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      • KCI등재후보
      • KCI등재

        세균독소로 자극시킨 사람 섬유아 세포에서의 Interleukin-6와 Interleukin-8의 생성

        정인교,양동규,홍시영,이성근,김욱규,김광혁,김종렬 大韓顎顔面成形再建外科學會 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.4

        Cytokines are hormone-like proteins which mediate and regulate inflammatory and immune responses. Interleukin-6 (IL-6) is involved in the final differentiation of B cells into antibody-producing cells. Interleukin-8 (IL-8) is a neutrophil chemotactic factor that plays an important role in the recruitment of neutrophil to inflammatory loci. Inflammatory mediators by cells in the gingiva have been implicated in the initiation and progression of periodontitis and oral infection. The purpose of this study was conducted to investigate the effect of lipopolysaccharide (LPS), staphylococcus enterotoxin B (SEB) on production ofIL-6 and IL-8 by human gingival and facial dermal fibroblasts. Primary cultured human gingival and facial dermal fibroblasts were incubated with LPS(0.01, 0.1, 1.0㎍/ml), SEB (0.01, 0.1, 1.0㎍/ml) or LPS (0.1㎍/ml) plus SEB (0.1㎍/ml). Culture supernatants were collected at 24, 48, and 72 hrs and assessed for IL-6 and IL-8 production by enzyme-linked immunosorbent assay. IL-6 production in gingival fibroblasts stimulated with LPS was higher than that with SEB. IL-6 production by double exposure with LPS plus SEB was amplified in comparison with single exposure of LPS or SEB. IL-6 production in facial demal fibroblasts was increased only by stimulation with a high concertration of LPS (1.0㎍/ml). Its production in facial dermal fibroblasts by exposure with SEB was decreased in comparison with control, nontreated cells. Therefore, gingival fibroblasts showed higher sensitivity than facial dermal fibroblasts in response to low concentration of LPS. Also, IL-6 production by double exposure with LPS plus SEB was amplified in comparison with single exposure of LPS or SEB.IL-6 production in facial dermal fibroblasts was increased only by stimulation with a high concentration of LPS(1.0㎍/ml). Its production in facial dermal fibroblasts by exposure with SEB was decreased in comparison with control, nontreated cells. Therefore, gingival fibroblasts showed higher sensitvity than facial dermal fibroblasts in response to low concentration of LPS. Also, IL-6 production by double exposure with LPS plus SEB was amplified in comparison with single exposure of LPS or SEB. IL-8 production in gingival fibroblasts was enhanced greatly only by stimulation of high concentration of LPS (1.0㎍/ml). That by exposure with SEB was increased only in 24 hrs cultivation. IL-8 production by double exposure with LPS plus SEB was amplified in comparison with single exposure of LPS or SEB. IL-8 production in facial dermal fibroblasts was decreased by LPS and increased only in 48 hrs cultivation by SEB. IL-8 production by double exposure with LPS plus SEB was enhanced only in 48 hrs cultivation in comparison with single exposure of LPS or SEB. therefore, IL-6 and IL-8 production were released at various quantities according to bacterial toxin applied and site of fibroblast harvested. These results suggest that gingival fibroblasts may be concerned with IL-6 and IL-8 related inflammatory response more than facial dermal fibroblasts.

      • 획을 이용한 소형 전자기기용 한글 입력 시스템

        정영준,엄종진,박민현,한욱표 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

        With advance of cellular phone technologies, the use of short message transmission with small or portable electronic devices has been explosively increasing. In spite of such demands there have been not many studies for Korean characters and their symbol combinations (below "Hangul"). While some other studies have been focused on the Hangul vowel, in this paper we proposed a new Hangul input system which presents Hangul consonants with basic symbol components (called as "hweok"). And we have performed performance evaluation with comparison to SK's Chunjiin and LG's Naragul in terms of the number of key buttons, finger moving distance and key strokes. The proposed system can make all of Korean characters with 5 or 6 Hangul hweoks without significant degradation of system performance.

      • KCI등재후보

        위험평가(Risk Assessment)에 의한 업종별 위험(Risk)의 구분

        박동욱,박덕묵,정광수,윤충식,김태형,노영만,이경남,이송권,김현욱 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

        A total of 514 workplaces in 17 industries were inbestigated through walk-through survey. These industries were all small companies with less than five workers and didn't have work environmental measurement data. These industries were ranked by risk that was evaluated by combination of toxicity and possibility of exposure to chemical hazardous agents produced at operations of industry. Risk Index(RI) was qualitatively combined by the combination between hazard and potential of exposure to chemical hazardous agents. Industries that were regarded as having the highest risk were wood and products of wood, chemicals and chemical products, basic metals, other vehicles, trailers and semi-trailers, and fumiture manufacturing. These industries were found to have operations with higher risk than other industries. This study found that more attentions should be paid to these industries with that more attentions should be paid to these industries with high risk.

