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Standardized Ecklonia Stolonifera Extract attenuates Lipid Accumulation in High-Fat Diet-Fed Mice
Xionggao Han,Sun Il Choi,Xiao Men,Se Jeong Lee,Uhyeok Kim,Heegu Jin,Hyun Ji Oh,Dahye Kang,Hyung Bin Kim,Boo Yong Lee,Ok Hwan Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Obesity develops due to an energy imbalance and manifests as the storage of excess triglyceride (TG) in white adipose tissue (WAT). The purpose of this study was to evaluate the anti-obesity activity of Ecklonia stolonifera extracts test material (ESETM) in obese ICR mice fed with a high-fat diet using obesity-related in vivo experiments. We report that ESETM-treated groups of ICR mice showed reduced body weights and adipose tissue weight with improving plasma lipid profiles in obese ICR mice fed with a high-fat diet. ESETM inhibits body mass gain by regulating the expression of proteins involved in adipogenesis and lipogenesis. In addition, ESETM activates protein kinase A (PKA) and increases the expression of lipolytic enzymes including phosphorylated hormone-sensitive lipase (p-HSL), and monoacylglycerol lipase (MGL), and also thermogenic genes, such as carnitine palmitoyltransferase 1(CPT1), and uncoupling protein 1 (UCP1). These findings indicate that ESETM may represent a promising natural means of preventing obesity and obesity-related metabolic diseases and provide preclinical (animal) data.
Anti-obesity Activity of Standardized Ecklonia stolonifera Extract in 3T3-L1 Adipocytes
Xionggao Han,Sun Il Choi,Xiao Men,Se Jeong Lee,Uhyeok Kim,Heegu Jin,Hyun Ji Oh,Dahye Kang,Hyung Bin Kim,Boo Yong Lee,Ok Hwan Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The purpose of this study was to evaluate the anti-obesity activity of Ecklonia stolonifera extract test material (ESETM) in 3T3-L1 adipocytes using various obesity-related in vitro experiments. During adipocyte differentiation, ESETM significantly inhibited lipid accumulation and ROS production compared to controls. Effects of ESETM reduces adipogenesis and lipogenesis seemed to be mediated by the inhibition of Peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and other related proteins. In addition, ESETM activates protein kinase A (PKA) and promotes the expression of lipolytic enzymes including, phosphorylated hormone-sensitive lipase (p-HSL), and monoacylglycerol lipase (MGL), and adipose browning proteins, such as carnitine palmitoyltransferase 1 (CPT1), and uncoupling protein 1 (UCP1). These results suggest that ESETM might have an anti-obesity effect on adipogenesis and lipid metabolism. This presents the possibility of developing a treatment for obesity using nontoxic natural resources.