzymes including phosphorylated hormone-sensitive lipase (p-HSL), and monoacylglycerol lipase (MGL), and also thermogenic genes, such as carnitine palmitoyltransferase 1(CPT1), and uncoupling protein 1 (UCP1). These findings indicate that ESETM may represent a promising natural means of preventing obesity and obesity-related metabolic diseases and provide preclinical (animal) data.
Han, Xionggao,Choi, Sun-Il,Choi, Seung-Hyun,Cho, Bong-Yeon,Sim, Wan-Sup,Jang, Gill-Woong,Kwon, Hee-Yeon,Choi, Ye-Eun,Kim, Dan-Bi,Lee, Ok-Hwan The Korean Society of Food and Nutrition 2019 韓國食品營養學會誌 Vol.32 No.4
This study was to investigate the sorbic acid, benzoic acid and sulfur dioxide in commonly consumed beverages, snacks and instant ramens in Korea. A total of 150 food samples including 50 beverages, 50 snacks and 50 instant ramens were examined using the Korea Food Code method. Sorbic and benzoic acid were analyzed by the HPLC method, whereas sulfur dioxide was measured by Monnier-Williams method. Our results indicated that benzoic acid was detected in six beverages samples, and its concentration was in the range of 3.08-11.94 mg/kg. The contents of both sorbic and benzoic acid in 50 beverage samples did not exceed the residue allowance standards set by the Ministry of Food and Drug Safety (MFDS). Sulfur dioxide was detected in 12 beverages samples, but its content was lower than the detection limit specified in the method by the Korea Food Code. On the other hand, sorbic acid was not detected all samples. These results provide a basic data regarding sorbic acid, benzoic acid and sulfur dioxide in commonly consumed beverages, snacks and instant ramens in Korea.
Anti-obesity Activity of Standardized Ecklonia stolonifera Extract in 3T3-L1 Adipocytes
Xionggao Han,Sun Il Choi,Xiao Men,Se Jeong Lee,Uhyeok Kim,Heegu Jin,Hyun Ji Oh,Dahye Kang,Hyung Bin Kim,Boo Yong Lee,Ok Hwan Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The purpose of this study was to evaluate the anti-obesity activity of Ecklonia stolonifera extract test material (ESETM) in 3T3-L1 adipocytes using various obesity-related in vitro experiments. During adipocyte differentiation, ESETM significantly inhibited lipid accumulation and ROS production compared to controls. Effects of ESETM reduces adipogenesis and lipogenesis seemed to be mediated by the inhibition of Peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and other related proteins. In addition, ESETM activates protein kinase A (PKA) and promotes the expression of lipolytic enzymes including, phosphorylated hormone-sensitive lipase (p-HSL), and monoacylglycerol lipase (MGL), and adipose browning proteins, such as carnitine palmitoyltransferase 1 (CPT1), and uncoupling protein 1 (UCP1). These results suggest that ESETM might have an anti-obesity effect on adipogenesis and lipid metabolism. This presents the possibility of developing a treatment for obesity using nontoxic natural resources.
고려엉겅퀴 주정 추출물을 함유하는 임상시험제품의 항비만 활성 평가
조봉연,최선일,최승현,심완섭,Han Xionggao,라문진,김선영,강일준,한경찬,이옥환 한국식품위생안전성학회 2018 한국식품위생안전성학회지 Vol.33 No.5
본 연구는 고려엉겅퀴 주정추출물을 가지고 제작된 임 상시험용제품(CNTM)이 3T3-L1 지방세포 및 고지방식이 로 유도된 비만 쥐에 미치는 항비만 효능 관찰을 통하여 체지방 개선 기능성식품을 개발하기위하여 인체적용시험 시료를 제작한 후, 인체적용시험전에 그 효력이 유지됨을 확인하기위해 수행되었다. 본 연구에 사용된 시료 CNTM 은 80~320 μg/mL 농도에서 세포독성이 관찰되지 않았 며, 지방 축적억제 효능 및 지방세포 분화, 지질대사 관련 유전인자들을 유의적으로 변화시키는 것으로 확인되었다. 또한 동물실험에서 CNTM 처리에 의하여 체중의 감소를 확인하였으며 혈중지질 성분 가운데 HDL-C/TC의 비율은 유의적으로 증가하며 LDL-cholesterol (LDL-C)과 nonesterified fatty acid (NEFA)의 비율은 유의적으로 감소하 여 혈중 유리지방산 농도를 감소시키며 혈중 콜레스테롤 상승을 억제시키고 혈당을 감소시키는 효과가 있는 것으로 평가되었다. 따라서 고려엉겅퀴 주정추출물이 함유된 인체적용시험시료(CNTM)는 체지방 개선에 우수한 효과가 있는 것으로 확인되었다. The purpose of this study was to evaluate anti-obesity activity of Cirsium setidens Nakai test material (CNTM) in 3T3-L1 adipocytes and obese C57BL/6J mice fed with a high-fat diet using various obesity-related in vitro experiments. During adipocyte differentiation, CNTM significantly inhibited lipid accumulation and ROS production compared to controls. To evaluate whether CNTM could exert glycerol release effects on mature 3T3-L1 adipocytes, we treated cells with various concentrations of CNTM for 1 h. Treatment of mature adipocytes with 160-320 μg/mL of CNTM increased the release of glycerol, but not in a significant dose-dependent manner. Anti-adipogenic and anti-lipogenic effects of CNTM seemed to be mediated by the inhibition of PPARγ and C/EBPα. Moreover, CNTM stimulated fatty acid oxidation in an AMPK-dependent manner. CNTM-treated groups of C57BL/6J mice showed reduced body weights and adipose tissue weight with improving serum lipid profiles and adiponectin protein expression in obese C57BL/6J mice fed with a high-fat diet. These results suggest that CNTM might have anti-obesity effect on adipogenesis and lipid metabolism in vitro and in vivo. This presents the possibility of developing a treatment for obesity using nontoxic natural resources.
강원도 10종 산채류의 항산화 및 인지능력개선 효능 평가
한웅호,최선일,김민종,이옥환,Han, Xionggao,Choi, Sun-Il,Kim, Min-Jong,Lee, Ok-Hwan 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.6
The purpose of this study was to investigate effect of methanolic extracts of 10 kinds of wild vegetables cultivated in Gangwon province on antioxidant activity, acetylcholinesterase, and β-secretase inhibitory activities. Results showed that among the wild vegetables, Aralia elata(Miq.) Seem shoot extract exhibited the highest total phenol content (84.65±1.08 mg GAE/g) and total flavonoids content (70.77±0.55 mg RE/g), respectively. The antioxidant activity of wild vegetables extracts was measured by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. Aralia elata(Miq.) Seem shoot extracts had the highest DPPH and ABTS scavenging activity (90.16%, 40.18% at 2 mg/mL). As a result, Aralia elata(Miq.) Seem shoot extract was the most effective in terms of acetylcholinesterase inhibitory activity (35.94% at 1 mg/mL). In the β-secretase activity assay, all 10 kinds wild vegetables extracts showed low inhibitory activity, and Aralia elata(Miq.) Seem shoot extract had highest inhibitory activity among the 10 wild vegetables extracts was 14.99%. Taken together, these results showed that Aralia elata(Miq.) Seem shoot extract has potential cognition improvement impact, suggesting that it may provide an effective strategy for improving cognition.