      • 보건관리 대행사업 평가도구의 타당성, 신뢰도 및 인과관계 검증에 관한 연구

        박정일,조병희,구정완,김광종,김현욱,원종욱,이명숙,정문희 가톨릭대학교 산업의학센터 2001 韓國의 産業醫學 Vol.40 No.1

        In order to verify the validity, reliability and relativeness of preliminary evaluation tool for the group occupational health services(GOHS), a questionnaire survey for doctors, nurses and hygienists of 18 GOSH institutions, and employers, health managers and employees of 340 enterprises was conducted. A factor analysis and correlation test for the statistical validity of the variables in the evaluation tool, a Chronbach's Alpha value for the reliability in the evaluation indices and a regression analysis for the relations of the evaluation model were performed. The results were as follows: 1.In factor analysis, thirty-three variables among 43 variables were selected as significant variables, ie 9 out of 11 for input index, 11 out of 14 for throughout index and 13 out of 18 for out put index. 2.Three evaluation(outcome) scales(evaluation by employer, health manager and employee) which composed of 16 identical items were used. 3.The Chronbach's Alpha values of input, throughout, out put and outcome indices were 0.5221, 0.5473, 0.7122 and 0.8546 respectively. 4.Regression equations of independent variables on the evaluation scales of employer, health manager and employee were all statistically significant.

      • 구강내 악성흑색종에 대한 임상연구

        김욱규,허진호,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

        The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark’s and Breslow’s classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to anlalyze key determinants of outcome, We reported on 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital recently and reviewed the literature. Immunohistochemical study on S100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be supporting therapy.

      • 早漏의 外治法에 對한 文獻的 考察

        朴贊旭,趙忠植,金哲中 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1

        According to the literatual study on the external treatment of premature ejaculation, the results were as follows. 1.Linition is inunction glans penis after infiltrate ASARI HERBA CUM RADICE(細辛), CARYOPHYLLI FLOS(丁香), CHEBULAE FRUCTUS(詞子), PAPAVERIS FRUCTUS(??栗??), FOSSILIA OSSIS MASTODI(龍骨), OSTREAE CONCHA(牡리) in oenostagma. 2.Retrojection or hypoatmism method is boiling CHINENSIS GALLA(五倍子), CNIDII FRUCTUS(蛇床子) and hypoatmism, down temperature infiltrate glans penis. 3.Mesompharion apposition method is calorization VESPAE NIDUS(露蜂房), ANGELICAE DAHARICAE RADIX(白芝), and utilization vineger apposite mesompharion. 4.Medicament belt method is belt on lumbus and bythus by ROSAE LAEVIGATAE FRUCTUS(金櫻子), EURYALES SEMEN(검實), OSTREAE CONCHA(牡리), TRIBULI FRUCTUS(白후蒙), AIPINIAE OXYPHYLLAE FRUCTUS(益智人), NELUMBINIS SEMEN(蓮子肉) powders. 5.Enema is injection in the rectum ANGELICAE GIGANTIS RADIX(當歸) effusion. 6.Much utilization agent are ASARI HERBA CUM RADICE(細腎), CHINENSIS GALLA(五倍子), OSTREAE CONCHA(모牡), CNIDII FRUCTUS(蛇床子), GRANATI PERICARPIUM(석류피), CARIYOPHYLLI FLOS(丁香), CHEBULAE FRUCTUS(詞子), FOSSILIA OSSIS MASTODI(龍骨), VESPAE NIDUS(露蜂房), PAPAVERIS FRUCTUS(罌粟殼) etc. They are occupied in adstringentia, juventia, divergence agent, liver stabilizer agent.

      • 무선 센서 네트워크를 위한 에너지 인식 하이브리드 클러스터링

        한욱표,김승남,이제현,정영준 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

        Many studies for the efficient utilization of node energy in wireless sensor networks has been done because sensor nodes operate with limited power based on battery. Existing cluster structure has problem that energy consumption is unbalanced because energy consumption is concentrated in cluster head. And in case distribution density of sensor node is low, the energy efficiency is declined because only a few members exist in cluster. In this paper, we submit an hybrid clustering mechanism to construct topology by mixing cluster structure and mesh structure selectively according to distribution of sensor nodes to improve energy efficiency. And we attempt to derive balanced energy consumption by selecting cluster head considering residual energy of each node. The performance of the proposed mechanism has been examined and evaluated with the NS-2 simulator in terms of network lifetime and end-to-end delay.

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